National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m020047

Testing Status of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) - M020047

 

CASRN: 21850-44-2

Formula: C21-H20-Br8-O2

Synonyms/Common Names

  • Benzene, 1,1'-(1-methylethylidene)bis(3,5-dibromo-4-(2,3-dibromopropoxy)-(9CI)
  • Flame Retardant 2
  • Propane,2,2-bis[3,5-dibromo-4-(2,3-dibromopropoxy)phenyl]-8CI
  • TBBPA-DBPE

Known Uses

Additive flame retardant in polyolefins

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Planned Carcinogenicity/Toxicity

  • 14-Day (Gavage)  (C02047B)   
    • Rats: Harlan Sprague-Dawley

Short-Term Toxicity

  • 13 weeks (Gavage)  (C20321)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R: 0, 62.5, 125, 250, 500, or 1000 mg/kg; 20/sex/dose M: 0, 125, 250, 500, 1000, or 2000 mg/kg; 10/sex/dose.

Special Studies

  • Metabolism (in-vitro)  (S0899)  Completed 
    • Citation: Chemical Disposition in Mammals Brominated Flame Retardants Tetrabromobisphenol A bis [2,3-Dibromopropyl Ether] (TBBPA-DBPE). Final Chemical Report
    • Citation: Knudsen GA, Jacobs LM, Kuester RK, Sipes IG. Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2,3-dibromopropyl ether] in male Fischer-344 rats. Toxicology. 2007 Jul 31;237(1-3):158-67. Epub 2007 May 13. Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Micronucleus  (A90104)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A44427)  Completed 
    •  Negative 

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T02047)  Assigned 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
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