Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) M020047

 

CASRN: 21850-44-2

Formula: C21-H20-Br8-O2

Synonyms/Common Names

  • Benzene, 1,1'-(1-methylethylidene)bis(3,5-dibromo-4-(2,3-dibromopropoxy)-(9CI)
  • Flame Retardant 2
  • Propane,2,2-bis[3,5-dibromo-4-(2,3-dibromopropoxy)phenyl]-8CI
  • TBBPA-DBPE

Known Uses

Additive flame retardant in polyolefins

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C02047B)  Data in Review 
    • Rats: Harlan Sprague-Dawley
  • 13 weeks (Gavage)  (C20321)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R: 0, 62.5, 125, 250, 500, or 1000 mg/kg; 20/sex/dose M: 0, 125, 250, 500, 1000, or 2000 mg/kg; 10/sex/dose.

Special Studies

  • Metabolism (in-vitro)  (S0899)  Completed 
    • Citation: Chemical Disposition in Mammals Brominated Flame Retardants Tetrabromobisphenol A bis [2,3-Dibromopropyl Ether] (TBBPA-DBPE). Final Chemical Report
    • Citation: Knudsen GA, Jacobs LM, Kuester RK, Sipes IG. Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2,3-dibromopropyl ether] in male Fischer-344 rats. Toxicology. 2007 Jul 31;237(1-3):158-67. Epub 2007 May 13. Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 20 mg/kg.

Genetic Toxicology

  • Comet Assay Selected (G02047)  
    • Micronucleus  (A90104)  Completed 
      • Mice: B6C3F1
      • Male Negative 
      • Female Negative 
    • Salmonella  (A44427)  Completed 
      •  Negative 

    Toxicogenomics

    • 5 days Microarray Analysis (Gavage)  (T02047)  Data in Review 
      • Rats: Hsd:Sprague Dawley SD
      • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.