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Testing Status of Toxic equivalency factor evaluation (PCB 118) M030022

 

CASRN: 31508-00-6

Formula: C12-H5-Cl5

Synonyms/Common Names

  • PCB-118 (Toxic equivalency factor evaluation)
  • Toxic equivalency factor evaluation (PCB 118)
  • Toxic equivalency factor evaluation (2,3',4,4',5-Pentachlorobiphenyl)

Known Uses

Polychlorinated biphenyls (PCBs) and their mixtures including 2,3',4,4',5-pentachlorobiphenyl (PCB 118) were produced commercially before 1977 for the electric industry as dielectric insulating fluids for transformers and capacitors. One of 2 dioxin-like being tested to determine if the toxic equivalency factors (TEFs) for these chemicals would be predictive of rodent carcinogenicity.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20304)  Completed 
    • TR-559 (NIH Number: 11-5900)  (Peer Review Approval 02/25/2009A )
      Toxicology and Carcinogenesis Studies of TEF evaluation (PCB 118) (CASRN 31508-00-6) in Harlan Sprague-Dawley Rats (Gavage Studies)
    • Rats: Harlan Sprague-Dawley
    • Carcinogenesis Results
      • Female Rats Clear Evidence 
    • Dose: 50 FEMALE RATS: 0, 100, 220, 460, 1000, 4600 UG/KG AND 4600 UG/KG (STOP EXPOSURE).