National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m030031

Testing Status of PCN 66/67 comparison study - M030031

 

CASRN: PCNCOMPARISN

Related: TOXIC EQUIVALENCY FACTOR

Secondary:

  • 103426-96-6 - 1,2,3,4,6,7-Hexachloronaphthalene (PCN 66)
  • 103426-97-7 - 1,2,3,5,6,7-Hexachloronaphthalene (PCN 67)
  • 1746-01-6 - Toxic equivalency factor evaluation (TCDD)
  • 1746-01-6 - TEF transgenics (TCDD)
  • 1746-01-6 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • 1746-01-6 - Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin)

Known Uses

Used in industry as dielectric fluids in capacitors, transformers, and cables. The purpose of these studies is to determine relative potency values for PCN 66 and PCN 67 based on various toxic and biochemical endpoints and to determine the half-life of PCN 66 and PCN 67.

Short-Term Toxicity

  • 2 weeks (Gavage)  (C20306)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: Female rats only: PCN 66 and PCN 67: 0, 500, 1500, 5000, 50000, or 500000 ng/kg (5/group); TCDD: 1, 3, 10, 100, or 300 ng/kg (5/group).
  • 13 weeks (Gavage)  (C20306)  Completed 
    • Rats: F344/N; Rats: Harlan Sprague-Dawley; Rats: Sprague Dawley
    • Dose: Females only: PCN 66 and PCN 67: 0, 1000, 10000, 50000, 100000, or 200000 ng/kg; TCDD: 0, 10, 50, 100, or 200 ng/kg.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.