National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m030032

Testing Status of Vincamine - M030032

 

CASRN: 1617-90-9

Formula: C21-H26-N2-O3

Synonyms/Common Names

  • 14,15-Dihydro-14-hydroxy-,methyl ester, (3 alpha, 14 beta, 16 alpha) - 9CI
  • Eburnameinie-14-carboxylic acid

Known Uses

Dietary supplement used to support cerebral metabolism and cognitive function and to enhance memory and concentration. Applications also include the treatment of tinnitus and hypertension.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14 days (Gavage)  (C20610)  Completed 
    • 14-Day Range Finding Study
    • Mice: B6C3F1
    • Dose: 14-Day RF = Male and female mice: 0, 62.5, 125, 250, 500, or 1000 mg/kg.
  • 2 weeks (Gavage)  (C20610)  Completed 
    • Pilot Perinatal Study
    • Rats: Harlan Sprague-Dawley
    • Dose: Pilot Perinatal = Female rats and pups: 0, 10, 30, 100, or 300 mg/kg.
  • Range finding (Gavage)  (C20610)  Completed 
    • Perinatal Range Finding Study
    • Rats: Harlan Sprague-Dawley
    • Dose: Perinatal RF = Female rats: 0, 10, 30, 100, 300, or 1, 000 mg/kg.

Genetic Toxicology

  • Salmonella  (A62042)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.