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Testing Status of Sodium Tungstate Dihydrate M030038


CASRN: 10213-10-2

Formula: O4-W.2Na.2H2-O

Synonyms/Common Names

  • Sodium tungstate dihydrate
  • Tungstic acid, sodium salt, dihydrate

Known Uses

Not found ; Fireproofing and waterproofing fabrics; preparing complex compds such as phosphotungstate and silicotungstate; as a protective colloid in biological development methods; precipitant for alkaloids; catalyst in oxidation reactions; corrosion inhibitor for steel

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C03038)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000, or 2000 mg/L; 10/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C03038)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 0, 250, 500, or 1000 mg/L; M: 0, 500, 1000, or 2000 mg/L; 50/sex/species/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Water; Gavage)  (S0865)  Completed 
    • Citation: Disposition of Sodium Tungstate in Female Rats and Mice After Oral, Intravenous, and Drinking Water Administration. Final Project Report No. 2. Period Covered: March 2004 to November 2007. December 30, 2008.
    • Citation: McDonald JD, Weber WM, Marr R, Kracko D, Khain H, Arimoto R. Disposition and clearance of tungsten after single-dose oral and intravenous exposure in rodents. J Toxicol Environ Health A. 2007 May 15;70(10):829-36.Pubmed Abstract
    • Citation: Weber WM, Marr R, Kracko D, Gao Z, McDonald, JD. Disposition of tungsten in rodents after repeat oral and drinking water exposures. Toxicol. Environ. Chem. 2008 May-June;90(3):445-55
    • Female Rats: F344/N; Female Mice: B6C3F1; Female Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0, 1, 10, 100 mg/kg gavage ; 560 mg/l drinking water.

Genetic Toxicology

  • Comet Assay  (G03038E)  Completed 
    • Mice
  • Comet Assay  (G03038F)  Completed 
    • Rats
  • Micronucleus  (G03038B)  Completed 
    • MM: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G03038C)  Completed 
    • RR: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (G03038D)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (I03038)  Data in Review 
    • Citation: Frawley RP, Smith MJ, White KL, Jr., Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR. Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water. J Immunotoxicol. 2016;13(5):666-675
    • Female Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000 or 2000 mg/L.