National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m030038

Testing Status of Sodium Tungstate Dihydrate - M030038

 

CASRN: 10213-10-2

Formula: O4-W.2Na.2H2-O

Synonyms/Common Names

  • Sodium tungstate dihydrate
  • Tungstic acid, sodium salt, dihydrate

Known Uses

Not found ; Fireproofing and waterproofing fabrics; preparing complex compds such as phosphotungstate and silicotungstate; as a protective colloid in biological development methods; precipitant for alkaloids; catalyst in oxidation reactions; corrosion inhibitor for steel

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C03038)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000, or 2000 mg/L; 10/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C03038)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 0, 250, 500, or 1000 mg/L; M: 0, 500, 1000, or 2000 mg/L; 50/sex/species/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Water; Gavage)  (S0865)  Completed 
    • Citation: Disposition of Sodium Tungstate in Female Rats and Mice After Oral, Intravenous, and Drinking Water Administration. Final Project Report No. 2. Period Covered: March 2004 to November 2007. December 30, 2008.
    • Citation: McDonald JD, Weber WM, Marr R, Kracko D, Khain H, Arimoto R. Disposition and clearance of tungsten after single-dose oral and intravenous exposure in rodents. J Toxicol Environ Health A. 2007 May 15;70(10):829-36.Pubmed Abstract
    • Citation: Weber WM, Marr R, Kracko D, Gao Z, McDonald, JD. Disposition of tungsten in rodents after repeat oral and drinking water exposures. Toxicol. Environ. Chem. 2008 May-June;90(3):445-55
    • Female Rats: F344/N; Female Mice: B6C3F1; Female Rats: F344/N; Female Mice: B6C3F1

Genetic Toxicology

  • Comet Assay  (G03038E)  Completed 
    • Mice
  • Comet Assay  (G03038F)  Completed 
    • Rats
  • Micronucleus  (G03038B)  Completed 
    • MM: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G03038C)  Completed 
    • RR: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (G03038D)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (I03038)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000 or 2000 mg/L.
  • Continuous Breeding Selected (R03038)  
    • Male and Female Rats: Harlan Sprague-Dawley
  • Conventional Teratology Selected (R03038B)  
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