National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m030039

Testing Status of Triclosan - M030039

 

CASRN: 3380-34-5

Synonyms/Common Names

  • 2,4,4-Trichloro-2-hydroxydiphenyl ether

Known Uses

A diphenyl either derivative used in cosmetics and soaps as an antiseptic.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C03039C)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 7.8, 15.6, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4.
  • 4 days (Gavage)  (C03039)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 1000 mg/kg/day.
  • 90 days (Dermal)  (C03039B)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 5.8, 12.5, 27, 58, or 125 mg/kg/bw/day; 10 M/ 10 F per dose.

Long-Term Carcinogenicity

  • 2 years (Dermal)  (C03039B)  Histopath in progress 
    • Mice: B6C3F1
    • Dose: 0, 1.25, 2.7, 5.8, or 12.5 mg/kg.

Modified One-Generation

  • Dose Range Finding (Gavage)  (MOG03039)  On Test 
    • Perinatal
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 100, 250, 500, 1000, or 2000 mg/kg/day.

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (K03039B)  Completed 
    • Male Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: 10 and 100 mg/kg bwt.
  • Toxicokinetic Study (Topical Application)  (K03039)  Completed 
    • Male Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: 10 or 100 mg/kg bwt/day.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T03039B)  Assigned 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
  • 4 days Microarray Analysis (Gavage)  (T03039)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: 1000 mg/kg; 6 rats.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.