Testing Status of Triclosan M030039

 

CASRN: 3380-34-5

Synonyms/Common Names

  • 2,4,4-Trichloro-2-hydroxydiphenyl ether

Known Uses

A diphenyl either derivative used in cosmetics and soaps as an antiseptic.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 days (Gavage)  (C03039)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 1000 mg/kg/day.

Modified One-Generation

  • Dose Range Finding (Gavage)  (MOG03039)  On Test 
    • Perinatal
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 100, 250, 500, 1000, or 2000 mg/kg/day.

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (K03039B)  Completed 
    • Male Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: 10 and 100 mg/kg bwt.
  • Toxicokinetic Study (Topical Application)  (K03039)  Completed 
    • Male Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: 10 or 100 mg/kg bwt/day.

Genetic Toxicology

  • (G03039B)  On Test 
    • Micronucleus  (G03039)  On Test 
      • Female Rats
      • Rats: Sprague Dawley

    Toxicogenomics

    • 5 days Transcriptome Sequencing (Gavage)  (T03039B)  Assigned 
      • 5-Day Transcriptomic Dose-Response Studies
      • Rats: Harlan Sprague-Dawley
    • 4 days Microarray Analysis (Gavage)  (T03039)  Completed 
      • Liver Targeted Testing study of Toxcast Chemicals
      • Rats: Harlan Sprague-Dawley
      • Dose: 1000 mg/kg; 6 rats.