National Toxicology Program

National Toxicology Program

Testing Status of Perfluorooctane Sulfonate - M040004


CASRN: 1763-23-1

Formula: C8-H-F17-O3-S

Synonyms/Common Names

  • C8 Sulfonate
  • Heptadecafluorooctane-1-sulphonic acid
  • 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro
  • Perfluorooctane sulfonic acid
  • PFOS

Known Uses

Surface-active agents in aqueous media. Chemical intermediate; acid catalyst for photoresists surfactant in fire fighting foam; surfactant for alkaline cleaners; emulsifier in floor polish; mist suppressant for metal plating baths; surfactant for etching acids for circuit boards; pesticide active ingredient for ant bait traps.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 28 days (Gavage)  (C20617)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley
    • Dose: M&F: 0, 0.312, 0.625, 1.25, 2.5, or 5 mg/kg.

Modified One-Generation

  • Dose Range Finding (Gavage)  (MOG04004)  Completed 
    • Dose Range finding
    • Rats: Harlan Sprague-Dawley

Genetic Toxicology

  • Micronucleus  (G04004)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Positive 
  • Salmonella  (A33826)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 6 GD to PND 21 Conventional Teratology (Gavage) Selected (R04046)  
    • Rats: Sprague Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.