National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m040006

Testing Status of Perfluorobutane sulfonate (PFBS) - M040006

 

CASRN: 375-73-5

Formula: C4-H-F9-O3-S

Synonyms/Common Names

  • 1-Butanesulfonic Acid, nonafluoro-
  • 1-Butanesulfonic acid, 1,1,2,2,3,3,4,4,4-nonafluoro-
  • C4 Sulfonate
  • 1-Perfluorobutanesulfonic acid

Known Uses

Used as surfactants, to make fluoropolymers and as water and stain protective coatings for carpets, paper and textiles

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 28 days (Gavage)  (C07040)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley
    • Dose: M&F: 0, 31.3, 62.5, 125, 250, or 500 mg/kg/2x day.

Genetic Toxicology

  • Micronucleus  (G04006)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (A32037)  Completed 
    •  Equivocal 

Organ Systems Toxicity

  • 6 GD to PND 21 Conventional Teratology (Gavage) Selected (R07040)  
    • Rats: Sprague Dawley
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