National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m040024

Testing Status of Ephedrine + caffeine combination - M040024

 

CASRN: EPHEDCOMBO

Secondary:

  • 58-08-2 - Caffeine
  • 299-42-3 - L-Ephedrine

Known Uses

Combination of ephedrine-L and caffeine. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Short-Term Toxicity

  • 10 days (Gavage)  (C04024B)  Completed 
    • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
    • Dose: Study A (beginning on 6/2/10): 0, 12.5/30, 23/30, 50/30, 100/30, 200/30 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 50/30, 100/30, 200/30 mg/kg.
  • 3 days (Gavage)  (C04024B)  Completed 
    • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
    • Dose: Study A (beginning on 6/2/10): 0, 12.5/30, 23/30, 50/30, 100/30, 200/30 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 50/30, 100/30, 200/30 mg/kg. Study A (beginning on 6/2/10): 0, 12.5/30, 23/30, 50/30, 100/30, 200/30 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 50/30, 100/30, 200/30 mg/kg.
  • 3 days (Gavage)  (C04024)  Completed 
    • Mice: B6C3F1
    • Dose: MM: 0, 12.5/30, 25/30, 50/15, 50/30, or 75/30 mg/kg.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0976)  Completed 
    • Citation: Ephedrine+Ma Huang+ Caffeine Toxicokinetic Study Pharmacokinetics of Ephedring (EPH) following Intravenous or Oral Administration alone, in Combination with Caffeine or in MA Huang to Male Fischer 344 Rats. August 15, 2013.
    • Male Rats: Wistar Han
    • Dose: Ephedrine 6.25, 12.5, and 25 mg/kg/day. Ephedrine + Caffeine: 12.5 and 30 mg/kg. Ma Huang: 625 mg/kg. Ephedrine only at 6.25 mg/kg for IV study.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.