National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m040049

Testing Status of Perfluorononanoic Acid - M040049

 

CASRN: 375-95-1

Formula: C9-H-F17-O2

Synonyms/Common Names

  • C9 Carboxylic acid
  • Nonanoic acid, heptadecafluoro-
  • PFNA

Known Uses

Breakdown product of stain- and grease-proof coatings on food packaging, couches, carpets. A 9-carbon version of PFOA; persistent; bioaccumulative.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 28 days (Gavage)  (C04049)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley
    • Dose: Males: 0, 0.625, 1.25, 2.5, 5, or 10 mg/kg; Females: 0, 1.56, 3.12, 6.25, 12.5, or 25 mg/kg.

Genetic Toxicology

  • Micronucleus  (G04049)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (A59563)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to PND 21 Developmental Toxicity (Gavage) Selected (R04049)  
    • Rats: Harlan Sprague-Dawley
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