National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m040057

Testing Status of Toluenes (2,4-diaminotoluene, p-nitrotoluene, 4-chloro-o-phenylenediamine) - M040057

 

CASRN: TOLUENES

Known Uses

Intermediate for polyurethanes and dyes; in hair dyes (formerly), Synthesis of intermediates and explosives, stilbene and fuchsin dyes, OXIDATION BASE; CHEMICAL INTERMEDIATE FOR CI VAT BROWN 22 & 5-CHLOROBENZOTRIAZOLE; INGREDIENT IN HAIR DYES; CURING AGENT FOR EPOXY RESINS; REAGENT IN GAS CHROMATOGRAPHIC ANALYSES

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM86001)  Completed 
    • Female Mice: B6C3F1
    • Dose: 150 MG/KG (2-4-DIAMINOTOLUENE),400 MG/KG (P-NITROTOLUENE), 200 MG/KG (4-CHLOROTOLUENE).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.