Testing Status of Metal Working Fluids: TRIM® VX M040093

 

CASRN: TRIMVX

Synonyms/Common Names

  • TRIM VX
  • TRIM® VX (metal working fluids)

Known Uses

Soluble oil; metalworking fluid

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C20523)  Completed 
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; 5/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20523)  Completed 
    • TR-591 (NIH Number: 17-5943)  (Peer Review Approval 02/16/2016A )
      Toxicology and Carcinogenesis Studies of Trim® VX (CASRN TRIMVX) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: Wistar Han; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (G04093B)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G04093)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A94339)  Completed 
    •  Negative