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Testing Status of Metal Working Fluids: CIMSTAR 3800 M040094

 

CASRN: CIMSTAR3800

Synonyms/Common Names

  • Cimstar 3800 (metal working fluids)

Known Uses

Semisynthetic; metalworking fluid

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C20515)  Completed 
    • Citation: Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. 2016 Jun
    • Rats: F344/NTac; Mice: B6C3F1/N
    • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; R: 20/sex/dose; M: 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20515)  Completed 
    •   (Peer Review Approval 05/22/2014A ) Citation: Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. 2016 Jun
    • TR-586 (NIH Number: 15-5928)  (Peer Review Approval 05/22/2014A )
      Toxicology and Carcinogenesis Studies of CIMSTAR® 3800 (CASRN CIMSTAR3800) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: Wistar Han; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (A06575)  On Test 
    • Micronucleus  (A64536)  On Test 
      • Micronucleus  (F06575)  Completed 
        • Mice: B6C3F1
        • Male Negative 
        • Female Negative 
      • Micronucleus  (F64536)  Completed 
        • Rats: F344/NTac
        • Male Negative 
        • Female Negative 
      • Salmonella  (A69652)  Completed 
        •  Weakly Positive