National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m050016

Testing Status of Garcinia Cambogia Extract - M050016

 

CASRN: 90045-23-1

Formula: n/a

Synonyms/Common Names

  • Brindal berry
  • Gamboge
  • GCE

Known Uses

Dietary Supplement; Garcinia cambogia extract, used alone or in combination with other ingredients, is marketed as a dietary aid that suppresses the appetite, inhibits the synthesis of lipids, and burns fat via thermogenesis

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14 days (Dosed-Feed)  (C20611)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R&M: 0, 1000, 3000, 10000, 30000 or 50000 ppm; 10/sex/species/dose.

Modified One-Generation

  • Dose Range Finding Selected (MOG05016)  
    • Developmental Toxicity Selected (MOG05016B)  
      • Rats: Harlan Sprague-Dawley
    • F0 Generation Selected (MOG05016B)  
      • Rats: Harlan Sprague-Dawley
    • Fertility Assessment Selected (MOG05016B)  
      • Rats: Harlan Sprague-Dawley
    • Maternal Transfer Selected (MOG05016B)  
      • Rats: Harlan Sprague-Dawley
    • 13-Week Subchronic Selected (MOG05016B)  
      • Rats: Harlan Sprague-Dawley

    Genetic Toxicology

    • Salmonella  (G05016)  Completed 
      •  Negative 

    Organ Systems Toxicity

    • in utero Teratology Pilot Studies (Dosed-Feed) Selected (R05016)  
      NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.