Testing Status of Toxicogenomics study of allylbenzene & propenylbenzene class flavor constituents (TGMX) M050029

 

CASRN: TGMXFLAVCLAS

Secondary:

  • 104-46-1 - Anethole
  • 104-46-1 - Anethole (TGMX)
  • 140-67-0 - Estragole
  • 140-67-0 - Estragole (TGMX)
  • 97-53-0 - Eugenol
  • 97-53-0 - Eugenol (TGMX)
  • 97-54-1 - Isoeugenol
  • 97-54-1 - Isoeugenol (TGMX)
  • 120-58-1 - Isosafrole
  • 120-58-1 - Isosafrole (TGMX)
  • 93-15-2 - Methyleugenol
  • 93-15-2 - Methyleugenol (TGMX)
  • 93-15-2 - Methyleugenol (TGMX rat liver evaluation)
  • 607-91-0 - Myristicin
  • 607-91-0 - Myristicin (TGMX)
  • 94-59-7 - Safrole
  • 94-59-7 - Safrole (TGMX)

Known Uses

NTP toxicogenomics Study of Allylbenzene & Propenylbenzene Class Flavor Constituents (methyleugenol, eugenol, Isoeugenol, safrole, estragole, myristicin, anethole, isosafrole). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Short-Term Toxicity

  • 90 days (Gavage)  (C20704)  Histopath in progress 
    • Rats: F344/NTac
    • Dose: MALE RATS: 0, 0.2 mM/kg, OR 2m M/kg; 2/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; in-vitro)  (K05029)  Completed 
    • Citation: Final Study Report Study of Propenyl/allyl Benzenes.
    • Male Rats: Fischer 344; Male Rats: Wistar Han; Human (Cell Lines)
    • Dose: 0, 1, 10, 100 micromolar. 2 mmol propenyl/allyl benzene/kg body weight in a final dose volume of 5 mL/kg. Dosing once a day for five consecutive days.