National Toxicology Program

National Toxicology Program

Testing Status of Ionic Liquid: 1-Butyl-3-methylimidazolium Chloride - M050050


CASRN: 79917-90-1

Formula: C8-H15-Cl-N2

Synonyms/Common Names

  • (Bmim)Cl
  • 1-Butyl-3-methylimidazolium chloride (ionic liquid)

Known Uses

Catalyst, electrolyte component; reactant; solvent; cosmetic ingredient

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 90 days (Dosed-Water)  (C50050)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 0.1, 0.3, or 1 mg/mL; M: 0, 0.3, 1, or 3 mg/mL; 10/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0930)  Completed 
    • Citation: Chemical Disposition in Mammals, Ionic Liquids, 1-Butyl-3-methylimidazolium Chloride (Bmim-Cl)
    • Citation: Sipes IG, Knudsen GA, Kuester RK. The effects of dose and route on the toxicokinetics and disposition of 1-butyl-3-methylimidazolium chloride in male F344 rats and female B6C3F1 mice. Drug Metab Dispos. 2008 Feb;36(2):284-93. Epub 2007 Oct 29. Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1; Male Rats: F344/N; Female Mice: B6C3F1; Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0.5, 5.0, 50 mg/kg. 5 mg/kg.
  • C. elegans  (W05050)  Completed 
    • C. elegans
    • Dose: Feeding:0,1,4,8,12,16,20,24,28,32,36,40mM; Repro:0,4,8,16,24,32,40,48,56,64,72,80mM Growth:0,1,2,4,6,8,10,12,14,16,18,20 mM.

Genetic Toxicology

  • Micronucleus  (G05050B)  Completed 
    • Male & Female B6C3F1 Mice
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G05050)  Completed 
    • Male & Female Sprague Dawley Rats
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (A33096)  Completed 
    •  Negative 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (I05050)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 3.12, 6.25, 12.5 or 25% BMIM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.