National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m050052

Testing Status of Ionic Liquid: N-Butylpyridinium Chloride - M050052

 

CASRN: 1124-64-7

Formula: C9 H14 ClN

Synonyms/Common Names

  • NBPC
  • [NBuPy]Cl
  • N-Butylpyridinium chloride (ionic liquid)

Known Uses

Catalyst; electrolyte component; reactant; solvent

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 90 days (Dosed-Water)  (C05052)  On Test 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 0.3, 1 or 3 mg/mL; M: 0, 1, 3 or 6 mg/mL; 10/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K03020)  Completed 
    • Citation: Cheng Y, Martinez-Guerrero LJ, Wright SH, Kuester RK, Hooth MJ, Sipes IG. Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo. Drug Metab Dispos. 2011 Sep;39(9):1755-61. doi: 10.1124/dmd.110.035865. Epub 2011 Jun 6.Pubmed Abstract
    • Citation: Cheng Y, Wright SH, Hooth MJ, Sipes IG. Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2. Drug Metab Dispos. 2009 Apr;37(4):909-16. doi: 10.1124/dmd.108.022681. Epub 2009 Jan 26.Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1; Male Rats: F344/N; Female Mice: B6C3F1; Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0.5, 5.0, 50 mg/kg. 5 mg/kg.
  • C. elegans  (W05052)  Completed 
    • C. elegans
    • Dose: Feeding:0,.25,.1,2,3,4,5,6,7,8,9,10mM; Repro:2.5,5,10,15,20,25,30,35,40,45,50mM Growth:1,2,4,6,8,10,12,14,16,18,20 mM.

Genetic Toxicology

  • Salmonella  (A75013)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Topical Application)  (I05052)  Completed 
    • Female Mice: BALB/c
    • Dose: 1.65%, 3.125%, 6.25% or 12.5%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.