National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m050066

Testing Status of Gum Guggul Extract - M050066

 

CASRN: GUMGUGGULEXT

Known Uses

Dietary supplement; herbal remedy; used in pharmaceuticals and cosmetics

Nomination Background

Short-Term Toxicity

  • 13 weeks (Gavage)  (C20605)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 62.5, 125, 250, 500, or 1000; Mice: 0, 15.5, 31, 62.5, 125, 250, or 500 mg/kg.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0939)  Completed 
    • Citation: Final Study Report Study of Gum Guggul Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition In Mammals. December 20, 2010.
    • Human (Cell Lines)

Genetic Toxicology

  • Micronucleus  (G05066B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G05066)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (IMM20701)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG/DAY.
  • Conventional Teratology (Dosed-Feed) Selected (R05066)  
    • Rats
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.