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Testing Status of Efavirenz (EFV) M050090

 

CASRN: 154598-52-4

Formula: C14-H9-Cl-F3-N-O2

Synonyms/Common Names

  • EFV
  • 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-

Known Uses

Non-nucleoside reverse transcriptase inhibitor; AIDS therapeutic

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Preliminary Toxicokinetic Study (Gavage)  (K05090)  Completed 
    • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 37.5, 75 and 150 mg/kg.

Genetic Toxicology

  • Salmonella  (G05090)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 5 - PND 21 Teratology Pilot Studies (Gavage)  (R05090)  Completed 
    • Prenatal/Perinatal Dose Range-Finding Study
    • Female Mice: CD-1
    • Dose: 0, 75, 150, 300, or 600 mg/kg/day.