National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m060007

Testing Status of Rat feed study (TGMX rat liver evaluation) - M060007

 

CASRN: TGMXRALVFEED

Synonyms/Common Names

  • Tgmx Rat Liver Evaluation (Rat Feed Study)

Secondary:

  • 103-90-2 - Acetaminophen (4-hydroxyacetanilide)
  • 103-90-2 - Acetaminophen (TGMX rat liver evaluation)
  • 1162-65-8 - Aflatoxin-B1
  • 1162-65-8 - Aflatoxin B1 (TGMX)
  • 1162-65-8 - Aflatoxin-B1 (TGMX rat liver evaluation)
  • 81-49-2 - 1-Amino-2,4-dibromoanthraquinone
  • 81-49-2 - 1-Amino-2,4-dibromoanthraquinone (TGMX rat liver evaluation)
  • 50-81-7 - L-Ascorbic acid
  • 50-81-7 - L-Ascorbic acid (TGMX rat liver evaluation)
  • 73-22-3 - L-Tryptophan
  • 73-22-3 - L-Tryptophan (TGMX rat liver evaluation)

Known Uses

Toxicogenomic evaluation of rat liver carcinogens and non-carcinogens administered by feed in acetaminophen, Aflatoxin B1, 1-amino-2,4-dibromoanthraquinone, ascorbic acid, l-tryptophan

Short-Term Toxicity

  • 13 weeks & 8 weeks (Dosed-Feed)  (C20540A)  Completed 
    • Rats: F344/NTac
    • Dose: MALES ONLY: 0, 3000 (ACETAMINOPHEN), 1 (AFLATOXIN B1), 25000 (ASCORBIC ACID), 5000 (1, 2-DIBROMOANTHRAQUINONE), 2500 (L-TRYPTOPHAN) PPM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.