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Testing Status of Emtricitabine (FTC) M060018


CASRN: 143491-57-0

Formula: C8-H10-F-N3-O3-S

Synonyms/Common Names

  • 2'-Deoxy-5-fluoro-3'-thiacytidine
  • Emtricitabine (AIDS)
  • FTC

Known Uses

Nucleoside antiretroviral AIDS drug used to treat HIV infection

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Preliminary Toxicokinetic Study (Gavage)  (K06018)  Report in Preparation 
    • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 12.5, 25 and 50 mg/kg.

Genetic Toxicology

  • Comet Assay (CO)  (F46736B)  Completed 
    • Mice
  • Micronucleus  (A46736)  On Test 
    • Micronucleus  (F46736)  Completed 
      • Citation: Hobbs CA, Recio L, Shepard K, Baldetti C, Winters J, Caspary, W, Witt KL. Abstract, presented at the EMS Annual Meeting in Atlanta GA, October 20-24, 2007. Gender-Specific Genotoxicity in Mice Treated with Emtricitabine and Tenofovir as Assessed by the Flow Cytometry Micronucleus and Comet Assays.
      • Mice: B6C3F1
      • Male Positive 
      • Female Positive 
    • Salmonella  (A42705)  Completed 
      •  Negative