Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Emtricitabine (FTC) M060018

 

CASRN: 143491-57-0

Formula: C8-H10-F-N3-O3-S

Synonyms/Common Names

  • 2'-Deoxy-5-fluoro-3'-thiacytidine
  • Emtricitabine (AIDS)
  • FTC

Known Uses

Nucleoside antiretroviral AIDS drug used to treat HIV infection

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Preliminary Toxicokinetic Study (Gavage)  (K06018)  Completed 
    • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 12.5, 25 and 50 mg/kg.

Genetic Toxicology

  • Comet Assay (CO)  (F46736B)  Completed 
    • Mice
  • Micronucleus  (A46736)  On Test 
    • Micronucleus  (F46736)  Completed 
      • Citation: Hobbs CA, Recio L, Shepard K, Baldetti C, Winters J, Caspary, W, Witt KL. Abstract, presented at the EMS Annual Meeting in Atlanta GA, October 20-24, 2007. Gender-Specific Genotoxicity in Mice Treated with Emtricitabine and Tenofovir as Assessed by the Flow Cytometry Micronucleus and Comet Assays.
      • Mice: B6C3F1
      • Male Positive 
      • Female Positive 
    • Salmonella  (A42705)  Completed 
      •  Negative