Testing Status of Tenofovir M060019

 

CASRN: 147127-20-6

Formula: C9-H14-N5-O4-P

Synonyms/Common Names

  • Phosphonic acid, (((1R)-2-(6-amino-9H-purin-9-yl-1-methylethoxy)methyl)-
  • Tenofovir (AIDS)
  • Viread

Known Uses

Nucleoside antiretroviral AIDS drug used to treat HIV infection

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Comet Assay  (F27464B)  Completed 
    • Mice
  • Micronucleus  (A27464)  On Test 
    • Micronucleus  (F27464)  Completed 
      • Citation: Hobbs CA, Recio L, Shepard K, Baldetti C, Winters J, Caspary, W, Witt KL. Abstract, presented at the EMS Annual Meeting in Atlanta GA, October 20-24, 2007. Gender-Specific Genotoxicity in Mice Treated with Emtricitabine and Tenofovir as Assessed by the Flow Cytometry Micronucleus and Comet Assays.
      • Mice: B6C3F1
      • Male Negative 
      • Female Positive 
    • Salmonella  (A94329)  Completed 
      •  Positive