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Testing Status of 2-Methoxy-4-nitroaniline M060049

 

CASRN: 97-52-9

Formula: C7-H8-N2-O3

Synonyms/Common Names

  • 2-Amino-5-nitroanisole
  • Azoamine Pink O
  • 4-Nitro-o-anisidine

Known Uses

Used in dying textiles; as a dye in the printing industry, and intermediate in the synthesis of azo dyes used in tattoo inks, emulsion paints, and toy enamels.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14 days (Dosed-Feed)  (C06049)  Completed 
    • Mice: B6C3F1
    • Dose: R: 8/dose; M: 5/sex/dose; R&M: 0, 625, 1250, 2500, 5000, or 10000 ppm.
  • Perinatal range finding (Dosed-Feed)  (C06049)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: R: 8/dose; M: 5/sex/dose; R&M: 0, 625, 1250, 2500, 5000, or 10000 ppm.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K06049)  Completed 
    • Citation: Final Study Report Disposition and Metabolism of [14C]2-Methoxy-4Nitroaniline (CAS# 97-52-9) in Rats and Mice Following Dermal, Oral Gavage, and Intravenous Exposure.
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1
    • Dose: gavage; 1.5, 15, 150 mg/kg. intravenous; 15 mg/kg. topical application; 15 mg/kg.

Genetic Toxicology

  • Comet Assay  (G06049C)  Completed 
    • Mice
  • Salmonella  (G06049)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Varies Immunotoxicity (Dermal)  (I06049)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 2.5%, 5%, 10%, 25%, or 50%.