National Toxicology Program

National Toxicology Program

Testing Status of 4-Aminopyridine - M060053


CASRN: 504-24-5

Formula: C5-H6-N2

Synonyms/Common Names

  • p-Aminopyridine
  • 4-Pyridinamine

Known Uses

Pesticide (avian); pharmaceutical & agrochemical intermediate; experimental drug (potassium channel blocker). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14 days (Gavage)  (C06053)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R&M: 0, 0.78, 1.563, 3.125, 6.25, or 12.5 mg/kg -- Study I and 0, 625, or 12.5 mg/kg -- Study II.

Special Studies

  • C. elegans  (W06053)  Completed 
    • C. elegans
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.