National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m060053

Testing Status of 4-Aminopyridine - M060053

 

CASRN: 504-24-5

Formula: C5-H6-N2

Synonyms/Common Names

  • p-Aminopyridine
  • 4-Pyridinamine

Known Uses

Pesticide (avian); pharmaceutical & agrochemical intermediate; experimental drug (potassium channel blocker). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14 days (Gavage)  (C06053)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R&M: 0, 0.78, 1.563, 3.125, 6.25, or 12.5 mg/kg -- Study I and 0, 625, or 12.5 mg/kg -- Study II.

Special Studies

  • C. elegans  (W06053)  Completed 
    • C. elegans
    • Dose: feed: 0, 0.1, 0.16, 0.28, 0.46, 0.77, 1.3, 2.2, 3.6, 6.0, 10 mM repro: 0, 0.1, 0.16, 0.25, 0.40, 0.63, 1.0, 1.6, 2.5, 4.0, 6.3, 10 mM growth: 0, 0.1, 0.16, 0.25, 0.40, 0.63, 1.0, 1.6, 2.5, 4.0, 6.3, 10 mM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.