National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m060065

Testing Status of 2,2'-Dimorpholinodiethyl Ether - M060065

 

CASRN: 6425-39-4

Formula: C12-H24-N2-O3

Synonyms/Common Names

  • 2,2'-Dimorpholinyldiethyl ether
  • DMDEE
  • Morpholine
  • Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-

Known Uses

Blowing agent for the production of flexible, molded, and moisture-cured foams and coatings

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 28 days (Gavage)  (C06065)  On Test 
    • 4-week Toxicity Study
    • Mice: B6C3F1/N
    • Dose: 0, 62.5, 125, 250, 500, or 1000 mg/kg/day.

Modified One-Generation

  • GD 6 to PND 28 Repeated Dose (Gavage)  (MOG06065)  On Test 
    • Perinatal Investigative Study
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 31.3, 62.5, 125, 250, or 500 mg/kg/day.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dermal; Gavage; Intravenous)  (K06065)  Completed 
    • Citation: Disposition and Metabolism of 2,2'-Dimorpholinodiethyl Ether (CAS# 6425-39-4) in Harlan Sprague Dawley Rats and B6C3F1/N Mice after Oral Gavage, Intravenous Administration, and Dermal Application January 8, 2014
    • Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1

Genetic Toxicology

  • Micronucleus (Gavage)  (G06065C)  On Test 
    • Mice: B6C3F1/N
  • Micronucleus (Gavage)  (G06065D)  On Test 
    • Rats: Sprague Dawley
  • Salmonella  (G06065B)  On Test 
    • Salmonella  (G06065)  Completed 
      •  Negative 
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