Testing Status of Azure C M060110

 

CASRN: CELLPRADGSM

Synonyms/Common Names

  • Wireless Communication Devices

Known Uses

Cellular phones using Global System for Mobile communications (GSM)

Short-Term Toxicity

  • 5 days (Whole Body Exposure)  (C20105)  Completed 
    • Rats: Hsd:Sprague Dawley SD; Mice: B6C3F1/N
    • Dose: Rats: 0, 4, 6, 8, 10, or 12 W/kg 900 MHz. Mice: 0, 4, 6, 8, 10, or 12 W/kg 1900 MHz.
  • 28 days (Whole Body Exposure)  (C20105)  Completed 
    • Rats: Hsd:Sprague Dawley SD; Mice: B6C3F1/N
    • Dose: Rats: 0, 3, 6, and 9 W/kg 900 MHz. Mice: 0, 5, 10, and 15 W/kg 1900 MHz.

Long-Term Carcinogenicity

  • 2 years (Whole Body Exposure)  (C20105)  Report Draft 
    • Rats: Hsd:Sprague Dawley SD; Mice: B6C3F1/N
    • Dose: Rats: 0, 1.5, 3, and 6 W/kg 900 MHz. Mice: 0, 2.5, 5, or 10 W/kg 1900 MHz.

Genetic Toxicology

  • Comet Assay  (G08013C)  Completed 
    • Rats
  • Comet Assay  (G08013D)  Completed 
    • Mice
  • Micronucleus  (G08013B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G08013)  Completed 
    • GSM RFR
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
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CASRN: CELLPRADCDMA

Synonyms/Common Names

  • Wireless Communication Devices

Known Uses

Cellular phones using Code Division Multiple Access (CDMA) technology

Short-Term Toxicity

  • 5 days (Whole Body Exposure)  (C20105B)  Completed 
    • Rats: Hsd:Sprague Dawley SD; Mice: B6C3F1/N
    • Dose: Rats: 0, 4, 6, or 8, or 12 W/kg at 900 MHz. Mice: 0, 4, 6, 8, 10, or 12 W/kg 1900 MHz.
  • 28 days (Whole Body Exposure)  (C20105B)  Completed 
    • Rats: Hsd:Sprague Dawley SD; Mice: B6C3F1/N
    • Dose: Rats: 0, 3, 6, and 9 W/kg 900 MHz. Mice: 0, 5, 10, and 15 W/kg 30/sex 1900 MHz.

Long-Term Carcinogenicity

  • 2 years (Whole Body Exposure)  (C20105B)  Report Draft 
    • Rats: Hsd:Sprague Dawley SD; Mice: B6C3F1/N
    • Dose: Rats: 0, 1.5, 3, and 6 W/kg 900 MHz. Mice: 0, 5, 10, and 15 W/kg 30/sex 1900 MHz.

Genetic Toxicology

  • Comet Assay  (G08015C)  Completed 
    • Rats
  • Comet Assay  (G08015D)  Completed 
    • Mice
  • Micronucleus  (G08015B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G08015)  Completed 
    • CDMA RFR
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
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CASRN: INSERTMUT2

Known Uses

Insertional mutagenesis studies using vector exposures.

Short-Term Toxicity

  • 8 plus 3 weeks (Intravenous)  (C08020)  Completed 
    • Mice: B6.SJL-Ptprc[a] Pepc[b]/BoyJ
  • 8 plus 3 weeks (Intravenous)  (C08020)  Completed 
    • Mice: B6.SJL-Ptprc[a] Pepc[b]/BoyJ
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CASRN: ASPERGILLUS

Known Uses

Mold

Genetic Toxicology

  • 13 weeks Micronucleus (Inhalation)  (G08022)  Completed 
    • Male
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (G10334)  Completed 
    •  Negative 
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CASRN: ALTERNARIA

Known Uses

mold

Planned Carcinogenicity/Toxicity

  • 13-Week (Inhalation)  (C08023)   
    • Mice: B6C3F1
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CASRN: STACHYSTRN1

Known Uses

Mold

Planned Carcinogenicity/Toxicity

  • 13-Week (Inhalation) Selected (C08024)  
    • Mice: B6C3F1/N
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CASRN: STACHYSTRN2

Known Uses

Mold

Planned Carcinogenicity/Toxicity

  • 13-Week (Inhalation)  (C08025)   
    • Mice: B6C3F1/N
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CASRN: H2ODAMAGEMLD

Known Uses

Mold

Planned Carcinogenicity/Toxicity

  • 13-Week (Inhalation)  (C08026)   
    • Rats: Wistar Han; Mice: B6C3F1/N
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CASRN: DAMPBLDGMOLD

Known Uses

Mold

Planned Carcinogenicity/Toxicity

  • 13-Week (Inhalation)  (C08027)   
    • Mice: B6C3F1
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CASRN: RAV5SCTLA4IG

Known Uses

Vector to be used to explore gene therapy in the treatment of rheumatoid arthritis and other autoimmune disorders.

Short-Term Toxicity

  • 13 weeks (Intraductal Cannulation)  (C08043)  Completed 
    • Mice: BALB/c
    • Dose: Core Group M&F: 0, 2x10e7, 2x10e8, 2x10e9, or 2x10e10 particles 21/group; Special M&F: 0, 2x10e10 particles 10/group.
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CASRN: CARDIOGENEVL

Known Uses

Special study to evaluate cardio genes with and without transmitter

Short-Term Toxicity

  • 3 days (Not Applicable)  (C09005)  Completed 
    • Citation: Dunnick JK, Kissling G, Gerken DK, Vallant MA, Nyska A. Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model system. Toxicol Pathol, 35(5): 657-64. (2007)
    • Mice: C3H
    • Dose: no chemical treatment - C3H mice with and without transmitter.
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CASRN: PUBERTALTOX

Formula: N/A

Secondary:

  • 57-63-6 - Endocrine disruptor (Ethinyl estradiol)
  • 72-43-5 - Endocrine disruptor (Methoxychlor)
  • 50471-44-8 - Endocrine disruptor (Vinclozolin)
  • 57-63-6 - Ethinyl estradiol
  • 13311-84-7 - Flutamide
  • 72-43-5 - Kid pest project (Methoxychlor)
  • 72-43-5 - Methoxychlor
  • 50-06-6 - Phenobarbital
  • 57-63-6 - Pubertal ethinyl estradiol study
  • 13311-84-7 - Pubertal flutamide study
  • 72-43-5 - Pubertal methoxychlor study
  • 50-06-6 - Pubertal phenobarbital study
  • 50471-44-8 - Pubertal vinclozolin study
  • 57-63-6 - Transgenic model evaluation (Ethinyl estradiol)
  • 50471-44-8 - Vinclozolin

Known Uses

Study to evaluate the sensitivity EPA Pubertal Protocol in detection of endocrine disrupting chemicals (vinclozolin, flutamide, phenobarbital, methoxychlor, ethinyl estradiol and phenobarbital)

Organ Systems Toxicity

  • PND range from 22 to 53/53 Continuous Breeding (Legacy) (Gavage)  (R09008)  Completed 
    • Citation: Pubertal Toxicity Study of Vinclozolin, Flutamide and Phenobarbital in Male Sprague Dawley Rats and Methyxychlor, Ethinyl Estradiol and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage
    • Male and Female Rats: Sprague Dawley
    • Dose: Vinclozolin (males): 0, 10, 30, or 100 mg/kg/day; Flutamide (males): 0, 25, or 50 mg/kg/day; Phenobarbital (males & females): 0, 25, 50, or 100 mg/kg/day; Methoxychor (females): 0, 12.5, 25, or 50 mg/kg/day; Ethinyl estradiol (females): 0, 0.0025, or 0.005 mg/kg/day; The vehicle control for both males and females was corn oil with only one control group per sex..
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CASRN: GLUCOSCHONDN

Formula: N/A

Secondary:

  • 9007-28-7 - Chondroitin sulfate
  • 66-84-2 - Glucosamine hydrochloride

Known Uses

Dietary supplements often used with in combination to alleviates pain and inflammation from osteoarthritis and reportedly has a beneficial effect on degenerated joints

Short-Term Toxicity

  • 13 weeks (Gavage)  (C09029)  Completed 
    • Rats: Zucker - Lean (HsdHlr:ZUCKER-Lepr+); Rats: Zucker - Obese (HsdHlr:ZUCKER-Leprfa)
    • Dose: Male rats: 0/0; 30/24; 120/96; 300/240; or 600/480 mg/kg/bw/day; combination of glucosamine HCl/chondroitin sulfate; 12/dose lean and obese.
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CASRN: PREGRATECOMP

Formula: N/A

Known Uses

Special study to evaluate pregnancy rate in Harlan Sprague Dawley rats and evaluate gene expression data

Short-Term Toxicity

  • 16 weeks (Not Applicable)  (C09031)  Completed 
    • Rats: Harlan Sprague Dawley (Dublin Facility); Rats: Harlan Sprague Dawley (Indianapolis Facility)

Toxicogenomics

  • Microarray Analysis  (T09031)  Completed 
    • Rats: Harlan Sprague-Dawley
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CASRN: MOUSEPHENO1

Formula: N/A

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09045)  Histopath in progress 
    • Mice: 129S1/SvImJ
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CASRN: MOUSEPHENO2

Formula: N/A

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09046)  Histopath in progress 
    • Mice: A/J
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CASRN: MOUSEPHENO3

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09047)  Histopath in progress 
    • Mice: C3H/HeJ

Toxicogenomics

  • Whole Exome Sequencing Selected (T09047)  
    • Exome Sequencing Project for Uterine Endometrium Carcinomas
    • Mice: C3H/HeJ
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CASRN: MOUSEPHENO4

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09048)  Histopath in progress 
    • Mice: C57BL/6J (Jackson)
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CASRN: MOUSEPHENO5

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09049)  Histopath in progress 
    • Mice: CAST/EiJ (M. m. castaneus)

Toxicogenomics

  • Whole Exome Sequencing Selected (T09049)  
    • Exome Sequencing Project for Uterine Endometrium Carcinomas
    • Mice: CAST/EiJ (M. m. castaneus)
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CASRN: MOUSEPHENO6

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09050)  Histopath in progress 
    • Mice: B6C3F1/J (Jackson)
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CASRN: MOUSEPHENO7

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09051)  Histopath in progress 
    • Mice: NOD. B10Sn-H2(b)/J

Toxicogenomics

  • Whole Exome Sequencing Selected (T09051)  
    • Exome Sequencing Project for Uterine Endometrium Carcinomas
    • Mice: NOD. B10Sn-H2(b)/J
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CASRN: MOUSEPHENO8

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09052)  Histopath in progress 
    • Mice: PWK/PhJ

Toxicogenomics

  • Whole Exome Sequencing Selected (T09052)  
    • Exome Sequencing Project for Uterine Endometrium Carcinomas
    • Mice: PWK/PhJ
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CASRN: MOUSEPHENO9

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09053)  Histopath in progress 
    • Mice: WSB/EiJ (M. m. domesticus)
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CASRN: MOUSEPHENO10

Known Uses

Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice

Long-Term Carcinogenicity

  • 2 years (Not Applicable)  (C09054)  Histopath in progress 
    • Mice: NZO/HiLtJ
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CASRN: USNEALICHEN

Synonyms/Common Names

  • Extract of lichen

Known Uses

Usnea is used as a preservative, active ingredient in medicinal products, marketed as a dietary supplement to promote weight loss. This is a mixture of Usnea scabrata and Usnea carvernosa

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C20702)  Completed 
    • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: R: 0, 20, 60, 120, 360, or 1250 ppm; M: 0, 10, 30, 60, 180, or 600 ppm [usnic acid equivalent of herbal preparation from crude lichen].
  • 90 days (Dosed-Feed)  (C20702)  Completed 
    • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: Mice: 0, 15, 30, 60, 180, 360 ppm usnic acid delivered in ground usnea lichen prep. Rats: 0, 1, 60, 120, 260, 720 ppm usnic acid delivered in ground usnea lichen prep; Mice: 0, 15, 30, 60, 180, 360 ppm usnic acid delivered in ground usnea lichen prep.
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CASRN: MELCYANCOMB

Secondary:

  • 108-80-5 - Isocyanuric acid
  • 108-78-1 - Melamine

Known Uses

Melamine is used extensively by the industry in the preparation of polymers for the manufacture of a broad range of products, including countertops, fabrics, glues, houseware items, and flame retardants. Cyanuric acid, a deaminated derivative of melamine, is used in the preparation of herbicides, dyes, resins, and antimicrobial agents, and as a stabilizer and disinfectant in swimming pool water.

Short-Term Toxicity

  • 90 days (Gavage)  (C09074B)  Completed 
    • Rats: F344 (NCTR)
    • Dose: Melamine: 0, 0.63, 1.25, 2.5, 5.0 or 10.0 mg/kg/bw/day followed by Cynuric acid 0, 0.63, 1.25, 2.5, 5.0 or 10.0 mg/kg/bw/day. Cynuric acid gavage will be within 10 minutes after melamine gavage; 100.0 mg/kg/bw/day melamine only and 100.0 mg/kg/bw/day melamine only; 24 male / 24 female dose..
  • 90 days + recovery (Gavage)  (C09074C)  On Test 
    • Rats: F344 (NCTR)
    • Dose: 0. 1.25, 2.5, or 5.0 mg/kg.
  • 90 days (Gavage)  (C09074)  On Test 
    • Rats: F344 (NCTR)
    • Dose: Melamine: 0, 0.63, 1.25, 2.5, 5 or 10 mg/kg/bw/day followed by Cyanuric acid: 0, 0.63, 1.25, 2.5, 5 or 10 mg/kg/bw/day. Cyanuric acid gavage will be within 10 minutes after melamine gavage; 24 male/24 female dose.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (K09074)  Completed 
    • Citation: Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.Pubmed Abstract
    • Citation: Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.Pubmed Abstract
    • Male and Female Rats: F344 (NCTR)
    • Dose: 0, 2.5, 5, 10, 15, 20, 30 mg/kg bw/day target dose.
  • Toxicokinetic Study (Gavage; Intravenous)  (K09074C)  Completed 
    • Citation: Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.Pubmed Abstract
    • Citation: Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.Pubmed Abstract
    • Citation: Jacob CC, Von Tungeln LS, Vanlandingham M, Beland, FA, Gamboa da Costa G. Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats. Toxicol Sci. 2012 Apr;126(2):317-24. doi: 10.1093/toxsci/kfr348. Epub 2012 Jan 6.Pubmed Abstract
    • Male and Female Rats: F344 (NCTR)
    • Dose: 1 mg/kg.
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CASRN: LA2007

Known Uses

Mineral and Natural Fiber

Short-Term Toxicity

  • 14-Day (Inhalation)  (C09075)  Assigned 
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    CASRN: INSERTMUTRAD

    Formula: N/A

    Known Uses

    Exposure range finding study to determine the appropriate exposures/times to use for the insertional mutagenesis study.

    Short-Term Toxicity

    • 8 weeks (Whole Body Exposure)  (C10329)  Completed 
      • Mice: B6.SJL-Ptprc[a] Pepc[b]/BoyJ
      • Dose: 10, 9, 8.5, 8, 7.5, 7, 6.5, 6 Gy total exposures; based on an average exposure rate of 1.077Gy/min.
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    CASRN: AAV2HAQP1

    Formula: NA

    Known Uses

    Study to evaluate the biodistribution and toxicology of a recombinant adeno-associated viral (rAAV2) vector encoding hAQP1 in Balb/C mice

    Short-Term Toxicity

    • 13 weeks (Intraductal Cannulation)  (C10336)  Completed 
      • Mice: BALB/c
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    CASRN: VALERIAN

    Formula: NA

    Synonyms/Common Names

    • Valerian oil

    Secondary:

    • 8057-49-6 - Valerian (Valeriana officinalis L.) root extract
    • 8008-88-6 - Valerian (Valeriana officinalis L.) root oil

    Known Uses

    Various forms of valerian. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

    Genetic Toxicology

    • Salmonella  (G10345B)  Completed 
      •  Negative 
    • Salmonella  (G10345C)  Completed 
      •  Negative 
    • Salmonella  (G10345)  Completed 
      •  Negative 
    • Salmonella  (G10345D)  Completed 
      •  Negative 
    • Salmonella  (G10345E)  Completed 
      •  Negative 
    • Salmonella  (G10345F)  Completed 
      •  Negative 
    • Salmonella  (G10345G)  Completed 
      •  Negative 
    • Salmonella  (G10345H)  Completed 
      •  Negative 
    • Salmonella  (G10345I)  Completed 
      •  Negative 
    • Salmonella  (G10345J)  Completed 
      •  Negative 
    • Salmonella  (G10345K)  Completed 
      •  Negative 
    • Salmonella  (G10345L)  Completed 
      •  Negative 
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    CASRN: AMINOPYRCOMP

    Formula: N/A

    Secondary:

    • 462-08-8 - 3-Aminopyridine
    • 504-29-0 - 2-Aminopyridine
    • 504-24-5 - 4-Aminopyridine

    Known Uses

    Intermediates in the production of pharmaceuticals, agrochemicals, and dyes.

    Short-Term Toxicity

    • 1 & 4 hours (Gavage)  (C10485)  Completed 
      • Rats: F344/NTac; Mice: B6C3F1
      • Dose: Males only: 0, 50, or 100 mg/kg.
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    CASRN: DIESELFUEL

    Formula: N/F

    Synonyms/Common Names

    • DFM

    Known Uses

    Used in illuminating fuels, motor and jet fuels. Heating fuel. In paint thinners. Vehicle for insecticides and fungicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

    Short-Term Toxicity

    • 2 weeks (Topical Application)  (C54795B)  Completed 
      • Mice: B6C3F1
    • 13 weeks (Topical Application)  (C54795B)  Completed 
      • Mice: B6C3F1
      • Dose: 0, 250, 4000 MG/KG/10 PER GROUP.

    Long-Term Carcinogenicity

    • 2 years (Topical Application)  (C54795B)  Report Complete 
      • TR-310 (NIH Number: 86-2566)  (Peer Review Approval 08/14/1985A )
        Toxicology and Carcinogenesis Studies of Marine Diesel Fuel and JP-5 Navy Fuel (CASRN 8008-20-6) in B6C3F1 Mice (Dermal Studies)
      • Mice: B6C3F1
      • Carcinogenesis Results
        • Male Mice Equivocal Evidence 
        • Female Mice Equivocal Evidence 
      • Dose: FR: 0, 300, 600, MR: 0, 150, 300, M: 0, 250, 500 MG/KG/50 PER GROUP.

    Genetic Toxicology

    • Salmonella  (604964)  Completed 
      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
      •  Negative 
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    CASRN: EMTDP-74

    Formula: S2-Se

    Synonyms/Common Names

    • 2.4% w/v Selenium sulfide in aqueous suspension

    Known Uses

    Antidandruff shampoo

    Short-Term Toxicity

    • 13 weeks (Topical Application)  (C54546)  Completed 
      • Mice: Swiss
      • Dose: 0, 10, 50 %/10 PER GROUP.

    Long-Term Carcinogenicity

    • 2 years (Topical Application)  (C54546)  Report Complete 
      • TR-199 (NIH Number: 80-1755)  (Peer Review Approval 05/01/1979A )
        Bioassay of Selsun® for Possible Carcinogenicity
      • Mice: Swiss
      • Carcinogenesis Results
        • Male Mice Negative 
        • Female Mice Negative 
      • Dose: 0, 25, 50 %/50 PER GROUP.

    Genetic Toxicology

    • Salmonella  (238649)  Completed 
      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
      •  Negative 
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    CASRN: INSERTMUT3

    Secondary:

    • EFSSINVECTOR - EFS SIN Vector
    • LTRVECTOR - LTR Vector
    • NTPMOCKVEC - NTP MOCK Vector
    • PSINVECTOR - P(-) SIN Vector
    • SINVECTOR - SIN vector
    • UORFLTRVECTOR - uORF LTR Vector

    Known Uses

    Insertional mutagenesis studies using various vector exposures (LTR; uORF LTR, SIN, EFS LTR, and P(-) SIN vectors.

    Long-Term Carcinogenicity

    • 14 months (Intravenous)  (C10844B)  Assigned 
      • Mice: C57BL/6
      • Dose: Female mice: LTR and NTPMOCK 165/vector; uORF LTR; SIN; EFS SIN; and P(-) SIN 110/vector.
    • 14 months (Intravenous)  (C10844)  Histopath in progress 
      • Mice: C57BL/6
      • Dose: Female mice: 55/vector.
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    CASRN: TGMXBDECLASS

    Formula: N/A

    Secondary:

    • BDEMIXTURE - BDE Mixture (47, 99, 153)
    • 68631-49-2 - 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE 153)
    • 60348-60-9 - 2,2',4,4',5-Pentabromodiphenyl Ether
    • 32534-81-9 - Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]
    • 5436-43-1 - 2,2',4,4'-Tetrabromodiphenyl Ether

    Known Uses

    NTP toxicogenomics study of BDE 47, BDE 99, BDE 153, DE 71, and a mixture of BDE 47, 99, and 153

    Planned Carcinogenicity/Toxicity

    • 3 weeks (Gavage) Selected (C11048)  
      • Rats: Wistar Han; Mice: B6C3F1
    • GD 6 to PND 21 (gestation dams) (Gavage) Selected (C11048)  
      • Rats: Wistar Han
    • PND 1 to PND 4 (lactation dams) (Gavage) Selected (C11048)  
      • Rats: Wistar Han
    • PND 4 to PND 21 (female pups) (Gavage) Selected (C11048)  
      • Rats: Wistar Han
    • PND 4 to PND 21 (male pups) (Gavage) Selected (C11048)  
      • Rats: Wistar Han
    • 13 weeks (Gavage) Selected (C11048)  
      • Rats: Wistar Han; Mice: B6C3F1

    Toxicogenomics

    • Selected (T11048)  
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      CASRN: DLVDEV

      Formula: N/A

      Known Uses

      Vehicle being developed for use in NTP dermal toxicity studies.

      Organ Systems Toxicity

      • 3 to 7 days Immunotoxicity (Topical Application)  (I11052)  Completed 
        • Female Mice: BALB/c
        • Dose: 0, 25, 50, or 100%.
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      CASRN: EMTDP-75

      Formula: N/F

      Known Uses

      Used in newsprint inks

      Short-Term Toxicity

      • 4 weeks (Topical Application)  (C61869)  Completed 
        • Rats: F344/N; Mice: C3H
      • 13 weeks (Topical Application)  (C61869)  Report Complete 
        • TOX-17 (NIH Number: 92-3340)
          Toxicity Studies of Black Newsprint Inks Administered Topically to F344/N Rats and C3H Mice
        • Rats: F344/N; Mice: C3H
        • Dose: R&M:UNTREATED CONTROLS & NEAT APPLICATION WITH USP MINERAL OIL, PRINTING INK MINERAL OIL, LETTER PRESS INK, & OFFSET INK. R: 5 TREATMENT GROUPS/10 PER GROUP; M: 13 TREATMENT GROUPS/ 10 PER GROUP.

      Genetic Toxicology

      • Salmonella  (810135)  Completed 
        •  Positive 
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      CASRN: DIETEVAL

      Formula: N/A

      Known Uses

      Evaluation of various rodent diets

      Short-Term Toxicity

      • 90 days (Dosed-Feed)  (C12004)  Completed 
        • AIN-93 (SPC-EW+ISF)M
        • Mice: CD-1 Reg.[Crl:CD1(ICR)]
      • 13-Week (Dosed-Feed)  (C12004)  Completed 
        • NIH-41 [PMI 5K0L] (growth)
        • Mice: CD-1 Reg.[Crl:CD1(ICR)]
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      CASRN: TRICOMBOHIV

      Formula: C19H30N5O10P.C14H9ClF3NO2.C8H10FN3O3S.C4H4O4

      Synonyms/Common Names

      • Tri-Combo Therapy (TDF/EFV/FTC)
      • Tri-combo therapy (TDF/EFV/FTC) (AIDS)

      Secondary:

      • 154598-52-4 - Efavirenz (EFV)
      • 143491-57-0 - Emtricitabine (FTC)
      • 202138-50-9 - Tenofovir Disoproxil Fumarate (TDF)

      Known Uses

      Tri-combo therapy of Tenofovir Disopropxil fumarate (TDF), Efavirenz (EFV) and Emtricitabine (FTC) used in HIV treatment. Efavirenz mixture with emtricitabine, tenofovir and disoproxil fumarate.

      Modified One-Generation

      • F0 Generation (Gavage)  (MOG13067)   
        • Mice: CD-1 Reg.[Crl:CD1(ICR)]

      Special Studies

      • GD 5 - GD 15 Preliminary Toxicokinetic Study (Gavage) Selected (K13067)  
        • Mice

      Organ Systems Toxicity

      • GD 5-15 Maternal Transfer (Gavage)  (R13067D)  Completed 
        • Mice: CD-1
        • Dose: Emtricitabine 50 mg/kg/day, Tenofovir 75 mg/kg/day, and Efavirenz 150 mg/kg/day.
      • (R13067C)  Assigned 
        • Teratology Pilot Studies (Gavage)  (R13067B)  Assigned 
          • Teratology
          • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
        • GD 5 - GD 18 Teratology Pilot Studies (Gavage)  (R13067)  Completed 
          • Dose Range-Finding
          • Mice: CD-1
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        CASRN: ECOLI_LPS

        Formula: N/A

        Synonyms/Common Names

        • LPS
        • LPS

        Known Uses

        Lipopolysaccharides (LPS), also known as lipoglycans, are large molecules consisting of a lipid and apolysaccharide joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, act as endotoxins and elicit strong immune responses in animals.

        Short-Term Toxicity

        • 4 days (Intraperitoneal Injection)  (C13113)  Completed 
          • Liver Targeted Testing study of Toxcast Chemicals
          • Rats: Harlan Sprague-Dawley
          • Dose: Male rats: 0, 2 mg/kg/day.

        Toxicogenomics

        • 4 days Microarray Analysis (Intraperitoneal Injection)  (T13113)  Completed 
          • Liver Targeted Testing study of Toxcast Chemicals
          • Rats: Harlan Sprague-Dawley
          • Dose: not provided; 6 rats.
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        CASRN: CRUDEMCHM

        Secondary:

        • 94-60-0 - Dimethyl 1,4-cyclohexanedicarboxylate
        • 105-08-8 - 1,4-Cyclohexanedimethanol
        • 67-56-1 - Methanol
        • 98955-27-2 - 4-Methoxymethylcyclohexylmethanol
        • 51181-40-9 - Methyl 4-methylcyclohexanecarboxylate
        • 34885-03-5 - 4-Methylcyclohexanemethanol

        Known Uses

        Industrial Function: flotation agent.

        Short-Term Toxicity

        • 5 days (Gavage)  (C14013)  Completed 
          • Rats: Harlan Sprague-Dawley
          • Dose: MR: 0, 0.1, 1, 10, 100, 300, or 500 mg/kg; 8 rats in 0 mg/kg group, 6 rats in each treated group.

        Special Studies

        • C. elegans  (W14013)  Completed 
          • C. elegans: N2
          • Dose: Feeding: 200, 100, 75, 50uM Repro: 200, 100, 75, 50uM Growth: 200, 100, 75, 50uM.
        • 5 days Zebrafish (Dosed-Water)  (Z14013)  Completed 
          • Zebrafish
          • Fish: Zebra (Danio rerio)

        Genetic Toxicology

        • Micronucleus  (G14013)  Completed 
          • Rats: Harlan Sprague-Dawley
          • Male Negative 
        • Salmonella  (G14013B)  Completed 
          •  Negative 

        Organ Systems Toxicity

        • 7 days Immunotoxicity (Topical Application)  (I14013B)  Completed 
          • Female Mice: BALB/c
          • Dose: 1, 5, 25, 50, or 75.
        • 7 days Immunotoxicity (Topical Application)  (I14013)  Completed 
          • Female Mice: BALB/c
          • Dose: 1, 2, 5, 20, 40, or 100%.

        Toxicogenomics

        • Microarray Analysis (Gavage)  (T14013)  Completed 
          • Short Term Toxicogenomic Studies
          • Rats: Harlan Sprague-Dawley
          • Dose: 0.1, 1, 10, 100, 300, or 500 mg/kg; 6 rats/dose group.
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        CASRN: DOWANOLDIPPH

        Formula: C12-H18-O3

        Synonyms/Common Names

        • Technical grade dipropylene glycol phenyl ether

        Known Uses

        Solvent for Cleaning Applications

        Special Studies

        • C. elegans  (W15004)  Completed 
          • C. elegans: N2
          • Dose: Feeding: 200, 100, 75uMRepro: 200, 100, 75, 50uM.
        • 5 days Zebrafish (Dosed-Water)  (Z15004)  Completed 
          • Zebrafish
          • Fish: Zebra (Danio rerio)

        Genetic Toxicology

        • Salmonella  (G15004)  Completed 
          •  Negative 
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        CASRN: ASPERGILLUSV

        Known Uses

        MOLD

        Short-Term Toxicity

        • 13 weeks (Inhalation)  (C15017)  Completed 
          • Subchronic Toxicity of Aspergillus versicolor in B6C3F1/N Mice
          • Mice: B6C3F1/N
          • Dose: Air control, biological particle control, test article (1 x 10^5 viable A. Fumigatus conidia); 10/sex/group.
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        CASRN: CRUMBRUBBERVARIOUS

        Known Uses

        Crumb rubber is made from waste tires and is used in the manufacturing of synthetic turf and playground mats. There is an urgent need for information on toxicological studies to understand the health impacts of chemical released from synthetic turf in children and young athletes due to exposure from playground mats, athletic fields and synthetic turf fields.

        Short-Term Toxicity

        • 14 days  (C16008)  On Test 
          • Mice: B6C3F1/N
          • Dose: Mice: 0 or 1250 mg/kg (oral gavage), 0 or 50, 000 ppm (dosed-feed), 100% bedding or 50:50 wt:wt% crumb rubber:bedding (bedding exposure).
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        CASRN: MICROBIOME

        Known Uses

        This study is to analyze the gut microbiome.

        Short-Term Toxicity

        • 14-Day (Not Applicable)  (C16021)  On Test 
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          CASRN: DEIONWATER

          Known Uses

          No information available

          Genetic Toxicology

          • (G17021B)  Assigned 
            • (G17021C)  Assigned 
              • (G17021D)  Assigned 
                • Micronucleus  (G17021)  Assigned 
                  • Mice: CD-1 Reg.[Crl:CD1(ICR)]
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                CASRN: TRICOMBOHIV2

                Synonyms/Common Names

                • Tri-Combo Therapy (ABC/DTG/3TC)
                • Tri-combo therapy (ABC/DTG/3TC) (AIDS)

                Secondary:

                • 134678-17-4 - 3TC (AIDS initiative)

                Known Uses

                Tri-combo therapy of Abacavir (ABC), Dolutegravir (DTG), Lamivudine (3TC) used in HIV treatment.

                Modified One-Generation

                • Dose Range Finding (Gavage) Selected (MOG18001)  
                  • Rats: Harlan Sprague-Dawley
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                CASRN: PHTHALOCYAN

                Formula: C32-H16-N8

                Synonyms/Common Names

                • C.I. Pigment Blue 16
                • Phthalocyanine Blue 15B

                Known Uses

                Green dye used in paints, printing, inks, plastics, rubber, paper

                Genetic Toxicology

                • Salmonella  (499445)  Completed 
                  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                  •  Positive 
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                CASRN: INIT/PROM

                Formula: C20-H16 / C36-H56-O8 / C14-H10-O4 / C2-H5-N5-O3

                Synonyms/Common Names

                • Benzoyl peroxide
                • Benzoyl peroxide
                • 7,12-Dimethylbenz(A)anthracene
                • 7,12-Dimethylbenz(A)anthracene (DMBA)
                • DMBA/TPA/BPO/MNNG
                • N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG)
                • N-Methyl-N'-nitro-N-nitrosoguanidine
                • Tetradecanoylphorbol acetate (TPA)
                • Tetradecanoylphorbol acetate

                Secondary:

                • 94-36-0 - Benzoyl peroxide
                • 57-97-6 - 7,12-Dimethylbenzanthracene
                • 70-25-7 - 1-Methyl-3-nitro-1-nitroso-guanidine
                • 16561-29-8 - Tetradecanoyl phorbol acetate (TPA)
                • 16561-29-8 - Transgenic LECM (Tetradecanoyl phorbol acetate (TPA))

                Known Uses

                Tumor initiator and promoter

                Long-Term Carcinogenicity

                • 1 year (Topical Application)  (C61994A)  Report Complete 
                  • TR-441 (NIH Number: 96-3357)  (Peer Review Approval 06/21/1994A )
                    Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
                  • Mice: B6C3F1
                  • Dose: DMBA/ACETONE(50, 25, 2.5UG), DMBA 2.5, TPA 5UG, BPO 20MG, DMBA/TPA(2.5, 25, 50UG/5UG), DMBA/BPO(2.5, 25UG/20MG) AND MNNG/ACETONE(1000, 500, 100UG), MNNG 100UG, TPA 5UG, BPO 20MG, MNNG/BPO(100, 500, 1000UG/20MG), MNNG/TPA(100, 1000UG/5UG).
                • 1 year (Topical Application)  (C61994B)  Report Complete 
                  • TR-441 (NIH Number: 96-3357)  (Peer Review Approval 06/21/1994A )
                    Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
                  • Mice: Swiss CD-1
                  • Dose: DMBA/ACETONE(25, 2.5, .25UG), DMBA 2.5, TPA 5 UG, BPO 20MG, DMBA/TPA(.25, 2.5, 25/5UG), DMBA/BPO(2.5, 25UG/20MG) AND MNNG/ACETONE(1000, 500, 100UG), MNNG 100UG, TPA 5UG, BPO 20MG, MNNG/BPO(100, 500, 1000UG/20MG), MNNG/TPA(1000, 1000UG/5UG).
                • 1 year (Topical Application)  (C61994C)  Report Complete 
                  • TR-441 (NIH Number: 96-3357)  (Peer Review Approval 06/21/1994A )
                    Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
                  • Mice: B6C3F1; Mice: Sencar; Mice: Swiss CD-1
                  • Dose: DMBA/ACETONE(25, 2.5, .25UG):DMBA 2.5:TPA 1UG:BPO 20MG:DMBA/TPA(.25, 2.5, 25/1UG):DMBA/BPO(2.5, 25UG/20MG) AND MNNG/ACETONE(1000, 500, 100UG):MNNG 100UG:TPA 5UG:BPO 20MG:MNNG/BPO(100, 500, 1000 UG/20MG).
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                CASRN: MOUSEAGE

                Formula: N/F

                Known Uses

                Mouse ageing study.

                Long-Term Carcinogenicity

                • 2 years  (C62419)  Completed 
                  • Citation: GN Rao. Growth, Body Weight Patterns, and life Span of the B6C3F1 Mouse. Pathology of the Mouse (R. Maronpot, Ed.) Cache River Press, Vienna, IL. (1999)
                  • Mice: B6C3F1
                  • Dose: M: 0.
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                CASRN: EMTDP-01

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cotton seed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (718019)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-02

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species ,occurs naturally in peanuts, cotton seed meal, corn, etc.

                Genetic Toxicology

                • Salmonella  (019579)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-03

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (554431)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-04

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (621808)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-05

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cotton seed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (490568)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-06

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (179868)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-07

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cotton seed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (858170)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-08

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (209919)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-09

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (110066)  Completed 
                  •  Positive 
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                CASRN: EMTDP-11

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (545529)  Completed 
                  • Citation: Haworth, S., Lawlor, T.E., Zeiger, E., Lee, L.S., and Park, D.L., Mutagenic Potential of Ammonia-Related Aflatoxin Reaction Products in a Model System J. Amer. Oil Chem. Soc. Vol. 66 (1) (1989) 102-104
                  •  Positive 
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                CASRN: EMTDP-12

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (783880)  Completed 
                  •  Positive 
                • Salmonella  (997676)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Positive 
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                CASRN: EMTDP-13

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (743404)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-14

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cotton seed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (262157)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-15

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (321357)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Equivocal 
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                CASRN: EMTDP-16

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (879892)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-17

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (500243)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-18

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (509271)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-19

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (311802)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-20

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (155095)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Equivocal 
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                CASRN: EMTDP-21

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cotton seed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (090302)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-22

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (120719)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-23

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cotton seed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (491211)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-24

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cotton seed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (327249)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-25

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (525143)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-26

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (559540)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Positive 
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                CASRN: EMTDP-27

                Formula: N/F

                Known Uses

                Isolated from Aspergillis species, occurs naturally in peanuts, cottonseed meal, corn, etc

                Genetic Toxicology

                • Salmonella  (244237)  Completed 
                  • Citation: Lawlor, T.E., Haworth, S.R., Zeiger, E., Park, D.L., and Lee, L.S. Mutagenic potential of ammonia-related aflatoxin reaction products in cottonseed meal J. Amer. Oil Chem. Soc. Vol. 62 (1985) 1136-1138
                  •  Negative 
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                CASRN: EMTDP-46

                Known Uses

                Disinfectant & germicide

                Genetic Toxicology

                • Salmonella  (637553)  Completed 
                  •  Equivocal 
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                CASRN: EMTDP-69

                Known Uses

                Aromatic solvent

                Genetic Toxicology

                • Salmonella  (860923)  Completed 
                  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                  •  Negative 
                • Salmonella  (994098)  Completed 
                  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                  •  Negative 
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                CASRN: EMTDP-77

                Formula: N/F

                Known Uses

                Used in offset newsprint inks

                Genetic Toxicology

                • Salmonella  (982306)  Completed 
                  •  Positive 
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                CASRN: MEL+INDOLCAR

                Synonyms/Common Names

                • Melatonin + indole-3-carbinol (Prevention 4)

                Secondary:

                • 700-06-1 - Indole-3-carbinol
                • 73-31-4 - Melatonin
                • 73-31-4 - Prevention 1 (Melatonin)
                • 73-31-4 - Prevention 2 (Melatonin)
                • 73-31-4 - Prevention 3 (Melatonin)
                • 73-31-4 - Prevention 6 (Melatonin)
                • 700-06-1 - Prevention 4 (Indole-3-carbinol)
                • 73-31-4 - Prevention 4 (Melatonin)
                • 73-31-4 - Prevention 5 (Melatonin)

                Known Uses

                Prevention 4 is a special study to investigate dietary intervention to prevent/delay mammary cancer using melatonin & indole-3-carbinol combination.

                Short-Term Toxicity

                • 26 weeks (Dosed-Feed)  (C20010D)  Completed 
                  • Mice: MMTV/NEU (Tg.Nk)
                  • Dose: MEL 0.028% OR 280 PPM + I3C 0.10% OR 1000 PPM.
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                CASRN: MEL+CURCUMIN

                Formula: C13-H16-N2-O2 + C21-H20-O6

                Synonyms/Common Names

                • Melatonin + curcumin (Prevention 4)

                Secondary:

                • 458-37-7 - Curcumin
                • 73-31-4 - Melatonin
                • 73-31-4 - Prevention 1 (Melatonin)
                • 73-31-4 - Prevention 2 (Melatonin)
                • 73-31-4 - Prevention 3 (Melatonin)
                • 73-31-4 - Prevention 6 (Melatonin)
                • 458-37-7 - Prevention 4 (Curcumin)
                • 73-31-4 - Prevention 4 (Melatonin)
                • 73-31-4 - Prevention 5 (Melatonin)

                Known Uses

                Dyeing cotton, wool, silk; coloring oils & waxes; boron indicator; stain in microscopy; alkali indicator; preparing curcuma paper; food dye; analytical agent. Will be used in special study to investigate the dietary intervention to prevent/delay mammary cancer.

                Short-Term Toxicity

                • 26 weeks (Dosed-Feed)  (C20010E)  Completed 
                  • Mice: MMTV/NEU (Tg.Nk)
                  • Dose: (MEL 0.028% OR 280 PPM) + (CUR 0.50% OR 5000 PPM).
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                CASRN: AZT3TCCOMBO

                Synonyms/Common Names

                • AZT + 3TC (Lamivudine) + NVP (Nevirapine)

                Secondary:

                • 134678-17-4 - 3TC (AIDS initiative)
                • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                • 30516-87-1 - AZT transplacental carcinogenesis study
                • 129618-40-2 - Nevirapine

                Known Uses

                Special combination to study AIDS therapeutics

                Short-Term Toxicity

                • 28 days (Gavage)  (C20310B)  Completed 
                  • Mice: C3B6F1-+/TRP53<TM1BRD> (NCTR)
                  • Dose: 0, 80, 160, or 240 mg/kg bwt.

                Long-Term Carcinogenicity

                • 45 weeks (Gavage)  (C20310B)  Completed 
                  • GMM-16 (NIH Number: 14-5973)  (Peer Review Approval 02/00/2012A )
                    Toxicology and Carcinogenicity Study of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CASRNs 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Studies)
                  • Mice: C3B6F1-+/TRP53<TM1BRD> (NCTR)
                  • Dose: 25 animals/group; dose combinations AZT, 3TC, NVP, AZT/3TC, AZT/3TC/NVP.

                Genetic Toxicology

                • Micronucleus  (A40581)  Completed 
                  • Mice: Swiss CD-1
                  • Male Positive 
                  • Female NA 
                • Micronucleus  (A62246)  Completed 
                  • Mice: Swiss CD-1
                  • Male Negative 
                • Micronucleus  (A62527)  Completed 
                  • Mice: Swiss CD-1
                  • Male Negative 
                • Micronucleus  (A75317)  Completed 
                  • Mice: Swiss CD-1
                  • Male Positive 
                • Micronucleus  (A78223)  Completed 
                  • Mice: Swiss CD-1
                  • Male Negative 
                • Micronucleus  (A83804)  Completed 
                  • Mice: Swiss CD-1
                  • Male Positive 

                Organ Systems Toxicity

                • 2nd generation Continuous Breeding (Legacy) (Gavage)  (RACB20204)  Completed 
                  • Male and Female Mice: Swiss CD-1
                  • Dose: 0, 25/50, 35.5/75, 50/100, OR 75/150 MG/KG/DAY.
                • 6 to 16 GD Conventional Teratology (Gavage)  (TER20203)  Completed 
                  • Citation: Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and (-) 2', 3'-Dideoxy-3'-thiacytidine (3TC; CASRN 134678-17-4) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 16
                  • Citation: Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and (-)2',3'-Dideoxy-3'-thiacytidine (3TC; CASRN 134678-17-4) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 Through 16
                  • Female Mice: Swiss CD-1
                  • Dose: 0/0, 0/50, 0/100, 0/200, 0/1000, 100/0, 200/0, 400/0, 100/50, 200/100, 400/200 AND 400/1000 MG/KG/DAY (AZT/3TC).
                • 6 to 16 GD Teratology Pilot Studies (Gavage)  (TRP20202)  Completed 
                  • Female Mice: Swiss CD-1
                  • Dose: 0/0, 0/200, 0/1000, 100/50, 200/100, 400/0, 400/200, 400/400, OR 400/1000 AZT/3TC MG/KG/DAY.
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                CASRN: ALGAEBLUEGRE

                Known Uses

                Dietary supplement used in the treatment of attention deficit disorder

                Genetic Toxicology

                • Micronucleus  (A32817)  Completed 
                  • Mice: B6C3F1
                  • Male Negative 
                  • Female NA 
                • Salmonella  (A57047)  Completed 
                  •  Negative 
                • Salmonella  (A62641)  Completed 
                  •  Negative 
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                CASRN: DDI/D4TCOMB

                Synonyms/Common Names

                • AIDS initiative
                • 2',3'-Didioxyinosine/2',3'-Didehydro-3'-Deoxythymidine Combination

                Secondary:

                • 3056-17-5 - 2',3'-Didehydro-3'-deoxythymidine
                • 69655-05-6 - 2',3'-Dideoxyinosine (AIDS Initiative)
                • 124516-24-1 - 2',3'-Dideoxyinosine-[2',3'-3H] (AIDS initiative)

                Known Uses

                Combination for experimental treatment of HIV

                Organ Systems Toxicity

                • 6 to 17 GD Conventional Teratology (Gavage)  (TER20201)  Completed 
                  • Citation: Developmental Toxicity Evaluation of 2',3'-Dideoxyinosine (ddI; CASRN 69655-05-6) and 2',3'-Didehydro-3'-Deoxythymidine (d4T; CASRN 3056-17-5) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 16
                  • Citation: Developmental Toxicity Evaluation of 2',3'-Dideoxyinosine (ddl; CASRN 69655-05-6) and 2',3'-Didehydro-3'-Deoxythymidine (d4T; CASRN 3056-17-5) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 Through 16
                  • Female Mice: Swiss CD-1
                  • Dose: 0/0 (MAALOX), 0/60, 0/240, 0/480, 360/0, 1440/0, 2880/0, 360/60, 1440/240, OR 2880/480 DDI/D4T MG/KG/DAY.
                • 6 to 16 GD Teratology Pilot Studies (Gavage)  (TRP20101)  Completed 
                  • Female Mice: Swiss CD-1
                  • Dose: 0/0 (WATER), 0/0 (MAALOX TC), 0/240, 1440/0, 180/30, 360/60, 720/120, 1440/240 MG/KG/DAY OF DDI/D4T.
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                CASRN: ISOFLAVCONCN

                Synonyms/Common Names

                • Isoflavone concentrate (Prevention 6)

                Known Uses

                Special study to examine dietary intervention to prevent/delay mammary cancer

                Short-Term Toxicity

                • 26 weeks (Dosed-Feed)  (C20104B)  Completed 
                  • Mice: MMTV/NEU (Tg.Nk)
                  • Dose: 0, 33, 145, OR 470 (NTP-2000 DIET); 0, 80, 240, OR 720 (AIN DIET).
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                CASRN: PREVENTION7

                Known Uses

                Special study to examine dietary intervention to prevent/delay mammary cancer

                Short-Term Toxicity

                • 26 & 30 weeks (Dosed-Feed)  (C20106)  Completed 
                  • Mice: MMTV/NEU (Tg.Nk)
                  • Dose: FEMALE MICE ONLY. 2 FEED GROUPS: NTP-2000 FEED (COL 1); AIN-93G FEED (COL 2).
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                CASRN: ANTIOXCOMBO2

                Secondary:

                • NAOSPINEXTR - Antioxidant model (TRAMP) - NAO (spinach extract)
                • NAOSPINEXTR - Natural antioxidant spinach leaf extract
                • 7784-46-5 - Sodium arsenite
                • 16561-29-8 - Tetradecanoyl phorbol acetate (TPA)
                • 58-95-7 - D-alpha-Tocopheryl acetate
                • 16561-29-8 - Transgenic LECM (Tetradecanoyl phorbol acetate (TPA))

                Known Uses

                Special study to examine the effect of the antioxidants vitamin E acetate and natural antioxidant (NAO, spinach extract) on female homozygous Tg.AC mice treated with sodium arsenite

                Short-Term Toxicity

                • 26 weeks (Dosed-Water)  (C20109B)  Completed 
                  • Mice: Tg.AC (FVB/N) Homozygous
                  • Dose: FEMALE MICE ONLY: (START DATES 7/00 AND 10/00) 0, 150, OR 200 MG/L SODIUM ARSENITE; NAO 80 MG/KG; VITAMIN E - 200 U/KG; TPA - .625 MG/UL; (START DATE 12/00) 0, 150, OR 200 MG/L SODIUM ARSENITE; NAO - 200 MG/KG; VITAMIN E - 200 U/KG; TPA - .625 MG/UL.
                • NTE 26 weeks (Dosed-Water)  (C20109)  Completed 
                  • Mice: Tg.AC (FVB/N) Hemizygous
                  • Dose: FEMALE MICE ONLY: TPA CONTROL (DERMAL); 150 MG/L SODIUM ARSENITE.
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                CASRN: NAOSPINEXTR

                Synonyms/Common Names

                • NAO (Spinach Extract) - Antioxidant Model (TRAMP)

                Known Uses

                Special study to assess effects of antioxidants in the transgenic mouse model of prostate cancer (TRAMP)

                Short-Term Toxicity

                • 12 weeks (Gavage)  (C20108A)  Completed 
                  • Mice: C57BL/6; Mice: TRAMP (C57BL/6 PB-TAG TRANSGENE)
                  • Dose: 0 OR 200 MG/KG; 32/GROUP.
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                CASRN: ISOFLAVSOYPT

                Formula: N/A

                Synonyms/Common Names

                • Low isoflavone soy protein powder (Prevention 6)

                Known Uses

                Protein powder from soybeans to be used in prevention 6 studies

                Short-Term Toxicity

                • 26 weeks (Dosed-Feed)  (C20104D)  Completed 
                  • Mice: MMTV/NEU (Tg.Nk)
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                CASRN: AIDSTHERAPEU

                Synonyms/Common Names

                • AZT/3TC/NFV/NVP/EFV

                Known Uses

                Drugs used in the treatment of HIV - AIDS therapeutics

                Short-Term Toxicity

                • 28 days (In Utero)  (C20311)  Completed 
                  • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)

                Long-Term Carcinogenicity

                • 2 years (In Utero)  (C20311)  Completed 
                  • TR-569 (NIH Number: 11-5911)
                    Toxicology and Carcinogenesis Studies of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), Nevirapine (NVP), and Nelfinavir Mesylate (NFV) (CASRNs 30516-87-1, 134678-17-4, 129618-40-2, 159989-65-8) in B6C3F1 Mice (Transplacental Exposure Studies)
                  • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                  • Dose: AZT: 80 (low), 160 (mid), or 240 (high) mg AZT/kg body weight; AZT +3TC: 80/40 (low), 160/80 (mid), or 240/120 (high) mg AZT/3TC/kg body weight; AZT+ 3TC +NVP: 80/40/56 (low), 160/80/112 (mid), or 240/120/168 (high) mg AZT/3TC/NVP/kg body weight; AZT + 3TC + NFV: 80/40/336 (low), 160/80/672 (mid), or 240/120/1, 008 (high) mg AZT/3TC/NFV/kg body weight.
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                CASRN: AIDSNLFRCOMB

                Synonyms/Common Names

                • AZT/Lamivudine/Nelfinavir Combination

                Secondary:

                • 134678-17-4 - 3TC (AIDS initiative)
                • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                • 30516-87-1 - AZT transplacental carcinogenesis study
                • 159989-65-8 - Nelfinavir mesylate

                Known Uses

                Combination of therapeutic agents used in the treatment of HIV

                Genetic Toxicology

                • Salmonella  (A02219)  Completed 
                  •  Negative 
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                CASRN: PINEBARKEXT

                Formula: N/A

                Known Uses

                Dietary supplement

                Genetic Toxicology

                • Salmonella  (A91384)  Completed 
                  •  Positive 
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                CASRN: GRAPESEEDEXT

                Known Uses

                Dietary supplement

                Special Studies

                • Absorption Disposition Metabolism Elimination (in-vitro)  (S0858)  Completed 
                  • Citation: Final Study Report. Grape Seed Extract: Interaction of Extracts with Cytochrome P450 Enzymes and P-glycoprotein. Studies of Chemical Disposition in Mammals. 10/14/2002 - 02/28/2006.
                  • Human (Cell Lines)
                  • Dose: 0, 1, 10, 100 uM..

                Genetic Toxicology

                • Salmonella  (A03106)  Completed 
                  •  Negative 
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                CASRN: BENZANILINMX

                Synonyms/Common Names

                • Aniline and benzene mixture

                Secondary:

                • 62-53-3 - Aniline
                • 71-43-2 - Benzene
                • 71-43-2 - Transgenic model evaluation II (Benzene)

                Known Uses

                Combination of benzene and aniline

                Genetic Toxicology

                • Micronucleus  (A02197)  Completed 
                  • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
                  • Mice: B6C3F1
                  • Male Positive 
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                CASRN: TEFTGMIXTURE

                Synonyms/Common Names

                • PCB 126/PECDF mixture (TEF transgenics)
                • TEF Transgenics (3,3',4,4',5-Pentachlorobiphenyl/2,3,4,7,8-Pentachlorodibenzofuran mixture)

                Secondary:

                • 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126)
                • 57117-31-4 - 2,3,4,7,8-Pentachlorodibenzofuran
                • 57117-31-4 - Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran))
                • 57465-28-8 - TEF transgenics (PCB 126)
                • 57117-31-4 - TEF transgenics (PECDF)
                • 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)

                Known Uses

                Special evaluation of relative potency factors for papilloma induction by dioxin-like compounds in transgenic Tg.AC mice

                Short-Term Toxicity

                • 26 weeks (Topical Application)  (C20201D)  Subchronic Toxicology Review 
                  • Mice: Tg.AC (FVB/N) Hemizygous
                  • Dose: Female mice: 0, 36/180, 121/605, 360/1800, or 760/3800 ng/kg; 20/group; 3x/week.
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                CASRN: STEELWELDFUM

                Known Uses

                Widespread occupational exposure; evidence for toxicity of mixture and components; gaps in available health effects data

                Short-Term Toxicity

                • NTP / NIOSH Interagency Agreement (IAG)  (C20221)  Completed 
                  • Citation: Antonini JM, Afshari AA, Stone S, Chen B, Schwegler-Berry D, Fletcher WG, Goldsmith WT, Vandestouwe KH, McKinney W, Castranova V, Frazer DG. (2006) Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals. J Occup Environ Hyg. Apr;3(4):194-203.
                  • Citation: Antonini JM, Keane M, Chen BT, Stone S, Roberts JR, Schwegler-Berry D, Andrews RN, Frazer DG, Sriram K. (2011) Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity. Nanotoxicology. Dec;5(4):700-10. 1.
                  • Citation: Antonini JM, O'Callaghan JP, Miller DB. (2006) Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation. Neurotoxicology. Sep;27(5):745-51.
                  • Citation: Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Chapman R, Zeidler-Erdely PC, Andrews RN, Frazer DG. (2011) Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats. Arch Toxicol. May;85(5):487-98.
                  • Citation: Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Frazer DG (2009) Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats. Inhal Toxicol. Feb;21(3):182-92.
                  • Citation: Antonini JM, Sriram K, Benkovic SA, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Jefferson AM, Billig BK, Felton CM, Hammer MA, Ma F, Frazer DG, O'Callaghan JP, Miller DB. (2009) Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure. Neurotoxicology. Nov;30(6):915-25.
                  • Citation: Antonini JM, Stone S, Roberts JR, Chen B, Schwegler-Berry D, Afshari AA, Frazer DG. (2007) Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats. Toxicol Appl Pharmacol. 223:234-245.
                  • Citation: Leonard SS, Chen BT, Stone SG, Schwegler-Berry D, Kenyon AJ, Frazer D, Antonini JM. (2010) Comparison of stainless steel and mild steel welding fumes in generation of reactive oxygen species. Particle Fibre Toxicol. 7:32.
                  • Citation: Zeidler-Erdely PC, Batelli LA, Stone S, Chen BT, Frazer DG, Young, S-H, Erdely A, Kashon ML, Andrews R, Antonini JM. (2011) Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice. Inhal Toxicol. 23(2):112-120.
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                CASRN: ADNVIRVECHGH

                Synonyms/Common Names

                • Adenoviral Vector (Ad-Human Growth Hormone)

                Known Uses

                Study to evaluate the toxic response of associated with infusion of the submandibular gland with an adenoviral factor encoding the gene for human growth hormone (HGH).

                Short-Term Toxicity

                • 4 weeks (Intraductal Cannulation)  (C20212)  Completed 
                  • Rats: F344/N
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                CASRN: PREVENTION10

                Synonyms/Common Names

                • Soy isoflavone concentrate (Prevention 10)

                Known Uses

                Special study to examine dietary intervention to prevent/delay mammary cancer

                Short-Term Toxicity

                • 39 weeks (Dosed-Feed)  (C20223)  Completed 
                  • Mice: MMTV/NEU (Tg.Nk)
                  • Dose: FEMALE MICE: 0, 30, 140, OR 460 MG/KG; 40/GROUP.
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                CASRN: GREENTEAEXTR

                Synonyms/Common Names

                • GTE

                Known Uses

                Extract of green tea used as dietary supplement

                Short-Term Toxicity

                • 5 days (Gavage)  (C03008)  On Test 
                  • 5 day
                  • Rats: F344/NCrl (SAS FISCH)
                  • Dose: Green Tea Extract; 0, 3, 30, 100, 300, or 1000 mg/kg; 6 males/group.
                • 13 weeks (Gavage)  (C20203)  Completed 
                  • Rats: F344/NTac; Mice: B6C3F1/N
                  • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/kg; R: 20/sex/dose; M: 10/sex/dose.

                Long-Term Carcinogenicity

                • 2 years (Gavage)  (C20203)  Completed 
                  • TR-585 (NIH Number: 16-5927)  (Peer Review Approval 05/22/2014A )
                    Toxicology Studies of Green Tea Extract (CASRN GREENTEAEXTR) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Green Tea Extract in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
                  • Rats: Wistar Han; Mice: B6C3F1/N
                  • Carcinogenesis Results
                    • Male Rats No Evidence 
                    • Female Rats No Evidence 
                    • Male Mice No Evidence 
                    • Female Mice No Evidence 
                  • Dose: R: 0, 100, 300, or 1, 000 mg/kg; M: 0, 30, 100, or 300 mg/kg; 50/sex/species/dose.

                Genetic Toxicology

                • Micronucleus  (A70207)  Completed 
                  • Mice: B6C3F1
                  • Male Negative 
                  • Female Negative 
                • Micronucleus (Gavage)  (G03008)  On Test 
                  • Rats: F344/N Charles River
                • Salmonella  (A43286)  Completed 
                  •  Positive 

                Toxicogenomics

                • Microarray Analysis (Gavage) Selected (T03008)  
                  • Rats: F344/NTac
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                CASRN: AAVIRVECEPO

                Synonyms/Common Names

                • Adeno-Associated Viral Vector (Human Erythropoietin)
                • Serotype 2 Adeno-Associated Viral Vector

                Known Uses

                Study to evaluate the toxic response associated with infusion of the submandibular gland with a rAAV2 vector encoding the gene for hEPO (human erythropoietin)

                Short-Term Toxicity

                • 13 weeks (Intraductal Cannulation)  (C20305)  Completed 
                  • Mice: BALB/c
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                CASRN: PCNCOMPARISN

                Secondary:

                • 103426-96-6 - 1,2,3,4,6,7-Hexachloronaphthalene (PCN 66)
                • 103426-97-7 - 1,2,3,5,6,7-Hexachloronaphthalene (PCN 67)
                • 1746-01-6 - Toxic equivalency factor evaluation (TCDD)
                • 1746-01-6 - TEF transgenics (TCDD)
                • 1746-01-6 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
                • 1746-01-6 - Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin)

                Known Uses

                Used in industry as dielectric fluids in capacitors, transformers, and cables. The purpose of these studies is to determine relative potency values for PCN 66 and PCN 67 based on various toxic and biochemical endpoints and to determine the half-life of PCN 66 and PCN 67.

                Short-Term Toxicity

                • 2 weeks (Gavage)  (C20306)  Completed 
                  • Rats: Harlan Sprague-Dawley
                  • Dose: Female rats only: PCN 66 and PCN 67: 0, 500, 1500, 5000, 50000, or 500000 ng/kg (5/group); TCDD: 1, 3, 10, 100, or 300 ng/kg (5/group).
                • 13 weeks (Gavage)  (C20306)  Completed 
                  • Rats: F344/N; Rats: Harlan Sprague-Dawley; Rats: Sprague Dawley
                  • Dose: Females only: PCN 66 and PCN 67: 0, 1000, 10000, 50000, 100000, or 200000 ng/kg; TCDD: 0, 10, 50, 100, or 200 ng/kg.
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                CASRN: ALOEVLEAFEXT

                Formula: N/A

                Synonyms/Common Names

                • Aloe vera leaf ext.
                • Aloe vera whole leaf extract (nondecolorized)
                • Nondecolorized Aloe vera whole leaf extract
                • Nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera)

                Known Uses

                Recognized as a therapeutic dermatologic agent; extracts incorporated in a variety of topical health care products and cosmetics

                Short-Term Toxicity

                • 13 weeks (Dosed-Water)  (C20116B)  Completed 
                  • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                  • Dose: 0, 1%, or 3% in drinking water.

                Long-Term Carcinogenicity

                • 2 years (Dosed-Water)  (C20116B)  Report Complete 
                  • TR-577 (NIH Number: 11-5919)  (Peer Review Approval 04/05/2011A )
                    Toxicology and Carcinogenesis Studies of a Nondecolorized Whole Leaf Extract of Aloe Barbadensis Miller (Aloe Vera) (CASRN ALOEVLEAFEXT) in F344/N Rats and B6C3F1 Mice (Drinking Water Study)
                  • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                  • Carcinogenesis Results
                    • Male Rats Clear Evidence 
                    • Female Rats Clear Evidence 
                    • Male Mice No Evidence 
                    • Female Mice No Evidence 
                  • Dose: R: 0, 0.5%, 1.0% or 1.5%; M: 0, 1%, 2% or 3%.
                • 40 weeks (Topical Application)  (C20116D)  Report Complete 
                  • TR-553 (NIH Number: 10-5894)  (Peer Review Approval 02/27/2008A )
                    Photococarcinogenesis Study of Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study)
                  • Mice: SKH-1 Hairless
                  • Dose: 0, 3%, or 6% compound with simulated solar light exposure.

                Genetic Toxicology

                • Salmonella  (G03041)  Completed 
                  •  Negative 
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                CASRN: ALOEVFILTER

                Formula: N/A

                Synonyms/Common Names

                • Aloe vera decolorized whole leaf
                • Aloe vera whole leaf extract (decolorized)
                • decolorized Aloe vera whole leaf extract
                • decolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera)
                • Whole leaf Aloe vera gel

                Known Uses

                Recognized as a therapeutic dermatologic agent; extracts incorporated in a variety of topical health care products and cosmetics

                Long-Term Carcinogenicity

                • 40 weeks (Topical Application)  (C20116E)  Report Complete 
                  • TR-553 (NIH Number: 10-5894)  (Peer Review Approval 02/27/2008A )
                    Photococarcinogenesis Study of Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study)
                  • Mice: SKH-1 Hairless
                  • Dose: 0, 3%, or 6% compound in cream with similated solar light exposure.

                Genetic Toxicology

                • Salmonella  (G03042)  Completed 
                  •  Negative 
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                CASRN: BITTERORANGE

                Synonyms/Common Names

                • caffeine
                • Citrus aurantium L. var. amara
                • Synephrine

                Secondary:

                • 58-08-2 - Caffeine
                • 94-07-5 - p-Synephrine

                Known Uses

                Dietary supplement and flavoring in foods and beverages; used in herbal weight loss formulas

                Organ Systems Toxicity

                • 3 to 20 GD Conventional Teratology (Gavage)  (TER20502)  Completed 
                  • Citation: Deborah K. Hansen, Beth E. Juliar, Gene E. White, and Linda S. Pellicore. Developmental Toxicity of Citrus aurantium (bitter orange) in Rats. Birth Defects Res. (Part B) 92:216-223 (2011)
                  • Citation: Hansen DK, George NI, White GE, Abdel-Rahman A, Pellicore LS, Fabricant D. Cardiovascular toxicity of Citrus aurantium in exercised rats. Cardiovasc Toxicol. (3): 208-19. (2013)
                  • Citation: Hansen, D.K., George, N.I., White, G.E., Pellicore, L.S., Abdel-Rahman, A., and Fabricant, D. Physiological effects following administration of Citrus aurantium for 28 days in rats. Toxicology and Applied Pharmacology, 261(3), 236-27 (2012).
                  • Female Rats: Sprague Dawley
                  • Dose: Dose 1: Control vehicle; Dose 2: Bitter Orange (BO) (6% Extract) - 10 MG/KG BWT; Dose 3: BO (6% EXTRACT) - 25 MG/KG BWT; DOSE 4: BO (6% EXTRACT) - 50 MG/KG BWT; DOSE 5: BO (6% EXTRACT) - 100 MG/KG BWT. 25 mg/kg caffeine; 10 mg/kg BO (6% extract) +/- 25 mg/kg caffeine; 50 mg/kg BO (6% extract) +/- 25 mg/kg caffeine; 10 mg/kg synephrine (90% extract) +/- 25 mg/kg caffeine; 50 mg/kg synephrine (90% extract) +/- 25 mg/kg caffeine..
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                CASRN: EPHEDCOMBO

                Secondary:

                • 58-08-2 - Caffeine
                • 299-42-3 - L-Ephedrine

                Known Uses

                Combination of ephedrine-L and caffeine. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                Short-Term Toxicity

                • 10 days (Gavage)  (C04024B)  Completed 
                  • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
                  • Dose: Study A (beginning on 6/2/10): 0, 12.5/30, 23/30, 50/30, 100/30, 200/30 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 50/30, 100/30, 200/30 mg/kg.
                • 3 days (Gavage)  (C04024B)  Completed 
                  • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
                  • Dose: Study A (beginning on 6/2/10): 0, 12.5/30, 23/30, 50/30, 100/30, 200/30 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 50/30, 100/30, 200/30 mg/kg. Study A (beginning on 6/2/10): 0, 12.5/30, 23/30, 50/30, 100/30, 200/30 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 50/30, 100/30, 200/30 mg/kg.
                • 3 days (Gavage)  (C04024)  Completed 
                  • Mice: B6C3F1
                  • Dose: MM: 0, 12.5/30, 25/30, 50/15, 50/30, or 75/30 mg/kg.

                Special Studies

                • Toxicokinetic Study (Gavage; Intravenous)  (S0976)  Completed 
                  • Citation: Ephedrine+Ma Huang+ Caffeine Toxicokinetic Study Pharmacokinetics of Ephedring (EPH) following Intravenous or Oral Administration alone, in Combination with Caffeine or in MA Huang to Male Fischer 344 Rats. August 15, 2013.
                  • Male Rats: Wistar Han
                  • Dose: Ephedrine 6.25, 12.5, and 25 mg/kg/day.Ephedrine + Caffeine: 12.5 and 30 mg/kg.Ma Huang: 625 mg/kg.Ephedrine only at 6.25 mg/kg for IV study.
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                CASRN: SCUTELLARIA

                Synonyms/Common Names

                • Scutellaria lateriflora
                • Skullcap

                Known Uses

                Used in Chinese herbal medicine as an anti-inflammatory, antibacterial. Skullcap is also indicated as a classic sedative herb. Nerve nourisher.

                Genetic Toxicology

                • Salmonella  (A27924)  On Test 
                  • Salmonella  (A91630)  Completed 
                    •  Negative 
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                  CASRN: DONGQUAI

                  Synonyms/Common Names

                  • Angelica sinensis

                  Known Uses

                  Used in chinese herbal medicine as an antispasmodic, or blood purifier. Has also demonstrated activities that may translate into reduction of pain, dilation of blood vessels, and stimulation as well as relaxation of uterine muscles.

                  Genetic Toxicology

                  • Salmonella  (A72844)  Completed 
                    •  Negative 
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                  CASRN: NCTSTANDARD

                  Synonyms/Common Names

                  • APAP & AMAP (NCT/DERT standardization experiment)
                  • NCT/DERT standardization experiment (Acetaminophen)
                  • NCT/DERT standardization experiment (N-Acetyl-m-aminophenol)
                  • Toxicogenomics standardization experiment

                  Known Uses

                  Standardization experiment for the toxicogenomics research consortium (TRC) using APAP and AMAP

                  Short-Term Toxicity

                  • 1 day (Gavage)  (C20404)  Completed 
                    • Mice: C57BL/6J (Jackson)
                    • Dose: MM: 0 OR 300 MG/KG; SINGLE DOSE AT 6, 12, OR 24 HOURS -- 5 PER GROUP; CORE 5 PER GROUP; PROTHROMBIN TIME 5 PER GROUP.
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                  CASRN: ALOEPHOTOTOX

                  Known Uses

                  Phototoxicity studies using 3 forms of aloe. Aloe is recognized as a therapeutic dermatologic agent; extracts incorporated in a variety of topical health care products and cosmetics

                  Long-Term Carcinogenicity

                  • 40 weeks (Topical Application)  (C20406)  Report Complete 
                    • TR-553 (NIH Number: 10-5894)  (Peer Review Approval 02/27/2008A )
                      Photococarcinogenesis Study of Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study)
                    • Mice: SKH-1 Hairless
                    • Dose: Mice only: 0, 3%, or 6% compound in cream with and without simulated light.
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                  CASRN: TOLUENES

                  Known Uses

                  Intermediate for polyurethanes and dyes; in hair dyes (formerly), Synthesis of intermediates and explosives, stilbene and fuchsin dyes, OXIDATION BASE; CHEMICAL INTERMEDIATE FOR CI VAT BROWN 22 & 5-CHLOROBENZOTRIAZOLE; INGREDIENT IN HAIR DYES; CURING AGENT FOR EPOXY RESINS; REAGENT IN GAS CHROMATOGRAPHIC ANALYSES

                  Organ Systems Toxicity

                  • 14 days Immunotoxicity (Gavage)  (IMM86001)  Completed 
                    • Female Mice: B6C3F1
                    • Dose: 150 MG/KG (2-4-DIAMINOTOLUENE), 400 MG/KG (P-NITROTOLUENE), 200 MG/KG (4-CHLOROTOLUENE).
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                  CASRN: QUANTUMDOTS

                  Synonyms/Common Names

                  • Quantum dots (Nanoscale materials)

                  Known Uses

                  Part of an NTP evaluation of nanoscale materials (a broadly defined set of substances where at least one critical dimension is less than 100 nm) to evaluate the tox properties of major nanoscale materials classes representing a cross-section of composition, size, surface coatings, & physico-chemical properties, and use these as model systems to investigate how they interact w/ biological systems.

                  Short-Term Toxicity

                  • 2 weeks (Topical Application)  (C20409)  Completed 
                    • Mice: SKH-1 Hairless (NCTR)
                    • Dose: M1.

                  Special Studies

                  • Toxicokinetic Study (Subcutaneous Injection; Topical Application)  (S0918)  Completed 
                    • Citation: Gopee NV, Roberts DW, Webb P, Cozart CR, Siitonen PH, Latendresse JR, Warbitton AR, Yu WW, Colvin VL, Walker NJ, Howard PC. Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin. Toxicol Sci. 2009 Sep;111(1):37-48. doi: 10.1093/toxsci/kfp139. Epub 2009 Jul 2.Pubmed Abstract
                    • Mice: SKH-1 Hairless
                    • Dose: doses at 0, 4, 8 and 24 hour intervals w/ various mice per group.
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                  CASRN: SUPEREDG6768

                  Synonyms/Common Names

                  • Superedge 6768 (metal working fluids)

                  Known Uses

                  Soluble oil; metalworking fluid

                  Genetic Toxicology

                  • Salmonella  (A83619)  Completed 
                    •  Positive 
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                  CASRN: CMPERIAL1070

                  Synonyms/Common Names

                  • Cimperial 1070 (metal working fluids)

                  Known Uses

                  Soluble oil; metalworking fluid

                  Genetic Toxicology

                  • Salmonella  (A29455)  Completed 
                    •  Positive 
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                  CASRN: TRIMVX

                  Synonyms/Common Names

                  • TRIM VX
                  • TRIM® VX (metal working fluids)

                  Known Uses

                  Soluble oil; metalworking fluid

                  Short-Term Toxicity

                  • 13 weeks (Inhalation)  (C20523)  Completed 
                    • Rats: Wistar Han; Mice: B6C3F1
                    • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; 5/sex/species/dose.

                  Long-Term Carcinogenicity

                  • 2 years (Inhalation)  (C20523)  Completed 
                    • TR-591 (NIH Number: 17-5943)  (Peer Review Approval 02/16/2016A )
                      Toxicology and Carcinogenesis Studies of Trim® VX (CASRN TRIMVX) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
                    • Rats: Wistar Han; Mice: B6C3F1
                    • Carcinogenesis Results
                      • Male Rats Equivocal Evidence 
                      • Female Rats Equivocal Evidence 
                      • Male Mice Clear Evidence 
                      • Female Mice Clear Evidence 
                    • Dose: R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose.

                  Genetic Toxicology

                  • Micronucleus  (G04093B)  Completed 
                    • Rats: Wistar Han
                    • Male Negative 
                    • Female Negative 
                  • Micronucleus  (G04093)  Completed 
                    • Mice: B6C3F1
                    • Male Negative 
                    • Female Negative 
                  • Salmonella  (A94339)  Completed 
                    •  Negative 
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                  CASRN: CIMSTAR3800

                  Synonyms/Common Names

                  • Cimstar 3800 (metal working fluids)

                  Known Uses

                  Semisynthetic; metalworking fluid

                  Short-Term Toxicity

                  • 13 weeks (Inhalation)  (C20515)  Completed 
                    • Rats: F344/NTac; Mice: B6C3F1/N
                    • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; R: 20/sex/dose; M: 10/sex/dose.

                  Long-Term Carcinogenicity

                  • 2 years (Inhalation)  (C20515)  Completed 
                    • TR-586 (NIH Number: 15-5928)  (Peer Review Approval 05/22/2014A )
                      Toxicology and Carcinogenesis Studies of CIMSTAR® 3800 (CASRN CIMSTAR3800) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
                    • Rats: Wistar Han; Mice: B6C3F1/N
                    • Carcinogenesis Results
                      • Male Rats Equivocal Evidence 
                      • Female Rats Equivocal Evidence 
                      • Male Mice No Evidence 
                      • Female Mice Some Evidence 
                    • Dose: R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose.

                  Genetic Toxicology

                  • Micronucleus  (A06575)  On Test 
                    • Micronucleus  (A64536)  On Test 
                      • Micronucleus  (F06575)  Completed 
                        • Mice: B6C3F1
                        • Male Negative 
                        • Female Negative 
                      • Micronucleus  (F64536)  Completed 
                        • Rats: F344/NTac
                        • Male Negative 
                        • Female Negative 
                      • Salmonella  (A69652)  Completed 
                        •  Weakly Positive 
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                      CASRN: TRIMSC210

                      Synonyms/Common Names

                      • Trim SC210 (metal working fluids)

                      Known Uses

                      Semisynthetic; metalworking fluid

                      Short-Term Toxicity

                      • 13 weeks (Inhalation)  (C20516)  Completed 
                        • Rats: F344/NTac; Mice: B6C3F1
                        • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; R: 20/sex/dose; M: 10/sex/dose.

                      Genetic Toxicology

                      • Micronucleus  (F07614)  Completed 
                        • Rats: Fischer 344
                        • Male Equivocal 
                        • Female Equivocal 
                      • Micronucleus  (F26791)  Completed 
                        • Mice: B6C3F1
                        • Male Negative 
                        • Female Negative 
                      • Salmonella  (A22108)  Completed 
                        •  Positive 
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                      CASRN: CLEAREDG6584

                      Synonyms/Common Names

                      • Clearedge 6584 (metal working fluids)

                      Known Uses

                      Semisynthetic; metalworking fluid

                      Genetic Toxicology

                      • Salmonella  (A05866)  Completed 
                        •  Negative 
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                      CASRN: CIMTECH310

                      Synonyms/Common Names

                      • Cimtech 310 (metal working fluids)

                      Known Uses

                      Synthetic; metalworking fluid

                      Genetic Toxicology

                      • Salmonella  (A41562)  Completed 
                        •  Negative 
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                      CASRN: SYNTILO1023

                      Synonyms/Common Names

                      • Syntilo 1023 (metal working fluids)

                      Known Uses

                      Synthetic; metalworking fluid

                      Short-Term Toxicity

                      • 13 weeks (Inhalation)  (C20519)  Completed 
                        • Rats: Wistar Han; Mice: B6C3F1
                        • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; 10/sex/species/dose.

                      Genetic Toxicology

                      • Micronucleus  (G04098B)  Completed 
                        • Mice: B6C3F1
                        • Male Equivocal 
                        • Female Negative 
                      • Micronucleus  (G04098)  Completed 
                        • Rats: Wistar Han
                        • Male Negative 
                        • Female Negative 
                      • Salmonella  (A29479)  Completed 
                        •  Negative 
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                      CASRN: TRIM229

                      Synonyms/Common Names

                      • Trim 229 (metal working fluids)

                      Known Uses

                      Synthetic; metalworking fluid

                      Genetic Toxicology

                      • Salmonella  (A13077)  Completed 
                        •  Negative 
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                      CASRN: MICROCYSTNMX

                      Synonyms/Common Names

                      • Microcystin mixture (Toxicogenomics)

                      Secondary:

                      • 96180-79-9 - Microcystin-LA
                      • 96180-79-9 - Microcystin-LA (TGMX)
                      • 101043-37-2 - Microcystin LR
                      • 101043-37-2 - Microcystin-LR (TGMX)

                      Known Uses

                      Mixture of microcystins; toxins produced by algae

                      Short-Term Toxicity

                      • 1/2/6/24 hours (Intravenous)  (C20501)  Completed 
                        • Rats: Wistar Han
                        • Dose: MR: 0, 1.49, 3.73, 7.46, or 14.93 mg/kg.
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                      CASRN: TGMXFLAVCLAS

                      Secondary:

                      • 104-46-1 - Anethole
                      • 104-46-1 - Anethole (TGMX)
                      • 140-67-0 - Estragole
                      • 140-67-0 - Estragole (TGMX)
                      • 97-53-0 - Eugenol
                      • 97-53-0 - Eugenol (TGMX)
                      • 97-54-1 - Isoeugenol
                      • 97-54-1 - Isoeugenol (TGMX)
                      • 120-58-1 - Isosafrole
                      • 120-58-1 - Isosafrole (TGMX)
                      • 93-15-2 - Methyleugenol
                      • 93-15-2 - Methyleugenol (TGMX)
                      • 93-15-2 - Methyleugenol (TGMX rat liver evaluation)
                      • 607-91-0 - Myristicin
                      • 607-91-0 - Myristicin (TGMX)
                      • 94-59-7 - Safrole
                      • 94-59-7 - Safrole (TGMX)

                      Known Uses

                      NTP toxicogenomics Study of Allylbenzene & Propenylbenzene Class Flavor Constituents (methyleugenol, eugenol, Isoeugenol, safrole, estragole, myristicin, anethole, isosafrole). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                      Short-Term Toxicity

                      • 90 days (Gavage)  (C20704)  Histopath in progress 
                        • Rats: F344/NTac
                        • Dose: MALE RATS: 0, 0.2 mM/kg, OR 2m M/kg; 2/GROUP.

                      Special Studies

                      • Absorption Disposition Metabolism Elimination (Gavage; in-vitro)  (K05029)  Completed 
                        • Citation: Final Study Report Study of Propenyl/allyl Benzenes.
                        • Male Rats: Fischer 344; Male Rats: Wistar Han; Human (Cell Lines)
                        • Dose: 0, 1, 10, 100 micromolar. 2 mmol propenyl/allyl benzene/kg body weight in a final dose volume of 5 mL/kg. Dosing once a day for five consecutive days.
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                      CASRN: ADNVIRVECAQP

                      Known Uses

                      Study of adenoviral vector adhaqp1

                      Short-Term Toxicity

                      • 13 weeks (Intraductal Cannulation)  (C20537)  Completed 
                        • Rats: F344/N
                        • Dose: NA 1X, SUBCHRONIC LENGTH OF STUDY 1 X 10(8)-10(11) DOSES.
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                      CASRN: IONICLIQUIDS

                      Synonyms/Common Names

                      • Ionic liquid (1-Butyl-3-methylimidazolium chloride)
                      • Ionic liquid (1-Butyl-1-methylpyrrolidinium chloride)
                      • Ionic liquid (1-Ethyl-3-methylimidazolium chloride)
                      • Ionic liquid (N-Butylpyridinium chloride)

                      Secondary:

                      • 79917-90-1 - 1-Butyl-3-methylimidazolium chloride
                      • 479500-35-1 - 1-Butyl-1-methylpyrrolidinium Chloride
                      • 1124-64-7 - N-Butylpyridinium Chloride
                      • 65039-09-0 - 1-Ethyl-3-methylimidazolium chloride
                      • 79917-90-1 - Ionic Liquid: 1-Butyl-3-methylimidazolium Chloride
                      • 479500-35-1 - Ionic Liquid: 1-Butyl-1-methylpyrrolidinium Chloride
                      • 1124-64-7 - Ionic Liquid: N-Butylpyridinium Chloride
                      • 65039-09-0 - Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride

                      Known Uses

                      Salts of organic cations being widely investigated as replacements for volatile organic solvents in industrial and laboratory processes

                      Short-Term Toxicity

                      • 14 days (Dosed-Water)  (C05049)  Completed 
                        • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
                        • Dose: Bmim Cl Rats: 3, 1, 0.3 mg/ml; Bmim Cl Mice: 6, 3, 1 mg/ml; Emim Cl Rate: 100, 30, 10, 3 mg/ml; Emim Cl Mice: 100 20, 10 3 mg/ml; Bmpy Cl Rats: 6, 3, 1 mg/ml; Bmpy Mice: 10, 6, 3 mg/ml; NBuPy Cl Rats: 6, 3, 1 mg/ml; NBuPy Cl Mice: 6, 3, 1 mg/ml; Common Controls for all studies.
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                      CASRN: BLASTINGSAND

                      Synonyms/Common Names

                      • Blasting Sand (Abrasive Blasting Agents)

                      Known Uses

                      Sand used as abrasive blasting agents

                      Short-Term Toxicity

                      • 14 days (Inhalation)  (C20213)  Completed 
                        • Rats: F344/NTac
                        • Dose: MR: 0, 3, 15, or 30 mg/kg; 5/conc.
                      • 39 weeks (Inhalation)  (C20213)  Report Draft 
                        • Rats: Harlan Sprague-Dawley
                        • Dose: MR: 0, 15, 30, or 60 mg/m3; 62/conc and control.

                      Organ Systems Toxicity

                      • Varies Immunotoxicity (Inhalation)  (I05054)  Completed 
                        • Male and Female Rats: Harlan Sprague-Dawley
                        • Dose: 0, 15, 30, or 60 mg/m3.
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                      CASRN: COALSLAG

                      Synonyms/Common Names

                      • Coal Slag (Abrasive Blasting Agents)

                      Known Uses

                      Agent used as abrasive blasting agent

                      Short-Term Toxicity

                      • 14 days (Inhalation)  (C20532)  Completed 
                        • Rats: F344/NTac
                        • Dose: MR: 0, 3, 15, OR 30 MG/KG; 5/DOSE.
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                      CASRN: GARNET

                      Synonyms/Common Names

                      • Garnet (Abrasive Blasting Agents)

                      Known Uses

                      Used as an abrasive blasting agent

                      Short-Term Toxicity

                      • 14 days (Inhalation)  (C20533)  Completed 
                        • Rats: F344/NTac
                        • Dose: MR: 0, 3, 15, OR 30 MG/KG; 5/DOSE.
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                      CASRN: CRUSHEDGLASS

                      Synonyms/Common Names

                      • Crushed Glass (Abrasive Blasting Agents)

                      Known Uses

                      Agents used as abrasive blasting agent

                      Short-Term Toxicity

                      • 14 days (Inhalation)  (C20534)  Completed 
                        • Rats: F344/NTac
                        • Dose: MR: 0, 3, 15, OR 30 MG/KG; 5/DOSE.
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                      CASRN: HEMATITESPEC

                      Synonyms/Common Names

                      • Specular Hematite (Abrasive Blasting Agents)

                      Known Uses

                      Used as an abrasive blasting agent

                      Short-Term Toxicity

                      • 14 days (Inhalation)  (C20536)  Completed 
                        • Rats: F344/NTac
                        • Dose: MR: 0, 3, 15, 30, or 60 mg/kg; 5/conc.
                      • 39 weeks (Inhalation)  (C20536)  Report Draft 
                        • Rats: Harlan Sprague-Dawley
                        • Dose: MR: 0, 15, 30, or 60 mg/m3; 62/conc and control.

                      Organ Systems Toxicity

                      • Varies Immunotoxicity (Inhalation)  (I05059)  Completed 
                        • Male and Female Rats: Harlan Sprague-Dawley
                        • Dose: 0, 15, 30, or 60 mg/m3.
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                      CASRN: GUMGUGGULEXT

                      Known Uses

                      Dietary supplement; herbal remedy; used in pharmaceuticals and cosmetics

                      Short-Term Toxicity

                      • 13 weeks (Gavage)  (C20605)  Report Draft 
                        • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
                        • Dose: Rats: 0, 62.5, 125, 250, 500, or 1000; Mice: 0, 15.5, 31, 62.5, 125, 250, or 500 mg/kg.

                      Special Studies

                      • Absorption Disposition Metabolism Elimination (in-vitro)  (S0939)  Completed 
                        • Citation: Final Study Report Study of Gum Guggul Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition In Mammals. December 20, 2010.
                        • Human (Cell Lines)
                        • Dose: 0, 1, 10 µM.

                      Genetic Toxicology

                      • Micronucleus  (G05066B)  Completed 
                        • Mice: B6C3F1
                        • Male Negative 
                        • Female Negative 
                      • Micronucleus  (G05066)  Completed 
                        • Rats: Harlan Sprague-Dawley
                        • Male Negative 
                        • Female Negative 

                      Organ Systems Toxicity

                      • 28 days Immunotoxicity (Gavage)  (IMM20701)  Completed 
                        • Female Mice: B6C3F1
                        • Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG/DAY.
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                      CASRN: ANTICD4MNCLN

                      Known Uses

                      Monoclonal antibody protein therapeutics study

                      Organ Systems Toxicity

                      • single dose Immunotoxicity (Intraperitoneal Injection)  (IMM20508)  Completed 
                        • Female Mice: B6C3F1
                        • Dose: 15 ug/mouse.
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                      CASRN: ANTICD8MNCLN

                      Known Uses

                      Monoclonal antibody protein therapeutic study

                      Organ Systems Toxicity

                      • single dose Immunotoxicity (Intraperitoneal Injection)  (IMM20509)  Completed 
                        • Female Mice: B6C3F1
                        • Dose: 3 ug/mouse.
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                      CASRN: CIMSTAR3733

                      Synonyms/Common Names

                      • Cimstar 3733 (metal working fluids)

                      Known Uses

                      Semisynthetic; metalworking fluid

                      Genetic Toxicology

                      • Salmonella  (A69741)  Completed 
                        •  Equivocal 
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                      CASRN: TGMXRALVFEED

                      Synonyms/Common Names

                      • Tgmx Rat Liver Evaluation (Rat Feed Study)

                      Secondary:

                      • 103-90-2 - Acetaminophen (4-hydroxyacetanilide)
                      • 103-90-2 - Acetaminophen (TGMX rat liver evaluation)
                      • 1162-65-8 - Aflatoxin-B1
                      • 1162-65-8 - Aflatoxin B1 (TGMX)
                      • 1162-65-8 - Aflatoxin-B1 (TGMX rat liver evaluation)
                      • 81-49-2 - 1-Amino-2,4-dibromoanthraquinone
                      • 81-49-2 - 1-Amino-2,4-dibromoanthraquinone (TGMX rat liver evaluation)
                      • 50-81-7 - L-Ascorbic acid
                      • 50-81-7 - L-Ascorbic acid (TGMX rat liver evaluation)
                      • 73-22-3 - L-Tryptophan
                      • 73-22-3 - L-Tryptophan (TGMX rat liver evaluation)

                      Known Uses

                      Toxicogenomic evaluation of rat liver carcinogens and non-carcinogens administered by feed in acetaminophen, Aflatoxin B1, 1-amino-2,4-dibromoanthraquinone, ascorbic acid, l-tryptophan

                      Short-Term Toxicity

                      • 13 weeks & 8 weeks (Dosed-Feed)  (C20540A)  Completed 
                        • Rats: F344/NTac
                        • Dose: MALES ONLY: 0, 3000 (ACETAMINOPHEN), 1 (AFLATOXIN B1), 25000 (ASCORBIC ACID), 5000 (1, 2-DIBROMOANTHRAQUINONE), 2500 (L-TRYPTOPHAN) PPM.
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                      CASRN: INSERTMUT

                      Known Uses

                      Insertional mutagenesis studies using vector exposures

                      Short-Term Toxicity

                      • 12 weeks (Intravenous)  (C20703)  Completed 
                        • Mice: B6.SJL-Ptprc[a] Pepc[b]/BoyJ
                        • Dose: Female mice/LTR vector (PRSF91.EGFP.PRE*): radiated 10 GY; 50k cells LTR; female mice/SIN vector (PSERS11.SF.EGFP.PRE*): radiated 10 GY; 50k cells SIN; female mice/controls: radiated 10 GY; empty vector cells; 15/group.
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                      CASRN: ROSEWDTRUCOL

                      Secondary:

                      • PERMANMAKEUP - Permanent makeup inks

                      Known Uses

                      Ink used for cosmetic tattooing or permanent makeup

                      Organ Systems Toxicity

                      • 6 days Immunotoxicity (Subcutaneous Injection)  (IMM20703)  Completed 
                        • Female Mice: CBA/ Ca Jackson
                        • Dose: 1:1, 1:3, 1:7 dilutions of permanent make up inks.
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                      CASRN: DDFUDGETRUCOL

                      Secondary:

                      • PERMANMAKEUP - Permanent makeup inks

                      Known Uses

                      Ink used in cosmetic tattooing or permanent makeup

                      Organ Systems Toxicity

                      • Immunotoxicity (Subcutaneous Injection)  (IMM20706)  Completed 
                        • Female Mice: CBA/ Ca Jackson
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                      CASRN: DBLFUDGECONC

                      Secondary:

                      • PERMANMAKEUP - Permanent makeup inks

                      Known Uses

                      Ink used in cosmetic tattooing or permanent makeup

                      Organ Systems Toxicity

                      • Immunotoxicity (Subcutaneous Injection)  (IMM20707)  Completed 
                        • Female Mice: CBA/ Ca Jackson
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                      CASRN: ATMSUNTRUCOL

                      Secondary:

                      • PERMANMAKEUP - Permanent makeup inks

                      Known Uses

                      Ink used in cosmetic tattooing or permanent makeup

                      Organ Systems Toxicity

                      • 6 days Immunotoxicity (Subcutaneous Injection)  (IMM20708)  Completed 
                        • Female Mice: CBA/ Ca Jackson
                        • Dose: 1:1, 1:3, 1:7 dilutions of permanent make up ink.
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                      CASRN: AAVIRAAVHEPO

                      Known Uses

                      Study to evaluate the toxic response of Balb/c mice associated with infusion of the submandibular gland with the Serotype 2 Adeno-associated viral Vector rAAV2rapahEpo.

                      Short-Term Toxicity

                      • 13 weeks (Intraductal Cannulation)  (C20722)  Completed 
                        • Mice: BALB/c
                        • Dose: Core group: male & female: 0, 2x10e7, 2x10e8, 2x10e9 or 2x10e10 particles 21/group; Special: male & female: 0, 2x10e10 particles 10/group.
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                      CASRN: L-MWNT-1020

                      Known Uses

                      Diameter: 10-20 nm, Length: 5-15 um, SA: 40-300, Long Multiwalled Carbon Nanotube

                      Short-Term Toxicity

                      • 30 days (Inhalation)  (C07062B)  On Test 
                        • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
                        • Dose: Female rats (N = 72/exp. group) and mice (N = 48/exp. group) shipped to immunotoxicity contract lab (exp. concs = 0, 0.06, 0.2, or 0.6 mg/m3).
                      • 30 days (Inhalation)  (C07062)  Report Draft 
                        • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
                        • Dose: R&M: 0, 0.1, 0.3, 1, 3, 10 mg/m3; 35 sex/species.

                      Long-Term Carcinogenicity

                      • 2 years (Inhalation)  (C07062B)  On Test 
                        • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
                        • Dose: 0, 0.06, 0.2, or 0.6 mg/m3.

                      Genetic Toxicology

                      • Micronucleus  (G07062B)  On Test 
                        • Male
                        • Mice: B6C3F1/N
                      • Micronucleus  (G07062)  On Test 
                        • Male
                        • Rats: Harlan Sprague-Dawley

                      Organ Systems Toxicity

                      • 30 days Immunotoxicity (Inhalation)  (I07062B)  Report in Preparation 
                        • Female Mice: B6C3F1
                        • Dose: 0, 0.06, 0.2, or 0.6 mg/m3.
                      • 90 days Immunotoxicity (Inhalation)  (I07062C)  Report in Preparation 
                        • Female Mice: B6C3F1
                        • Dose: 0, 0.06, 0.2, or 0.6 mg/m3.
                      • 30 days Immunotoxicity (Inhalation)  (I07062)  Report in Preparation 
                        • Female Rats: Harlan Sprague-Dawley
                        • Dose: 0, 0.06, 0.2, or 0.6 mg/m3.
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                      CASRN: AIDSDRUGSNEO

                      Secondary:

                      • 134678-17-4 - 3TC (AIDS initiative)
                      • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                      • 30516-87-1 - AZT transplacental carcinogenesis study
                      • 154598-52-4 - Efavirenz (EFV)
                      • 159989-65-8 - Nelfinavir mesylate
                      • 129618-40-2 - Nevirapine

                      Known Uses

                      Study of the effects of drugs used in the treatment of HIV-AIDS on neonates

                      Short-Term Toxicity

                      • 28 days (Gavage)  (C20311B)  Completed 
                        • Mice: B6C3F1

                      Long-Term Carcinogenicity

                      • 2 years (Gavage)  (C20311B)  Histopath in progress 
                        • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                        • Dose: 240 (Dams GD 12-20); 40, 26.6, 13.3 (Neonates PND 1-8) mg/kg/bwt AZT+3TC: 240 AZT, 120 3TC (Dams GD 12-20); 40 AZT, 20 3TC; 26.6 AZT, 13.3 3TC; 13.3 AZT, 6.7 3TC (Neonates PND 1-8) mg/kg/bwt AZT+3TC+NVP: 240 AZT, 120 3TC, 168 NVP (Dams GD 12-20); 40 AZT, 20 3TC, 56 NVP; 26.6 AZT, 13.3 3TC, 37.2 NVP; 13.3 AZT, 6.7 3TC, 18.6 NVP (Neonates PND 1-8) mg/kg/bwt AZT+3TC+NVF: 160 AZT, 80 3TC, 672 NFV (Dams GD 12-20); 40 AZT, 20 3TC, 168 NFV; 26.6 AZT, 13.3 3TC, 112 NFV; 13.3 AZT, 6.7 3TC, 56 NFV (Neonates PND 1-8) mg/kg/bwt AZT+3TC+EFV: 160 AZT, 80 3TC, 160 EFV (Dams GD 12-20); 40 AZT, 20 3TC, 40 EFV; 26.6 AZT, 13.3 3TC, 26.6 EFV; 13.3 AZT, 6.7 3TC, 13.3 EFV (Neonates PND 1-8) mg/kg/bwt.
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                      CASRN: BUTTERFLAVMX

                      Secondary:

                      • 513-86-0 - Acetoin
                      • 431-03-8 - 2,3-Butanedione
                      • 65381-09-1 - Caprylic/capric triglyceride
                      • 705-86-2 - delta-decalactone
                      • 713-95-1 - delta-Dodecalactone
                      • 85409-09-2 - Glycerides, C8-10
                      • 110-43-0 - Methyl amyl ketone

                      Known Uses

                      Artificial butter flavoring used in food manufacture such as popcorn

                      Planned Carcinogenicity/Toxicity

                      • Selected (C20723)  
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                        CASRN: EMTDP-70

                        Formula: N/F

                        Synonyms/Common Names

                        • Aloe ferox

                        Known Uses

                        Purgative

                        Genetic Toxicology

                        • Salmonella  (823010)  Completed 
                          •  Equivocal 
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                        CASRN: EMTDP-78

                        Formula: N/F

                        Known Uses

                        Cathartic

                        Genetic Toxicology

                        • Salmonella  (684432)  Completed 
                          •  Negative 
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                        CASRN: AMSCO65SOLF

                        Known Uses

                        Aromatic solvent

                        Genetic Toxicology

                        • Salmonella  (746428)  Completed 
                          • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                          •  Positive 
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                        CASRN: CHEMMIXH2O

                        Formula: N/F

                        Secondary:

                        • 67-64-1 - Acetone
                        • 11096-82-5 - Arochlor 1260 (9CI)
                        • 1327-53-3 - Arsenic trioxide
                        • 71-43-2 - Benzene
                        • 5743-04-4 - Cadmium acetate dihydrate
                        • 10108-64-2 - Cadmium chloride
                        • 56-23-5 - Carbon tetrachloride
                        • 108-90-7 - Chlorobenzene
                        • 67-66-3 - Chloroform
                        • 1333-82-0 - Chromium trioxide
                        • 10060-12-5 - Chromium chloride hexahydrate (9CI)
                        • 75-34-3 - 1,1-Dichloroethane
                        • 107-06-2 - 1,2-Dichloroethane
                        • 156-60-5 - trans-1,2-Dichloroethylene
                        • 117-81-7 - Di(2-ethylhexyl) Phthalate
                        • 100-41-4 - Ethylbenzene
                        • 71-55-6 - Halogenated ethanes CS (1,1,1-Trichloroethane)
                        • 301-04-2 - Lead(2+) acetate
                        • 7487-94-7 - Mercuric chloride
                        • 75-09-2 - Methylene chloride
                        • 6018-89-9 - Nickel acetate tetrahydrate
                        • 7786-81-4 - Nickel sulfate
                        • 108-95-2 - Phenol
                        • 127-18-4 - Tetrachloroethylene
                        • 108-88-3 - Toluene
                        • 108-88-3 - Toluene (technical)
                        • 117-81-7 - Transgenic model evaluation (Di(2-ethylhexyl) phthalate)
                        • 71-43-2 - Transgenic model evaluation II (Benzene)
                        • 75-25-2 - Tribromomethane
                        • 71-55-6 - 1,1,1-Trichloroethane
                        • 79-01-6 - Trichloroethylene
                        • 75-35-4 - Vinylidene Chloride
                        • 67-66-3 - Water disinfection byproducts (Chloroform)
                        • 1330-20-7 - Xylenes (mixed)

                        Known Uses

                        Chemicals found in drinking water

                        Short-Term Toxicity

                        • 2 weeks (Dosed-Water)  (C62420)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                        • 26 weeks (Dosed-Water)  (C62420)  Report Complete 
                          • TOX-35 (NIH Number: 93-3384)
                            Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R&M: 0, 11, 38, 113, & 378 PPM; 20/GROUP.

                        Genetic Toxicology

                        • Micronucleus  (A10845)  Completed 
                          • Male Negative 
                          • Female Negative 
                        • Micronucleus  (A18666)  Completed 
                          • Rats/Mice: B6C3F1
                          • Male Negative 
                          • Female Equivocal 
                        • Sister Chromatid Exchanges  (A18666)  Completed 
                          • Mice
                          • Sister Chromatid  Negative (Nonstandard Protocol) 

                        Organ Systems Toxicity

                        • 27 weeks Continuous Breeding (Legacy) (Dosed-Water)  (RACB88036)  Completed 
                          • Citation: Final Report on the Reproductive Toxicity of a Chemical MIxture in CD-1 Swiss Mice-Laboratory Supplement
                          • Citation: Final Report on the Reproductive Toxicity of a Chemical Mixture in CD-1 Swiss Mice
                          • Male and Female Mice: Swiss
                          • Dose: N/A; OX, 10X, 50X, 100X; N/A; 0X, 10X, 50X, 100X.
                        • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB90062)  Completed 
                          • Citation: Final Report on the Reproductive Toxicity of a Complex Mixture of Groundwater Contaminants in Sprague-Dawley Rats
                          • Male and Female Rats: Sprague Dawley
                          • Dose: N/A; 0, 10X, 50X, 100XL; N/A; 0, 100X.
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                        CASRN: EMTDP-76

                        Formula: C9H11ClN2OS

                        Synonyms/Common Names

                        • 2-amino-6-methoxy-3-methyl-1,3-benzothiazol-3-ium chloride

                        Known Uses

                        No information found

                        Short-Term Toxicity

                        • 3 weeks (Gavage)  (C61814B)  Completed 
                          • Rats: F344/N
                        • 2 weeks (Dosed-Feed)  (C61814)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                        • 13 weeks (Dosed-Feed)  (C61814)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R&M: 0, 0.25, 0.5, 1.0, 2.0, 4.0 MG/G.

                        Genetic Toxicology

                        • Micronucleus  (A57759)  Completed 
                          • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                          • Mice: B6C3F1
                          • Male Negative 
                          • Female Negative 
                        • Salmonella  (287304)  Completed 
                          •  Positive 
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                        CASRN: DIET88+EGMEE

                        Formula: C4-H10-O2

                        Synonyms/Common Names

                        • Ethoxyethanol
                        • Ethylene glycol monoethyl ether, NTP-88 diet study

                        Known Uses

                        Testing NTP-88 feed concurrently with EGMEE study.

                        Short-Term Toxicity

                        • 13 weeks (Dosed-Water)  (C54853C)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: M: 0, 20000, OR 40000 PPM R: 0, 5000, OR 10000 PPM.
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                        CASRN: DIET88+EGMME

                        Formula: C3-H8-O2

                        Synonyms/Common Names

                        • Ethylene glycol monomethyl ether, NTP-88 diet study
                        • Methoxyethanol

                        Known Uses

                        NTP-88 diet being tested concurrently with EGMME.

                        Short-Term Toxicity

                        • 13 weeks (Dosed-Water)  (C62135B)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R: 0, 3000, OR 4500 PPM M: 0, 6000, OR 8000 PPM.

                        Genetic Toxicology

                        • Salmonella  (057075)  Completed 
                          • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                          •  Negative 
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                        CASRN: DIET88+EGMBE

                        Formula: C6-H14-O2

                        Synonyms/Common Names

                        • Butoxyethanol
                        • Ethylene glycol monobutyl ether, NTP-88 diet study

                        Known Uses

                        Testing NTP-88 feed concurrently with EGMBE study.

                        Short-Term Toxicity

                        • 13 weeks (Dosed-Water)  (C62077B)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R&M: 0, 4500, OR 6000 PPM.
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                        CASRN: DIET88+MNITR

                        Formula: C7-H7-N-O2

                        Synonyms/Common Names

                        • 1-Methyl-3-nitrobenzene (9CI)

                        Known Uses

                        NTP-88 diet being tested concurrently with m-nitrotoluene.

                        Short-Term Toxicity

                        • 13 weeks (Dosed-Feed)  (C62351B)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R: 0, 25, OR 5000 PPM M: 0, 5000, OR 10000 PPM; 10 PER GROUP.
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                        CASRN: DIET88+PNITR

                        Formula: C7-H7-N-O2

                        Synonyms/Common Names

                        • 1-Methyl-4-nitrobenzene (9CI)

                        Known Uses

                        NTP-88 diet being tested concurrently with p-nitrotoluene.

                        Short-Term Toxicity

                        • 13 weeks (Dosed-Feed)  (C60537C)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R: 0, 625, 1250, 2500, 5000, OR 10000 PPM; M: 0, 388, 625, 1250, 2500, OR 5000 PPM.
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                        CASRN: DIET88+ONITR

                        Formula: C7-H7-N-O2

                        Synonyms/Common Names

                        • 1-Methyl-2-nitrobenzene (9CI)

                        Known Uses

                        NTP-88 diet being tested concurrently with o-nitrotoluene

                        Short-Term Toxicity

                        • 13 weeks (Dosed-Feed)  (C62340B)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R: 0, 2500, OR 5000 PPM; M: 0, 5000, OR 10000 PPM.
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                        CASRN: OZONNNKCOMB

                        Formula: O3/C10-H13-N3-O2

                        Synonyms/Common Names

                        • 1-BUTANONE, 4-(METHYLNITROSOAMINO)-1-3-PYRIDINYL)- (9CI)
                        • NNK

                        Secondary:

                        • 64091-91-4 - 4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanone
                        • 10028-15-6 - Ozone
                        • 10028-15-6 - Ozone (Airways Disease Project)

                        Known Uses

                        Byproduct of tobacco smoke. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Long-Term Carcinogenicity

                        • 2 years (Inhalation)  (C88034C)  Report Complete 
                          • TR-440 (NIH Number: 95-3371)  (Peer Review Approval 11/16/1993A )
                            Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                          • Rats: F344/N
                          • Dose: MALE RATS ONLY: 0, 0.5 PPM OZONE WITH 0, 0.1, 1.0 MG/KG NNK BY S.C. INJECTION (20 WEEKS ONLY).
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                        CASRN: INTERFERONAD

                        Formula: N/F

                        Known Uses

                        Experimental AIDS therapy

                        Short-Term Toxicity

                        • 4 weeks (Subcutaneous Injection)  (C89003)  Completed 
                          • Mice: B6C3F1
                          • Dose: 500, 5000, 50000, OR 500000 UNITS DAY.

                        Long-Term Carcinogenicity

                        • 2 years (Subcutaneous Injection)  (C89003)  Report Complete 
                          • TR-469 (NIH Number: 99-3959)  (Peer Review Approval 12/11/1996A )
                            Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)
                          • Mice: B6C3F1
                          • Dose: MICE ONLY: 500 OR 5000 UNITS 3X/WEEK; 50/SEX/GROUP.
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                        CASRN: INTAZTCOMB

                        Formula: N/F

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • INTERFERONAD - Interferon AD (AIDS Initiative)

                        Known Uses

                        Used in the experimental treatment of AIDS

                        Short-Term Toxicity

                        • 4 weeks (Subcutaneous Injection and Gavage)  (C89006)  Completed 
                          • Mice: B6C3F1
                          • Dose: DUAL ROUTES: IFN-AD (SC/IJ): 500, 5000, 50000, OR 500000 UNITS/MOUSE/DAY AZT (GAVAGE): 0, 500, OR 1000 MG/KG.

                        Long-Term Carcinogenicity

                        • 2 years (Subcutaneous Injection and Gavage)  (C89006)  Report Complete 
                          • TR-469 (NIH Number: 99-3959)  (Peer Review Approval 12/11/1996A )
                            Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)
                          • Mice: B6C3F1
                          • Dose: DUAL ROUTES WITH BOTH COMPOUNDS: AZT: 0, 30, 60, OR 120 (GAV) MG/KG; IFN: 500 OR 5000 UNITS 3X/WEEK.
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                        CASRN: AZTDDCCOMB

                        Formula: C10-H13-N5-O4 C9-H13-N3-O3

                        Synonyms/Common Names

                        • 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AIDS initiative)
                        • AZT + DDC

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 7481-89-2 - 2',3'-Dideoxycytidine

                        Known Uses

                        Used in the experimental treatment of AIDS; synthetic nucleoside antiviral

                        Short-Term Toxicity

                        • 4 weeks (Gavage)  (C89007)  Completed 
                          • Mice: B6C3F1
                          • Dose: M: VARIOUS COMBINATIONS OF AZT 0, 500, OR 1000 MG/KG/DAY WITH DDC 0, 10, 100, 500, OR 1000 MG/KG/DAY.

                        Genetic Toxicology

                        • Micronucleus  (848765)  Completed 
                          • Mice: B6C3F1
                          • Male Negative 
                        • Micronucleus  (A72656)  Completed 
                          • Mice: Swiss CD-1
                          • Male Positive 

                        Organ Systems Toxicity

                        • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93149)  Completed 
                          • Male and Female Mice: Swiss
                          • Dose: N/A; N/A; N/A; N/A.
                        • 6 to 15 GD Conventional Teratology (Gavage)  (TER97001)  Completed 
                          • Citation: Final Study Report Developmental Toxicity Evaluation of 3'-Azido-3'-Deoxythymidine (AZT; CASRN 30516-87-1) and 2',3'-Dideoxycytidine (ddC; CASRN 7481-89-2) Administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 15
                          • Female Mice: Swiss CD-1
                          • Dose: AZT -- 0, 100, 200, OR 400 MG/KG/DAY AND DDC -- 0, 200, OR 500 MG/KG/DAY.
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                        CASRN: PESTFERTMIX2

                        Formula: N/F

                        Synonyms/Common Names

                        • California mixture

                        Secondary:

                        • 116-06-3 - Aldicarb
                        • 1646-87-3 - Aldicarb sulfoxide
                        • 1646-88-4 - Aldicarb sulfone
                        • 6484-52-2 - Ammonium nitrate
                        • 1912-24-9 - Atrazine
                        • 96-12-8 - 1,2-Dibromo-3-chloropropane
                        • 106-93-4 - 1,2-Dibromoethane
                        • 78-87-5 - 1,2-Dichloropropane (propylene dichloride)
                        • 122-34-9 - Simazine

                        Known Uses

                        Groundwater contamination by pesticides and fertilizers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Short-Term Toxicity

                        • 26 weeks (Dosed-Water)  (C89009)  Report Complete 
                          • TOX-36 (NIH Number: 93-3385)
                            Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: RATS AND MICE (0, 0.1X, 1X, 10X, OR 100X); RATS 40/GROUP; MICE 30/GROUP.

                        Genetic Toxicology

                        • Micronucleus  (A53723)  Completed 
                          • Mice: MICE
                          • Female Negative (Nonstandard Protocol) 

                        Organ Systems Toxicity

                        • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB90027)  Completed 
                          • Citation: Final Report on the Reproductive Toxicity of Pesticide/Fertilizer Mixture II in CD-1 Swiss Mice
                          • Male and Female Mice: Swiss
                          • Dose: N/A; 0, 1, 10, 100 X; N/A; 0, 100X.
                        • 6 to 20 GD Conventional Teratology (Dosed-Water)  (TER90031)  Completed 
                          • Citation: Final Report on the Developmental Toxicity of California Pesticide/Fertilizer Mixture in Sprague-Dawley (CD) Rats
                          • Rats: Sprague Dawley
                          • Rats Maternal Negative 
                          • Rats Fetal Negative 
                          • Dose: 0X, 1X, 10X, 100X.
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                        CASRN: PESTFERTMIX3

                        Formula: N/F

                        Synonyms/Common Names

                        • Iowa mixture

                        Secondary:

                        • 15972-60-8 - Alachlor
                        • 6484-52-2 - Ammonium nitrate
                        • 1912-24-9 - Atrazine
                        • 21725-46-2 - Cyanazine
                        • 51218-45-2 - Metolachlor
                        • 21087-64-9 - Metribuzin

                        Known Uses

                        Groundwater contamination by pesticides and fertilizers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Short-Term Toxicity

                        • 26 weeks (Dosed-Water)  (C89010)  Report Complete 
                          • TOX-36 (NIH Number: 93-3385)
                            Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: RATS AND MICE (0, 0.1X, 1X, 10X, OR 100X); RATS 40/GROUP, MICE 30/GROUP.

                        Genetic Toxicology

                        • Micronucleus  (A48542)  Completed 
                          • Mice: MICE
                          • Female Positive (Nonstandard Protocol) 

                        Organ Systems Toxicity

                        • Continuous Breeding (Legacy) (Dosed-Water)  (RACB90029)  Completed 
                          • Citation: Final Report on the Reproductive Toxicity of Iowa Pesticide/Fertilizer Mixture (IWA) in CD-1 Swiss Mice
                          • Citation: Heindel JJ, Chapin RE, Gulati DK, George JD, Price CJ, Marr MC, Myers CB, Barnes LH, Fail PA, Grizzle TB, Schwetz BA, and Yang RSH. Assessment of the Reproductive and Developmental Toxicity of Pesticide/Fertilizer Mixtures Based on Confirmed Pesticide Contamination in California and Iowa Groundwater. Fund. Appl. Toxicol. 22:605-621 (1994).
                          • Male and Female Mice: Swiss
                          • Dose: N/A; 0, 1, 10, 100 X; N/A; 0, 100 X.
                        • 6 to 20 GD Conventional Teratology (Dosed-Water)  (TER91032)  Completed 
                          • Citation: Final Report on the Developmental Toxicity of Iowa Pesticide/Fertilizer Mixture (IWA) in Sprague-Dawley Rats and Supplement
                          • Citation: Heindel JJ, Chapin RE, Gulati DK, George JD, Price CJ, Marr MC, Myers CB, Barnes LH, Fail PA, Grizzle TB, Schwetz BA, and Yang RSH. Assessment of the Reproductive and Developmental Toxicity of Pesticide/Fertilizer Mixtures Based on Confirmed Pesticide Contamination in California and Iowa Groundwater. Fund. Appl. Toxicol. 22:605-621 (1994).
                          • Rats: Sprague Dawley
                          • Rats Maternal Negative 
                          • Rats Fetal Negative 
                          • Dose: 0X, 1X, 10X, AND 100X.
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                        CASRN: FEEDRESTRICT

                        Formula: N/F

                        Known Uses

                        Feed restriction studies

                        Organ Systems Toxicity

                        • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB88120)  Completed 
                          • Citation: Final Report on the Reproductive Toxicity of Dietary Restriction in CD-1 Swiss Mice
                          • Male and Female Mice: Swiss
                          • Dose: 6, 6/5, 5/4, 4/3, 3 MG/KG/DAY; 100, 90, 80, 70% CPW; N/A; N/A.
                        • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89041)  Completed 
                          • Citation: Final Report on the Reproductive Toxicity Associated with Feed Restriction in Sprague-Dawley Rats
                          • Male and Female Rats: Sprague Dawley
                          • Dose: 100, 90, 80, 70, 60 % AD LIB; AD LIB, 90%, 80%, 70% AD LIB; N/A; N/A.
                        • Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89121)  Completed 
                          • Citation: Final Report on the Reproductive Toxicity Associated with Feed Restriction in CD-1 Swiss Mice
                          • Male and Female Mice: Swiss
                          • Dose: 100, 90, 80, 70% AD LIB; 100, 90, 80, 70% AD LIB; N/A; N/A.
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                        CASRN: EMTDP-36

                        Formula: C9-H12-N2-O2

                        Synonyms/Common Names

                        • N-ethyl-2-methyl-4-nitroaniline benzenamine

                        Known Uses

                        Environmental Mutagen Test Development Program chemical.

                        Genetic Toxicology

                        • Salmonella  (322942)  Completed 
                          •  Positive 
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                        CASRN: EMTDP-79

                        Formula: N/F

                        Known Uses

                        Asphalt product

                        Genetic Toxicology

                        • Salmonella  (763529)  Completed 
                          •  Positive 
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                        CASRN: EMTDP-80

                        Formula: N/F

                        Known Uses

                        Asphalt product

                        Genetic Toxicology

                        • Salmonella  (421793)  Completed 
                          •  Weakly Positive 
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                        CASRN: EMTDP-81

                        Formula: N/F

                        Known Uses

                        Asphalt product

                        Genetic Toxicology

                        • Salmonella  (360329)  Completed 
                          •  Positive 
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                        CASRN: EMTDP-82

                        Formula: N/F

                        Known Uses

                        Asphalt product

                        Genetic Toxicology

                        • Salmonella  (984892)  Completed 
                          •  Positive 
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                        CASRN: EMTDP-83

                        Formula: N/F

                        Known Uses

                        Asphalt product

                        Genetic Toxicology

                        • Salmonella  (212686)  Completed 
                          •  Weakly Positive 
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                        CASRN: EMTDP-84

                        Formula: N/F

                        Known Uses

                        Asphalt product

                        Genetic Toxicology

                        • Salmonella  (356843)  Completed 
                          •  Negative 
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                        CASRN: EMTDP-85

                        Formula: N/F

                        Known Uses

                        Asphalt product

                        Genetic Toxicology

                        • Salmonella  (452602)  Completed 
                          •  Positive 
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                        CASRN: ELECTROMAG

                        Formula: N/F

                        Synonyms/Common Names

                        • Powerline frequencies and electromagnetic fields

                        Known Uses

                        Low frequency magnetic fields; power-line frequency; electric and magnetic fields (EMF)

                        Short-Term Toxicity

                        • 150 days (Whole Body Exposure)  (C89029B)  Completed 
                          • Mice: P53 +/- (C57BL/6); Mice: PIM
                        • 8 weeks (Whole Body Exposure)  (C89029C)  Report Complete 
                          • TOX-58 (NIH Number: 96-3939)  (Tox Peer Review 06/00/1996A )
                            Toxicity Studies of 60-Hz Magnetic Fields Administered by Whole Body Exposure to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: 60 HZ MAGNETIC FIELDS - 20 MG, 2 G, 10 G CONTINUOUS AND 10 G INTERMITTENT; 10/GROUP.
                        • 8 weeks (Whole Body Exposure)  (C89029)  Completed 
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: 60 HZ MAGNETIC FIELDS - 20 MG, 2 G, 10 G CONTINUOUS AND 10 G INTERMITTENT; 10/GROUP.

                        Long-Term Carcinogenicity

                        • 2 years (Whole Body Exposure)  (C89029)  Report Complete 
                          • TR-488 (NIH Number: 99-3978)  (Peer Review Approval 03/11/1998A )
                            Toxicology and Carcinogenesis Studies of 60-HZ Magnetic Fields in F344/N Rats and B6C3F1 Mice (Whole-Body Exposure Studies)
                          • Rats: F344/N; Mice: B6C3F1
                          • Carcinogenesis Results
                            • Male Rats Equivocal Evidence 
                            • Female Rats No Evidence 
                            • Male Mice No Evidence 
                            • Female Mice No Evidence 
                          • Dose: 60 HZ MAGNETIC FIELDS - 0 G (control), 0.02 G, 2 G, or 10 G CONTINUOUS AND 10 G INTERMITTENT; 100/GROUP.

                        Organ Systems Toxicity

                        • Continuous Breeding (Legacy) (Whole Body Exposure)  (RACB89029)  Completed 
                          • Male and Female Rats: Sprague Dawley
                          • Dose: 60 HZ MAGNETIC FIELDS, 20 MG, 2 G, 10 G CONTINUOUS AND 10 G INTERMITTENT.
                        • 6 to 19 days Conventional Teratology (Whole Body Exposure)  (TER94001)  Completed 
                          • Female Rats: Sprague Dawley
                          • Dose: 60 HZ MAGNETIC FIELDS, 20 MG, 2 G, 10 G CONTINUOUS AND 10G INTERMITTENT, 55/GROUP.
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                        CASRN: INTDDCCOMB

                        Formula: + C9-H13-N3-O3

                        Synonyms/Common Names

                        • Interferon AD + Dideoxycytidine

                        Secondary:

                        • 7481-89-2 - 2',3'-Dideoxycytidine
                        • INTERFERONAD - Interferon AD (AIDS Initiative)

                        Known Uses

                        Experimental drug used for AIDS therapy.

                        Short-Term Toxicity

                        • 4 weeks (Subcutaneous Injection)  (C89030)  Completed 
                          • Mice: B6C3F1
                          • Dose: MICE ONLY - DUAL ROUTES: IFN/AD (SC/IJ): 500, 5000, 50000, OR 500000 UNITS/MOUSE/DAY: DDC (GAVAGE): 0, 250, OR 1000 MG/KG.
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                        CASRN: AZTDDICOMB

                        Formula: C10-H13-N5-O4 C10-H12-N4-O3

                        Synonyms/Common Names

                        • AZT + DDI
                        • AZT + DDI (AIDS initiative)

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 69655-05-6 - 2',3'-Dideoxyinosine (AIDS Initiative)

                        Known Uses

                        Experimental therapy for AIDS

                        Short-Term Toxicity

                        • 4 weeks (Gavage)  (C90001)  Completed 
                          • Mice: B6C3F1
                          • Dose: M: VARIOUS COMBINATIONS OF AZT 0, 250, 500, OR 1000 MG/KG/DAY (DIVIDED IN 2 DOSES) WITH DDI 0, 500, 1000, OR 2000 MG/KG/DAY (DIVIDED IN 2 DOSES).

                        Special Studies

                        • Toxicokinetic Study (Gavage; Intravenous)  (S0408)  Completed 
                          • Female Mice: Swiss CD-1
                          • Dose: METHYLCELLULOSE: 250, 500, 1000 MG/KG MAALOX: 250 MG/KG MAALOX-TC: 50, 125, 250, 500 MG/KG IV: 20 MG/KG.

                        Genetic Toxicology

                        • Micronucleus  (A03310)  Completed 
                          • Citation: Bishop JB, Witt KL, Tice RR, Wolfe G. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen. 2004;43(1):3-9.
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A07834)  Completed 
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A10804)  Completed 
                          • Citation: Bishop JB, Witt KL, Tice RR, Wolfe G. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen. 2004;43(1):3-9.
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A24399)  Completed 
                          • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
                          • Mice: Swiss CD-1
                          • Male Negative 
                          • Female NA 
                        • Micronucleus  (A28891)  Completed 
                          • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A29422)  Completed 
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A38558)  Completed 
                          • Mice: Swiss CD-1
                          • Male Positive 
                          • Female NA 
                        • Micronucleus  (A43440)  Completed 
                          • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A53298)  Completed 
                          • Mice: Swiss CD-1
                          • Male Positive 
                          • Female NA 
                        • Micronucleus  (A54094)  Completed 
                          • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A60084)  Completed 
                          • Citation: Bishop JB, Witt KL, Tice RR, Wolfe G. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen. 2004;43(1):3-9.
                          • Mice: Swiss CD-1
                          • Male Positive 
                        • Micronucleus  (A64786)  Completed 
                          • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
                          • Mice: Swiss CD-1
                          • Male Positive 
                          • Female NA 
                        • Micronucleus  (A68101)  Completed 
                          • Citation: Bishop JB, Witt KL, Tice RR, Wolfe G. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen. 2004;43(1):3-9.
                          • Mice: Swiss CD-1
                          • Female Positive 
                        • Micronucleus  (A70649)  Completed 
                          • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
                          • Mice: Swiss CD-1
                          • Male NA 
                          • Female Positive 
                        • Micronucleus  (A76722)  Completed 
                          • Citation: Bishop JB, Witt KL, Tice RR, Wolfe G. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen. 2004;43(1):3-9.
                          • Mice: Swiss CD-1
                          • Male Positive 

                        Organ Systems Toxicity

                        • 6 months in-life Continuous Breeding (Legacy) (Gavage)  (RACB20003)  Completed 
                          • Male and Female Mice: C57BL/6
                          • Dose: 0/0, 50/250, 75/375, OR 150/750 MG/KG/DAY.
                        • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93153)  Completed 
                          • Male and Female Mice: Swiss CD-1
                          • Dose: N/A; N/A; N/A; N/A.
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                        CASRN: SPANISHOIL

                        Formula: N/F

                        Known Uses

                        Oil used for cooking

                        Special Studies

                        • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0154)  Completed 
                          • Dog: Beagles
                          • Dose: 3.0 ML/KG.
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                        CASRN: EMTDP-28

                        Known Uses

                        Orange dye

                        Genetic Toxicology

                        • Salmonella  (655778)  Completed 
                          •  Negative 
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                        CASRN: BINARYMIX

                        Formula: NA

                        Secondary:

                        • 56-23-5 - Carbon tetrachloride
                        • 95-50-1 - 1,2-Dichlorobenzene (o-dichlorobenzene)
                        • 541-73-1 - 1,3-Dichlorobenzene
                        • 106-46-7 - 1,4-Dichlorobenzene (p-dichlorobenzene)

                        Known Uses

                        In linseed & soybean oils. Naturally occurring in food; in refrigerants; metal degreasing; production of semiconductors; Fumigant. Insecticide. Industrial solvent. Intermediate. Degreaser for metals. Heat transfer medium; Insecticidal fumigant, germicide, intermediate, dyes, in pharmaceuticals, deodorant for garbage, Fumigant & insecticide; in manufacture chlorophenols, arylene sulfide polymers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Special Studies

                        • Absorption Disposition Metabolism Elimination (Dosed-Water; Intraperitoneal Injection)  (S0119)  Completed 
                          • Citation: Final Report Chemical Disposition in Mammals. November 29, 1988.
                          • Male Rats: F344/N
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                        CASRN: CHLORWATERMX

                        Synonyms/Common Names

                        • Chlorine/Sodium hypochlorite
                        • Chlorine/Sodium hypochlorite

                        Secondary:

                        • 7782-50-5 - Chlorine
                        • 7681-52-9 - Hypochlorous acid, sodium salt

                        Known Uses

                        Chemicals used in the chlorination and chloramination of drinking water. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Long-Term Carcinogenicity

                        • 2 years (Dosed-Water)  (C91004)  Report Complete 
                          • TR-392 (NIH Number: 92-2847)  (Peer Review Approval 11/19/1990A )
                            Toxicology and Carcinogenesis Studies of Chlorinated Water (CASRNs 7782-50-5 and 7681-52-9) and Chloraminated Water (CASRN 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
                          • Rats: F344/N; Mice: B6C3F1
                          • Carcinogenesis Results
                            • Male Rats No Evidence 
                            • Female Rats Equivocal Evidence 
                            • Male Mice No Evidence 
                            • Female Mice No Evidence 
                          • Dose: R&M: 0, 70, 140, 275 PPM/70 PER GROUP.
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                        CASRN: EMTDP-88

                        Formula: C2-H4

                        Known Uses

                        Used in making fibers for home furnishings, beverage containers, synthetic plastics (Kirk-Othmer)

                        Genetic Toxicology

                        • Salmonella  (A60101)  Completed 
                          •  Negative 
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                        CASRN: EMTDP-90

                        Formula: C2-H4

                        Known Uses

                        Used for water pipes, water treatment, latex paints, in packaging, flotation devices (Kirk-Othmer)

                        Genetic Toxicology

                        • Salmonella  (A09638)  Completed 
                          •  Negative 
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                        CASRN: EMTDP-91

                        Formula: C2-H4

                        Known Uses

                        Used for water pipes, water treatment, latex paints, packaging, flotation devices (Kirk-Othmer)

                        Genetic Toxicology

                        • Salmonella  (A60602)  Completed 
                          •  Negative 
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                        CASRN: CHLORAMINEMX

                        Synonyms/Common Names

                        • Chloramine/Sodium hypochlorite

                        Secondary:

                        • 10599-90-3 - Chloramine
                        • 7681-52-9 - Hypochlorous acid, sodium salt

                        Known Uses

                        Reagent, water disinfectant

                        Long-Term Carcinogenicity

                        • 2 years (Dosed-Water)  (C91008)  Report Draft 
                          • TR-392 (NIH Number: 92-2847)  (Peer Review Approval 11/19/1990A )
                            Toxicology and Carcinogenesis Studies of Chlorinated Water (CASRNs 7782-50-5 and 7681-52-9) and Chloraminated Water (CASRN 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
                          • Rats: F344/N; Mice: B6C3F1
                          • Carcinogenesis Results
                            • Male Rats No Evidence 
                            • Female Rats Equivocal Evidence 
                            • Male Mice No Evidence 
                            • Female Mice No Evidence 
                          • Dose: R&M: 0, 50, 100, 200 PPM/ 70 PER GROUP.
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                        CASRN: RETROVIRVECT

                        Known Uses

                        Experimental treatment for immune deficiency disorders

                        Short-Term Toxicity

                        • 1 week (Intraperitoneal Injection)  (C91009B)  Completed 
                          • Rats: F344/N
                        • 2 weeks (Whole Body Exposure)  (C91009C)  Completed 
                          • Rats: F344/N; Mice: B6C3F1; Mice: P53 +/- (C57BL/6)
                        • 3 days (Intravenous)  (C91009D)  Completed 
                          • Mice: B6C3F1; Mice: P53 +/- (C57BL/6)
                        • 2 weeks (Intraperitoneal Injection)  (C91009)  Completed 
                          • Mice: B6C3F1
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                        CASRN: LEADORES

                        Synonyms/Common Names

                        • Black Cloud Mine Ore (Colorado)
                        • Red Dog Mine Ore (Alaska)
                        • West Fork Mine Ore (Missouri)

                        Known Uses

                        Lead ores from various geographical locations

                        Short-Term Toxicity

                        • 13 & 26 weeks (Dosed-Feed)  (C92001)  Completed 
                          • Rats: F344/N
                          • Dose: ORES: MALE RATS, 30/GROUP; PB SULFIDE USED AS STANDARD: MALE AND FEMALE 30/GROUP; 10 ADD'L MALES TREATED 180 DAYS (PB SULFIDE) 0, 10, 30, & 100 PPM; PARTICLE SIZE <38 MICRONS; 30, 60, 90-DAY SACRIFICE.

                        Special Studies

                        • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0375)  Completed 
                          • Male Rats: F344/N
                          • Dose: 10, 30, 100 PPM.
                        • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0478)  Completed 
                          • Citation: Dieter MP, Matthews HB, Jeffcoat RA, Moseman RF. Comparison of lead bioavailability in F344 rats fed lead acetate, lead oxide, lead sulfide, or lead ore concentrate from Skagway, Alaska. J Toxicol Environ Health. 1993 May;39(1):79-93.Pubmed Abstract
                          • Male Rats: F344/N
                          • Dose: 0, 10, 30 OR 100 PPM.
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                        CASRN: DIET90

                        Known Uses

                        NTP feed comparison study

                        Long-Term Carcinogenicity

                        • 2 years (Dosed-Feed)  (C92003)  Completed 
                          • Citation: GN Rao, J Edmondson and MR Elwell. Influence of dietary fat and fiber on growth and tumor incidences in Fischer 344 rats (presented in an abstract at the 33rd annual meeting of the Society of Toxicology in March 1994). Toxicologist 14(1):303, 1994.
                          • Rats: Not Available; Mice: B6C3F1
                          • Dose: Feed administered ad libitum (60 per group).
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                        CASRN: DIET9192

                        Known Uses

                        Feed comparison study

                        Long-Term Carcinogenicity

                        • 2 years (Dosed-Feed)  (C92004)  Completed 
                          • Citation: GN Rao, J Edmondson and MR Elwell. Influence of dietary fat and fiber on growth and tumor incidences in Fischer 344 rats (presented in an abstract at the 33rd annual meeting of the Society of Toxicology in March 1994). Toxicologist 14(1):303, 1994.
                          • Rats: F344/N
                          • Dose: Feed administered ad libitum (60 per group).
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                        CASRN: AZTMETHCOMB

                        Synonyms/Common Names

                        • 3'-Azido-3'-deoxythymidine + Methadone Hydrochloride

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 1095-90-5 - Methadone hydrochloride

                        Known Uses

                        Aids therapeutic

                        Short-Term Toxicity

                        • 13 weeks (Gavage)  (C92014)  Completed 
                          • Mice: B6C3F1
                          • Dose: AZT: 200, 400, OR 800 MG/KG/DAY WITH METHADONE HCL: 5, 15, OR 30 MG/KG/DAY.

                        Special Studies

                        • Toxicokinetic Study (Gavage; Intravenous)  (S0305)  Completed 
                          • Citation: Part of Short Term Toxicity Study C92014 & RACB STUDY 92023
                          • Female Mice: B6C3F1; Female Mice: Swiss CD-1; Male Mice: B6C3F1; Female Mice: B6C3F1; Female Mice: Swiss CD-1
                          • Dose: IV: AZT: 100 MG/KG METHADONE: 0 MG/KG & AZT: 0 MG/KG METHADONE: 2.5 ORAL: AZT: 100 METHADONE: 0 AZT: 200 METHADONE: 0 AZT: 400 METHADONE: 0 OR 15 AND AZT: 0 METHADONE: 2.5 AZT: 0 METHADONE: 7.5 AZT: 0 OR 400 METHADONE: 15 MG/KG chemtasks chem00207 & 208.

                        Organ Systems Toxicity

                        • Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB92023)  Completed 
                          • Male and Female Mice: Swiss
                          • Dose: AZT:0, 200, 400, 800 MG/KG/DAY; METHADONE: 0, 5, 15, 30 MG/KG/DAY.
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                        CASRN: URETHCOMB

                        Formula: C3-H7-N-O2 + C2-H6-O

                        Secondary:

                        • 64-17-5 - Ethanol
                        • 51-79-6 - Urethane

                        Known Uses

                        (Urethane) chemical intermediate; solubilizer for cosmetics and pesticides; (ethanol) solvent; in alcoholic beverages and manufacture of denatured alcohols; in gasohol; anti-freeze agent; chemical intermediate; in synthetic rubber, pharmaceuticals, disinfectants. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Short-Term Toxicity

                        • 13 weeks (Dosed-Water)  (C00602C)  Report Complete 
                          • TOX-52 (NIH Number: 96-3937)  (Tox Peer Review 06/00/1995A )
                            Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol in F344/N Rats and B6C3F1 Mice (CASRN 51-79-6)
                          • Rats: F344/N; Mice: B6C3F1
                          • Dose: R&M:(WITH 5% ETHANOLIN WATER)0.011, 0.033, 0.11, 0.33, OR 1.0 G/100 ML.

                        Long-Term Carcinogenicity

                        • 2 years (Dosed-Water)  (C00602F)  Report Complete 
                          • TR-510 (NIH Number: 04-4444)  (Peer Review Approval 09/05/2002A )
                            Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
                          • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                          • Carcinogenesis Results
                            • Male Mice Clear Evidence 
                            • Female Mice Clear Evidence 
                          • Dose: 0, 10, 30, OR 90 PPM.

                        Genetic Toxicology

                        • Micronucleus  (A23852)  Completed 
                          • Mice: B6C3F1
                          • Male Positive 
                          • Female Positive 
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                        CASRN: TASKTHREEALT

                        Formula: N/A

                        Known Uses

                        Special. No chemical involved - study designed to develop an alternate design for task three used in reproductive assessment and continuous breeding studies

                        Organ Systems Toxicity

                        • Continuous Breeding (Legacy)  (RACB88127)  Completed 
                          • Citation: Final Report on the Development of Alternate Task 3 Design in CD Sprague-Dawley Rats
                          • Male and Female Rats: Crl:CD (SD)
                          • Dose: NA; NA; NA; NA.
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                        CASRN: DIETH/DIMETH

                        Secondary:

                        • 84-66-2 - Diethyl phthalate
                        • 131-11-3 - Dimethyl phthalate

                        Known Uses

                        Diethyl: celluloid manufacture, cosmetics, varnishes, dopes, insecticidal soaps, plasticizer. Dimethyl: insecticides, plasticizer, solvent, dye carrier, rocket fuel. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Long-Term Carcinogenicity

                        • 2 years (Topical Application)  (C55914)  Report Complete 
                          • TR-429 (NIH Number: 95-3356)  (Peer Review Approval 11/17/1993A )
                            Toxicology and Carcinogenesis Studies of Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CASRN 131-11-3) in Male Swiss (CD-1®) Mice
                          • Mice: Swiss CD-1
                          • Dose: 100 UL (PROMOTOR) NEAT CHEMICAL ON UNINITIATED AND DMBA INITIATED SKIN.
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                        CASRN: AZTZINAMIDE

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 98-96-4 - Pyrazinamide

                        Known Uses

                        Combination therapeutic agents for use in AIDS therapy

                        Short-Term Toxicity

                        • 13 weeks (Gavage)  (C93003)  Completed 
                          • Mice: B6C3F1

                        Organ Systems Toxicity

                        • 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT95001)  Completed 
                          • NIH Number: 02-4408
                            Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3'-Azido-3'-deoxythymidine (AZT) and Pyrazinamide Combinations (CASRNs 30516-87-1 and 98-96-4) Administered by Gavage to Swiss (CD-1®) Mice
                          • Male and Female Mice: Swiss
                          • Dose: Multiple.
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                        CASRN: AZTRIFAMPIN

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 13292-46-1 - Rifampin

                        Known Uses

                        Drug combination to be used as AIDS therapy

                        Short-Term Toxicity

                        • 13 weeks (Gavage)  (C93002)  Completed 
                          • Mice: B6C3F1

                        Special Studies

                        • Toxicokinetic Study (Gavage; Intravenous)  (S0553)  Completed 
                          • Male and Female Mice: B6C3F1
                          • Dose: IV: 100 MG AZT/KG BW; PO: 200 MG AZT/KG BW & 200 MG AZT + 200 MG RIFAMPIN/KG BW Repeated dose study: all doses for AZT and RIF are 100 mg/kg BW.
                        • Toxicokinetic Study (Gavage; Intravenous)  (S0643)  Completed 
                          • Citation: The Effect of Multiply Administered Rifampicin (RIF) on the Toxicokinetics and Metabolism of 3'-Azido-Deoxythymidine (AZT) in Male and Female B6C3F1 Mice.
                          • Male and Female Mice: B6C3F1
                          • Dose: AZT: 100 mg/kg Rif: 100 mg/kg.
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                        CASRN: AZTISONIAZID

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 54-85-3 - Isoniazid

                        Known Uses

                        Drug combination to be used as AIDS therapy

                        Short-Term Toxicity

                        • 13 weeks (Gavage)  (C93001)  Completed 
                          • Mice: B6C3F1
                          • Dose: AZT: 100, 200, or 400 mg/kg/day; isoniazid: 50, 100, or 150 mg/kg/day.

                        Organ Systems Toxicity

                        • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93150)  Completed 
                          • NIH Number: 99-3941
                            Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-dioxythymidine (AZT) and Isoniazid Combinations (CASRNs 30516-87-1 and 54-85-3) Administered by Gavage to Swiss (CD-1®) Mice
                          • Male and Female Mice: Swiss CD-1
                          • Dose: N/A; N/A; N/A; N/A.
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                        CASRN: PBCONTAMSOIL

                        Formula: NONE

                        Secondary:

                        • 7439-92-1 - Lead
                        • 301-04-2 - Lead(2+) acetate
                        • 1314-87-0 - Lead sulfide

                        Known Uses

                        Soil contaminated with lead. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                        Short-Term Toxicity

                        • 7 weeks (Dosed-Feed)  (C93006)  Completed 
                          • Rats: F344/N
                          • Dose: MR: PB/SOIL (0, CNTRL SOIL(1.5%), PB SOIL(1.5%) 120PPM, PB SOIL(0.5%)+CTRL SOIL(1.5%) 40PPM, PB SOIL(0.2%)+CTRL SOIL (1.3%) 16PPM), PB S/SOIL (PB S 120PPM; PB S+CTRL SOIL(1.5%) 120PPM), PB ACE/SOIL (PB ACE 16, 40, 120 PPM; PB ACE+CTRL SOIL(1.5%) 120PPM.
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                        CASRN: EMTDP-97

                        Known Uses

                        Chemotherapeutic agent

                        Genetic Toxicology

                        • Micronucleus  (A72378)  Completed 
                          • Mice: B6C3F1
                          • Male Negative 
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                        CASRN: EMTDP-98

                        Known Uses

                        Chemotherapeutic agent

                        Genetic Toxicology

                        • Micronucleus  (A93030)  Completed 
                          • Mice: B6C3F1
                          • Male Negative 
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                        CASRN: AZT/ETOHCOMB

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 64-17-5 - Ethanol

                        Known Uses

                        Study to investigate the combined drug effects of AZT and alcohol users.

                        Organ Systems Toxicity

                        • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage & Dosed-Water)  (RACB93152)  Completed 
                          • Male and Female Mice: Swiss CD-1
                          • Dose: N/A; N/A; N/A; N/A.
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                        CASRN: GLYCINEBENZA

                        Formula: N/A

                        Secondary:

                        • 140-11-4 - Benzyl acetate
                        • 56-40-6 - Glycine

                        Known Uses

                        Study of influence of benzyl acetate on hippurate synthetic pathways and glycine nutritional status and the effect of supplemental glycine on benzyl acetate toxicity

                        Short-Term Toxicity

                        • 4 weeks (Dosed-Feed)  (C93017)  Completed 
                          • Rats: F344/N
                          • Dose: 7 GROUPS - MALE RATS ONLY: BENZYL AC: 0, 20000, 35000 PPM - 30/GROUP; BENZYL AC: 50000 PM - 50/GROUP; BENZYL AC: 50000 PPM + GLYCINE 27000 PPM 10/GROUP; BENZYL AC: 50000 PM + ALANINE 32000 PPM 10/GROUP; ALANINE 32000 PPM 10/GROUP.
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                        CASRN: RETINOID1

                        Formula: NA

                        Secondary:

                        • 514-78-3 - Canthaxanthin
                        • 65646-68-6 - 4-(Hydroxyphenyl)retinamide
                        • 65646-68-6 - Retinoid project 2 (4-(Hydroxyphenyl)retinamide)
                        • 127-47-9 - Retinoid project 3 (Retinol acetate)
                        • 65646-68-6 - Retinoid project 4 (4-(Hydroxyphenyl)retinamide)
                        • 65646-68-6 - Retinoid project 5 (4-(Hydroxyphenyl)retinamide)
                        • 65646-68-6 - Retinoid project 6 (4-HPR)
                        • 127-47-9 - Retinol acetate
                        • 68-26-8 - All-trans retinol

                        Known Uses

                        Project combining various retinoids to examine their use in the prevention and intervention of breast cancer

                        Short-Term Toxicity

                        • 26 weeks (Dosed-Feed)  (C93028)  Completed 
                          • Citation: Rao G, Ney E, Herbert R. Changes associated with delay of mammary cancer by retinoid analogues in transgenic mice bearing c-neu oncogene. Breast Cancer Research and Treatment 58:241-254. (2000)
                          • Citation: Rao G, Ney E, Herbert R. Effect of retinoid analogues on mammary cancer in transgenic mice with c-neu breast cancer oncogene. Breast Cancer Research and Treatment 48:265-271. (1998)
                          • Citation: Rao G, Ney E, Herbert R. Influence of Diet on Mammary Cancer in Transgenic Mice Bearing an Oncogene Expressed in Mammary Tissue.
                          • Mice: MMTV/NEU (Tg.Nk)
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                        CASRN: MICROWAVES

                        Known Uses

                        Electromagnetic spectrum having wavelengths in the range between the far infrared and the radiofrequencies (9th condensed chemical dictionary)

                        Organ Systems Toxicity

                        • Neurotoxicology Assessment (Whole Body Exposure)  (NTA94002)  Completed 
                          • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
                          • Male and Female Rats: F344/N
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                        CASRN: AZTTMPSMX

                        Synonyms/Common Names

                        • AZT + TMP/SMX (mixture) combination (AIDS)
                        • AZT + Trimethoprim/Sulfamethoxazole (mixture) combination

                        Secondary:

                        • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                        • 30516-87-1 - AZT transplacental carcinogenesis study
                        • 723-46-6 - Sulfamethoxazole
                        • 738-70-5 - Trimethoprim
                        • TMPSMXMIXNTP - Trimethoprim/sulfamethoxazole (mixture)

                        Known Uses

                        Experimental AIDS therapy

                        Short-Term Toxicity

                        • 13 weeks (Gavage)  (C95004B)  Completed 
                          • Mice: B6C3F1
                        • 13 weeks (Gavage)  (C95004)  Completed 
                          • Mice: B6C3F1

                        Special Studies

                        • Toxicokinetic Study (Gavage; Intravenous)  (S0609)  Completed 
                          • Citation: 3'-Azido-3'-Deoxythymidine (AZT) + TMP/SMX. Toxicokinetic study report. The toxicokinetics of 3'-azido-3'deoxythymidine (AZT) when administered alone and in combination with trimethoprim (TMP) and sulfamethoxazole (SMX) to male and female B6C3F1 mice. February 20, 2007
                          • Male and Female Mice: B6C3F1
                          • Dose: Single Administration: azt (iv&gav): 15, 25, 50, 100 mg/kg; azt+tmp smx (iv): 2/5 and 1/20, (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250. Multiple Administration: azt+tmpsmx (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250.. Single Administration: azt (iv&gav): 15, 25, 50, 100 mg/kg; azt+tmp smx (iv): 2/5 and 1/20, (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250. Multiple Administration: azt+tmpsmx (gav): 100/1000, 100/500, 100/250, 50/1000, 50/250, 25/1000, 25/250..
                        • Toxicokinetic Study (Gavage)  (S0610)  Completed 
                          • Male and Female Mice: B6C3F1
                          • Dose: AZT: 0, 50, 100, 200 mg/kg TMP/SMX: 500, 1000, 2000 mg/kg Folinic Acid: 50 mg/kg.

                        Organ Systems Toxicity

                        • 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT95002)  Completed 
                          • NIH Number: 99-3940
                            Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-dioxythymidine (AZT), Trimethoprim (TMP)/ Sulfamethoxazole (SMX), and Folinic Acid Combinations Administered by Gavage to Swiss (CD-1®) Mice
                          • Male and Female Mice: Swiss
                          • Dose: Multiple.
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                        CASRN: ASBESTOSFIB

                        Formula: N/A

                        Secondary:

                        • 12172-73-5 - Asbestos, amosite
                        • 12172-73-5 - Asbestos, amosite + Dimethyl hydrazine

                        Known Uses

                        Naturally occurring fibrous material used to fireproof fabrics; in brake linings; gaskets; roofing compositions; electrical & heat insulation; paint filler; chemical filters reinforcing agent in rubber & plastics; diaphragm cells. (chem dic. 9th ed)

                        Planned Carcinogenicity/Toxicity

                        • Selected (C98006)  
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                          CASRN: AZT/PYRIMETH

                          Secondary:

                          • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                          • 30516-87-1 - AZT transplacental carcinogenesis study
                          • 58-14-0 - Pyrimethamine

                          Known Uses

                          Aids therapeutic

                          Organ Systems Toxicity

                          • 14 days Immunotoxicity (Gavage)  (IMM94007)  Completed 
                            • Female Mice: B6C3F1
                            • Dose: PYM: (2.5, 5.0, OR 10.0 MG/KG + 200 MG/KG AZT) PYM: 10 MG/KG AZT: 200 MG/KG CYCLOPHOSPHAMIDE 25 MG/KG X 4.
                          • 28 days Immunotoxicity (Gavage)  (IMM96013)  Completed 
                            • Female Mice: B6C3F1
                            • Dose: AZT: (50, 100, OR 200 MG/KG + 10 MG/KG PYM) AZT: 200 MG/KG PYM: 10 MG/KG.
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                          CASRN: DIET2000

                          Known Uses

                          NTP feed comparison study

                          Short-Term Toxicity

                          • 13 weeks (Dosed-Feed)  (C95001)  Completed 
                            • Rats: F344/N
                            • Dose: NIH-07 FEED AND NTP-2000 FEED AD LIBITUM/25 PER GROUP.
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                          CASRN: AZTRIFABUTIN

                          Secondary:

                          • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                          • 30516-87-1 - AZT transplacental carcinogenesis study
                          • 72559-06-9 - Rifabutin

                          Known Uses

                          Combination therapy for treatment of AIDS

                          Organ Systems Toxicity

                          • 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT95003)  Completed 
                            • NIH Number: 00-3948
                              Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3'-Azido-3'-deoxythymidine (AZT) and Rifabutin Combinations (CASRNs 30516-87-1 and 72559-06-9) Administered by Gavage to Swiss (CD-1®) Mice
                            • Male and Female Mice: Swiss CD-1
                            • Dose: 200 or 400 mg of AZT/kg/day and 80, 320, or 640 mg of rifabutin/kg/day.
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                          CASRN: FEEDRESTRICT

                          Known Uses

                          Feed restriction studies. Two chemicals, butyl benzyl phthalate and t-butylhydroquinone, were administered in feed; one chemical, salicylazosulfapyridine, was administered in corn oil by gavage; and one chemical, scopolamine hydrobromide trihydrate, was administered in distilled water by gavage.

                          Long-Term Carcinogenicity

                          • 2 years (Multiple Routes)  (C95006)  Report Complete 
                            • TR-460 (NIH Number: 97-3376)  (Peer Review Approval 06/20/1995A )
                              Effects of Dietary Restrictions on Toxicology and Carcinogenesis Studies of in F344 Rats and B6C3F1 Mice
                            • Rats: F344/N; Mice: B6C3F1
                            • Dose: VARIOUS.
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                          CASRN: CELLULOSEINS

                          Synonyms/Common Names

                          • CI

                          Known Uses

                          Cellulose insulation is a type of thermal insulation consisting of recycled newspapers treated with fire retardant chemicals. (Executive Summary 6/95)

                          Short-Term Toxicity

                          • 28 days (Intratracheal)  (C96004)  Completed 
                            • Rats: F344/N
                            • Dose: MALE RATS: 0, 5 MG/KG.
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                          CASRN: TEFBINARYMIX

                          Formula: N/A

                          Synonyms/Common Names

                          • Binary mixture (Toxic equivalency factor evaluation)
                          • Toxic equivalency factor evaluation (Binary Mixture)

                          Secondary:

                          • 35065-27-1 - 2,2'-4,4',5,5'-Hexachlorobiphenyl (PCB 153)
                          • 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126)
                          • 57465-28-8 - TEF transgenics (PCB 126)
                          • 35065-27-1 - Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl)
                          • 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)

                          Known Uses

                          Used in the electric industry as dielectric insulating fluids for transformers and capacitors. PCBs were also produced for use in hydraulic fluids, solvents, plastics, and paints. One of 2 mixtures being tested along with 5 dioxin-like compounds to determine if the toxic equivalency factors (TEFs) for these chemicals would be predictive of rodent carcinogenicity.

                          Long-Term Carcinogenicity

                          • 2 years (Gavage)  (C96020)  Report Complete 
                            • TR-530 (NIH Number: 06-4466)  (Peer Review Approval 12/09/2004A )
                              Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
                            • Rats: Harlan Sprague-Dawley
                            • Carcinogenesis Results
                              • Female Rats Clear Evidence 
                            • Dose: Female rats only: 0; (PCB126) 10, 100, 300, or 1000 ng/kg; (PCB 153) 10, 100, 300, or 1000 ug/kg; 50/dose.
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                          CASRN: TEFDIOXINMIX

                          Formula: N/A

                          Synonyms/Common Names

                          • Dioxin mixture (Toxic equivalency factor evaluation)
                          • Toxic equivalency factor evaluation (Dioxin mixture)

                          Secondary:

                          • 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126)
                          • 57117-31-4 - 2,3,4,7,8-Pentachlorodibenzofuran
                          • 57117-31-4 - Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran))
                          • 1746-01-6 - Toxic equivalency factor evaluation (TCDD)
                          • 57465-28-8 - TEF transgenics (PCB 126)
                          • 57117-31-4 - TEF transgenics (PECDF)
                          • 1746-01-6 - TEF transgenics (TCDD)
                          • 1746-01-6 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
                          • 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)
                          • 1746-01-6 - Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin)

                          Known Uses

                          The main sources of TCDD and PeCDF releases into the environment are from metal smelting, refining, & processing; combustion & incineration sources; chemical manufacturing & processing; biological & photochemical processes; and existing reservior sources that reflect past releases. Used as dielectric insulating fluids in transformers & capacitors and used in hydraulic fluids, plastics, & paints.

                          Long-Term Carcinogenicity

                          • 2 years (Gavage)  (C96007B)  Report Complete 
                            • TR-526 (NIH Number: 06-4462)  (Peer Review Approval 02/17/2004A )
                              Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CASRN 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
                            • Rats: Harlan Sprague-Dawley
                            • Carcinogenesis Results
                              • Female Rats Clear Evidence 
                            • Dose: Female rats only: 0, (TCDD) 3.3, 7.3, 15.2, or 33 ng/kg; (PECDF) 6.6, 14.5, 30.4, or 66 ng/kg; (PCB 126) 33.3, 73.3, 153, or 333 ng/kg; 100/dose.
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                          CASRN: EMF+DMBA

                          Formula: N/A

                          Synonyms/Common Names

                          • DMBA + EMF init prom
                          • EMF + DMBA init prom
                          • Magnetic fields (EMF) + Dimethylbenzanthracene initiation promotion

                          Secondary:

                          • 57-97-6 - 7,12-Dimethylbenzanthracene
                          • ELECTROMAG - Magnetic fields (EMF)

                          Known Uses

                          Special exposure study to evaluate the potential of 50/60 Hz magnetic fields to promote breast cancer in DMBA treated female Sprague Dawley rats.

                          Short-Term Toxicity

                          • 13 & 26 weeks (Gavage, Whole Body Exposure)  (C89029D)  Completed 
                            • Rats: Sprague Dawley
                            • Carcinogenesis Results
                              •  Equivocal Evidence 
                            • Dose: 13-WEEK STUDY (female rats only): 5 mg/rat DMBA @ 4 wkly intervals (total 20 mg DMBA) followed by 50 hz (1 gauss), 60 hz (1 gauss) or 50 hz (5 gauss)/18.5 hr/day. 26-WEEK STUDY (female rats only): 10 mg/rat DMBA followed by 50 hz (1 gauss), 60 hz (1 gauss), or 50 hz (5 gauss)/18.5 hr/day. Controls will receive vehicle (sesame oil) or DMBA with <1 milligauss. 100 per group..
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                          CASRN: PEROXISOMES

                          Known Uses

                          Peroxisome Project

                          Special Studies

                          • Absorption Disposition Metabolism Elimination (in-vitro)  (S0846)  Completed 
                            • Citation: Final Report Chemical Disposition in Mammals. 03/15/98 - 06/30/99.
                            • Human (Cell Lines)
                            • Dose: 1 mM.
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                          CASRN: AZTCLARITHRO

                          Formula: N/A

                          Synonyms/Common Names

                          • 3'-Azido-3'-deoxythymidine + clarithromycin combination
                          • Clarithromycin + AZT combination

                          Secondary:

                          • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                          • 30516-87-1 - AZT transplacental carcinogenesis study
                          • 81103-11-9 - Clarithromycin

                          Known Uses

                          Combination of AZT& clarithromycin in experimental treatment of AIDS

                          Special Studies

                          • Toxicokinetic Study (Gavage)  (S0646)  Completed 
                            • Male and Female Mice: B6C3F1
                            • Dose: PTKS doses: 3mg/mL clarithro & 3 mg/mL clarithro + 15 mg/mL AZT..

                          Organ Systems Toxicity

                          • 10 to 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT96002)  Completed 
                            • NIH Number: 04-4418
                              Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-deoxythymidine (AZT) and Clarithromycin Combinations (CASRNs 30516-87-1 and 81103-11-9) Administered by Gavage to Swiss (CD-1®) Mice
                            • Male and Female Mice: Swiss CD-1
                            • Dose: 200 or 400 mg/kg AZT; 500, 1250, or 2500 mg clarithromycin.
                          • 10 to 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT97001)  Completed 
                            • NIH Number: 04-4418
                              Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-deoxythymidine (AZT) and Clarithromycin Combinations (CASRNs 30516-87-1 and 81103-11-9) Administered by Gavage to Swiss (CD-1®) Mice
                            • Male and Female Mice: Swiss CD-1
                            • Dose: 200 or 400 mg AZT: 250, 500, or 1000 mg clarithromycin.
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                          CASRN: HYDROXGLYSAL

                          Synonyms/Common Names

                          • Glycolic acid (alpha/beta Hydroxy acids)
                          • Salicylic acid (alpha/beta Hydroxy acids)

                          Secondary:

                          • 79-14-1 - Glycolic acid
                          • 69-72-7 - Salicylic acid

                          Known Uses

                          Chemical peels of the skin. As part of the alpha/beta-hydroxy acids initiative. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                          Long-Term Carcinogenicity

                          • 1 year (Topical Application)  (C97010A)  Report Review 
                            • TR-524 (NIH Number: 07-4472)  (Peer Review Approval 09/27/2005A )
                              Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light and Topical Application Studies)
                            • Mice: SKH-1 Hairless
                            • Carcinogenesis Results
                              • Male Mice No Evidence 
                              • Female Mice No Evidence 
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                          CASRN: TEFPCBMIX

                          Synonyms/Common Names

                          • PCB Mixture (Toxic equivalency factor evaluation)
                          • Toxic equivalency factor evaluation (PCB Mixture (PCB 126/PCB 118))

                          Secondary:

                          • 31508-00-6 - 2,3',4,4',5-Pentachlorobiphenyl
                          • 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126)
                          • 31508-00-6 - Toxic equivalency factor evaluation (PCB 118)
                          • 57465-28-8 - TEF transgenics (PCB 126)
                          • 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)

                          Known Uses

                          One of 2 dioxin-like compounds plus mixtures being tested to determine if the TEFs for these chemicals would be predictive of rodent carcinogenicity. This mixture consists of PCB 118 (2,3',4,4',5- pentachlorobiphenyl) & PCB 126 (3,3',4,4',5- pentachlorobiphenyl) Mixtures were produced commercially before 1977 for the electric industry as dielectric insulating fluids for transformers & capacitors

                          Long-Term Carcinogenicity

                          • 2 years (Gavage)  (C96022)  Report Complete 
                            • TR-531 (NIH Number: 07-4467)  (Peer Review Approval 12/09/2004A )
                              Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
                            • Rats: Harlan Sprague-Dawley
                            • Carcinogenesis Results
                              • Female Rats Clear Evidence 
                            • Dose: Female rats only (PCB 118/PCB 126): 0, 7, 22, 72, 216, or 360 ng/kg; 50/dose.
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                          CASRN: AZT+NITAZOX

                          Secondary:

                          • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                          • 30516-87-1 - AZT transplacental carcinogenesis study
                          • 55981-09-4 - Nitazoxanide (AIDS initiative)

                          Known Uses

                          Combination of AZTand nitazoxanide for treatment of AIDS

                          Short-Term Toxicity

                          • 13 weeks (Gavage)  (C98002)  Completed 
                            • Mice: B6C3F1
                            • Dose: AZT: 0, 200, OR 400 MG/KG/DAY NITAZOXANIDE 250, 500, OR 1000 MG/KG/DAY.

                          Organ Systems Toxicity

                          • 28 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT97003)  Completed 
                            • Male and Female Mice: Swiss CD-1
                            • Dose: NITAZOXANIDE: 250, 500, OR 1000 MG/KG/DAY AZT: 200 OR 400 MG/KG/DAY.
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                          CASRN: AGNTORANGEMX

                          Formula: N/A

                          Synonyms/Common Names

                          • Simulated Agent Orange

                          Secondary:

                          • 94-75-7 - 2,4-Dichlorophenoxyacetic acid
                          • 94-75-7 - Peroxisome project (2,4-Dichlorophenoxyacetic acid)
                          • 1746-01-6 - Toxic equivalency factor evaluation (TCDD)
                          • 1746-01-6 - TEF transgenics (TCDD)
                          • 1746-01-6 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
                          • 1746-01-6 - Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin)
                          • 93-76-5 - 2,4,5-Trichlorophenoxyacetic acid

                          Known Uses

                          Special study of the mixture of 2,4-D, 2,4,5-T & TCDD (simulated agent orange). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                          Organ Systems Toxicity

                          • Other Reproductive Studies (Dosed-Feed)  (ORST80001)  Completed 
                            • Citation: Evaluation of 2,4-Dichlorophenoxyacetic Acid (2,4-D), 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Toxicity in C57BL/6 Mice: Reproduction and Fertility in Treated Male Mice and Evaluation of Congenital Malformations in their Offspring.
                            • Male Mice: C57BL/6
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                          CASRN: AZT+DAPSONE

                          Synonyms/Common Names

                          • 3'Azido-3'-deoxythymidine + dapsone
                          • Dapsone + AZT

                          Secondary:

                          • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
                          • 30516-87-1 - AZT transplacental carcinogenesis study
                          • 80-08-0 - 4,4'-Sulfonyldianiline (Dapsone)

                          Known Uses

                          Combination of drugs being investigated for treatment of HIV

                          Organ Systems Toxicity

                          • 6 to 15 GD Conventional Teratology (Gavage)  (TER98001)  Completed 
                            • Citation: Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and Dapsone (CASRN 80-08-0) Administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 Through 15 (Laboratory Supplement)
                            • Citation: Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and Dapsone (CASRN 80-08-0) Administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 15
                            • Female Mice: Swiss CD-1
                            • Dose: ALL COMBINATIONS OF AZT (0, 100, 200, OR 400 MG/KG/DAY) PLUS DAPSONE (0, 50, 100, OR 200 MG/KG/DAY).
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                          CASRN: FLAXSEED+MEL

                          Formula: N/A

                          Synonyms/Common Names

                          • Flaxseed oil + melatonin (Prevention 1)

                          Secondary:

                          • 8001-26-1 - Linseed oil
                          • 73-31-4 - Melatonin
                          • 73-31-4 - Prevention 1 (Melatonin)
                          • 73-31-4 - Prevention 2 (Melatonin)
                          • 73-31-4 - Prevention 3 (Melatonin)
                          • 73-31-4 - Prevention 6 (Melatonin)
                          • 8001-26-1 - Prevention 1 (Flaxseed oil)
                          • 73-31-4 - Prevention 4 (Melatonin)
                          • 73-31-4 - Prevention 5 (Melatonin)

                          Known Uses

                          Special study examining dietary intervention of prevent/delay breast cancer

                          Short-Term Toxicity

                          • 26 weeks (Gavage)  (C98003D)  Completed 
                            • Mice: MMTV/NEU (Tg.Nk)
                            • Dose: FLAXSEED OIL: 0.10 ML + 2.2 MG/KG MELATONIN.
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                          CASRN: GOLDENSEALRT

                          Synonyms/Common Names

                          • Powdered root of goldenseal

                          Known Uses

                          A natural herbal remedy

                          Short-Term Toxicity

                          • 2 weeks (Dosed-Feed)  (C99007)  Completed 
                            • Rats: F344/N; Mice: B6C3F1/N
                            • Dose: R&M: 0, 1560, 3121, 6250, 12500, 25000 OR 50000 PPM; 5/SEX/SPECIES.
                          • 13 weeks (Dosed-Feed)  (C99007B)  Completed 
                            • Rats: F344/N; Mice: B6C3F1/N
                            • Dose: R&M: 0, 3125, 6250, 12500, 25000, OR 50000 PPM; 10/SEX/SPECIES.

                          Long-Term Carcinogenicity

                          • 2 years (Dosed-Feed)  (C99007B)  Completed 
                            • TR-562 (NIH Number: 10-5903)  (Peer Review Approval 02/25/2009A )
                              Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (HYDRASTIS CANADENSIS) in F344/N Rats and B6C3F1 Mice (Feed studies)
                            • Rats: F344/N; Mice: B6C3F1/N
                            • Carcinogenesis Results
                              • Male Rats Clear Evidence 
                              • Female Rats Clear Evidence 
                              • Male Mice Some Evidence 
                              • Female Mice No Evidence 
                            • Dose: R&M: 0, 3000, 9000, OR 25, 000 PPM.

                          Special Studies

                          • Absorption Disposition Metabolism Elimination (in-vitro)  (S0856)  Completed 
                            • Citation: Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5. PubMed PMID: 17611934.Pubmed Abstract
                            • Citation: Final Study Report. Goldensealrt: Interaction of Extracts with Cytochrome P450 Enzymes and P-glycoprotein. Studies of Chemical Disposition in Mammals. 10/14/2002 - 02/28/2006.
                            • Human (Cell Lines)
                            • Dose: 0, 1, 10, 100 uM..

                          Genetic Toxicology

                          • Micronucleus  (A21831)  Completed 
                            • Mice: B6C3F1
                            • Male Negative 
                            • Female Negative 
                          • Salmonella  (A83314)  Completed 
                            •  Negative 

                          Organ Systems Toxicity

                          • 6 to 20 GD Conventional Teratology (Dosed-Feed)  (TER98007)  Completed 
                            • Citation: FINAL STUDY REPORT DEVELOPMENTAL TOXICITY EVALUTATION FOR GOLDENSEAL ROOT POWDER (HYDRASTIS CANADENSIS) ADMINISTERED IN THE FEED TO SPRAGUE-DAWLWY (CD(r)) RATS ON GESTATIONAL DAYS 6 TO 20
                            • Citation: Final Study Report Developmental Toxicity Evaluation for Goldenseal Root Powder (Hydrastis Canadensis) Administered in the Feed to Sprague-Dawley (CD®) Rats on Gestational Days 6 to 20
                            • Female Rats: Sprague Dawley
                            • Dose: 0, 3125, 6250, 12, 500 OR 18, 400 PPM.
                          • 6 to 17 GD Conventional Teratology (Dosed-Feed)  (TER99004)  Completed 
                            • Citation: Final Study Report Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) root powder Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6-17
                            • Citation: Final Study Report?Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) root powder Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6-17
                            • Female Mice: Swiss CD-1
                            • Dose: 0, 3125, 12, 500, OR 50, 000 PPM.
                          • 6 to 20 GD Teratology Pilot Studies (Dosed-Feed)  (TRP98007)  Completed 
                            • Rats: Sprague Dawley
                            • Dose: 0, 3125, 6250, 12, 500, 25, 000, OR 50, 000 PPM.
                          • 6 to 17 GD Teratology Pilot Studies (Dosed-Feed)  (TRP99007)  Completed 
                            • Female Mice: Swiss CD-1
                            • Dose: 0, 3125, 6250, 12, 500, 25, 000 OR 50, 000 PPM.
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                          CASRN: SANTRIMER2

                          Known Uses

                          SAN Trimer is a by-product of the production of acrylonitrile styrene plastics and is created in specific manufacturing processes for polymers of acrylonitrile and styrene.

                          Short-Term Toxicity

                          • 7 weeks (Dosed-Feed)  (C99013)  Completed 
                            • Rats: F344/N
                            • Dose: R: 0, 250, 500, 1000, 2000, OR 4000 PM; 10/SEX/DOSE.
                          • 18 weeks (Dosed-Feed)  (C99013)  Completed 
                            • Rats: F344/N
                            • Dose: R: 0, 100, 200, 400, 800, OR 1600 PPM; 20/SEX/DOSE.

                          Long-Term Carcinogenicity

                          • 2 years (Dosed-Feed)  (C99013)  Report Complete 
                            • TR-573 (NIH Number: 11-5915)  (Peer Review Approval 01/26/2011A )
                              Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in F344/N Rats (Perinatal and Postnatal Feed Studies)
                            • Rats: F344/N
                            • Carcinogenesis Results
                              • Male Rats No Evidence 
                              • Female Rats No Evidence 
                            • Dose: R: 0, 400, 800, OR 1600 PPM; 50/SEX/DOSE.

                          Genetic Toxicology

                          • Comet Assay Selected (G99020)  
                            • Rats: F344/NTac
                          • Comet Assay (Gavage)  (G99020C)  Completed 
                            • Rats: Fischer 344
                          • Micronucleus  (G99020B)  Completed 
                            • Rats: F344/NTac
                            • Male Positive 
                            • Female Positive 
                          • Salmonella  (A04901)  Completed 
                            •  Negative 
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                          CASRN: SILYMARN+MEL

                          Synonyms/Common Names

                          • Melatonin + silymarin (Prevention 2)
                          • Silymarin + melatonin (Prevention 2)

                          Secondary:

                          • 73-31-4 - Melatonin
                          • 73-31-4 - Prevention 1 (Melatonin)
                          • 73-31-4 - Prevention 2 (Melatonin)
                          • 65666-07-1 - Prevention 2 (Silymarin)
                          • 73-31-4 - Prevention 3 (Melatonin)
                          • 73-31-4 - Prevention 6 (Melatonin)
                          • 73-31-4 - Prevention 4 (Melatonin)
                          • 73-31-4 - Prevention 5 (Melatonin)
                          • 65666-07-1 - Silymarin

                          Known Uses

                          Drug/therapeutic agent. Prevention 2 is a special study to examine dietary intervention to prevent/delay breast cancer.

                          Short-Term Toxicity

                          • 26 weeks (Dosed-Feed)  (C99014C)  Completed 
                            • Mice: MMTV/NEU (Tg.Nk)
                            • Dose: MEL 0.028% + SIL 0.05%; MEL 0.112% + SIL 0.20%.
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                          CASRN: 1478-61-1

                          Formula: C15-H10-F6-O2

                          Synonyms/Common Names

                          • 2,2-Bis(4-hydroxyphenyl)perfluoropropane
                          • BP-AF
                          • BPAF
                          • Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-

                          Known Uses

                          Moderate production and use in polymer synthesis.

                          Chemical Properties

                          Toxicity Effects (HSDB)

                          Short-Term Toxicity

                          • 5 days (Gavage)  (C08002)  On Test 
                            • 5-Day Transcriptomic Dose-Response Studies
                            • Rats: Harlan Sprague-Dawley
                            • Dose: Male rats: 0, 8, 16, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4.

                          Modified One-Generation

                          • Dose Range Finding (Dosed-Feed)  (MOG08002)  Completed 
                            • Female Rats: Harlan Sprague-Dawley
                            • Dose: 0, 937.5, 1875, 3750, or 7500 ppm.
                          • Developmental Toxicity (Dosed-Feed)  (MOG08002B)  Completed 
                            • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
                            • Rats: Harlan Sprague-Dawley
                          • F0 Generation (Dosed-Feed)  (MOG08002B)  Completed 
                            • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
                            • Rats: Harlan Sprague-Dawley
                            • Dose: 0, 338, 1125, or 3750 ppm.
                          • Fertility Assessment (Dosed-Feed)  (MOG08002B)  Completed 
                            • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
                            • Rats: Harlan Sprague-Dawley
                          • Maternal Transfer (Dosed-Feed)  (MOG08002B)  Completed 
                            • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
                            • Rats: Harlan Sprague-Dawley
                          • 13-Week Subchronic (Dosed-Feed)  (MOG08002B)  Completed 
                            • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
                            • Rats: Harlan Sprague-Dawley

                          Special Studies

                          • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08002)  Completed 
                            • Citation: Final Study Report Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of [14C]Bisphenol AF (CAS #1478-61-1) in Harlan Sprague Dawiey Rats (HSD) and B6C3F1/N Mice
                            • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
                            • Dose: 3.4, 34, 340 mg/kg. 34 mg/kg.
                          • (K08002D)  Assigned 
                            • Preliminary Toxicokinetic Study (Gavage; Intravenous)  (K08002B)  Report in Preparation 
                              • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
                              • Dose: 3.4 mg/kg. 34 mg/kg. 34, 340 mg/kg.
                            • Toxicokinetic Study (Gavage; Intravenous)  (K08002C)  On Test 
                              • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
                              • Dose: 34 mg/kg. 34, 110 and 340 mg/kg.

                            Genetic Toxicology

                            • 20 weeks Micronucleus (Dosed-Feed)  (G08002B)  Completed 
                              • Rats: Harlan Sprague-Dawley
                              • Male Negative 
                              • Female Negative 
                            • Salmonella  (G08002)  Completed 
                              •  Negative 

                            Organ Systems Toxicity

                            • GD 6 - PND 96 Immunotoxicity (Dosed-Feed)  (I08002)  Report in Preparation 
                              • Male and Female Rats: Harlan Sprague-Dawley
                              • Dose: 0, 250, 500, or 1000 ppm.
                            • Utero-Lactational (In Utero)  (R08002)  Completed 
                              • Rats: Harlan Sprague-Dawley

                            Toxicogenomics

                            • 5 days Transcriptome Sequencing (Gavage)  (T08002)  Assigned 
                              • 5-Day Transcriptomic Dose-Response Studies
                              • Rats: Harlan Sprague-Dawley
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                            CASRN: 27774-13-6

                            Formula: O5-S-V

                            Synonyms/Common Names

                            • Vanadium, oxo(sulfato(2-)-O)-

                            Known Uses

                            Production of steel and nonferrous alloys, production of pigments. Also used as a dietary supplement.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 14 days (Dosed-Water)  (C08004)  Completed 
                              • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
                              • Dose: Rats and mice: 0, 83.8, 167.5, 335, 670 or 1340 mg/L.
                            • 90 days (Dosed-Water)  (C08004)  On Test 
                              • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
                              • Dose: Rats and mice: 0, 21, 41.9, 83.8, 167.5, 335 ppm or mg/L.

                            Genetic Toxicology

                            • Micronucleus  (G08004B)  On Test 
                              • Rats
                            • Micronucleus  (G08004C)  On Test 
                              • Mice
                            • Salmonella  (G08004)  Completed 
                              •  Negative 
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                            CASRN: 13721-39-6

                            Formula: Na.1/3O4-V

                            Known Uses

                            Production of steel and nonferrous alloys, production of pigments. Occurrence as a drinking water contaminant and use as a dietary supplement.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G08006)  Completed 
                              •  Negative 
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                            CASRN: 82-86-0

                            Formula: C12-H6-O2

                            Synonyms/Common Names

                            • 1,2-Acenaphthenedione

                            Known Uses

                            FUNGICIDE DYE SYNTHESIS /QUINONES/

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Organ Systems Toxicity

                            • 28 days Immunotoxicity (Gavage)  (I08007)  Report in Preparation 
                              • Female Mice: B6C3F1
                              • Dose: 0, 3.1, 6.3, 12.5, 25, 50, 100, or 200 mg/kg.
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                            CASRN: 600-14-6

                            Formula: C5-H8-O2

                            Synonyms/Common Names

                            • Acetyl propionyl
                            • 2,3-Pentadione

                            Known Uses

                            Used As a Substitute for 2,3-butanedione. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 90 days (Inhalation)  (C08010)  Report Draft 
                              • Rats: Wistar Han; Mice: B6C3F1
                              • Dose: 0, 6.25, 12.5, 25, 50, or 100; R: 20/sex/conc; M: 10/sex/conc.

                            Genetic Toxicology

                            • Micronucleus  (G08010B)  Completed 
                              • Mice: B6C3F1
                              • Male Negative 
                              • Female Negative 
                            • Micronucleus  (G08010)  Completed 
                              • Rats: Wistar Han
                              • Male Negative 
                              • Female Negative 

                            Organ Systems Toxicity

                            • Varies Immunotoxicity (Topical Application)  (I08010)  Completed 
                              • Female Mice: BALB/c
                              • Dose: 0, 1%, 2.5%, 5%, 10%, or 25%.
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                            CASRN: 548472-68-0

                            Formula: C30-H30-Cl2-N4-O4

                            Synonyms/Common Names

                            • Nutlin-3
                            • Nutlin-3B

                            Known Uses

                            Antineoplastic agent; MDM2 antagonist; chemotherapeutic drug candidate under investigation for treating certain types of cancers.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G08018)  Completed 
                              •  Negative 
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                            CASRN: 578-54-1

                            Formula: C8-H11-N

                            Synonyms/Common Names

                            • o-Ethylaniline

                            Known Uses

                            Intermediate for pharmaceuticals, dyestuffs, pesticides, and other products. [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 461]. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G08029)  Completed 
                              •  Negative 
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                            CASRN: 587-02-0

                            Formula: C8-H11-N

                            Synonyms/Common Names

                            • Aniline, m-ethyl-
                            • 3-EA

                            Known Uses

                            Chemical intermediate in the synthesis of several compounds; Reactant/monomer in production of conductive polymers; Reactant in the preparation of polymerizable thiophene azo dyes; Additive in aviation gasoline. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G08030)  Completed 
                              •  Negative 
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                            CASRN: 299184-76-2

                            Synonyms/Common Names

                            • Dong quai

                            Known Uses

                            Widespread use as a dietary supplement; suspicion of toxicity based on estrogenic activity and chemical structure; lack of adequate toxicity data

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Planned Carcinogenicity/Toxicity

                            • 14 days (Gavage) Selected (C08032)  
                              • Mice: B6C3F1
                            • 13 weeks (Gavage) Selected (C08032)  
                              • Mice: B6C3F1

                            Modified One-Generation

                            • 14 days Dose Range Finding (Gavage) Selected (MOG08032)  
                              • Rats: Harlan Sprague-Dawley
                            • Developmental Toxicity (Gavage) Selected (MOG08032B)  
                              • Rats: Harlan Sprague-Dawley
                            • F0 Generation (Gavage) Selected (MOG08032B)  
                              • Rats: Harlan Sprague-Dawley
                            • Fertility Assessment (Gavage) Selected (MOG08032B)  
                              • Rats: Harlan Sprague-Dawley
                            • Neurotoxicology Assessment (Gavage) Selected (MOG08032B)  
                              • Rats: Harlan Sprague-Dawley
                            • 90 days Subchronic (Gavage) Selected (MOG08032B)  
                              • Rats: Harlan Sprague-Dawley

                            Toxicogenomics

                            • Microarray Analysis (Gavage) Selected (T08032)  
                              • Mice: B6C3F1
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                            CASRN: 1559-35-9

                            Formula: C10-H22-O2

                            Synonyms/Common Names

                            • EGEHE
                            • Ethanol, 2-((2-ethylhexyl)oxy)-

                            Known Uses

                            The application of EGEHE for use in various formulations also appears to have increased (e.g., ink-jet inks, gas supply pipe sealant, electrodeposition coatings for catalytic converters, lens manufacturing cleaning solutions, termite repellent, liquid bleach and dishwashing detergents, flower preservatives, and air fresheners).

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Modified One-Generation

                            • GD 6 to PND 28 Dose Range Finding (Gavage)  (MOG08033)  On Test 
                              • Dose Range Finding
                              • Rats: Harlan Sprague-Dawley
                              • Dose: 0, 312.5, 625, 1250, or 2500 mg/kg/day.
                            • F0 Generation (Gavage) Selected (MOG08033B)  
                              • Rats: Harlan Sprague-Dawley
                            • Fertility Assessment (Gavage) Selected (MOG08033B)  
                              • Rats: Harlan Sprague-Dawley
                            • Maternal Transfer (Gavage) Selected (MOG08033B)  
                              • Rats: Harlan Sprague-Dawley
                            • Neurotoxicology Assessment (Gavage) Selected (MOG08033B)  
                              • Rats: Harlan Sprague-Dawley
                            • 90 days Subchronic (Gavage) Selected (MOG08033B)  
                              • Rats: Harlan Sprague-Dawley

                            Special Studies

                            • Absorption Disposition Metabolism Elimination (Gavage)  (K08033)  Completed 
                              • Citation: Absorption, Distribution, Metabolism, and Excretion Studies of Ethylene Glycol 2-ethylhexyl ether (CAS# 1559-35-9) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Following Gavage Administration, Intravenous Administration, or Dermal Application
                              • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
                              • Dose: 150 mg/kg. 50, 150 or 500 mg/kg.

                            Organ Systems Toxicity

                            • Immunotoxicity Selected (I08033)  
                              • Developmental Immunotoxicity
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                            CASRN: 15920-93-1

                            Formula: C4-H10-N2-O2

                            Synonyms/Common Names

                            • L-BMAA
                            • 3-(Methylamino)-L-alanine

                            Known Uses

                            A neurotoxic non-protein amino acid produced naturally by cyanobacteria found in freshwater, marine and terrestrial ecosystems.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Special Studies

                            • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08035)  Completed 
                              • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1
                              • Dose: 1 mg/kg. 1, 10, 100 mg/kg.
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                            CASRN: 27575-78-6

                            Synonyms/Common Names

                            • TCPMe

                            Known Uses

                            Production of synthetic high polymers and lightfast dyes for acrylic fibers. Occupational Exposure: Exposure may occur during manufacture of synthetic high polymers, lightfast dyes for acrylic fibers, anthelmintic drugs, and agrochemical formulations (e.g., DDT).

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Modified One-Generation

                            • 10 days prior to mating - PND60 Dose Range Finding (Dosed-Feed)  (MOG08036)  Assigned 
                              • Perinatal Dose Range-Finding MOG Study of Tris(4-chlorophenyl)methane
                              • Rats: Harlan Sprague-Dawley
                              • Dose: 0, 10, 50, 150, or 500 ppm.

                            Special Studies

                            • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08036)  Completed 
                              • Citation: Amended Final Study Report Absorption, Distribution, Metabolism and Excretion (ADME) and Toxicokinetic (TK) Studies of Tris(4-Chlorophenyl)Methane (TCPME, CAS # 27575-78-6) and Tris(4-Chlorophenyl)Methanol (TCPMOH, CAS # 3010-80-8) in Harlan Sprague Dawley Rats (HSD) and B6C3F1/N Mice
                              • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
                              • Dose: 1, 10, 100 mg/kg. 10 mg/kg.

                            Genetic Toxicology

                            • Micronucleus  (G08036B)  On Test 
                              • Male Rats
                              • Rats: Sprague Dawley
                            • Salmonella  (G08036)  Completed 
                              •  Negative 
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                            CASRN: 3010-80-8

                            Formula: C19-H13-Cl3-O

                            Synonyms/Common Names

                            • TCPMOH

                            Known Uses

                            Production of synthetic high polymers and lightfast dyes for acrylic fibers. Occupational Exposure: Exposure may occur during manufacture of synthetic high polymers, lightfast dyes for acrylic fibers, anthelmintic drugs, and agrochemical formulations (e.g., DDT).

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Special Studies

                            • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08037)  Completed 
                              • Citation: Amended Final Study Report Absorption, Distribution, Metabolism and Excretion (ADME) and Toxicokinetic (TK) Studies of Tris(4-Chlorophenyl)Methane (TCPME, CAS # 27575-78-6) and Tris(4-Chlorophenyl)Methanol (TCPMOH, CAS # 3010-80-8) in Harlan Sprague Dawley Rats (HSD) and B6C3F1/N Mice
                              • Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1/N; Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1/N
                              • Dose: 10 mg/kg.

                            Genetic Toxicology

                            • Salmonella  (G08037)  Completed 
                              •  Negative 
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                            CASRN: 3648-21-3

                            Formula: C22-H34-O4

                            Synonyms/Common Names

                            • 1,2-Benzenedicarboxylic acid, 1,2-diheptyl ester
                            • Diheptyl phthalate
                            • Phthalic acid, diheptyl ester

                            Known Uses

                            Plasticizer suitable for higher temperature applications such as wire & cable and automotive interior trim, roofing membranes

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Organ Systems Toxicity

                            • Utero-Lactational (Gavage)  (R09001)  Completed 
                              • Rats: F344/N
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                            CASRN: 71888-89-6

                            Formula: none provided

                            Synonyms/Common Names

                            • 1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich
                            • Diisoheptyl phthalate

                            Known Uses

                            plasticizer used in applications such as vinyl flooring, tile, and carpet backing, molding and coating plastisols, partial replacement for higher molecular weight phthalate plasticizers in extrusion, injection molding

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Organ Systems Toxicity

                            • Utero-Lactational (Gavage)  (R09002)  Completed 
                              • Mice: B6C3F1
                            • Utero-Lactational (Intravenous)  (R09002)  Completed 
                              • Mice: B6C3F1
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                            CASRN: 146-50-9

                            Formula: C20-H30-O4

                            Synonyms/Common Names

                            • 1,2-Benzenedicarboxylic acid, bis(4-methylpentyl) ester
                            • Bis(4-methylpentyl) 1,2-benzenedicarboxylate

                            Known Uses

                            plasticizer;main raw materials in producing soft plastic, extensively used in processing PVC plastic products such as leatheroid, cable materials, pellicle, mould plastics and sheet materials

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Organ Systems Toxicity

                            • Utero-Lactational (Dosed-Water & Dosed-Feed)  (R09003)  Completed 
                              • Rats: Harlan Sprague-Dawley
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                            CASRN: 68515-48-0

                            Formula: C26-H42-O4

                            Synonyms/Common Names

                            • 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich
                            • Di(isononyl) phthalate branched
                            • DINP-1

                            Known Uses

                            General purpose plasticizer with a broad range of applications used in flexible PVC; widely used in the toy, construction, and general consumer product markets.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Organ Systems Toxicity

                            • Utero-Lactational (Dosed-Water)  (R09004)  Completed 
                              • Mice: B6C3F1
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                            CASRN: 7562-61-0

                            Formula: C18-H16-O7

                            Synonyms/Common Names

                            • 1,3(2H,9bH)-dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy- 8,9b-dimethyl-, (9bR)-
                            • D-Usnic acid

                            Known Uses

                            Preservative, active ingredient in medicinal products, marketed as a dietary supplement to promote weight loss

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 2 weeks (Dosed-Feed)  (C20609)  Completed 
                              • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                              • Dose: R: 0, 60 120, 360, 1250, or 2500 ppm in chow; M: 0, 30, 60, 180, 600, or 1200 ppm in chow.
                            • 90 days (Dosed-Feed)  (C20609)  Completed 
                              • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                              • Dose: R: 0, 30, 60, 120, 360, or 720 ppm; M: 0, 15, 30, 60, 180, or 360 ppm.
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                            CASRN: 202138-50-9

                            Formula: C19-H30-N5-O10-P.C4-H4-O4

                            Synonyms/Common Names

                            • TDF
                            • Tenofovir DF

                            Known Uses

                            Pharmaceutical used in the treatment of HIV (AIDS)

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Special Studies

                            • Preliminary Toxicokinetic Study (Gavage)  (K09014)  Report in Preparation 
                              • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
                              • Dose: 18.8, 37.5, 75 mg/kg.

                            Organ Systems Toxicity

                            • GD 5 - PND 21 Teratology Pilot Studies (Gavage)  (R09014)  Report in Review 
                              • Prenatal/Perinatal Dose Range-Finding
                              • Female Mice: CD-1
                              • Dose: 0, 75, 150, 300, or 600 mg/kg/day.
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                            CASRN: 99685-96-8

                            Formula: C60

                            Synonyms/Common Names

                            • Fullerene-C60 200 nanometers (Nanoscale material)

                            Known Uses

                            Part of an NTP evaluation of nanoscale materials (a broadly defined set of substances where at least one critical dimension is less than 100 nm) to evaluate the tox properties of major nanoscale materials classes representing a cross-section of composition, size, surface coatings, & physico-chemical properties, and use these as model systems to investigate how they interact w/ biological systems.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Planned Carcinogenicity/Toxicity

                            • 13 weeks (Gavage) Selected (C09099)  
                              • Rats: Wistar Han; Mice: B6C3F1
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                            CASRN: 99685-96-8

                            Formula: C60

                            Synonyms/Common Names

                            • Fullerene-C60 18 microns (Nanoscale material)

                            Known Uses

                            Part of an NTP evaluation of nanoscale materials (a broadly defined set of substances where at least one critical dimension is less than 100 nm) to evaluate the tox properties of major nanoscale materials classes representing a cross-section of composition, size, surface coatings, & physico-chemical properties, and use these as model systems to investigate how they interact w/ biological systems.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Planned Carcinogenicity/Toxicity

                            • 13 weeks (Gavage) Selected (C09033)  
                              • Rats: Wistar Han; Mice: B6C3F1
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                            CASRN: 24549-06-2

                            Formula: C9-H13-N

                            Synonyms/Common Names

                            • 6-Ethyl-o-toluidine

                            Known Uses

                            Herbicide

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G09034)  Completed 
                              •  Negative 
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                            CASRN: 579-66-8

                            Formula: C10-H15-N

                            Synonyms/Common Names

                            • Aniline, 2,6-diethyl-
                            • 2,6-DEA

                            Known Uses

                            One of the major metabolites of the herbicide alachlor.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G09035)  Completed 
                              •  Equivocal 
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                            CASRN: 589-16-2

                            Formula: C8-H11-N

                            Synonyms/Common Names

                            • 4-EA

                            Known Uses

                            Drug, therapeutic agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G09036)  Completed 
                              •  Negative 
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                            CASRN: 90028-66-3

                            Formula: No Structure

                            Synonyms/Common Names

                            • Evening primrose, Oenothera biennis, ext.

                            Known Uses

                            Dietary supplement used in the treatment of various disorders including bronchitis, premenstrual syndrome (PMS), menopause, diabetes, and rheumatoid arthritis.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Modified One-Generation

                            • GD 6 to PND 28 Dose Range Finding (Gavage) Selected (MOG09040)  
                              • Dose Range Finding
                              • Rats: Harlan Sprague-Dawley
                            • Conventional Teratology (Gavage) Selected (MOG09040B)  
                              • Prenatal Developmental Tox
                              • Rats: Harlan Sprague-Dawley
                            • F0 Generation (Gavage) Selected (MOG09040B)  
                              • Rats: Harlan Sprague-Dawley
                            • Fertility Assessment (Gavage)  (MOG09040B)   
                              • Rats: Harlan Sprague-Dawley
                            • 90 days Subchronic (Gavage) Selected (MOG09040B)  
                              • Rats: Harlan Sprague-Dawley

                            Organ Systems Toxicity

                            • Immunotoxicity (Gavage) Selected (I09040)  
                              • Rats: Harlan Sprague-Dawley
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                            CASRN: 8057-49-6

                            Formula: Unspecified

                            Synonyms/Common Names

                            • Valerian extract, powdered

                            Known Uses

                            Dietary supplement used to treat a variety of ailments including insomnia, mood disorders, anxiety, menstrual cramps, and psychological stress conditions

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 90 days (Gavage)  (C09042)  On Test 
                              • Mice: B6C3F1/N
                              • Dose: 0, 125, 250, 500, 1000, or 2000 mg/kg.

                            Modified One-Generation

                            • Dose Range Finding (Gavage)  (MOG09042)  On Test 
                              • Rats: Harlan Sprague-Dawley
                              • Dose: 0, 125, 250, 500, 1000, or 2000 mg/kg.

                            Genetic Toxicology

                            • Micronucleus  (G09042)  On Test 
                              • Male
                              • Mice: B6C3F1
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                            CASRN: 53306-54-0

                            Formula: C28-H46-O4

                            Synonyms/Common Names

                            • 1,2-Benzenedicarboxylic acid, 1,2-bis(2-propylheptyl) ester
                            • Bis-(2-propylheptyl) phthalate

                            Known Uses

                            Plasticizer

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Organ Systems Toxicity

                            • Utero-Lactational (Gavage)  (R09055)  Completed 
                              • Mice: B6C3F1
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                            CASRN: 123-93-3

                            Formula: C4-H6-O4-S

                            Synonyms/Common Names

                            • (Carboxymethylthio) Acetic acid
                            • 2,2'-Thiobisacetic acid

                            Known Uses

                            Metabolite of bis(2-chloroethoxy)methane which is used as a starting compound to produce polysulfide elastomers. Also used as a solvent

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (G09076)  Completed 
                              •  Negative 
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                            CASRN: 1338-23-4

                            Formula: C8-H14-O4

                            Synonyms/Common Names

                            • 2-Butanone, peroxide

                            Known Uses

                            Hardening agent for fiberglass reinforced plastics. Curing agent for unsaturated polyester resins.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 2 weeks (Topical Application)  (C55447B)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: R: 0, 50.6, 101.3, 202.5, 405, OR 810 MG/KG; M: 0, 112.5, 225, 450, 900, OR 1800 MG/KG (5/S/S).
                            • 13 weeks (Topical Application)  (C55447B)  Report Complete 
                              • TOX-18 (NIH Number: 93-3341)
                                Toxicity Studies of Methyl Ethyl Ketone Peroxide (CASRN 1338-23-4) in Dimethyl Phthalate (CASRN 131-11-3) (45:55)
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: R: 0, 1.07, 3.57, 10.7, 35.7, OR 107 MG/ANIMAL; M: 0, 0.357, 1.19, 3.57, 11.9, OR 35.7 MG/ANIMAL (10/S/S).

                            Genetic Toxicology

                            • In Vitro Cytogenetics (CA/SCE)  (774268)  Completed 
                              • Sister Chromatid Exchange Positive 
                              • Chromosome Aberrations Positive 
                            • Mouse Lymphoma  (091264)  Completed 
                              • Mice
                              •  Positive 
                            • Micronucleus  (A70805)  Completed 
                              • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                              • Mice: B6C3F1
                              • Male Negative 
                              • Female Negative 
                            • Salmonella  (594981)  Completed 
                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                              •  Negative 
                            • Salmonella  (784039)  Completed 
                              •  Positive 
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                            CASRN: 50-00-0

                            Formula: C-H2-O

                            Synonyms/Common Names

                            • Formalin

                            Known Uses

                            Chemical intermediate, disinfectant, textile industry dyes & treatments, wood products, dyes, explosives, photography, fumigant, germicide, fungicide, mildewcide, present in coal & wood smoke (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 2 weeks (Inhalation)  (C02799)  Completed 
                              • Mice: B6C3F1
                            • 2 weeks (Inhalation)  (C10002)  Completed 
                              • Mice: C57BL/6
                              • Dose: Males: 0, 5, 10, or 20 ppm; 6/concentration.
                            • 13 weeks (Inhalation)  (C02799)  Completed 
                              • Mice: B6C3F1
                              • Dose: M: 0, 2, 4, 10, 20, OR 40 PPM.
                            • 8 weeks (Inhalation)  (C10002)  Completed 
                              • Mice: B6.129-Trp53<TM1BRD>; Mice: C3B6.129F1-Trp53<TM1BRD>
                              • Dose: Males: 0, 7.5, or 15 ppm; 25/concentration.

                            Genetic Toxicology

                            • In Vitro Cytogenetics (CA/SCE)  (378046)  Completed 
                              • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
                              • Sister Chromatid Exchange Positive 
                              • Chromosome Aberrations Positive 
                            • In Vitro Cytogenetics (CA/SCE)  (590863)  Completed 
                              • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
                              • Sister Chromatid Exchange Weakly Positive 
                              • Chromosome Aberrations Positive 
                            • Drosophila  (084415)  Completed 
                              • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
                              • Sex-Linked Recessive Lethal Positive 
                              • Reciprocal Translocation Positive 
                            • Drosophila  (103506)  Completed 
                              • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                            • Drosophila  (247261)  Completed 
                              • Sex-Linked Recessive Lethal Positive 
                              • Reciprocal Translocation Negative 
                            • Drosophila  (370104)  Completed 
                              • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
                              • Sex-Linked Recessive Lethal Positive 
                              • Reciprocal Translocation Positive 
                            • Drosophila  (907177)  Completed 
                              • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                              • Sex-Linked Recessive Lethal Positive 
                              • Reciprocal Translocation Negative 
                            • Salmonella  (000304)  Completed 
                              •  Positive 
                            • Salmonella  (164784)  Completed 
                              •  Positive 
                            • Salmonella  (680724)  Completed 
                              •  Positive 
                            • Salmonella  (761375)  Completed 
                              • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                              •  Weakly Positive 
                            • Salmonella  (763375)  Completed 
                              • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                              •  Positive 
                            • Salmonella  (768375)  Completed 
                              • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                              •  Positive 
                            • Salmonella  (830333)  Completed 
                              •  Weakly Positive 
                            • Salmonella  (A25847)  Completed 
                              •  Positive 
                            • Salmonella  (A83562)  Completed 
                              •  Positive 

                            Organ Systems Toxicity

                            • 6 to 15 GD Conventional Teratology (Gavage)  (T0001A)  Completed 
                              • Female Mice
                              • Dose: 0, 80, 160, 200 MG/KG/DAY.
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                            CASRN: 111-30-8

                            Formula: C5-H8-O2

                            Synonyms/Common Names

                            • Pentanedial (9CI)

                            Known Uses

                            Disinfectant and sterilizing agent. Embalming fluid. Chemical intermediate for adhesives, electrical products, tanning soft leathers (HSDB 1990). In photographic developing, dental materials.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 2 weeks (Inhalation)  (C55425B)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: R&M: 0, 0.16, 0.5, 1.6, 5 OR 16 PPM (5/S/S).
                            • 13 weeks (Inhalation)  (C55425B)  Report Complete 
                              • TOX-25 (NIH Number: 93-3348)
                                Toxicity Studies of Glutaraldehyde (CASRN 111-30-8) Adminstered by Inhalation to F344/N Rats and B6C3F1 Mice.
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: R&M: 0, 62.5, 125, 250, 500 OR 1000 PPB (10/S/S).

                            Long-Term Carcinogenicity

                            • 2 years (Inhalation)  (C55425C)  Report Complete 
                              • TR-490 (NIH Number: 99-3980)  (Peer Review Approval 10/30/1998A )
                                Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                              • Rats: F344/N; Mice: B6C3F1
                              • Carcinogenesis Results
                                • Male Rats No Evidence 
                                • Female Rats No Evidence 
                                • Male Mice No Evidence 
                                • Female Mice No Evidence 
                              • Dose: R: 0, 250, 500, OR 750 PPB; 50/SEX/GROUP M: 0, 62.5, 125, OR 250 PPB; 50/SEX/ GROUP.

                            Genetic Toxicology

                            • Chromosome Aberrations  (212368)  Completed 
                              • Mice
                              •  Positive 
                            • In Vitro Cytogenetics (CA/SCE)  (004326)  Completed 
                              • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
                              • Sister Chromatid Exchange Positive 
                              • Chromosome Aberrations Negative 
                            • In Vitro Cytogenetics (CA/SCE)  (146021)  Completed 
                              • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
                              • Sister Chromatid Exchange Weakly Positive 
                              • Chromosome Aberrations Weakly Positive 
                            • Drosophila  (779687)  Completed 
                              • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
                              • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                            • Drosophila  (887025)  Completed 
                              • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
                              • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                            • Mouse Lymphoma  (558174)  Completed 
                              • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
                              • Mice
                              •  Positive 
                            • Micronucleus  (212368)  Completed 
                              • Mice: B6C3F1
                              • Male Equivocal 
                            • Micronucleus  (462636)  Completed 
                              • Mice: B6C3F1
                              • Male Negative 
                            • Micronucleus  (A57716)  Completed 
                              • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                              • Mice: B6C3F1
                              • Male Negative 
                              • Female Negative 
                            • Salmonella  (502523)  Completed 
                              •  Positive 
                            • Salmonella  (684635)  Completed 
                              • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                              •  Equivocal 
                            • Salmonella  (761374)  Completed 
                              • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                              •  Weakly Positive 

                            Organ Systems Toxicity

                            • 5 days (mice) and 14 days (guinea pigs) Immunotoxicity (Topical Application)  (IMM87098)  Completed 
                              • Female Mice: B6C3F1
                              • Dose: M: 0, 0.03, 0.1, 0.3, 1.0, 3.0, OR 10%; GP: 0, 0.3, 1.0 OR 3.0% SENSITIZATION AND 10% CHALLENGE.
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                            CASRN: 1330-20-7

                            Formula: C8-H10

                            Synonyms/Common Names

                            • Dimethylbenzene (9CI)

                            Known Uses

                            Solvent, component of gasoline, protective coatings, in manufacture of dyes, pharmaceuticals, perfumes, pesticides, paints, adhesives, indirect food additive for use as component of adhesives. A solvent, cleaning agent, degreaser & is a constituent of aviation & automobile fuels. Used in the production of benzoic acid, phthalate anhydride, & isophthalic & terephthalic acids & their dimethyl esters. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 14-Day (Gavage)  (C55232)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                            • 13-Week (Gavage)  (C55232)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: R: 0, 6.25, 1000, M: 0, 125, 2000 MG/KG/10 PER GROUP.

                            Long-Term Carcinogenicity

                            • 2 years (Gavage)  (C55232)  Report Complete 
                              • TR-327 (NIH Number: 87-2583)  (Peer Review Approval 03/26/1986A )
                                Toxicology and Carcinogenesis Studies of Xylenes (Mixed) (60%m-Xylene, 14%p-Xylene, 9%o-Xylene, and 17% Ethylbenzene)(CASRN 1330-20-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                              • Rats: F344/N; Mice: B6C3F1
                              • Carcinogenesis Results
                                • Male Rats No Evidence 
                                • Female Rats No Evidence 
                                • Male Mice No Evidence 
                                • Female Mice No Evidence 
                              • Dose: R: 0, 250, 500, M: 0, 500, 1000 MG/KG/50 PER GROUP.

                            Genetic Toxicology

                            • In Vitro Cytogenetics (CA/SCE)  (744839)  Completed 
                              • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                              • Sister Chromatid Exchange Negative 
                              • Chromosome Aberrations Negative 
                            • Mouse Lymphoma  (196823)  Completed 
                              • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                              • Mice
                              •  Positive 
                            • Salmonella  (719358)  Completed 
                              • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                              •  Negative 

                            Organ Systems Toxicity

                            • 6 to 15 GD Conventional Teratology  (T0118)  Completed 
                              • Female Mice: Swiss
                              • Dose: 0, 0.6, 1.2, 2.4, 3.0, 3.6, 4.8 ML/KG/DAY.
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                            CASRN: 99-57-0

                            Formula: C6-H6-N2-O3

                            Synonyms/Common Names

                            • C.I. 76530

                            Known Uses

                            Intermediate for dyes; in hair dyes

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 14-Day (Gavage)  (C55958)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                            • 13-Week (Gavage)  (C55958)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: 0, 6.3, 200 MG/ML/10 PER GROUP.

                            Long-Term Carcinogenicity

                            • 2 years (Gavage)  (C55958)  Report Complete 
                              • TR-339 (NIH Number: 88-2595)  (Peer Review Approval 07/14/1987A )
                                Toxicology and Carcinogenesis Studies of 2-Amino-4-Nitrophenol (CASRN 99-57-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                              • Rats: F344/N; Mice: B6C3F1
                              • Carcinogenesis Results
                                • Male Rats Some Evidence 
                                • Female Rats No Evidence 
                                • Male Mice No Evidence 
                                • Female Mice No Evidence 
                              • Dose: 0, 125, 250 MG/KG/50 PER GROUP.

                            Genetic Toxicology

                            • In Vitro Cytogenetics (CA/SCE)  (483411)  Completed 
                              • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                              • Sister Chromatid Exchange Positive 
                              • Chromosome Aberrations Positive 
                            • Mouse Lymphoma  (705388)  Completed 
                              • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                              • Mice
                              •  Positive 
                            • Micronucleus  (A12647)  Completed 
                              • Mice: B6C3F1
                              • Male Negative 
                            • Micronucleus  (A57599)  Completed 
                              • Rats: Fischer 344
                              • Male Negative 
                            • Salmonella  (138517)  Completed 
                              • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                              •  Positive 
                            • Salmonella  (870165)  Completed 
                              • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                              •  Positive 
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                            CASRN: 463-04-7

                            Formula: C5-H11-N-O2

                            Synonyms/Common Names

                            • Nitramyl
                            • Nitrous acid, pentyl ester

                            Known Uses

                            Coronary vasodilator for angina. Organic intermediate for nitrosation.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (143235)  Completed 
                              •  Weakly Positive 
                            • Salmonella  (404915)  Completed 
                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                              •  Positive 
                            • Salmonella  (555017)  Completed 
                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                              •  Positive 
                            • Salmonella  (704674)  Completed 
                              •  Positive 
                            • Salmonella  (904928)  Completed 
                              •  Weakly Positive 
                            • Salmonella  (922816)  Completed 
                              •  Positive 
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                            CASRN: 104-55-2

                            Formula: C9-H8-O

                            Synonyms/Common Names

                            • Cinnamic aldehyde
                            • 3-Phenyl-2-propenal

                            Known Uses

                            Cinnamon flavor agent. Perfume industry. Filtering agent. chief ingredient of oil of cinnamon. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 2 weeks (Dosed-Feed)  (C56111)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: R&M: 0, 321, 642, 1285, 2570, OR 5140 MG/KG.

                            Special Studies

                            • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0708)  Completed 
                              • Citation: Yuan J, Bucher JR, Goehl TJ, Dieter MP, Jameson CW. Quantitation of cinnamaldehyde and cinnamic acid in blood by HPLC. J Anal Toxicol. 1992 Nov-Dec;16(6):359-62.Pubmed Abstract
                              • Male Rats: F344/N
                            • Absorption Disposition Metabolism Elimination (Gavage)  (S0710)  Completed 
                              • Citation: Yuan J, Dieter MP, Bucher JR, Jameson CW. Application of microencapsulation for toxicology studies. III. Bioavailability of microencapsulated cinnamaldehyde. Fundam Appl Toxicol. 1993 Jan;20(1):83-7.Pubmed Abstract
                              • Male Rats: F344/N
                              • Dose: 50, 250, & 500 mg/kg.
                            • Toxicokinetic Study (Dosed-Feed)  (S0709)  Completed 
                              • Citation: Yuan JH, Dieter MP, Bucher JR, Jameson CW. Toxicokinetics of cinnamaldehyde in F344 rats. Food Chem Toxicol. 1992 Dec;30(12):997-1004.Pubmed Abstract
                              • Male and Female Rats: F344/N

                            Genetic Toxicology

                            • Micronucleus  (A60799)  Completed 
                              • Mice: B6C3F1
                              • Male Negative 

                            Organ Systems Toxicity

                            • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0054A)  Completed 
                              • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                              • Female Mice: Swiss
                              • Dose: 1200 MG/KG BODY WEIGHT.
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                            CASRN: 548-62-9

                            Formula: C25-H30-N3.Cl

                            Synonyms/Common Names

                            • Gentian violet
                            • Gentian violet
                            • Methanaminium, N-(4-(bis(4-(dimethylamino)phenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-methyl-, chloride

                            Known Uses

                            Topical anti-infective. Anthelmintic. Acid-base reagent. Biological stain. Dye for textiles and leather.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 13 weeks (Dosed-Feed)  (C55969B)  Completed 
                              • NR-304
                                Chronic Toxicity and Carcinogenesis Studies of Gentian Violet in Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                              • Mice: B6C3F1
                            • 13 weeks (Dosed-Feed)  (C55969)  Completed 
                              • NR-338
                                Chronic Toxicity and Carcinogenesis Study of Gentian Violet in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                              • Rats: F344/N

                            Long-Term Carcinogenicity

                            • 2 years (Dosed-Feed)  (C55969B)  Completed 
                              • NR-304  (Peer Review Approval NA)
                                Chronic Toxicity and Carcinogenesis Studies of Gentian Violet in Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                              • Mice: B6C3F1
                              • Dose: 0, 100, 300, 600 PPM/50 PER GROUP.
                            • 2 years (Dosed-Feed)  (C55969)  Report Complete 
                              • NR-338  (Peer Review Approval NA)
                                Chronic Toxicity and Carcinogenesis Study of Gentian Violet in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                              • Rats: F344/N
                              • Dose: 0, 100, 300, 600 PPM/50 PER GROUP.

                            Genetic Toxicology

                            • In Vitro Cytogenetics (CA/SCE)  (126650)  Completed 
                              • Sister Chromatid Exchange Negative 
                              • Chromosome Aberrations Negative 
                            • Drosophila  (088988)  Completed 
                              • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
                              • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                            • Drosophila  (724862)  Completed 
                              • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                              • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
                            • Salmonella  (643487)  Completed 
                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                              •  Equivocal 

                            Organ Systems Toxicity

                            • 6 to 15 GD Conventional Teratology (Gavage)  (TER82079)  Completed 
                              • Citation: Teratologic Evaluation of Gentian Violet in CD Rats
                              • Female Rats: Sprague Dawley
                              • Rats Maternal Positive 
                              • Rats Fetal Positive 
                              • Dose: 2.5, 5, 10 MG/KG/DAY.
                            • 6 to 19 GD Conventional Teratology (Gavage)  (TER82080)  Completed 
                              • Citation: Teratologic Evaluation of Gentian Violet in New Zealand White Rabbits
                              • Female Rabbit: New Zealand White
                              • Rabbits Maternal Positive 
                              • Rabbits Fetal Positive 
                              • Dose: .5, 1, 2 MG/KG/DAY.
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                            CASRN: 108-88-3

                            Formula: C7-H8

                            Synonyms/Common Names

                            • Methylbenzene (9CI)

                            Known Uses

                            Chemical intermediate; solvent; denaturant. Used to back-blend gasoline. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 13 weeks (Inhalation)  (C07272B)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: GAV:(C07272A) 0, 312, 625, 1250, 2500, 5000 MG/KG; INHAL:0, 100, 625, 1250, 2500, 3000 PPM/10 PER GROUP.
                            • 13-Week (Gavage)  (C07272C)  Completed 
                              • Rats: F344/N; Mice: B6C3F1
                              • Dose: 0, 312, 5000 MG/KG/10 PER GROUP.

                            Long-Term Carcinogenicity

                            • 15 months & 2 years (Inhalation)  (C07272B)  Report Complete 
                              • TR-371 (NIH Number: 90-2826)  (Peer Review Approval 03/13/1989A )
                                Toxicology and Carcinogenesis Studies of Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                              • Rats: F344/N; Mice: B6C3F1
                              • Carcinogenesis Results
                                • Male Rats No Evidence 
                                • Female Rats No Evidence 
                                • Male Mice No Evidence 
                                • Female Mice No Evidence 
                              • Dose: R: 0, 600, 1200, M: 0, 120, 600, 1200 PPM/60 PER GROUP.

                            Special Studies

                            • Absorption Disposition Metabolism Elimination (Gavage)  (S0615)  Completed 
                              • Male Rats: F344/N; Male Mice: B6C3F1
                              • Dose: Rats: 45, 1.9, 1.5, 0.05, and 0.005 mg/kg Mice: 50, 5, 0.5, and 0.005 mg/kg.
                            • Metabolism  (S0714)  Completed 
                              • Citation: Chapman DE, Moore TJ, Michener SR, Powis G. Metabolism and covalent binding of [14C]toluene by human and rat liver microsomal fractions and liver slices. Drug Metab Dispos. 1990 Nov-Dec;18(6):929-36.Pubmed Abstract
                              • Male Rats: F344/N; Human (Cell Lines)

                            Genetic Toxicology

                            • In Vitro Cytogenetics (CA/SCE)  (638654)  Completed 
                              • Sister Chromatid Exchange Negative 
                              • Chromosome Aberrations Negative 
                            • Mouse Lymphoma  (434629)  Completed 
                              • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                              • Mice
                              •  Equivocal 
                            • Salmonella  (132615)  Completed 
                              • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                              •  Negative 

                            Organ Systems Toxicity

                            • Neurotoxicology Assessment (Inhalation)  (NTA94013)  Completed 
                              • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
                              • Male Rats: F344/N
                            • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0063A)  Completed 
                              • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
                              • Female Mice: Swiss
                              • Dose: 2350 MG/KG BD WT.
                            • 6 to 13 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0063B)  Completed 
                              • Female Mice: Swiss
                              • Dose: 3000 MG/KG/D.
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                            CASRN: 404-86-4

                            Formula: C18-H27-N-O3

                            Synonyms/Common Names

                            • (E)-N-((4-Hydroxy-3-methoxyphenyl)-methyl)-8-methyl-6-nonenamide
                            • 6-Nonenamide

                            Known Uses

                            Flavoring agent, used in pepper and paprika, therapeutic counter-irritant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Genetic Toxicology

                            • Salmonella  (A96033)  Completed 
                              •  Negative 
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                            CASRN: 75-15-0

                            Formula: C-S2

                            Synonyms/Common Names

                            • Carbon bisulfide

                            Known Uses

                            Manufacture of rayon, carbon tetrachloride, cellophane and other regenerated cellulosics, rubber chemicals and soil disinfectants; solvent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                            Chemical Properties

                            Toxicity Effects (HSDB)

                            Short-Term Toxicity

                            • 13-Week (Inhalation)  (C04591B)  Completed 
                              • Rats: Not Available
                            • 13 weeks (Inhalation)  (C04591C)  Completed 
                              • Rats: F344/N
                              • Dose: RATS ONLY: 0, 50, 500, OR 800 PPM.
                            • 20 weeks (Inhalation)  (C04591D)  Completed 
                              • Mice: C57BL/6
                              • Dose: MICE ONLY: 0, 50, 500, OR 800 PPM.

                            Special Studies

                            • Absorption Disposition Metabolism Elimination (Intravenous)  (K00284)  Completed 
                              • Rats
                            • (K00285)  Completed 
                              • (K00466)  Completed 
                                • (K00571)  Completed 
                                  • Toxicokinetic Study (Inhalation; Intravenous)  (S0559)  Completed 
                                    • Citation: Moorman MP, Sills RC, Collins BJ, Morgan DL. Carbon disulfide neurotoxicity in rats: II. Toxicokinetics. Neurotoxicology. 1998 Feb;19(1):89-97.Pubmed Abstract
                                    • Male Rats: F344/N; Female Rats: F344/N

                                  Genetic Toxicology

                                  • In Vitro Cytogenetics (CA/SCE)  (635693)  Completed 
                                    • Sister Chromatid Exchange Positive 
                                    • Chromosome Aberrations Negative 
                                  • Salmonella  (105153)  Completed 
                                    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                    •  Negative 
                                  • Salmonella  (436781)  Completed 
                                    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                    •  Negative 

                                  Organ Systems Toxicity

                                  • Neurotoxicology Assessment (Inhalation)  (NTA94007)  Completed 
                                    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
                                    • Male Rats: F344/N
                                  • 0 to 21 GD, or 7 to 21 GD, or 7 hour/day, 5 day/week for 3 weeks plus 0 to 21 GD or 7 hour/day, 5 days/week for 3 weeks plus 7 to 21 GD Conventional Teratology (Inhalation)  (T0023A)  Completed 
                                    • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
                                    • Female Rabbit: New Zealand White
                                    • Dose: 20, 40 ppm 7 hr/day.
                                  • 0 to 18 GD, or 6 to 18 GD, or 7 hour/day 5 day/week for 3 weeks plus 0 to 18 GD, or 7 hour/day 5 day/week for 3 weeks plus 6 to 18 GD Conventional Teratology (Inhalation)  (T0023B)  Completed 
                                    • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
                                    • Female Rats: Sprague Dawley
                                    • Dose: 20, 40 ppm 7 hr/day.
                                  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84053)  Completed 
                                    • Citation: Final Report - Teratologic Evaluation of Carbon Disulfide Administered to CD Rats on Gestational Days 6 through 15
                                    • Female Rats: Sprague Dawley
                                    • Rats Maternal Positive 
                                    • Rats Fetal Positive 
                                    • Dose: 0, 100, 200, 400, 600 MG/KG/DAY.
                                  • 6 to 19 GD Conventional Teratology (Gavage)  (TER84054)  Completed 
                                    • Citation: Final Report - Teratologic Evaluation of Carbon Disulfide Administered to New Zealand White Rabbits on Gestational Days 6 through 19
                                    • Female Rabbit: New Zealand White
                                    • Rabbits Maternal Positive 
                                    • Rabbits Fetal Positive 
                                    • Dose: 0, 25, 75, 150 MG/KG/DAY.
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                                  CASRN: 470-82-6

                                  Formula: C10-H18-O

                                  Synonyms/Common Names

                                  • 1,8-Cineole
                                  • Eucalyptol
                                  • 1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane

                                  Known Uses

                                  In cough syrups and expectorants. In perfumery and flavoring. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                  Chemical Properties

                                  Toxicity Effects (HSDB)

                                  Short-Term Toxicity

                                  • 4 weeks (Microencapsulation in Feed)  (C56575A)  Completed 
                                    • Rats: F344/N; Mice: B6C3F1
                                  • 4 weeks (Gavage)  (C56575B)  Completed 
                                    • Rats: F344/N; Mice: B6C3F1

                                  Genetic Toxicology

                                  • In Vitro Cytogenetics (CA/SCE)  (590755)  Completed 
                                    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                    • Sister Chromatid Exchange Positive 
                                    • Chromosome Aberrations Negative 
                                  • Salmonella  (246429)  Completed 
                                    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                    •  Negative 
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                                  CASRN: 96-13-9

                                  Formula: C3-H6-Br2-O

                                  Synonyms/Common Names

                                  • 2,3-Dibromopropyl alcohol

                                  Known Uses

                                  Chemical intermediate for flame retardants, insecticides and pharmaceuticals.

                                  Chemical Properties

                                  Toxicity Effects (HSDB)

                                  Short-Term Toxicity

                                  • 14-Day (Topical Application)  (C55436)  Completed 
                                    • Rats: F344/N; Mice: B6C3F1
                                  • 13-Week (Topical Application)  (C55436)  Completed 
                                    • Rats: F344/N; Mice: B6C3F1
                                    • Dose: 0, 44, 750 MG/KG/5 PER GROUP.

                                  Long-Term Carcinogenicity

                                  • 46 weeks (Topical Application)  (C55436)  Report Complete 
                                    • TR-400 (NIH Number: 94-2855)  (Peer Review Approval 06/23/1992A )
                                      Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
                                    • Mice: B6C3F1
                                    • Carcinogenesis Results
                                      • Male Rats Clear Evidence 
                                      • Female Rats Clear Evidence 
                                      • Male Mice Clear Evidence 
                                      • Female Mice Clear Evidence 
                                    • Dose: R: 0, 188, 375, M: 0, 88, 177 MG/KG/50 PER GROUP.
                                  • 56 weeks (Topical Application)  (C55436)  Report Complete 
                                    • TR-400 (NIH Number: 94-2855)  (Peer Review Approval 06/23/1992A )
                                      Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
                                    • Rats: F344/N
                                    • Carcinogenesis Results
                                      • Male Rats Clear Evidence 
                                      • Female Rats Clear Evidence 
                                      • Male Mice Clear Evidence 
                                      • Female Mice Clear Evidence 
                                    • Dose: R: 0, 188, 375, M: 0, 88, 177 MG/KG/50 PER GROUP.

                                  Special Studies

                                  • Toxicokinetic Study (Intravenous)  (S0249)  Completed 
                                    • Male Rats: F344/N

                                  Genetic Toxicology

                                  • In Vitro Cytogenetics (CA/SCE)  (390611)  Completed 
                                    • Sister Chromatid Exchange Positive 
                                    • Chromosome Aberrations Positive 
                                  • Drosophila  (420840)  Completed 
                                    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
                                    • Sex-Linked Recessive Lethal Positive 
                                    • Reciprocal Translocation Positive 
                                  • Mouse Lymphoma  (512622)  Completed 
                                    • Mice
                                    •  Positive 
                                  • Micronucleus  (137189)  Completed 
                                    • Mice: B6C3F1
                                    • Male Negative 
                                  • Salmonella  (075374)  Completed 
                                    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                    •  Positive 
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                                  CASRN: 62-73-7

                                  Formula: C4-H7-Cl2-O4-P

                                  Synonyms/Common Names

                                  • DDVP
                                  • 2,2-Dichloroethenyl phosphoric acid dimethyl ester

                                  Known Uses

                                  Insecticide. Fumigant. Veterinary use for quick knockdown of insects. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                  Chemical Properties

                                  Toxicity Effects (HSDB)

                                  Short-Term Toxicity

                                  • 14-Day (Dosed-Feed)  (C00113A)  Completed 
                                    • Rats: Osborne Mendel; Mice: B6C3F1
                                  • 13-Week (Dosed-Feed)  (C00113A)  Completed 
                                    • Rats: Osborne Mendel; Mice: B6C3F1
                                    • Dose: 0, 4000, 12000 PPM/10 PER GROUP.
                                  • 13-Week (Gavage)  (C00113B)  Completed 
                                    • Rats: F344/N; Mice: B6C3F1
                                    • Dose: R: 0, 2, 64, M: 0, 5, 160 MG/KG/10 PER GROUP.

                                  Long-Term Carcinogenicity

                                  • 2-Year (Dosed-Feed)  (C00113A)  Report Complete 
                                    • TR-010 (NIH Number: 77-810)  (Peer Review Approval 09/00/1976A )
                                      Bioassay of Dichlorvos for Possible Carcinogenicity (CASRN 62-73-7)
                                    • Rats: Osborne Mendel; Mice: B6C3F1
                                    • Carcinogenesis Results
                                      • Male Rats Negative 
                                      • Female Rats Negative 
                                      • Male Mice Negative 
                                      • Female Mice Negative 
                                    • Dose: R: 0, 150, 650 (AVG), M: 0, 650, 1300 (AVG) PPM/50 PER GROUP.
                                  • 2 years (Gavage)  (C00113B)  Report Complete 
                                    • TR-342 (NIH Number: 89-2598)  (Peer Review Approval 07/14/1987A )
                                      Toxicology and Carcinogenesis Studies of Dichlorvos (CASRN 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                    • Rats: F344/N; Mice: B6C3F1
                                    • Carcinogenesis Results
                                      • Male Rats Some Evidence 
                                      • Female Rats Equivocal Evidence 
                                      • Male Mice Some Evidence 
                                      • Female Mice Clear Evidence 
                                    • Dose: R: 0, 4, 8, MM: 0, 10, 20, FM: 0, 20, 40 MG/KG/50 PER GROUP.

                                  Special Studies

                                  • Cell Proliferation (Dosed-Feed)  (S0223)  Completed 
                                    • Citation: Cunningham ML, Elwell MR, Matthews HB. Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs carcinogens. III. Organophosphate pesticides vs tris(2,3-dibromopropyl)phosphate. Fundam Appl Toxicol. 1994 Oct;23(3):363-9.Pubmed Abstract
                                    • Male Rats: F344/N
                                    • Dose: UP TO 400 PPM.
                                  • C. elegans  (S0901)  Completed 
                                    • C. elegans
                                    • Dose: feed (0, .01, .021, .046, .1, .21, .46, 1, 2.1, 4.6, 10, 21) uM 5/17/07; growth (0, .1, .16..25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10) uM 6/19/06; repro (0, .1, .16, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10) uM 6/14/06.

                                  Genetic Toxicology

                                  • Chromosome Aberrations  (755734)  Completed 
                                    • Mice
                                    •  Negative 
                                  • Chromosome Aberrations  (918411)  Completed 
                                    • Mice
                                    •  Negative (Nonstandard Protocol) 
                                  • In Vitro Cytogenetics (CA/SCE)  (584062)  Completed 
                                    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                    • Sister Chromatid Exchange Positive 
                                    • Chromosome Aberrations Positive 
                                  • Mouse Lymphoma  (282595)  Completed 
                                    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                    • Mice
                                    •  Positive 
                                  • Micronucleus  (A02017)  Completed 
                                    • Rats: Fischer 344
                                    • Male Negative 
                                  • Micronucleus  (A26112)  Completed 
                                    • Mice: B6C3F1
                                    • Male Negative 
                                  • Salmonella  (632911)  Completed 
                                    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                    •  Positive 
                                  • Sister Chromatid Exchanges  (755734)  Completed 
                                    • Mice
                                    • Sister Chromatid  Negative 
                                  • Sister Chromatid Exchanges  (918411)  Completed 
                                    • Mice
                                    • Sister Chromatid  Negative (Nonstandard Protocol) 
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                                  CASRN: 37640-57-6

                                  Formula: C3-H6-N6.C3-H3-N3-O3

                                  Synonyms/Common Names

                                  • 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, compd. with 1,3,5-triazine-2,4,6-triamine (1:1)

                                  Known Uses

                                  Flame retardant

                                  Chemical Properties

                                  Toxicity Effects (HSDB)

                                  Special Studies

                                  • Toxicokinetic Study (Gavage; Intravenous)  (K10018)  Completed 
                                    • Citation: Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.Pubmed Abstract
                                    • Citation: Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.Pubmed Abstract
                                    • Male and Female Rats: F344 (NCTR)
                                    • Dose: 1 mg/kg.
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                                  CASRN: 100-41-4

                                  Formula: C8-H10

                                  Synonyms/Common Names

                                  • Benzene, ethyl-(8CI) (9CI)
                                  • EB
                                  • Phenylethane

                                  Known Uses

                                  Manufacture of synthetic rubber. Solvent. Fuel additive. Chemical intermediate.

                                  Chemical Properties

                                  Toxicity Effects (HSDB)

                                  Short-Term Toxicity

                                  • 13 weeks (Inhalation)  (C56393)  Report Complete 
                                    • TOX-10 (NIH Number: 92-3129)
                                      Toxicity Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                    • Rats: F344/N; Mice: B6C3F1
                                    • Dose: R&M:0, 100, 250, 500, 750, 1000PPM.

                                  Long-Term Carcinogenicity

                                  • 2 years (Inhalation)  (C56393B)  Report Complete 
                                    • TR-466 (NIH Number: 99-3956)  (Peer Review Approval 12/11/1996A )
                                      Toxicology and Carcinogenesis Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                    • Rats: F344/N; Mice: B6C3F1
                                    • Carcinogenesis Results
                                      • Male Rats Clear Evidence 
                                      • Female Rats Some Evidence 
                                      • Male Mice Some Evidence 
                                      • Female Mice Some Evidence 
                                    • Dose: R&M: 0, 75, 250, OR 750 PPM (50/SEX/SPECIES/GROUP).

                                  Special Studies

                                  • Toxicokinetic Study (Dosed-Feed)  (S0636)  Completed 
                                    • Citation: Ethylbenzene Two-Week Repeated-Dose Inhalation Toxicokinetic Study Report. December 1998. Revised January 2000
                                    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

                                  Genetic Toxicology

                                  • In Vitro Cytogenetics (CA/SCE)  (228892)  Completed 
                                    • Sister Chromatid Exchange Negative 
                                    • Chromosome Aberrations Negative 
                                  • Mouse Lymphoma  (746837)  Completed 
                                    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                    • Mice
                                    •  Positive 
                                  • Micronucleus  (A97698)  Completed 
                                    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                    • Mice: B6C3F1
                                    • Male Negative 
                                    • Female Negative 
                                  • Salmonella  (450636)  Completed 
                                    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                    •  Negative 

                                  Organ Systems Toxicity

                                  • 5 consecutive days Dominant Lethal (Intraperitoneal Injection)  (T0048C)  Completed 
                                    • Male Rats: Sprague Dawley
                                    • Dose: 850 mg/kg for 5 consecutive days.
                                  • 1 to 24 GD Conventional Teratology (Inhalation)  (T0048A)  Completed 
                                    • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
                                    • Female Rabbit: New Zealand White
                                    • Dose: 100 or 960 ppm.
                                  • Pregestation: 7 hr/day, 5 day/wk for 3 wks. Gestation: 7 hr/day , 1 to 19 GD Conventional Teratology (Inhalation)  (T0048B)  Completed 
                                    • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
                                    • Female Rats: Wistar
                                    • Dose: Pregestation: 95, 960 ppm. Gestation: 95, 985 ppm..
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                                  CASRN: 75-00-3

                                  Formula: C2-H5-Cl

                                  Synonyms/Common Names

                                  • Ethane, chloro-
                                  • Ethyl chloride

                                  Known Uses

                                  This compound is used in the manufacture of tetraethyl lead, ethyl cellulose, sulfanol and trional; as an anesthetic; in organic synthesis; as an alkylating agent; in refrigeration; as an analytical reagent; as a solvent for phosphorous , sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs (Radian H&S, 1991). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                  Chemical Properties

                                  Toxicity Effects (HSDB)

                                  Short-Term Toxicity

                                  • 14-Day (Inhalation)  (C06224)  Completed 
                                    • Rats: F344/N; Mice: B6C3F1
                                  • 13-Week (Inhalation)  (C06224)  Completed 
                                    • Rats: F344/N; Mice: B6C3F1
                                    • Dose: 0, 2500, 19000 PPM/10 PER GROUP.

                                  Long-Term Carcinogenicity

                                  • 2 years (Inhalation)  (C06224)  Report Complete 
                                    • TR-346 (NIH Number: 90-2801)  (Peer Review Approval 10/03/1988A )
                                      Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                    • Rats: F344/N; Mice: B6C3F1
                                    • Carcinogenesis Results
                                      • Male Rats Equivocal Evidence 
                                      • Female Rats Equivocal Evidence 
                                      • Male Mice Inadequate Study 
                                      • Female Mice Clear Evidence 
                                    • Dose: R&M: 0, 15000 PPM/50 PER GROUP.

                                  Genetic Toxicology

                                  • Micronucleus  (A92751)  Completed 
                                    • Mice: B6C3F1
                                    • Male Not a Valid Test 
                                  • Salmonella  (306504)  Completed 
                                    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                    •  Positive 
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                                  CASRN: 50585-40-5

                                  Formula: C12-H4-Br2-Cl2-O2

                                  Synonyms/Common Names

                                  • Dibenzo(b,e)(1,4)dioxin, 2,3-dibromo-7,8-dichloro-

                                  Known Uses

                                  Dioxin compound

                                  Chemical Properties

                                  Toxicity Effects (HSDB)

                                  Organ Systems Toxicity

                                  • Single dose Immunotoxicity (Gavage)  (I10324)  Completed 
                                    • Female Mice: B6C3F1
                                    • Dose: 0, 0.1, 0.3, 0.5, 1, or 3 ug/kg.

                                  Toxicogenomics

                                  • Microarray Analysis  (T10324)  Completed 
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                                    CASRN: 75-21-8

                                    Formula: C2-H4-O

                                    Synonyms/Common Names

                                    • Oxirane (9CI)

                                    Known Uses

                                    Accelerates ripening in fruit and maturing of tobacco leaves. Fungistat. Rocket propellant. Fumigant for foodstuffs and textiles. Organic synthesis. Sterilize surgical instruments. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                    Chemical Properties

                                    Toxicity Effects (HSDB)

                                    Short-Term Toxicity

                                    • 14-Day (Inhalation)  (C50088)  Completed 
                                      • Mice: B6C3F1
                                    • 13-Week (Inhalation)  (C50088)  Completed 
                                      • Mice: B6C3F1
                                      • Dose: 0, 50, 100, 200, 400, 600 PPM/10 PER GROUP.

                                    Long-Term Carcinogenicity

                                    • 2 years (Inhalation)  (C50088)  Report Complete 
                                      • TR-326 (NIH Number: 88-2582)  (Peer Review Approval 08/19/1986A )
                                        Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies)
                                      • Mice: B6C3F1
                                      • Carcinogenesis Results
                                        • Male Mice Clear Evidence 
                                        • Female Mice Clear Evidence 
                                      • Dose: 0, 50, 100 PPM/50 PER GROUP.

                                    Organ Systems Toxicity

                                    • Biochemical Specific Locus (Inhalation)  (BSLM38)  Completed 
                                      • Citation: Lewis, S.E., Barnett, L.B., Felton, C., Johnson, F.M., Skow, L.C., Cacheiro, N., and Shelby, M.D. Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation. Environ. Mutagen. 8:867-872 (1986).
                                      • Male Mice: DBA/2J
                                      • Mice Male Positive 
                                    • Dominant Lethal (Female) (Dosed-Feed)  (DLF023)  Completed 
                                      • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
                                      • Female Mice: C3H X C57BL
                                      • Mice Female Positive 
                                    • Dominant Lethal (Male)  (DLM022)  Completed 
                                      • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
                                      • Male Mice: C3H X 101
                                      • Mice Male Positive 
                                    • Heritable Translocation Test (Dosed-Feed)  (HTM32)  Completed 
                                      • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
                                      • Male Mice: C3H X 101
                                      • Mice Male Positive 
                                    • Morphological Specific Locus (Dosed-Feed)  (MSLM42)  Completed 
                                      • Citation: Russell, L.B., Cummings, R.B., and Hunsicker, P.R. Specific-Locus mutation rates in the mouse following inhalation of ethylene oxide and application of the results estimation of human genetic risk. Mutation Res. 129:381-388 (1984).
                                      • Male Mice: 101 X C3H
                                      • Mice Male Negative 
                                    • Preimplantation Zygote Effects (Dosed-Feed)  (PZEF48)  Completed 
                                      • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
                                      • Female Mice: C3H X C57BL
                                      • Mice Female Positive 
                                    • 5 consecutive days Continuous Breeding (Legacy) (Inhalation)  (T0024C)  Completed 
                                      • Male Mice: C3H
                                      • Dose: 100 ppm 7 hr/day for 5 days.
                                    • 4 to 6 GD, 6 to 8 GD, 8 to 10 GD, 10 to 12 GD Conventional Teratology (Intravenous)  (T0024A)  Completed 
                                      • Citation: Teratologic Evaluation of Ethylene Oxide
                                      • Female Mice: Swiss
                                      • Dose: 75, 150 mg/kg/day.
                                    • 8 to 16 GD or 1 to 16 GD or 3 weeks before breeding plus 1 to 16 GD Conventional Teratology (Inhalation)  (T0024D)  Completed 
                                      • Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate
                                      • Female Rats: Sprague Dawley
                                      • Dose: 150 ppm 7 hr/day.
                                    • 7 to 19 GD or 1 to 19 GD Conventional Teratology (Inhalation)  (T0024E)  Completed 
                                      • Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate
                                      • Female Rabbit: New Zealand White
                                      • Dose: 150 ppm 7 hr/day.
                                    • 6 to 14 GD and 6 to 9 GD Conventional Teratology (Intravenous)  (TER82078)  Completed 
                                      • Citation: Teratologic Evaluation of Ethylene Oxide in New Zealand White Rabbits
                                      • Female Rabbit: New Zealand White
                                      • Rabbits Maternal Positive 
                                      • Rabbits Fetal Positive 
                                      • Dose: PART A: GD 6-14, WATER VEHICLE AT 0, 9, 18, & 36 MG/KG. PART B: GD 6-9, 5% DEXTROSE VEHICLE AT 0, 18, & 36 MG/KG..
                                    • Total Reproductive Capacity (Gavage)  (TRC98017)  Completed 
                                      • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
                                      • Female Mice
                                      • Mice Female Positive 
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                                    CASRN: 51974-40-4

                                    Formula: C12-H5-Br3-O2

                                    Synonyms/Common Names

                                    • 2,3,7-Tribromobenzo-4-dioxin
                                    • 2,3,7-Tribromobenzo-p-dioxin

                                    Known Uses

                                    Dioxin compound

                                    Chemical Properties

                                    Toxicity Effects (HSDB)

                                    Organ Systems Toxicity

                                    • Single dose Immunotoxicity (Gavage)  (I10325)  Completed 
                                      • Female Mice: B6C3F1
                                      • Dose: 0, 1, 3, 5, 10, or 30 ug/kg.

                                    Toxicogenomics

                                    • Microarray Analysis  (T10325)  Completed 
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                                      CASRN: 67733-57-7

                                      Formula: C12-H4-Br4-O

                                      Synonyms/Common Names

                                      • Dibenzofuran, 2,3,7,8-tetrabromo-

                                      Known Uses

                                      used in organic synthesis

                                      Chemical Properties

                                      Toxicity Effects (HSDB)

                                      Organ Systems Toxicity

                                      • Single dose Immunotoxicity (Gavage)  (I10326)  Completed 
                                        • Female Mice: B6C3F1
                                        • Dose: 0, 3, 9, 15, 30 and 90 ug/kg.

                                      Toxicogenomics

                                      • Microarray Analysis  (T10326)  Completed 
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                                        CASRN: 123-31-9

                                        Formula: C6-H6-O2

                                        Synonyms/Common Names

                                        • 1,4-Benzenediol (9CI)

                                        Known Uses

                                        Photographic developer. In manufacture of dyes, rubber antioxidants. Polymerization inhibitor, stabilizer. In skin-lightening creams; hair dyes. Found in coal tar effluent. An antioxidant in the rubber industry & as a developing agent in photography. Also an intermediate in the manufacture of rubber & food antioxidants & monomer inhibitors. Used as depigmenting agents to lighten skin. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                        Chemical Properties

                                        Toxicity Effects (HSDB)

                                        Short-Term Toxicity

                                        • 13-Week (Gavage)  (C55834B)  Completed 
                                          • Rats: F344/N; Mice: B6C3F1
                                          • Dose: 0, 25, 400 MG/KG/10 PER GROUP.

                                        Long-Term Carcinogenicity

                                        • 2 years (Gavage)  (C55834B)  Report Complete 
                                          • TR-366 (NIH Number: 89-2821)  (Peer Review Approval 10/03/1988A )
                                            Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                          • Rats: F344/N; Mice: B6C3F1
                                          • Carcinogenesis Results
                                            • Male Rats Some Evidence 
                                            • Female Rats Some Evidence 
                                            • Male Mice No Evidence 
                                            • Female Mice Some Evidence 
                                          • Dose: R: 0, 25, 50, M: 0, 50, 100 MG/KG/65 PER GROUP.

                                        Modified One-Generation

                                        • Dose Range Finding  (MOG10022)  Assigned 
                                          • Rats: Harlan Sprague-Dawley
                                        • Developmental Toxicity (Gavage) Selected (MOG10022B)  
                                          • Rats: Harlan Sprague-Dawley
                                        • F0 Generation (Gavage) Selected (MOG10022B)  
                                          • Rats: Harlan Sprague-Dawley
                                        • Fertility Assessment (Gavage) Selected (MOG10022B)  
                                          • Rats: Harlan Sprague-Dawley
                                        • Neurotoxicology Assessment (Gavage)  (MOG10022B)   
                                          • Rats: Harlan Sprague-Dawley

                                        Special Studies

                                        • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K10022)  Completed 
                                          • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
                                          • Dose: 0.5, 5, or 50 mg/kg. 2, 10 or 20%. 5 mg/kg.

                                        Genetic Toxicology

                                        • In Vitro Cytogenetics (CA/SCE)  (886668)  Completed 
                                          • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                          • Sister Chromatid Exchange Positive 
                                          • Chromosome Aberrations Positive 
                                        • Drosophila  (814626)  Completed 
                                          • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                          • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
                                        • Mouse Lymphoma  (327913)  Completed 
                                          • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
                                          • Mice
                                          •  Positive 
                                        • Micronucleus  (A06686)  Completed 
                                          • Mice: B6C3F1
                                          • Male Positive 
                                        • Salmonella  (296791)  Completed 
                                          • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                          •  Negative 
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                                        CASRN: 107555-93-1

                                        Formula: C12-H3-Br5-O

                                        Synonyms/Common Names

                                        • Dibenzofuran, 1,2,3,7,8-pentabromo-

                                        Known Uses

                                        no commercial use

                                        Chemical Properties

                                        Toxicity Effects (HSDB)

                                        Organ Systems Toxicity

                                        • Single dose Immunotoxicity (Gavage)  (I10327)  Completed 
                                          • Female Mice: B6C3F1
                                          • Dose: 0, 0.3, 0.9, 1.5, 3 and 9 ug/ml.

                                        Toxicogenomics

                                        • Microarray Analysis  (T10327)  Completed 
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                                          CASRN: 298-81-7

                                          Formula: C12-H8-O4

                                          Synonyms/Common Names

                                          • 9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
                                          • 8-MOP

                                          Known Uses

                                          Used in PUVA therapy for treatment of psoriasis & vitiligo, in tanning preparations (primarily production in Europe)

                                          Chemical Properties

                                          Toxicity Effects (HSDB)

                                          Short-Term Toxicity

                                          • 14-Day (Gavage)  (C55903)  Completed 
                                            • Rats: F344/N
                                          • 13-Week (Gavage)  (C55903)  Completed 
                                            • Rats: F344/N
                                            • Dose: 0, 25, 400 MG/KG/10 PER GROUP.

                                          Long-Term Carcinogenicity

                                          • 2 years (Gavage)  (C55903)  Report Complete 
                                            • TR-359 (NIH Number: 89-2814)  (Peer Review Approval 04/18/1988A )
                                              Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage Studies)
                                            • Rats: F344/N
                                            • Carcinogenesis Results
                                              • Male Rats Clear Evidence 
                                              • Female Rats No Evidence 
                                            • Dose: R: 0, 37.5, 75 MG/KG/50 PER GROUP.

                                          Genetic Toxicology

                                          • Chromosome Aberrations  (501444)  Completed 
                                            • Mice
                                            •  Positive 
                                          • In Vitro Cytogenetics (CA/SCE)  (421568)  Completed 
                                            • Sister Chromatid Exchange Positive 
                                            • Chromosome Aberrations Positive 
                                          • Micronucleus  (158726)  Completed 
                                            • Mice: B6C3F1
                                            • Male Equivocal 
                                          • Salmonella  (773087)  Completed 
                                            •  Positive 

                                          Organ Systems Toxicity

                                          • 6 to 9 GD Conventional Teratology (Gavage)  (TER91016)  Completed 
                                            • Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits
                                            • Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits
                                            • Female Rabbit: New Zealand White
                                            • Rabbits Maternal Positive 
                                            • Rabbits Fetal Negative 
                                            • Dose: 0, 40, 80, 105 MG/KG.
                                          • 6 to 16 GD Conventional Teratology (Gavage)  (TER91017)  Completed 
                                            • Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in Sprague-Dawley (CD) Rats
                                            • Rats: Sprague Dawley
                                            • Rats Maternal Positive 
                                            • Rats Fetal Positive 
                                            • Dose: 0, 20, 80, 120, 160 MG/KG/DAY.
                                          • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90007)  Completed 
                                            • Female Rats: Sprague Dawley
                                            • Dose: 0, 20, 100, 200, 400, 600 MG/KG.
                                          • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP90008)  Completed 
                                            • Female Rabbit: New Zealand White
                                            • Dose: 0, 10, 50, 80, 160 MG/KG.
                                          • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP91017)  Completed 
                                            • Female Rabbit: New Zealand White
                                            • Dose: 0, 10, 50, 80, 105 MG/KG.
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                                          CASRN: 13116-92-2

                                          Formula: N/A

                                          Synonyms/Common Names

                                          • Dibenzofuran, 2,3,4,7,8-pentabromo-

                                          Known Uses

                                          brominated flame retardant

                                          Chemical Properties

                                          Toxicity Effects (HSDB)

                                          Organ Systems Toxicity

                                          • Single dose Immunotoxicity (Gavage)  (I10328)  Completed 
                                            • Female Mice: B6C3F1
                                            • Dose: 0, 3, 9, 15, 30 and 90 ug/kg.

                                          Toxicogenomics

                                          • Microarray Analysis  (T10328)  Completed 
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                                            CASRN: 1825-21-4

                                            Formula: C7-H3-Cl5-O

                                            Synonyms/Common Names

                                            • Pentachloromethoxybenzene (9CI)

                                            Known Uses

                                            Degradation product of other chemicals such as pentachlorophenol and pentachloronitrobenzene

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 2 weeks (Gavage)  (C56520)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Dose: R: 0, 100, 125, 150, 175, or 200 mg/kg M: 0, 100, 175, 250, 325, or 400 mg/kg.
                                            • 13 weeks (Gavage)  (C56520)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Dose: R&M: 0, 40, 80, 120, 140, or 180 mg/kg; 10/sex/group.

                                            Long-Term Carcinogenicity

                                            • 2 years (Gavage)  (C56520)  Report Complete 
                                              • TR-414 (NIH Number: 93-3145)  (Peer Review Approval 11/21/1991A )
                                                Toxicology and Carcinogenesis Studies of Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and B6C3F1 Mice (Gavage Studies)
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Carcinogenesis Results
                                                • Male Rats Some Evidence 
                                                • Female Rats Equivocal Evidence 
                                                • Male Mice Some Evidence 
                                                • Female Mice No Evidence 
                                              • Dose: MR: 0, 10, 20, or 40 FR&M: 0, 20, or 40 mg/kg.

                                            Special Studies

                                            • Toxicokinetic Study (Intravenous)  (S0361)  Completed 
                                              • Citation: Yuan JH, Goehl TJ, Murrill E, Moore R, Clark J, Hong L, Irwin R. Toxicokinetics of pentachloroanisole in F344 rats and B6C3F1 mice. Xenobiotica. 1993 Apr;23(4):427-38.Pubmed Abstract
                                              • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

                                            Genetic Toxicology

                                            • In Vitro Cytogenetics (CA/SCE)  (259382)  Completed 
                                              • Sister Chromatid Exchange Positive 
                                              • Chromosome Aberrations Negative 
                                            • Mouse Lymphoma  (644226)  Completed 
                                              • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
                                              • Mice
                                              •  Positive 
                                            • Salmonella  (596505)  Completed 
                                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                              •  Positive 

                                            Organ Systems Toxicity

                                            • 6 to 15 GD Conventional Teratology (Gavage)  (T0120)  Completed 
                                              • Female Mice: Swiss
                                              • Dose: 0, 40, 80, 100, 160 MG/KG/DAY.
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                                            CASRN: 509-14-8

                                            Formula: C-N4-O8

                                            Synonyms/Common Names

                                            • TNM

                                            Known Uses

                                            Rocket propellants; additive to diesel fuel; explosive; reagent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 14-Day (Inhalation)  (C55947)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                            • 13-Week (Inhalation)  (C55947)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Dose: 0, .1, 10 PPM/10 PER GROUP.

                                            Long-Term Carcinogenicity

                                            • 2 years (Inhalation)  (C55947)  Report Complete 
                                              • TR-386 (NIH Number: 90-2841)  (Peer Review Approval 11/20/1989A )
                                                Toxicology and Carcinogenesis Studies of Tetranitromethane (CASRN 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Carcinogenesis Results
                                                • Male Rats Clear Evidence 
                                                • Female Rats Clear Evidence 
                                                • Male Mice Clear Evidence 
                                                • Female Mice Clear Evidence 
                                              • Dose: R: 0, 2, 5, M: 0, 0.5, 2 PPM/50 PER GROUP.

                                            Genetic Toxicology

                                            • In Vitro Cytogenetics (CA/SCE)  (247313)  Completed 
                                              • Sister Chromatid Exchange Positive 
                                              • Chromosome Aberrations Positive 
                                            • Salmonella  (631374)  Completed 
                                              • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                              •  Positive 
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                                            CASRN: 552-30-7

                                            Formula: C9-H4-O5

                                            Synonyms/Common Names

                                            • 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid (9CI)

                                            Known Uses

                                            In preparation of resins, adhesives, polymers, dyes, printing inks. Plasticizer. High-temperature plastics. Wire insulation gaskets. Automotive upholstery.

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 13 weeks (Dosed-Feed)  (C56633A)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                            • 13 weeks (Gavage)  (C56633B)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1

                                            Genetic Toxicology

                                            • Salmonella  (931027)  Completed 
                                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                              •  Negative 

                                            Organ Systems Toxicity

                                            • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0113A)  Completed 
                                              • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                              • Female Mice: Swiss
                                              • Dose: 550 MG/KG BD WT.
                                            • 6 to 13 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0113B)  Completed 
                                              • Female Mice: Swiss
                                              • Dose: 800 MG/KG/D.
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                                            CASRN: 13983-17-0

                                            Formula: Ca.H2-O3-Si

                                            Synonyms/Common Names

                                            • Wollastonite (9CI)

                                            Known Uses

                                            Component of ceramic mixes, glazes, and enamels. Pigment and extender for paints. Filler. Flocculant in wastewater treatment. Dental restorative.

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Long-Term Carcinogenicity

                                            • 2 years (Inhalation)  (C55470B)  Completed 
                                              •   (Peer Review Approval NA) Citation: McConnell EE, Hall L, Adkins B Jr., Studies on the Chronic Toxicity (Inhalation) of Wollastonite in Fischer 344 Rats. Inhalation Toxicology 3:323-337 (1991).
                                              • Rats: F344/N
                                              • Dose: 0, 10 MG/M3.

                                            Genetic Toxicology

                                            • Salmonella  (223222)  Completed 
                                              • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                              •  Negative 
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                                            CASRN: 115-28-6

                                            Formula: C9-H4-Cl6-O4

                                            Synonyms/Common Names

                                            • 1,4,5,6,7,7-Hexachlorobicyclo(2.2.1)-5-heptene-2,3-dicarboxylic acid

                                            Known Uses

                                            Flame retardant, intermediate for plasticizers, hardening agent (HSDB 1990)

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 14-Day (Dosed-Feed)  (C55072)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                            • 13-Week (Dosed-Feed)  (C55072)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Dose: R: 0, 620, 10000, M: 0, 1250, 20000 PPM/10 PER GROUP.

                                            Long-Term Carcinogenicity

                                            • 2-Year (Dosed-Feed)  (C55072)  Report Complete 
                                              • TR-304 (NIH Number: 87-2560)  (Peer Review Approval 08/14/1985A )
                                                Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Carcinogenesis Results
                                                • Male Rats Clear Evidence 
                                                • Female Rats Clear Evidence 
                                                • Male Mice Clear Evidence 
                                                • Female Mice No Evidence 
                                              • Dose: 0, 620, 1250 PPM/50 PER GROUP.

                                            Special Studies

                                            • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0074)  Completed 
                                              • Citation: Decad GM, Fields MT. Disposition and excretion of chlorendic acid in Fischer 344 rats. J Toxicol Environ Health. 1982 May-Jun;9(5-6):911-20.Pubmed Abstract
                                              • Male Rats
                                              • Dose: PO: 3 MG/KG IV: 3 MG/KG.

                                            Genetic Toxicology

                                            • In Vitro Cytogenetics (CA/SCE)  (179071)  Completed 
                                              • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                              • Sister Chromatid Exchange Positive 
                                              • Chromosome Aberrations Equivocal 
                                            • Drosophila  (960855)  Completed 
                                              • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
                                              • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                            • Mouse Lymphoma  (197818)  Completed 
                                              • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
                                              • Mice
                                              •  Positive 
                                            • Salmonella  (995372)  Completed 
                                              • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                              •  Negative 
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                                            CASRN: 58-93-5

                                            Formula: C7-H8-Cl-N3-O4-S2

                                            Synonyms/Common Names

                                            • 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

                                            Known Uses

                                            Diuretic for hypertension treatment and in veterinary medicine. Adjunct for treatment of edema.

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 14-Day (Dosed-Feed)  (C55925)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                            • 13-Week (Dosed-Feed)  (C55925)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Dose: R: 0, 250, 4000, M: 0, 3125, 50000 PPM/10 PER GROUP.

                                            Long-Term Carcinogenicity

                                            • 108 weeks (Dosed-Feed)  (C55925)  Report Complete 
                                              • TR-357 (NIH Number: 89-2812)  (Peer Review Approval 04/18/1988A )
                                                Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                              • Rats: F344/N
                                              • Carcinogenesis Results
                                                • Male Rats No Evidence 
                                                • Female Rats No Evidence 
                                                • Male Mice Equivocal Evidence 
                                                • Female Mice No Evidence 
                                              • Dose: R: 0, 250, 500, 2000 PPM/60 PER GROUP, M: 0, 2500, 5000 PPM/50 PER GROUP.
                                            • 2 years (Dosed-Feed)  (C55925)  Report Complete 
                                              • TR-357 (NIH Number: 89-2812)  (Peer Review Approval 04/18/1988A )
                                                Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                              • Mice: B6C3F1
                                              • Carcinogenesis Results
                                                • Male Rats No Evidence 
                                                • Female Rats No Evidence 
                                                • Male Mice Equivocal Evidence 
                                                • Female Mice No Evidence 
                                              • Dose: R: 0, 250, 500, 2000 PPM/60 PER GROUP, M: 0, 2500, 5000 PPM/50 PER GROUP.

                                            Genetic Toxicology

                                            • In Vitro Cytogenetics (CA/SCE)  (949863)  Completed 
                                              • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                              • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                              • Sister Chromatid Exchange Positive 
                                              • Chromosome Aberrations Negative 
                                            • Drosophila  (044099)  Completed 
                                              • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
                                              • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                            • Mouse Lymphoma  (573028)  Completed 
                                              • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                              • Mice
                                              •  Positive 
                                            • Salmonella  (715548)  Completed 
                                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                              •  Negative 

                                            Organ Systems Toxicity

                                            • 6 to 15 GD Conventional Teratology (Gavage)  (TER84084)  Completed 
                                              • Citation: Final Report - Teratologic Evaludation of Hydrochlorothiazide Administered to CD Rats on Gestational Days 6 through 15
                                              • Female Rats: Sprague Dawley
                                              • Rats Maternal Negative 
                                              • Rats Fetal Negative 
                                              • Dose: 100, 300, 1000 MG/KG/DAY.
                                            • 6 to 15 GD Conventional Teratology (Gavage)  (TER84085)  Completed 
                                              • Citation: Final Report - Teratologic Evaluation of Hydrochlorothiazide Administered to CD-1 Mice on Gestational Days 6 through 15
                                              • Female Mice: Swiss
                                              • Mice Maternal Negative 
                                              • Mice Fetal Negative 
                                              • Dose: 300, 1000, 3000 MG/KG/DAY.
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                                            CASRN: 474919-59-0

                                            Formula: unspecified

                                            Synonyms/Common Names

                                            • 1,2-Cyclohexanedicarboxylic acid, 1,2-dinonyl ester, branched and linear

                                            Known Uses

                                            phthalate (plasticizer)

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Organ Systems Toxicity

                                            • Utero-Lactational (Gavage)  (R10330)  Completed 
                                              • Mice: B6C3F1
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                                            CASRN: 75-09-2

                                            Formula: C-H2-Cl2

                                            Synonyms/Common Names

                                            • Dichloromethane
                                            • Dichloromethane

                                            Known Uses

                                            Solvent in paint removers, degreasers, aerosol propellants, extraction solvent in food processing; pharmaceutical aid, component of fire extinguishing compound (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 13-Week (Inhalation)  (C50102B)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Dose: 0, 525, 8400 PPM/10 PER GROUP.

                                            Long-Term Carcinogenicity

                                            • 2 years (Inhalation)  (C50102B)  Report Complete 
                                              • TR-306 (NIH Number: 86-2562)  (Peer Review Approval 03/29/1985A )
                                                Toxicology and Carcinogenesis Studies of Dichloromethane (Methylene Chloride) (CASRN 75-09-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Carcinogenesis Results
                                                • Male Rats Some Evidence 
                                                • Female Rats Clear Evidence 
                                                • Male Mice Clear Evidence 
                                                • Female Mice Clear Evidence 
                                              • Dose: R: 0, 1000, 2000, 4000, M: 0, 2000, 4000 PPM/50 PER GROUP.

                                            Genetic Toxicology

                                            • In Vitro Cytogenetics (CA/SCE)  (676332)  Completed 
                                              • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                              • Sister Chromatid Exchange Negative 
                                              • Chromosome Aberrations Negative 
                                            • Mouse Lymphoma  (502376)  Completed 
                                              • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                              • Mice
                                              •  Equivocal 
                                            • Salmonella  (070295)  Completed 
                                              • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
                                              •  Positive 
                                            • Salmonella  (413864)  Completed 
                                              • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
                                              •  Negative 
                                            • Salmonella  (A34199)  Completed 
                                              •  Positive 
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                                            CASRN: 58033-90-2

                                            Formula: C26-H42-O4

                                            Synonyms/Common Names

                                            • 1,2-Benzenedicarboxylic acid, diisononyl ester
                                            • DINP2
                                            • Isononyl alcohol, phthalate (2:1)

                                            Secondary:

                                            • 28553-12-0 - Diisononyl phthalate

                                            Known Uses

                                            A complex of branched C-9 isomers that is used as a general purpose plasticizer to render polyvinyl chloride (PVC) flexible

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Organ Systems Toxicity

                                            • Utero-Lactational (Dosed-Water)  (R10331)  Completed 
                                              • Rats: Harlan Sprague-Dawley
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                                            CASRN: 78-00-2

                                            Formula: C8-H20-Pb

                                            Synonyms/Common Names

                                            • Tetraethylplumbane (9CI)

                                            Known Uses

                                            Chemical intermediate for organomercury fungicides, mixed alkyl leads in gasoline

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Genetic Toxicology

                                            • Salmonella  (474795)  Completed 
                                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                              •  Negative 
                                            • Salmonella  (725476)  Completed 
                                              • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                              •  Negative 

                                            Organ Systems Toxicity

                                            • 14 days Immunotoxicity (Gavage)  (IMM20009)  Completed 
                                              • Female Mice: B6C3F1
                                              • Dose: 0, 0.5, 1.0, OR 2.0 MG/KG.
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                                            CASRN: 6422-86-2

                                            Formula: C24-H38-O4

                                            Synonyms/Common Names

                                            • 1,4-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester
                                            • Bis(2-ethylhexyl) terephthalate

                                            Known Uses

                                            Plasticizer adhesive

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Organ Systems Toxicity

                                            • Utero-Lactational (Intravenous)  (R10332)  Completed 
                                              • Rats: F344/N
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                                            CASRN: 25013-15-4

                                            Formula: C9-H10

                                            Synonyms/Common Names

                                            • Ethenylmethylbenzene (9CI)

                                            Known Uses

                                            Preparing polyester resins, modified alkyl resins, and drying oils. In orthopedic cast material.

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 14-Day (Inhalation)  (C56406)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                            • 13-Week (Inhalation)  (C56406)  Completed 
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Dose: R: 0, 25, 1000, M: 0, 10, 160 PPM/10 PER GROUP.

                                            Long-Term Carcinogenicity

                                            • 2 years (Inhalation)  (C56406)  Report Complete 
                                              • TR-375 (NIH Number: 90-2830)  (Peer Review Approval 11/20/1989A )
                                                Toxicology and Carcinogenesis Studies of Vinyl Toluene (Mixed Isomers) (65%-71% meta-isomer and 32%-35% para-isomer) (CASRN 25013-15-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                              • Rats: F344/N; Mice: B6C3F1
                                              • Carcinogenesis Results
                                                • Male Rats No Evidence 
                                                • Female Rats No Evidence 
                                                • Male Mice No Evidence 
                                                • Female Mice No Evidence 
                                              • Dose: R: 0, 100, 300, M: 0, 10, 25 PPM/50 PER GROUP.

                                            Genetic Toxicology

                                            • In Vitro Cytogenetics (CA/SCE)  (390795)  Completed 
                                              • Sister Chromatid Exchange Negative 
                                              • Chromosome Aberrations Negative 
                                            • Mouse Lymphoma  (327329)  Completed 
                                              • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                              • Mice
                                              •  Positive 
                                            • Salmonella  (527349)  Completed 
                                              • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                              •  Negative 

                                            Organ Systems Toxicity

                                            • 5 consecutive days Dominant Lethal (Intraperitoneal Injection)  (T0141)  Completed 
                                              • Male Rats: Sprague Dawley
                                              • Dose: 500 mg/kf for 5 cons d.
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                                            CASRN: 26040-51-7

                                            Formula: C24-H34-Br4-O4

                                            Synonyms/Common Names

                                            • 1,2-Benzenedicarboxylic acid, 3,4,5,6-tetrabromo-, 1,2-bis(2- ethylhexyl) ester
                                            • Flame Retardant 2
                                            • TBPH

                                            Known Uses

                                            fire retardant chemical

                                            Chemical Properties

                                            Toxicity Effects (HSDB)

                                            Short-Term Toxicity

                                            • 5 days (Gavage)  (C10333)  On Test 
                                              • Rats: Hsd:Sprague Dawley SD
                                              • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

                                            Organ Systems Toxicity

                                            • Utero-Lactational  (R10333)  Completed 

                                              Toxicogenomics

                                              • 5 days Microarray Analysis (Gavage)  (T10333)  Assigned 
                                                • Rats: Hsd:Sprague Dawley SD
                                                • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
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                                              CASRN: 82-68-8

                                              Formula: C6-Cl5-N-O2

                                              Synonyms/Common Names

                                              • Batrilex

                                              Known Uses

                                              Fungicide, soil fumigant and seed treatment. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                              Chemical Properties

                                              Toxicity Effects (HSDB)

                                              Short-Term Toxicity

                                              • 14-Day (Dosed-Feed)  (C00419A)  Completed 
                                                • Rats: Osborne Mendel; Mice: B6C3F1
                                              • 13-Week (Dosed-Feed)  (C00419A)  Completed 
                                                • Rats: Osborne Mendel; Mice: B6C3F1
                                                • Dose: 0, 2150, 46400 PPM/5 PER GROUP.
                                              • 13-Week (Dosed-Feed)  (C00419B)  Completed 
                                                • Mice: B6C3F1
                                                • Dose: MM: 0, .125, 2.00, FM: 0, .25, 4.00 %/10 PER GROUP.

                                              Long-Term Carcinogenicity

                                              • 2-Year (Dosed-Feed)  (C00419A)  Report Complete 
                                                • TR-061 (NIH Number: 78-1311)  (Peer Review Approval 01/18/1978A )
                                                  Bioassay of Pentachloronitrobenzene for Possible Carcinogenicity (CASRN 82-68-8)
                                                • Rats: Osborne Mendel; Mice: B6C3F1
                                                • Carcinogenesis Results
                                                  • Male Rats Negative 
                                                  • Female Rats Negative 
                                                  • Male Mice Negative 
                                                  • Female Mice Negative 
                                                • Dose: MR: 0, 5417, 10064 (AVG), FR: 0, 7875, 14635 (AVG), MM: 0, 2606, 5213 (AVG), FM: 0, 4043, 8187 (AVG) PPM/50 PER GROUP.
                                              • 2 years (Dosed-Feed)  (C00419B)  Report Complete 
                                                • TR-325 (NIH Number: 87-2581)  (Peer Review Approval 03/26/1986A )
                                                  Toxicology and Carcinogenesis Studies of Pentachloronitrobenzene (CASRN 82-68-8) in B6C3F1 Mice (Feed Studies)
                                                • Mice: B6C3F1
                                                • Carcinogenesis Results
                                                  • Male Mice No Evidence 
                                                  • Female Mice No Evidence 
                                                • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

                                              Genetic Toxicology

                                              • In Vitro Cytogenetics (CA/SCE)  (027750)  Completed 
                                                • Sister Chromatid Exchange Positive 
                                                • Chromosome Aberrations Positive 
                                              • In Vitro Cytogenetics (CA/SCE)  (114657)  Completed 
                                                • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                • Sister Chromatid Exchange Negative 
                                                • Chromosome Aberrations Positive 
                                              • Mouse Lymphoma  (303135)  Completed 
                                                • Mice
                                                •  Negative 
                                              • Salmonella  (251113)  Completed 
                                                • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                •  Negative 
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                                              CASRN: 80-05-7

                                              Formula: C15-H16-O2

                                              Synonyms/Common Names

                                              • BPA
                                              • 4,4'-(1-Methylethylidene)bisphenol

                                              Known Uses

                                              Intermediate for resins, flame retardants, & rubber chemicals, fungicide (HSDB 1990). An intermediate used in the manufacture of epoxy, polycarbonate, and polyester-styrene resins.

                                              Chemical Properties

                                              Toxicity Effects (HSDB)

                                              Short-Term Toxicity

                                              • 4 days (Gavage)  (C10034B)  Completed 
                                                • Liver Targeted Testing study of Toxcast Chemicals
                                                • Rats: Harlan Sprague-Dawley
                                                • Dose: Male rats: 0, 450 mg/kg/day.
                                              • 14-Day (Dosed-Feed)  (C50635)  Completed 
                                                • Rats: F344/N; Mice: B6C3F1
                                              • 90 days (Gavage)  (C10034C)  Report Draft 
                                                • Citation: Churchwell MI, Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, Delclos KB, Fisher JW, Doerge DR. Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. Toxicol Sci. 2014 May;139(1):4-20. doi: 10.1093/toxsci/kfu021. Epub 2014 Feb 4.
                                                • Citation: Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90. Toxicol Sci. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. Epub 2014 Feb 4.
                                                • Rats: Sprague Dawley (NCTR)
                                                • Dose: 0, 2.5, 8, 25, 80, 260, 840, 2700, 100,000, or 300,000 micrograms/kg bwt; 18-23 litters/group.
                                              • 13-Week (Dosed-Feed)  (C50635)  Completed 
                                                • Rats: F344/N; Mice: B6C3F1
                                                • Dose: R: 0, 250, 4000, M: 0, 5000, 25000 PPM/10 PER GROUP.

                                              Long-Term Carcinogenicity

                                              • 2-years (Gavage)  (C10034)  Histopath in progress 
                                                • Citation: Schug TT, Heindel JJ, Camacho L, Delclos KB, Howard P, Johnson AF, Aungst J, Keefe D, Newbold R, Walker NJ, Thomas Zoeller R, Bucher JR. A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. Reprod Toxicol. 2013 Sep;40:35-40. doi: 10.1016/j.reprotox.2013.05.010. Epub 2013 Jun 5.
                                                • Rats: Sprague Dawley (NCTR)
                                                • Dose: 0, 2.5, 25, 250, 2500, or 25000 ug/kg/bw/day.
                                              • 2-Year (Dosed-Feed)  (C50635)  Report Complete 
                                                • TR-215 (NIH Number: 82-1771)  (Peer Review Approval 10/15/1980A )
                                                  Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study)
                                                • Rats: F344/N; Mice: B6C3F1
                                                • Carcinogenesis Results
                                                  • Male Rats Equivocal 
                                                  • Female Rats Equivocal 
                                                  • Male Mice Equivocal 
                                                  • Female Mice Negative 
                                                • Dose: R: 0, 1000, 2000, FM: 0, 5000, 10000, MM: 0, 1000, 5000 PPM/50 PER GROUP.

                                              Special Studies

                                              • Absorption Disposition Metabolism Elimination (in-vitro)  (K10034)  Completed 
                                                • Citation: Camacho L, Basavarajappa MS, Chang CW, Han T, Kobets T, Koturbash I, Surratt G, Lewis SM, Vanlandingham MM, Fuscoe JC, Gamboa da Costa G, Pogribny IP, Delclos KB. Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats. Food Chem Toxicol. 2015 Jul;81:92-103. doi: 10.1016/j.fct.2015.04.009. Epub 2015 Apr 8.Pubmed Abstract
                                                • Male and Female Rats: Sprague Dawley (NCTR)
                                                • Dose: 0, 2.5, 8, 25, 80, 260, 840, 2700, 100000 and 300000 µg/kg bw/ day.
                                              • C. elegans  (W10034)  Completed 
                                                • C. elegans
                                                • Dose: Growth: 0, 50, 63, 79, 100, 130, 160, 200, 250, 320, 400, 500 uMFeed: 0, 450, 525, 600, 675, 750, 825, 900, 975, 1050, 1125, 1200uMRepro: 0, 50, 75, 150, 300, 450, 600, 750, 900, 1050, 1200, 1350 uM.

                                              Genetic Toxicology

                                              • Chromosome Aberrations  (070061)  Completed 
                                                • Mice
                                                •  Positive (Nonstandard Protocol) 
                                              • Comet Assay (Gavage)  (G10034B)  On Test 
                                                • Rats: Harlan Sprague-Dawley
                                              • Comet Assay  (G10034)  On Test 
                                                • In Vitro Cytogenetics (CA/SCE)  (791721)  Completed 
                                                  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
                                                  • Sister Chromatid Exchange Negative 
                                                  • Chromosome Aberrations Negative 
                                                • Drosophila  (839656)  Completed 
                                                  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
                                                  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                • Mouse Lymphoma  (831513)  Completed 
                                                  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
                                                  • Mice
                                                  •  Negative 
                                                • Micronucleus  (A24930)  Completed 
                                                  • Rats: Fischer 344
                                                  • Male Negative 
                                                • Salmonella  (121422)  Completed 
                                                  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                  •  Negative 
                                                • Salmonella  (441712)  Completed 
                                                  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                  •  Negative 
                                                • Salmonella  (680342)  Completed 
                                                  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                  •  Negative 
                                                • Sister Chromatid Exchanges  (070061)  Completed 
                                                  • Mice
                                                  • Sister Chromatid  Negative (Nonstandard Protocol) 

                                                Bioassay

                                                • Chronic Special (Gavage)  (C10034)  Report Draft 
                                                  • 52-week interim
                                                  • Rats: Sprague Dawley (NCTR)

                                                Organ Systems Toxicity

                                                • 120 day minimum Continuous Breeding (Legacy) (Subcutaneous Injection)  (RACB82081)  Completed 
                                                  • Citation: Final Report - Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered via Subcutaneous Silastic Implants
                                                  • Male and Female Mice: Swiss
                                                  • Dose: 0, 6.25, 12.5, 25, 50, 100 MG; 0, 25, 50, 100 MG/KG; N/A; N/A.
                                                • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84080)  Completed 
                                                  • Citation: Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered In the Feed
                                                  • Male and Female Mice: Swiss
                                                  • Dose: 0, .312, .625, 1.25, 2.5, 5.0%; 0, .25, .5, 1%; 0, 1%; 0, .25, .5, 1.0%; .
                                                • 6 to 15 GD Conventional Teratology (Gavage)  (TER85051)  Completed 
                                                  • Citation: Final Report - Teratologic Evaluation of Bisphenol A Administered to CD® Rats on Gestational Days 6 through 15
                                                  • Female Rats: Sprague Dawley
                                                  • Rats Maternal Negative 
                                                  • Rats Fetal Negative 
                                                  • Dose: 160, 320, 640, 1280 MG/KG/DY.
                                                • 6 to 15 GD Conventional Teratology (Gavage)  (TER85052)  Completed 
                                                  • Citation: Final Report - Teratologic Evaluation of Bisphenol A Administered to CD-1 Mice on Gestational Days 6 through 15
                                                  • Female Mice: Swiss
                                                  • Mice Maternal Positive 
                                                  • Mice Fetal Positive 
                                                  • Dose: 500, 750, 1000, 1250 MG/KG/DAY.
                                                • Utero-Lactational (Gavage)  (R10034)  Completed 

                                                  Toxicogenomics

                                                  • 4 days Microarray Analysis (Gavage)  (T10034)  Completed 
                                                    • Liver Targeted Testing study of Toxcast Chemicals
                                                    • Rats: Harlan Sprague-Dawley
                                                    • Dose: 450 mg/kg; 6 rats.
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                                                  CASRN: 10043-35-3

                                                  Formula: B-H3-O3

                                                  Synonyms/Common Names

                                                  • Boracic acid

                                                  Known Uses

                                                  Weatherproofing wood. Fireproofing fabrics. Printing and dyeing. Astringent. Antiseptic. In cosmetic powders. In manufacture of cements, crockery, glass, leather, carpets, hats and soaps.

                                                  Chemical Properties

                                                  Toxicity Effects (HSDB)

                                                  Short-Term Toxicity

                                                  • 2 weeks (Dosed-Feed)  (C56417)  Completed 
                                                    • Mice: B6C3F1
                                                  • 13 weeks (Dosed-Feed)  (C56417)  Completed 
                                                    • Mice: B6C3F1
                                                    • Dose: 0, 1200, 2000 PPM/10 PER GROUP.

                                                  Long-Term Carcinogenicity

                                                  • 2 years (Dosed-Feed)  (C56417)  Report Complete 
                                                    • TR-324 (NIH Number: 88-2580)  (Peer Review Approval 03/26/1986A )
                                                      Toxicology and Carcinogenesis Studies of Boric Acid (CASRN 10043-35-3) in B6C3F1 Mice (Feed Studies)
                                                    • Mice: B6C3F1
                                                    • Carcinogenesis Results
                                                      • Male Mice No Evidence 
                                                      • Female Mice No Evidence 
                                                    • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

                                                  Special Studies

                                                  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0787)  Completed 
                                                    • Citation: Ku WW, Chapin RE, Moseman RF, Brink RE, Pierce KD, Adams KY. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharmacol. 1991 Oct;111(1):145-51.Pubmed Abstract
                                                    • Male Rats: F344/N
                                                    • Dose: 9000 ppm (w/w) boric acid (1575 ppm boron).
                                                  • Mechanisms (Dosed-Feed)  (S0788)  Completed 
                                                    • Citation: Ku WW, Chapin RE, Wine RN, Gladen BC. Testicular toxicity of boric acid (BA): relationship of dose to lesion development and recovery in the F344 rat. Reprod Toxicol. 1993 Jul-Aug;7(4):305-19.Pubmed Abstract
                                                    • Male Rats: F344/N
                                                    • Dose: 3000, 4500, 6000, 9000 ppm.

                                                  Genetic Toxicology

                                                  • In Vitro Cytogenetics (CA/SCE)  (153962)  Completed 
                                                    • Sister Chromatid Exchange Negative 
                                                    • Chromosome Aberrations Negative 
                                                  • Mouse Lymphoma  (621739)  Completed 
                                                    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                    • Mice
                                                    •  Negative 
                                                  • Salmonella  (683471)  Completed 
                                                    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                    •  Negative 
                                                  • Salmonella  (789471)  Completed 
                                                    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                    •  Equivocal 

                                                  Organ Systems Toxicity

                                                  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB88034)  Completed 
                                                    • Citation: Reproductive Toxicity of Boric Acid in CD-1 Swiss Mice
                                                    • Male and Female Mice: Swiss
                                                    • Dose: N/A; 0, 1000, 4500, 9000 PPM; 0, 4500 PPM; 0, 1000 PPM.
                                                  • 10, 14, or 21 days Spermiation Inhibition (Dosed-Feed)  (RACB93162)  Completed 
                                                    • Male Rats: F344/N
                                                    • Dose: </= 9000 PPM.
                                                  • 0 to 20 GD Conventional Teratology (Dosed-Feed)  (TER89027)  Completed 
                                                    • Citation: Final Report on the Developmental Toxicity Evaluation of Boric Acid Administered in Feed to Sprague-Dawley (CD) Rats on Gestational Days 0-20 or 6-15
                                                    • Female Rats: Sprague Dawley
                                                    • Rats Maternal Positive 
                                                    • Rats Fetal Positive 
                                                    • Dose: 0, .1, .2, .4, .8%.
                                                  • 1 to 17 GD Conventional Teratology (Dosed-Feed)  (TER89028)  Completed 
                                                    • Citation: Final Report on the Developmental Toxicity Evaluation of Boric Acid Administered in Feed to CD-1 Mice on Gestational Days 0 to 17
                                                    • Female Mice: Swiss
                                                    • Mice Maternal Positive 
                                                    • Mice Fetal Positive 
                                                    • Dose: 0, 0.1, 0.2, 0.4%.
                                                  • 6 to 19 GD Conventional Teratology (Gavage)  (TER90003)  Completed 
                                                    • Citation: Final Report on the Developmental Toxicity of Boric Acid in New Zealand White Rabbits
                                                    • Female Rabbit: New Zealand White
                                                    • Rabbits Maternal Positive 
                                                    • Rabbits Fetal Positive 
                                                    • Dose: 0, 62.5, 125, 250 MG/KG/DAY.
                                                  • 14 to 17 GD Conventional Teratology (Dosed-Feed)  (TER90123)  Completed 
                                                    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 14-17
                                                    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 14-17
                                                    • Female Rats: Sprague Dawley
                                                    • Rats Maternal Positive 
                                                    • Rats Fetal Positive 
                                                    • Dose: 0, 0.8, 1.6, 2.4% AND PAIR FED CONTROL FOR 2.4%.
                                                  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER93138)  Completed 
                                                    • Citation: CNS Developmental Toxicity of Boric Acid (CASRN 10043-35-3) in Sprague-Dawley CD® Rats Exposed on Gestation Days 6-15. Volume II
                                                    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 6-15
                                                    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 6-15
                                                    • Female Rats: Sprague Dawley
                                                    • Rats Maternal Positive 
                                                    • Rats Fetal Positive 
                                                    • Dose: 0, .4, .5, .6, .8% *.
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                                                  CASRN: 58-08-2

                                                  Formula: C8-H10-N4-O2

                                                  Synonyms/Common Names

                                                  • 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

                                                  Known Uses

                                                  Multipurpose food substance, flavor enhancer, stimulant, diuretic used in the treatment of shock, asthma and heart disease. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                  Chemical Properties

                                                  Toxicity Effects (HSDB)

                                                  Short-Term Toxicity

                                                  • 2 weeks (Dosed-Water)  (C02733)  Completed 
                                                    • Rats: F344/N; Mice: B6C3F1
                                                  • 13 weeks (Dosed-Water)  (C02733)  Completed 
                                                    • Rats: F344/N; Mice: B6C3F1
                                                    • Dose: R: 0, 188, 3000, M: 0, 94, 1500 PPM/12 PER GROUP.

                                                  Special Studies

                                                  • C. elegans  (S0873)  Completed 
                                                    • C. elegans
                                                    • Dose: feed (0, .5, .79, 1.3, 2, 3.2, 5, 7.9, 13, 20, 32, 50) mM 03/23/05 repro (0, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25) mM 03/23/05growth (0, .25, .4, .63, 1, 1.6, 2.5, 3, 6.3, 10, 16, 25) mM 10/09/05.

                                                  Genetic Toxicology

                                                  • Salmonella  (075951)  Completed 
                                                    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                    •  Negative 
                                                  • Salmonella  (N-9342)  Completed 
                                                    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248

                                                  Organ Systems Toxicity

                                                  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB81078)  Completed 
                                                    • Citation: Final Report - Caffeine: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
                                                    • Male and Female Mice: Swiss
                                                    • Dose: 0, .012, .033, .1, .3, 1.0%; 0, .012, .025, .05%; N/A; 0, .05%.
                                                  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84044)  Completed 
                                                    • Citation: Final Report - Caffeine: Reproduction and Fertility Assessment In CD-1 Mice When Administered in Drinking Water
                                                    • Male and Female Mice: Swiss
                                                    • Dose: 0, .01, .03, .1, .3, 1.0%; 0, .012, .025, .05%; 0, .05%; N/A.
                                                  • 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB94006)  Completed 
                                                    • Citation: Reproductive Toxicity of Caffeine (CAS #58-08-2) Administered by Gavage to Sprague-Dawley Rats
                                                    • Male and Female Rats: Sprague Dawley
                                                    • Dose: TASK 1: 0, 50, 100, 150, OR 200 MG/KG; TASK 2: 0, 12.5, 25, OR 50 MG/KG; TASK 3: 0 OR 50 MG/KG; TASK 4: 0, 12.5, 25, OR 50 MG/KG.
                                                  • 11 GD Conventional Teratology (Intravenous)  (T0009A)  Completed 
                                                    • Female Rats: Sprague Dawley
                                                    • Dose: 37.5, 75, 112.5, 150 MG/KG/DAY.
                                                  • 0 to 19 GD Conventional Teratology (Gavage)  (T0009D)  Completed 
                                                    • Female Rats: Sprague Dawley
                                                    • Dose: 40, 80 MG/KG/DAY.
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                                                  CASRN: 51207-31-9

                                                  Formula: C12-H4-Cl4-O

                                                  Synonyms/Common Names

                                                  • TCDF

                                                  Known Uses

                                                  No industrial use. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                  Chemical Properties

                                                  Toxicity Effects (HSDB)

                                                  Special Studies

                                                  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0235)  Completed 
                                                    • Citation: Birnbaum LS, Decad GM, Matthews HB. Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat. Toxicol Appl Pharmacol. 1980 Sep 15;55(2):342-52.Pubmed Abstract
                                                    • Male Mice: B6C3F1
                                                  • Absorption Disposition Metabolism Elimination (Gavage)  (S0254)  Completed 
                                                    • Citation: Ioannou YM, Birnbaum LS, Matthews HB. Toxicity and distribution of 2,3,7,8-tetrachlorodibenzofuran in male guinea pigs. J Toxicol Environ Health. 1983 Oct-Dec;12(4-6):541-53.Pubmed Abstract
                                                    • Guinea Pigs
                                                  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0257)  Completed 
                                                    • Citation: Birnbaum LS, Decad GM, Matthews HB, McConnell EE. Fate of 2,3,7,8-tetrachlorodibenzofuran in the monkey. Toxicol Appl Pharmacol. 1981 Feb;57(2):189-96.Pubmed Abstract
                                                    • Monkey
                                                  • Absorption Disposition Metabolism Elimination  (S0429)  Completed 
                                                    • Citation: Decad GM, Birnbaum LS, Matthews HB. Disposition of 2,3,7,8-tetrachlorodibenzofuran in guinea pigs, rats & monkeys. In: Hutzinger O, Frei RW, Merian E, and Pocchiari F, eds. Chlorinated Dioxins & Related Compounds. Impact on the Environment. Pergamon Press; 1982;307-315.
                                                    • Male Rats: F344/N; Male Guinea Pigs; Male Monkey
                                                    • Dose: 14C-TCDF P.O. & IV GUINEA PIG 0.02 UMOLES/KG, F344 RATS 0.1 & 1.0 UMOLES/KG & IV RHESUS MONKEY 0.1 UMOLES/KG.
                                                  • Absorption Disposition Metabolism Elimination  (S0430)  Completed 
                                                    • Citation: King FG, Dedrick RL, Collins JM, Matthews HB, Birnbaum LS. Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species. Toxicol Appl Pharmacol. 1983 Mar 15;67(3):390-400.Pubmed Abstract
                                                    • Rats: F344/N; Mice: B6C3F1; Monkey
                                                  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0439)  Completed 
                                                    • Citation: Decad GM, Birnbaum LS, Matthews HB. Distribution and excretion of 2,3,7,8-tetrachlorodibenzofuran in C57BL/6J and DBA/2J mice. Toxicol Appl Pharmacol. 1981 Jul;59(3):564-73.Pubmed Abstract
                                                    • Male Mice: C57BL/6; Male Mice
                                                  • Absorption Disposition Metabolism Elimination  (S0489)  Completed 
                                                    • Citation: Decad GM, Birnbaum LS, Matthews HB. 2,3,7,8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pig. Toxicol Appl Pharmacol. 1981 Feb;57(2):231-40.Pubmed Abstract
                                                    • Guinea Pigs
                                                  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0686)  Completed 
                                                    • Citation: Brewster DW, Banks YB, Clark AM, Birnbaum LS. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66.Pubmed Abstract
                                                    • Male Rats: F344/N
                                                    • Dose: 0.1, 0.5, 1.0 µmol/kg.
                                                  • Metabolism (in-vitro)  (S0233)  Completed 
                                                    • Citation: Burka L, Mcgown SR, Tomer KB. Identification of the biliary metabolites of 2,3,7,8-tetrachlorodibenzofuran in the rat. Chemosphere.1990; 21(10-11):1231-1242.
                                                    • Male Rats: F344/N
                                                    • Dose: 270 UG/KG (0.92 UCI/KG).
                                                  • Other  (S0432)  Completed 
                                                    • Citation: Burka LT, Overstreet D. Synthesis of possible metabolites of 2,3,7,8-tetrachlorodibenzofuran. J. Agric. Food Chem. 1989; 37:1528-1532
                                                    • Rats

                                                  Organ Systems Toxicity

                                                  • Single dose Immunotoxicity (Gavage)  (I10037)  Completed 
                                                    • Female Mice: B6C3F1
                                                    • Dose: 0, 3, 9, 15, 30 and 90 ug/kg.

                                                  Toxicogenomics

                                                  • Microarray Analysis  (T10037)  Completed 
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                                                    CASRN: 106-46-7

                                                    Formula: C6-H4-Cl2

                                                    Synonyms/Common Names

                                                    • p-Dichlorobenzene

                                                    Known Uses

                                                    Insecticidal fumigant, germicide, intermediate in manufacture of dichloroaniline, dyes, in pharmaceuticals, deodorant for garbage & restrooms (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C54955A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C54955A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 37.5, 600, M: 0, 84.4, 900 MG/KG/60 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C54955A)  Report Complete 
                                                      • TR-319 (NIH Number: 87-2575)  (Peer Review Approval 03/26/1986A )
                                                        Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: MR: 0, 150, 300 MG/KG, FR: 0, 300, 600 MG/KG, M: 0, 300, 600 MG/KG/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Dosed-Water; Intraperitoneal Injection)  (S0064)  Completed 
                                                      • Male Rats: F344/N

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (576715)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (983738)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (465704)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Equivocal 
                                                    • Micronucleus  (447196)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                    • Micronucleus  (A90787)  Completed 
                                                      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                      • Female Negative 
                                                    • Salmonella  (590003)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 121-69-7

                                                    Formula: C8-H11-N

                                                    Synonyms/Common Names

                                                    • N,N-Dimethylbenzenamine

                                                    Known Uses

                                                    Dyes, intermediates; solvent; manufacture of vanillin; stabilizer (acid receptor). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C56428)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C56428)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 36.25, 500, M: 0, 62.5, 500 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C56428)  Report Complete 
                                                      • TR-360 (NIH Number: 90-2815)  (Peer Review Approval 03/13/1989A )
                                                        Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice Equivocal Evidence 
                                                      • Dose: R: 0, 3, 30, M: 0, 15, 30 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (609568)  Completed 
                                                      • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Mouse Lymphoma  (365373)  Completed 
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (840758)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0092)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Reproductive Hazards
                                                      • Female Mice: Swiss
                                                      • Dose: 365 MG/KG BODY WT..
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                                                    CASRN: 136-45-8

                                                    Formula: C13-H17-N-O4

                                                    Synonyms/Common Names

                                                    • Di-n-propyl 2,5-pyridinedicarboxylate
                                                    • Di-propylisocinchomeronate
                                                    • 2,5-PCADPE

                                                    Known Uses

                                                    Insect attractant, repellent and chemosterilant; agricultural chemical

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 4 days (Gavage)  (C10339)  Completed 
                                                      • Liver Targeted Testing study of Toxcast Chemicals
                                                      • Rats: Harlan Sprague-Dawley
                                                      • Dose: Male rats: 0, 600 mg/kg/day.

                                                    Genetic Toxicology

                                                    • 4 days Comet Assay (Gavage)  (G10339)  On Test 
                                                      • Rats: Sprague Dawley

                                                    Toxicogenomics

                                                    • 4 days Microarray Analysis (Gavage)  (T10339)  Completed 
                                                      • Liver Targeted Testing study of Toxcast Chemicals
                                                      • Rats: Harlan Sprague-Dawley
                                                      • Dose: 600 mg/kg; 6 rats.
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                                                    CASRN: 147-24-0

                                                    Formula: C17-H21-N-O.Cl-H

                                                    Synonyms/Common Names

                                                    • BAX

                                                    Known Uses

                                                    Antihistamine

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C56075)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C56075)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 156, OR 2500 M: 0, 78, OR 1250 PPM; 10/GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 113 weeks (Dosed-Feed)  (C56075)  Report Complete 
                                                      • TR-355 (NIH Number: 89-2810)  (Peer Review Approval 10/03/1988A )
                                                        Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: MR: 0, 313, OR 625 FR&M: 0, 156, OR 313 PPM; 50/GROUP.
                                                    • 2 years (Dosed-Feed)  (C56075)  Report Complete 
                                                      • TR-355 (NIH Number: 89-2810)  (Peer Review Approval 10/03/1988A )
                                                        Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: MR: 0, 313, OR 625 FR&M: 0, 156, OR 313 PPM; 50/GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0099)  Completed 
                                                      • Male Rats: F344/N
                                                      • Dose: 313, 625 PPM FOR 30 DAYS.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (195192)  Completed 
                                                      • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Positive 
                                                    • Mouse Lymphoma  (590709)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (637175)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
                                                    • She Cell Transformation  (A81866)  Completed 
                                                      • SHE Cell Transformation  Negative 

                                                    Organ Systems Toxicity

                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER82067)  Completed 
                                                      • Citation: Teratologic Evaluation of Diphenhydramine Hydrochloride in CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 25, 50, 100 MG/KG/DAY.
                                                    • 11 to 14 GD Conventional Teratology (Gavage)  (TER82068)  Completed 
                                                      • Citation: Teratologic Evaluation of Diphenhydramine Hydrochloride Administered to CD-1 Mice on Gestational Days 11 through 14
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Positive 
                                                      • Mice Fetal Positive 
                                                      • Dose: 80, 160, 200 MG/KG/DAY.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER82069)  Completed 
                                                      • Citation: Teratologic Evaluation of Diphenhydramine Hydrochloride in CD-1 Mice
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Positive 
                                                      • Mice Fetal Positive 
                                                      • Dose: 40, 80, 160 MG/KG/DAY.
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                                                    CASRN: 55-31-2

                                                    Formula: C9-H13-N-O3.Cl-H

                                                    Synonyms/Common Names

                                                    • (R)-4-(1-Hydroxy-2-(methylamino)ethyl)pyrocatechol hydrochloride

                                                    Known Uses

                                                    Adrenergic, vasoconstrictor, cardiac stimulant, bronchodilator

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Inhalation)  (C55663)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Inhalation)  (C55663)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 2.5, 40 MG/M3/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C55663)  Report Complete 
                                                      • TR-380 (NIH Number: 90-2835)  (Peer Review Approval 11/20/1989A )
                                                        Toxicology and Carcinogenesis Studies of l-Epinephrine Hydrochloride (CASRN 55-31-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Inadequate Study 
                                                        • Female Rats Inadequate Study 
                                                        • Male Mice Inadequate Study 
                                                        • Female Mice Inadequate Study 
                                                      • Dose: R: 0, 1.5, 5.0, M: 0, 1.5, 3.0 MG/M3/50 PER GROUP.
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                                                    CASRN: 64-17-5

                                                    Formula: C2-H6-O

                                                    Synonyms/Common Names

                                                    • Ethyl alcohol

                                                    Known Uses

                                                    Solvent. In alcoholic beverages and manufacture of denatured alcohols. In gasohol. Anti-freeze agent. Chemical intermediate. In synthetic rubber, coatings, cosmetics, disinfectants, and pharmaceuticals. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Water)  (C00602E)  Report Complete 
                                                      • TR-510 (NIH Number: 04-4444)  (Peer Review Approval 09/05/2002A )
                                                        Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
                                                      • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
                                                      • Carcinogenesis Results
                                                        • Male Mice Inadequate Study 
                                                        • Female Mice Inadequate Study 
                                                      • Dose: 0, 10, 30, 0R 90 PPM.

                                                    Special Studies

                                                    • C. elegans  (S0927)  Completed 
                                                      • C. elegans
                                                      • Dose: feed (0, .057, .114, .228, .342, .467, .570, .684, .798, .912, 1.03, 1.14) M; 10/30/06 repro (0, .5, .63, .79, 1.0, 1.3, 1.6, 2.0, 2.5, 3.2, 4.0, 5.0)%; 12/04/06growth (0.222, .274, .342, .427, .547, .684, .855, 1.08, 1.35, 1.71, 2.22) M; 06/27/07.

                                                    Genetic Toxicology

                                                    • Salmonella  (427021)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84095)  Completed 
                                                      • Citation: Ethanol: Reproduction and Fertility Assessment In CD-1 Mice When Administered In the Drinking Water
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 5, 10, 15%; N/A; N/A.
                                                    • 1 to 19 GD (sperm = 0 days) Conventional Teratology (Inhalation)  (T0014B)  Completed 
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 10000, 16000 AND 20000 PPM.
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                                                    CASRN: 517-28-2

                                                    Formula: C16-H14-O6

                                                    Synonyms/Common Names

                                                    • Cis-(+)-7,11b-dihydro-benz(B)indens(1,2-D)pyran-3,4,6A,9,10(6H)-pentol (9CI)

                                                    Known Uses

                                                    Biological stain in microscopy, histology, manufacture of inks, obtained from heart-wood of logwood tree (Merck 1989)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (554373)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 389-08-2

                                                    Formula: C12-H12-N2-O3

                                                    Synonyms/Common Names

                                                    • 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (9CI)

                                                    Known Uses

                                                    Veterinary use as antibacterial agent for urinary infections.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13-Week (Dosed-Feed)  (C56199)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R&M: 0, 1000, 2000, 4000, 8000, 16000/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 107 weeks (Dosed-Feed)  (C56199)  Report Complete 
                                                      • TR-368 (NIH Number: 89-2823)  (Peer Review Approval 03/13/1989A )
                                                        Toxicology and Carcinogenesis Studies of Nalidixic Acid (CASRN 389-08-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Clear Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R&M: 0, 2000, 4000 PPM/50 PER GROUP.
                                                    • 108 weeks (Dosed-Feed)  (C56199)  Report Complete 
                                                      • TR-368 (NIH Number: 89-2823)  (Peer Review Approval 03/13/1989A )
                                                        Toxicology and Carcinogenesis Studies of Nalidixic Acid (CASRN 389-08-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Clear Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R&M: 0, 2000, 4000 PPM/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0209)  Completed 
                                                      • Male Rats: F344/N; Male Mice: B6C3F1
                                                      • Dose: 20, 200, 500 MG/KG.
                                                    • Metabolism (Gavage)  (S0549)  Completed 
                                                      • Citation: Nomeir AA, Markham P, Burka LT, Griffin RJ, Ghanayem BI. Species differences in the disposition and metabolism of nalidixic acid. J Pharmacol Exp Ther. 1996 Oct;279(1):222-30.Pubmed Abstract
                                                      • Male Rats: F344/N; Male Mice: B6C3F1
                                                      • Dose: 500 MG/KG BW.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (404155)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (803923)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (253916)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Negative 
                                                    • Salmonella  (A06185)  Completed 
                                                      •  Weakly Positive 
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                                                    CASRN: 91-20-3

                                                    Formula: C10-H8

                                                    Synonyms/Common Names

                                                    • Napthene

                                                    Known Uses

                                                    Chemical intermediate, insecticides, repellants, antiseptic, vermicide, synthetic resins; in various commercial moth repellants and toilet bowl cleaners; topically in veterinary medicine. Prepared from coal tar. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C52904B)  Report Complete 
                                                      • TR-410 (NIH Number: 92-3141)  (Peer Review Approval 03/11/1991A )
                                                        Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Mice No Evidence 
                                                        • Female Mice Some Evidence 
                                                      • Dose: 0, 10 (75 mice/sex/group), 30 (150 mice/sex/group) PPM.
                                                    • 2 years (Inhalation)  (C52904C)  Report Complete 
                                                      • TR-500 (NIH Number: 01-4434)  (Peer Review Approval 05/18/2000A )
                                                        Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation Studies)
                                                      • Rats: F344/N
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Clear Evidence 
                                                      • Dose: R: 0, 10, 30, OR 60 PPM; 58/SEX/GROUP.

                                                    Special Studies

                                                    • Toxicokinetic Study (Intravenous)  (S0571)  Completed 
                                                      • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
                                                      • Dose: SINGLE ADMINISTRATION IV RATS 3, 10, & 30 MG/KG; Mice 1, 3, and 10 mg/kg..
                                                    • Toxicokinetic Study (Inhalation)  (S0606)  Completed 
                                                      • Male and Female Rats: F344/N
                                                      • Dose: Rats: 10, 30, 60 ppm; 58/sex/group.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (040612)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Salmonella  (471098)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0038)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                      • Female Mice: Swiss
                                                      • Dose: 300 MG/KG BODY WT..
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER91006)  Completed 
                                                      • Citation: Final Report on the Developmental Toxicity of Naphthalene in Sprague-Dawley (CD) Rats
                                                      • Rats: Sprague Dawley
                                                      • Rats Maternal Inadequate 
                                                      • Rats Fetal Inadequate 
                                                      • Dose: 0, 50, 150, 450 MG/KG/DAY.
                                                    • 6 to 19 GD Conventional Teratology (Gavage)  (TER91021)  Completed 
                                                      • Citation: Final Report on the Developmental Toxicity of Napthalene in New Zealand White Rabbits
                                                      • Female Rabbit: New Zealand White
                                                      • Rabbits Maternal Negative 
                                                      • Rabbits Fetal Negative 
                                                      • Dose: 0, 20, 80, 120 MG/KG/DAY.
                                                    • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90014)  Completed 
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 0, 100, 400, 500, 600, OR 800 MG/KG.
                                                    • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP90015)  Completed 
                                                      • Female Rabbit: New Zealand White
                                                      • Dose: 0, 75, 150, 300, OR 500 MG/KG.
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                                                    CASRN: 59-87-0

                                                    Formula: C6-H6-N4-O4

                                                    Synonyms/Common Names

                                                    • 2((5-Nitro-2-furanyl)methylene)hydrazinecarboxamide

                                                    Known Uses

                                                    Antibacterial agent, sensitizer and food additive, experimental carcinogen

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C56064)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 7 weeks (Dosed-Feed)  (C95005)  Completed 
                                                      • Mice: B6C3F1
                                                      • Dose: FEMALE MICE ONLY: 0 OR 310 PPM.
                                                    • 13-Week (Dosed-Feed)  (C56064)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 20 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C56064)  Report Complete 
                                                      • TR-337 (NIH Number: 88-2593)  (Peer Review Approval 07/14/1987A )
                                                        Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats Clear Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, 310, 620, M: 0, 150, 310 PPM/50 PER GROUP.
                                                    • 2 years (Dosed-Feed)  (C95005)  Completed 
                                                      • Mice: B6C3F1
                                                      • Dose: FEMALE MICE ONLY: 0 OR 310 PPM.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (356548)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Mouse Lymphoma  (267199)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Positive 
                                                    • Micronucleus  (A59017)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                    • Salmonella  (364720)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Positive 

                                                    Organ Systems Toxicity

                                                    • Immunotoxicity (Gavage)  (IMM90011)  Completed 
                                                      • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunotoxicity of Nitrofurazone in Female B6C3F1 Mice
                                                      • Female Mice: B6C3F1
                                                      • Mice Female Negative 
                                                      • Dose: 0, 40, 60, 80 MG/KG.
                                                    • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89020)  Completed 
                                                      • Citation: Final Report on the Reproductive Toxicity of Nitrofurazone in CD-1 Swiss Mice
                                                      • Male and Female Mice: Swiss
                                                      • Dose: 0, 100, 200, 400, 600, 900 PPM; 0, 100, 375, 750 PPM; 0, 750 PPM; 0, 100, 375 PPM.
                                                    • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0012A)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                      • Female Mice: Swiss
                                                      • Dose: 100 MG/KG BODY WT.
                                                    • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER85092)  Completed 
                                                      • Citation: Teratologic Evaluation of Nitrofurazone Administered to CD-1 Mice on Gestational Days 6 through 15
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Positive 
                                                      • Mice Fetal Positive 
                                                      • Dose: 0, 0.0038, 0.0075, 0.025, 0.050%.
                                                    • 6 to 19 GD Conventional Teratology (Gavage)  (TER87093)  Completed 
                                                      • Citation: Teratologic Evaluation of Nitrofurazone Administered to New Zealand White Rabbits on Gestational Days 6-19
                                                      • Female Rabbit: New Zealand White
                                                      • Rabbits Maternal Positive 
                                                      • Rabbits Fetal Positive 
                                                      • Dose: 0, 5, 10, 15, 20 MG/KG/DAY.
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                                                    CASRN: 144-62-7

                                                    Formula: C2-H2-O4

                                                    Synonyms/Common Names

                                                    • Ethanedioic acid (9CI)

                                                    Known Uses

                                                    Analytical reagent; calico printing & dyeing; cleaning wood; manufacture oxalates; ceramics & pigments; paper industry, photography; rubber manufacture industry; making glucose from starch; condensing agent in organic chemistry; auto radiator cleaner, plant constituent; naturally occurring in food. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (596374)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84064)  Completed 
                                                      • Citation: Oxalic Acid: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 0, .05, .1, .2%; N/A; N/A; .
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                                                    CASRN: 77-09-8

                                                    Formula: C20-H14-O4

                                                    Synonyms/Common Names

                                                    • 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone (9CI)

                                                    Known Uses

                                                    Laboratory reagent. Dyes. Cathartic drug in laxatives.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13 weeks (Dosed-Feed)  (C55798)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, .3, 5 %/5 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C55798B)  Report Complete 
                                                      • TR-465 (NIH Number: 97-3390)  (Peer Review Approval 12/05/1995A )
                                                        Toxicology and Carcinogenesis Studies of Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Some Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, 1.2, 2.5, OR 5%; M: 0, 0.3, 0.6, OR 1.2% IN FEED (50/SEX/SPECIES/GROUP).

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0755)  Completed 
                                                      • Citation: Griffin RJ, Godfrey VB, Burka LT. Metabolism and disposition of phenolphthalein in male and female F344 rats and B6C3F1 mice. Toxicol Sci. 1998 Apr;42(2):73-81.Pubmed Abstract
                                                      • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
                                                      • Dose: 800 mg/kg.
                                                    • Toxicokinetic Study (Dosed-Feed; Intravenous)  (S0594)  Completed 
                                                      • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
                                                      • Dose: Feed: Mice: 200, 375, 750, 3000, and 12000 ppm Feed: Rats: 375, 750, 3000, 12000, and 50000 ppm iv: 25 mg/kg for both species and sexes.

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (A53649)  Completed 
                                                      • Mice
                                                      •  Negative (Nonstandard Protocol) 
                                                    • In Vitro Cytogenetics (CA/SCE)  (101813)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Positive 
                                                    • Micronucleus  (A13109)  Completed 
                                                      • Mice: P16(Ink4a)/(+/-) (C57BL/6)
                                                      • Male Positive 
                                                      • Female Positive 
                                                    • Micronucleus  (A20259)  Completed 
                                                      • Mice: P16(Ink4a)/(+/-) (C57BL/6)
                                                      • Male Positive 
                                                      • Female Positive 
                                                    • Micronucleus  (A34828)  Completed 
                                                      • Mice: P16(Ink4a)/(+/-) (C57BL/6)
                                                      • Male Positive 
                                                      • Female Positive 
                                                    • Micronucleus  (A93351)  Completed 
                                                      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                                      • Mice: B6C3F1
                                                      • Male Positive 
                                                      • Female Positive 
                                                    • Micronucleus  (A93723)  Completed 
                                                      • Mice: P16(Ink4a)/(+/-) (C57BL/6)
                                                      • Male Positive 
                                                      • Female Positive 
                                                    • Micronucleus  (A93901)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Positive 
                                                    • Salmonella  (041772)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (768193)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (A71314)  Completed 
                                                      •  Equivocal 
                                                    • Salmonella  (A99430)  Completed 
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89066)  Completed 
                                                      • Citation: Final Report on the Reproductive Toxicology of Phenolphthalein in CD-1 Swiss Mice
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 0, .1, .7, 3%; 0, .7%; 0, .1, .7%.
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                                                    CASRN: 989-38-8

                                                    Formula: C28-H31-N2-O3.Cl

                                                    Synonyms/Common Names

                                                    • Basic Red 1
                                                    • C.I. Basic Red 1
                                                    • 2-(6-(Ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl)benzoic acid ethyl ester monohydrochloride (9CI)

                                                    Known Uses

                                                    Dye for silk, cotton, wool, leather, plastic, paper and bast fiber. Tracing agent in water pollution studies.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C56122)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C56122)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, .012, .2, M: 0, .05, .8 %/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C56122)  Report Complete 
                                                      • TR-364 (NIH Number: 89-2819)  (Peer Review Approval 10/04/1988A )
                                                        Toxicology and Carcinogenesis Studies of Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 120, 250, FM: 0, 500, 1000, MM: 0, 1000, 2000 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (199566)  Completed 
                                                      • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Mouse Lymphoma  (039603)  Completed 
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (666391)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 1344-00-9

                                                    Formula: Al.Na.Unspecified

                                                    Synonyms/Common Names

                                                    • Aluminosilicic acid, sodium salt (9CI)

                                                    Known Uses

                                                    Food additive, anticaking agent.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (693375)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 70356-09-1

                                                    Formula: C20-H22-O3

                                                    Synonyms/Common Names

                                                    • Butyl methoxydibenzoylmethane
                                                    • 1,3-Propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4- methoxyphenyl)-

                                                    Known Uses

                                                    Ingredient used in sunscreen products

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Special Studies

                                                    • 3 days Hershberger Assay (Gavage)  (K10380B)  Completed 
                                                      • Citation: FINAL Report: The Hershberger Bioassay for Ensulizole and Avobenzone 07 November 2012
                                                      • Female Rats: Harlan Sprague-Dawley
                                                      • Dose: 0, 320, 1000.
                                                    • 3 days Uterotrophic Assay (Gavage)  (K10380)  Completed 
                                                      • Citation: FINAL Report: The Uterotrophic Assay with Avobenzone, Ensulizole, Homosalate, and Padimate-O 07 November 2012
                                                      • Female Rats: Harlan Sprague-Dawley
                                                      • Dose: 0, 320, 1000.

                                                    in vitro Testing

                                                    • Androgen Receptor Binding Assay  (V10380)  Completed 
                                                      • Androgen Receptor Binding [ARB] (Rat Prostate Cytosol)
                                                    • Estrogen Receptor Binding Assay (Gavage)  (V10380)  Completed 
                                                      • Estrogen Receptor Binding [ERB] (Rat Uterine Cytosol)
                                                      • Rats: Harlan Sprague-Dawley
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                                                    CASRN: 57-50-1

                                                    Formula: C12-H22-O11

                                                    Synonyms/Common Names

                                                    • alpha-D-glucopyranoside, beta-D-fructofuranosyl (9CI)

                                                    Known Uses

                                                    Refined sugar, food and beverage sweetener, pharmaceutical preservative, antioxidant, demulcent, glycerol, as granulating agent, pill coatings, wines and spirits, used in industry. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Mouse Lymphoma  (330941)  Completed 
                                                      • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
                                                      • Mice
                                                      •  Negative 
                                                    • Mouse Lymphoma  (341303)  Completed 
                                                      • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
                                                      • Mice
                                                    • Mouse Lymphoma  (774043)  Completed 
                                                      • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
                                                      • Mice
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                                                    CASRN: 118-60-5

                                                    Formula: C15-H22-O3

                                                    Synonyms/Common Names

                                                    • 2-Ethylhexyl salicylate
                                                    • Octisalate
                                                    • Octyl Salate

                                                    Known Uses

                                                    an organic compound used as an ingredient in sunscreens and cosmetics to absorb UVB (ultraviolet) rays from the sun. It is an ester formed by the condensation of a salicylic acid with 2-ethylhexanol. It is a colorless oily liquid with a slight floral odor.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Special Studies

                                                    • 3 days Hershberger Assay (Gavage)  (K10431B)  Completed 
                                                      • Citation: Final Report: The Hershberger Bioassay; Oxybenzone, Octylmethoxycinnamate, Octylsalate, Octocrylene. 04 January 2012
                                                      • Male Rats: Harlan Sprague-Dawley
                                                      • Dose: 15, 47, or 150 mg/ml.
                                                    • 3 days Uterotrophic Assay (Gavage)  (K10431)  Completed 
                                                      • Citation: Final Report. The Uterotrophic Assay with Oxybenzone, Octylmethoxycinnamate, Octylsalate and Octocrylene. 01 September 2011 Revised: 20 April 2012
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 5 mL/kg.

                                                    in vitro Testing

                                                    • Androgen Receptor Binding Assay  (V10431B)  Completed 
                                                      • Androgen Receptor Binding Assay
                                                    • Estrogen Receptor Binding Assay  (V10431C)  Completed 
                                                      • Estrogen Receptor Binding Assay
                                                    • H295R Steroidogenesis Assay  (V10431)  Completed 
                                                      • H295R Steroidogenesis Assay
                                                    • Androgen Receptor Transactivation Assay  (V10431D)  Completed 
                                                      • Androgen Receptor Transactivation Assay
                                                    • Estrogen Receptor Transactivation Assay  (V10431E)  Completed 
                                                      • Estrogen Receptor Transactivation Assay
                                                    • Human Recombinant Aromatase Assay  (V10431G)  Completed 
                                                      • Human Recombinant Aromatase Assay
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                                                    CASRN: 57-68-1

                                                    Formula: C12-H14-N4-O2-S

                                                    Synonyms/Common Names

                                                    • 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide (9CI)

                                                    Known Uses

                                                    Veterinary medicine as an antimicrobial, antibacterial and coccidiostat.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13 weeks (Dosed-Feed)  (C56600B)  Completed 
                                                      • NR-418
                                                        Chronic Toxicity and Carcinogenesis Study of Sulfamethazine in B6C3F1 Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                                                      • Mice: B6C3F1
                                                    • 13 weeks (Dosed-Feed)  (C56600)  Completed 
                                                      • NR-420
                                                        Chronic Toxicity and Carcinogenesis Study on Sulfamethazine in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                                                      • Rats: F344/N

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C56600B)  Report Complete 
                                                      • NR-418  (Peer Review Approval NA)
                                                        Chronic Toxicity and Carcinogenesis Study of Sulfamethazine in B6C3F1 Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                                                      • Mice: B6C3F1
                                                      • Dose: M: 0, 300, 600, 1200, 2400, 4800 PPM.
                                                    • 2 years (Dosed-Feed)  (C56600)  Report Complete 
                                                      • NR-420  (Peer Review Approval NA)
                                                        Chronic Toxicity and Carcinogenesis Study on Sulfamethazine in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
                                                      • Rats: F344/N
                                                      • Dose: R: 0, 10, 40, 600, 1200, 2400 PPM.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (930871)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (768024)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB82108)  Completed 
                                                      • Citation: Final Report - Sulfamethazine: Reproduction and Fertility Assessment in CD-1 Mice When Administered Via the Diet
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 0, .25, .5, 1%; 0, 1%; N/A.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER81108)  Completed 
                                                      • Citation: Teratologic Evaluation of Sulfamethazine in CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 545, 685, 865 MG/KG/DAY.
                                                    • 6 to 19 GD Conventional Teratology (Gavage)  (TER81109)  Completed 
                                                      • Citation: Teratologic Evaluation of Sulfamethazine in New Zealand White Rabbits
                                                      • Female Rabbit: New Zealand White
                                                      • Rabbits Maternal Positive 
                                                      • Rabbits Fetal Positive 
                                                      • Dose: 0, 600, 1200, 1500, 1800 MG/KG/DAY.
                                                    • 20 GD Conventional Teratology (Dosed-Feed)  (TER84001)  Completed 
                                                      • Male and Female Rats: F344/N
                                                      • Dose: 0, 600, 1200, OR 2400 PPM.
                                                    • single exposure Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98050)  Completed 
                                                      • Female Mice: (SEC/E X C57BL/E)F1
                                                      • Dose: 775 MG/KG.
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                                                    CASRN: 3622-84-2

                                                    Formula: C10-H15-N-O2-S

                                                    Synonyms/Common Names

                                                    • Benzenesulfonic acid butyl amide
                                                    • NBBS

                                                    Known Uses

                                                    Plasticizer used in polyacetals, polycarbonates, polysulfones, and polyamides (Nylon 11 and Nylon 12).

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Planned Carcinogenicity/Toxicity

                                                    • 14-Day (Dosed-Feed)  (C10482B)   
                                                      • 13-weekToxicity (C10482B) of N-Butylbenzenesulfonamide (CAS 3622-84-2, TEST ARTICLE #10057) in B6C3F1/N Mice
                                                      • Mice: B6C3F1/N
                                                    • 13-Week (Dosed-Feed)  (C10482B)   
                                                      • Modified One-Generation Study (MOG R# MOG008) in Harlan Sprague Dawley Rats
                                                      • Rats: Harlan Sprague-Dawley

                                                    Short-Term Toxicity

                                                    • 14 days (Dosed-Feed)  (C10482)  On Test 
                                                      • Mice: B6C3F1/N
                                                      • Dose: 0, 1250, 2500, 5000, 10000, or 20000 ppm; 5/sex.

                                                    Modified One-Generation

                                                    • GD 6 to PND 28 Dose Range Finding (Dosed-Feed)  (MOG10482)  Completed 
                                                      • Female Rats: Harlan Sprague-Dawley
                                                      • Dose: 0, 625, 1250, 2500, 5000 or 10, 000 ppm.
                                                    • Developmental Toxicity (Dosed-Feed) Selected (MOG10482B)  
                                                      • Developmental Tox Cohort - (Subset C)
                                                      • Rats: Harlan Sprague-Dawley
                                                    • F0 Generation (Dosed-Feed)  (MOG10482B)  On Test 
                                                      • Definitive study (Dam dose start) - (Subset A)
                                                      • Rats: Harlan Sprague-Dawley
                                                    • Fertility Assessment (Dosed-Feed) Selected (MOG10482B)  
                                                      • Fertility Cohort
                                                      • Rats: Harlan Sprague-Dawley
                                                    • GD 18 (gestational transfer); PND 4 (lactational transfer) Maternal Transfer (Dosed-Feed) Selected (MOG10482B)  
                                                      • (Subset B)
                                                      • Rats: Harlan Sprague-Dawley
                                                    • 7 days Neurotoxicology Assessment (Dosed-Feed) Selected (MOG10482B)  
                                                      • Neurotoxicity Cohort
                                                      • Rats: Harlan Sprague-Dawley
                                                    • 90 days (up to 35 days for mammary analysis) Subchronic (Dosed-Feed) Selected (MOG10482B)  
                                                      • subchronic with post-weaning mammary gland analysis
                                                      • Rats: Harlan Sprague-Dawley; Rats

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K10482)  Completed 
                                                      • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
                                                      • Dose: 2, 20, or 200 mg/kg. 20 mg/kg. 20mg/kg.
                                                    • Toxicokinetic Study (Gavage; Intravenous)  (K10482B)  Completed 
                                                      • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
                                                      • Dose: 20 mg/kg. 20, 60, and 200 mg/kg. 20mg/kg.

                                                    Genetic Toxicology

                                                    • Micronucleus  (G10482B)  On Test 
                                                      • Male Mice
                                                      • Mice: B6C3F1/N
                                                    • Micronucleus  (G10482C)  On Test 
                                                      • Male Rats
                                                      • Rats: Sprague Dawley
                                                    • Salmonella  (G10482)  Completed 
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • GD 6 - PND 42 Immunotoxicity (Dosed-Feed)  (I10482B)  On Test 
                                                      • Male and Female Rats: Sprague Dawley
                                                      • Dose: 0, 500, 1000, or 2000 ppm.
                                                    • 28 days Immunotoxicity (Dosed-Feed)  (I10482)  Report in Preparation 
                                                      • Female Mice: B6C3F1/N
                                                      • Dose: 0, 313, 625, 1250, 2500, or 5000 ppm.
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                                                    CASRN: 271-89-6

                                                    Formula: C8-H6-O

                                                    Synonyms/Common Names

                                                    • Coumarone

                                                    Known Uses

                                                    Manufacture of coumarone-indene resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C56166)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C56166)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 31.25, 500 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C56166)  Report Complete 
                                                      • TR-370 (NIH Number: 89-2825)  (Peer Review Approval 03/13/1989A )
                                                        Toxicology and Carcinogenesis Studies of Benzofuran (CASRN 271-89-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats Some Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: FR&MM: 0, 60, 120, MR: 0, 30, 60, FM: 0, 120, 240 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (622347)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (158938)  Completed 
                                                      • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (524374)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 27503-81-7

                                                    Formula: C13-H10-N2-O3-S

                                                    Synonyms/Common Names

                                                    • Phenylbenzimidazole sulfonic acid
                                                    • 2-Phenylbenzimidazole-5-sulfonic acid

                                                    Known Uses

                                                    Sunscreen

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Special Studies

                                                    • 3 days Hershberger Assay (Gavage)  (K10504B)  Completed 
                                                      • Citation: FINAL Report: The Hershberger Bioassay for Ensulizole and Avobenzone 07 November 2012
                                                      • Female Rats: Harlan Sprague-Dawley
                                                      • Dose: 0, 320, 1000.
                                                    • 3 days Uterotrophic Assay (Gavage)  (K10504)  Completed 
                                                      • Citation: FINAL Report: The Uterotrophic Assay with Avobenzone, Ensulizole, Homosalate, and Padimate-O 07 November 2012
                                                      • Female Rats: Harlan Sprague-Dawley
                                                      • Dose: 0, 320, 1000.

                                                    in vitro Testing

                                                    • Androgen Receptor Transactivation Assay  (V10504)  Completed 
                                                      • Androgenic Receptor Transactivation Activity [ARTA] in MDA-kb2
                                                    • Estrogen Receptor Binding Assay (Dosed-Feed)  (V10504)  Completed 
                                                      • Estrogen Receptor Binding [ERB] (Rat Uterine Cytosol)
                                                      • Rats: Harlan Sprague-Dawley
                                                    • Androgen Receptor Binding Assay (Gavage)  (V10504)  Completed 
                                                      • Androgen Receptor Binding [ARB] (Rat Prostate Cytosol)
                                                      • Rats: Harlan Sprague-Dawley
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                                                    CASRN: 100-51-6

                                                    Formula: C7-H8-O

                                                    Synonyms/Common Names

                                                    • Benzenemethanol

                                                    Known Uses

                                                    Manufacture of other benzyl compounds. Solvent for gelatin, casein, cellulose acetate & shellac. Used in perfumery & flavoring. Virucide in lotions. Lacquer solvent. Plasticizer. Preservative in ophthalmic preparations. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C06111)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C06111)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 50, 800 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C06111)  Report Complete 
                                                      • TR-343 (NIH Number: 89-2599)  (Peer Review Approval 11/06/1987A )
                                                        Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CASRN 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 200, 400, M: 0, 100, 200 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (944840)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Weakly Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (419402)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (464779)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Equivocal 
                                                    • Salmonella  (597306)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0049A)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                      • Female Mice: Swiss
                                                      • Dose: 750 MG/KG BD WT.
                                                    • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0049B)  Completed 
                                                      • Female Mice: Swiss
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                                                    CASRN: 108-86-1

                                                    Formula: C6-H5-Br

                                                    Synonyms/Common Names

                                                    • Phenyl bromide

                                                    Known Uses

                                                    Chemical intermediate. Solvent. Organic synthesis. Motor oil additive.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 4 days (Inhalation)  (C55492C)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Inhalation)  (C55492C)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R&FM: 0, 10, 300, MM: 0, 10, 100 PPM/10 PER GROUP.
                                                    • 13-Week (Gavage)  (C55492D)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 50, 600 MG/KG/10 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (544069)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Weakly Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (818178)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 56802-99-4

                                                    Formula: (Na3-PO4·12H2O)4·Na-O-Cl

                                                    Synonyms/Common Names

                                                    • Sodium hypochlorite phosphate (Na13(ClO)(PO4)4)

                                                    Known Uses

                                                    Detergent and bactericide in food and dairy processing, in automatic dishwasher detergent, scouring cleansers, laundry soaps (HSDB 1990).

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C55754A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C55754A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 62, 1000 M: 0, 31, 500 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C55754A)  Report Complete 
                                                      • TR-294 (NIH Number: 87-2550)  (Peer Review Approval 11/02/1984A )
                                                        Toxicology and Carcinogenesis Studies of Chlorinated Trisodium Phosphate (CASRN 56802-99-4) in B6C3F1 Mice (Gavage Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Inadequate Study 
                                                        • Female Rats Inadequate Study 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 500, 1000, 2000 M: 0, 250, 500, 1000 MG/KG/50 PER GROUP.
                                                    • 2-Year (Gavage)  (C55754A)  Report Complete 
                                                      • TR-294 (NIH Number: 87-2550)  (Peer Review Approval 11/02/1984A )
                                                        Toxicology and Carcinogenesis Studies of Chlorinated Trisodium Phosphate (CASRN 56802-99-4) in B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N
                                                      • Carcinogenesis Results
                                                        • Male Rats Inadequate Study 
                                                        • Female Rats Inadequate Study 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 500, 1000, 2000 M: 0, 250, 500, 1000 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (387936)  Completed 
                                                      • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Salmonella  (610291)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Weakly Positive 
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                                                    CASRN: 108171-27-3

                                                    Formula: C24-H43-Cl7

                                                    Synonyms/Common Names

                                                    • Cereclor 42
                                                    • Chlorowax 40

                                                    Known Uses

                                                    Additive in extreme pressure lubricant; flame retardant in rubber, plastic, and paint

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C53543)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C53543)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 250, or 3750 M: 0, 469, or 7500 mg/kg/10 per group.

                                                    Long-Term Carcinogenicity

                                                    • 109 weeks (Gavage)  (C53543)  Report Complete 
                                                      • TR-305 (NIH Number: 86-2561)  (Peer Review Approval 08/14/1985A )
                                                        Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Equivocal Evidence 
                                                      • Dose: FR: 0, 100, 300, or 900, MR: 0, 1875, or 3750, M: 0, 2500, or 5000 mg/kg/50 per group.
                                                    • 2 years (Gavage)  (C53543)  Report Complete 
                                                      • TR-305 (NIH Number: 86-2561)  (Peer Review Approval 08/14/1985A )
                                                        Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Equivocal Evidence 
                                                      • Dose: FR: 0, 100, 300, or 900, MR: 0, 1875, or 3750, M: 0, 2500, or 5000 mg/kg/50 per group.

                                                    Genetic Toxicology

                                                    • Mouse Lymphoma  (010900)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (104775)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 108171-26-2

                                                    Formula: C12-H19-Cl7

                                                    Synonyms/Common Names

                                                    • Cereclor 54
                                                    • Chlorowax 500C

                                                    Known Uses

                                                    Additive for extreme pressure lubricant; flame retardant in rubber, plastic, and paint

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C53587)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C53587)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 313, 5000, M: 0, 469, 7500 MG/KG/5 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C53587)  Report Complete 
                                                      • TR-308 (NIH Number: 86-2564)  (Peer Review Approval 08/14/1985A )
                                                        Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C12, 60% Chlorine) (CASRN 108171-26-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Clear Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, 312, 625, M: 0, 125, 250 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (132281)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Mouse Lymphoma  (333321)  Completed 
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (731132)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 108-94-1

                                                    Formula: C6-H10-O

                                                    Synonyms/Common Names

                                                    • Pimelin ketone

                                                    Known Uses

                                                    Solvent for cellulose acetate, nitrocellulose, natural resins, vinyl resins, crude rubber, waxes, fats, shellac & DDT, in production of adipic acid for nylon, in preparation of cyclohexanone resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13-Week (Dosed-Water)  (C55005)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Dosed-Water)  (C55005)  Report Complete 
                                                      •   (Peer Review Approval NA) Citation: Lijinsky W, RM Kovatch, Chronic Toxicity Study of Cyclohexanone in Rats and Mice. J Natl Cancer Inst. 1986 Oct;77(4):941-9.
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 3500, 7000, MM: 0, 7000, 14000, FM: 0, 14000, 28000 PPM.

                                                    Genetic Toxicology

                                                    • Mouse Lymphoma  (910786)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (486795)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (587795)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 106-88-7

                                                    Formula: C4-H8-O

                                                    Synonyms/Common Names

                                                    • Ethyloxirane

                                                    Known Uses

                                                    For production of butanediols, glycol esters & ethers, preparation of surfactants & gasoline additives, intermediate For polymers, stabilizer (HSDB 1990).

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Inhalation)  (C55527)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Inhalation)  (C55527)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 50, 800 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C55527)  Report Complete 
                                                      • TR-329 (NIH Number: 88-2585)  (Peer Review Approval 08/19/1986A )
                                                        Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 200, 400, M: 0, 50, 100 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (333393)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (855451)  Completed 
                                                      • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
                                                      • Sex-Linked Recessive Lethal Positive 
                                                      • Reciprocal Translocation Positive 
                                                    • Mouse Lymphoma  (119097)  Completed 
                                                      • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
                                                      • Mice
                                                      •  Positive 
                                                    • Mouse Lymphoma  (G18246)  Completed 
                                                      • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
                                                      • Mice
                                                    • Mouse Lymphoma  (G71732)  Completed 
                                                      • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
                                                      • Mice
                                                    • Micronucleus  (A16097)  Completed 
                                                      • Rats: Fischer 344
                                                      • Male Negative 
                                                    • Salmonella  (970583)  Completed 
                                                      • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
                                                      •  Positive 
                                                    • Salmonella  (N-9093)  Completed 
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251

                                                    Organ Systems Toxicity

                                                    • 5 days/week for 3 weeks before breeding, or 1 to 19 GD, or 3 weeks before breeding plus 1 to 19 GD Conventional Teratology (Inhalation)  (T0056A)  Completed 
                                                      • Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
                                                      • Female Rats: Wistar
                                                      • Dose: 250 or 1000 ppm 7 hr/day.
                                                    • 1 to 24 GD Conventional Teratology (Inhalation)  (T0056B)  Completed 
                                                      • Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
                                                      • Female Rabbit: New Zealand White
                                                      • Dose: 250 or 1000 ppm 7 hr/day.
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                                                    CASRN: 74-96-4

                                                    Formula: C2-H5-Br

                                                    Synonyms/Common Names

                                                    • Bromoethane
                                                    • Ethyl bromide

                                                    Known Uses

                                                    Chemical intermediate for pharmaceuticals. Ethylating agent in organic synthesis. Refrigerant. Grain and fruit fumigant.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Inhalation)  (C55481)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Inhalation)  (C55481)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 100, 1600 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C55481)  Report Complete 
                                                      • TR-363 (NIH Number: 90-2818)  (Peer Review Approval 10/03/1988A )
                                                        Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CASRN 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R&M: 0, 100, 200, 400 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (496296)  Completed 
                                                      • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (024373)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (811571)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                                      •  Positive 
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                                                    CASRN: 54-31-9

                                                    Formula: C12-H11-Cl-N2-O5-S

                                                    Synonyms/Common Names

                                                    • 5-(Aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid (9CI)

                                                    Known Uses

                                                    Diuretic in the treatment of edema and hypertension. Diuretic in veterinary medicine.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C55936)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C55936)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: MR: 0, 625, 10000, FR&MM: 0, 938, 15000, FM: 0, 1250, 20000 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 107 weeks (Dosed-Feed)  (C55936)  Report Complete 
                                                      • TR-356 (NIH Number: 89-2811)  (Peer Review Approval 04/18/1988A )
                                                        Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice Some Evidence 
                                                      • Dose: R: 0, 350, 700, M: 0, 700, 1400 PPM/50 PER GROUP.
                                                    • 2 years (Dosed-Feed)  (C55936)  Report Complete 
                                                      • TR-356 (NIH Number: 89-2811)  (Peer Review Approval 04/18/1988A )
                                                        Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice Some Evidence 
                                                      • Dose: R: 0, 350, 700, M: 0, 700, 1400 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (169457)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Mouse Lymphoma  (219163)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Positive 
                                                    • Micronucleus  (912768)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                    • Salmonella  (312303)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
                                                    • Salmonella  (A84903)  Completed 
                                                      •  Negative 
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                                                    CASRN: 13098-39-0

                                                    Formula: C3-F6-O.3/2H2-O

                                                    Synonyms/Common Names

                                                    • 2-Propanone, 1,1,1,3,3,3-hexafluoro-, sesquihydrate (9CI)

                                                    Known Uses

                                                    Solvent for polymerization reaction. Propellant for aqueous aerosol systems. Fungicide. Herbicide.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (167078)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Negative 
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                                                    CASRN: 78-59-1

                                                    Formula: C9-H14-O

                                                    Synonyms/Common Names

                                                    • 3,5,5-Trimethyl-2-cyclohexen-1-one (9CI)

                                                    Known Uses

                                                    Solvent. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C55618)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C55618)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 62.5, 1000 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C55618)  Report Complete 
                                                      • TR-291 (NIH Number: 86-2547)  (Peer Review Approval 11/02/1984A )
                                                        Toxicology and Carcinogenesis Studies of Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: 0, 250, 500 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (783723)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (624279)  Completed 
                                                      • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (719644)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (490210)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (505090)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Sister Chromatid Exchanges  (783723)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Negative 
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                                                    CASRN: 5989-27-5

                                                    Formula: C10-H16

                                                    Synonyms/Common Names

                                                    • (R)-1-Methyl-4-(1-methylethenyl)-cyclohexene (9CI)

                                                    Known Uses

                                                    Industrial solvent, flavor & fragrance additive obtained from citrus fruit. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C55572)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C55572)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 150, 2400, M: 0, 125, 2000 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C55572)  Report Complete 
                                                      • TR-347 (NIH Number: 90-2802)  (Peer Review Approval 04/18/1988A )
                                                        Toxicology and Carcinogenesis Studies of d-Limonene (CASRN 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: FR: 0, 300, 600, MR: 0, 75, 150, FM: 0, 500, 1000, MM: 0, 250, 500 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (269844)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (861341)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (554149)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 74-87-3

                                                    Formula: C-H3-Cl

                                                    Synonyms/Common Names

                                                    • Chloromethane (9CI)

                                                    Known Uses

                                                    Chemical intermediate, solvent and diluent in rubber production, refrigerant, extraction solvent, local anesthetic, plastics industry, propellant, herbicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (329517)  Completed 
                                                      •  Positive 
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                                                    CASRN: 149-30-4

                                                    Formula: C7-H5-N-S2

                                                    Synonyms/Common Names

                                                    • 2(3H)-Benzothiazolethione (9Ci)
                                                    • MBT

                                                    Known Uses

                                                    Rubber vulcanization accelerator. Salts used as fungicide. Corrosion inhibitor for copper in aqueous systems, cutting oils and petroleum products. Additive in extreme-pressure greases.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C56519)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C56519)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, .1, 10 MG/M3/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C56519)  Report Complete 
                                                      • TR-332 (NIH Number: 88-2588)  (Peer Review Approval 03/04/1987A )
                                                        Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats Some Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice Equivocal Evidence 
                                                      • Dose: FR: 0, 188, 375, MR&M: 0, 375, 750 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (748636)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Not a Valid Test 
                                                      • Chromosome Aberrations Positive 
                                                    • In Vitro Cytogenetics (CA/SCE)  (997320)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Not Tested 
                                                    • Mouse Lymphoma  (920542)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Positive 
                                                    • Micronucleus  (A38881)  Completed 
                                                      • Rats: Fischer 344
                                                      • Male Negative 
                                                    • Micronucleus  (A62048)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                    • Salmonella  (855075)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Equivocal 
                                                    • Salmonella  (876400)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • Immunotoxicity (Topical Application)  (IMM90003)  Completed 
                                                      • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Assessment of Contact Hypersensitivity to 2-Mercaptobenzothiazole in Female B6C3F1 Mice
                                                      • Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
                                                      • Female Mice: B6C3F1
                                                      • Mice Female Positive 
                                                      • Dose: 0, 1, 3, 7.5%.
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                                                    CASRN: 108-95-2

                                                    Formula: C6-H6-O

                                                    Synonyms/Common Names

                                                    • Carbolic acid
                                                    • Hydroxybenzene
                                                    • Phenyl hydroxide

                                                    Known Uses

                                                    Disinfectant; antiseptic; in resins, organics, and dyes, obtained from coal tar (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Water)  (C50124)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Water)  (C50124)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 100, 10000 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Dosed-Water)  (C50124)  Report Complete 
                                                      • TR-203 (NIH Number: 80-1759)  (Peer Review Approval 02/15/1980A )
                                                        Bioassay of Phenol for Possible Carcinogenicity (CASRN108-95-2)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Negative 
                                                        • Female Rats Negative 
                                                        • Male Mice Negative 
                                                        • Female Mice Negative 
                                                      • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (170681)  Completed 
                                                      • Mice
                                                      •  Positive (Nonstandard Protocol) 
                                                    • Chromosome Aberrations  (329606)  Completed 
                                                      • Mice
                                                      •  Positive (Nonstandard Protocol) 
                                                    • In Vitro Cytogenetics (CA/SCE)  (340985)  Completed 
                                                      • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (726780)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (987728)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Positive 
                                                    • Micronucleus  (874983)  Completed 
                                                      • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
                                                      • Mice: B6C3F1
                                                      • Male Positive 
                                                    • Salmonella  (175560)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (759552)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Sister Chromatid Exchanges  (170681)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Negative (Nonstandard Protocol) 
                                                    • Sister Chromatid Exchanges  (329606)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Positive 

                                                    Organ Systems Toxicity

                                                    • 28 days Immunotoxicity (Dosed-Water)  (IMM20203)  Completed 
                                                      • Female Mice: B6C3F1
                                                      • Dose: 0, 5, 20, or 100 mg/L.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER80129)  Completed 
                                                      • Citation: Final Report - Teratologic Evaluation of Phenol in CD-1 Mice
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Positive 
                                                      • Mice Fetal Positive 
                                                      • Dose: 70, 140, 280 MG/KG/DAY.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER81104)  Completed 
                                                      • Citation: Teratologic Evaluation of Phenol in CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 0, 30, 60, 120 MG/KG/DAY.
                                                    • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98026)  Completed 
                                                      • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
                                                      • Female Mice
                                                      • Mice Female Negative 
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                                                    CASRN: 9009-54-5

                                                    Synonyms/Common Names

                                                    • Urethane polymers

                                                    Known Uses

                                                    In upholstery padding and clothing interlining, coatings, adhesives, medical devices. Insulating material.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C06984)  Completed 
                                                      • Rats: Sprague Dawley; Hamsters: Syrian Golden
                                                      • Dose: R, H: 0, 3.6, 20, 36 MG/M3 /40-240 ANIMALS PER GROUP.
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                                                    CASRN: 2058-46-0

                                                    Formula: C22-H24-N2-O9.Cl-H

                                                    Synonyms/Common Names

                                                    • (4S-(4-a,4a-a,5-a,5a-a,6-b,12a-a))-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12-a-heahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide HCl

                                                    Known Uses

                                                    Antibiotic, antimicrobial, animal feed additive

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C56473)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C56473)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 3100, 50000 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C56473)  Report Complete 
                                                      • TR-315 (NIH Number: 87-2571)  (Peer Review Approval 12/09/1985A )
                                                        Toxicology and Carcinogenesis Studies of Oxytetracycline Hydrochloride (CASRN 2058-46-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 25000, 50000 M: 0, 6300, 12500 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (604406)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Not Tested 
                                                    • In Vitro Cytogenetics (CA/SCE)  (682810)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Not a Valid Test 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (377666)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (739218)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (463949)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER82094)  Completed 
                                                      • Citation: Teratologic Evaluation of Oxytetracycline Hydrochloride in CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 1200, 1350, 1500 MG/KG/DAY.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER82095)  Completed 
                                                      • Citation: Teratologic Evaluation of Oxytetracycline Hydrochloride in CD-1 Mice
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Negative 
                                                      • Mice Fetal Negative 
                                                      • Dose: 1325, 1670, 2100 MG/KG/DAY.
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                                                    CASRN: 58-95-7

                                                    Formula: C31-H52-O3

                                                    Synonyms/Common Names

                                                    • alpha-Tocopherol acetate
                                                    • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-(9CI)
                                                    • Vitamin E acetate
                                                    • Vitamin E Acetate

                                                    Known Uses

                                                    Vitamin E supplement

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13-Week (Gavage)  (C61370)  Completed 
                                                      • Rats: F344/N; Rats: Sprague Dawley
                                                      • Dose: 0, 125, OR 2000 MG/KG; 10 PER GROUP.
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                                                    CASRN: 87-61-6

                                                    Formula: C6-H3-Cl3

                                                    Synonyms/Common Names

                                                    • vic-Trichlorobenzene

                                                    Known Uses

                                                    Manufacture of 2,5-dichlorophenol and insecticides, in polyester dyeing, glass tempering. As a synthetic heat transfer medium , transformer oil, lubricant and coolant in electrical installations.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (513040)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 81-49-2

                                                    Formula: C14-H7-Br2-N-O2

                                                    Synonyms/Common Names

                                                    • Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC).
                                                    • 9,10-Anthracenedione, 1-amino-2,4-dibromo-

                                                    Known Uses

                                                    In manufacture of dyes.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Dosed-Feed)  (C55458)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13 weeks (Dosed-Feed)  (C55458)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 2500, 50000 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C55458)  Report Complete 
                                                      • TR-383 (NIH Number: 96-2838)  (Peer Review Approval 06/21/1994A )
                                                        Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Clear Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, .2, .5, 1.0, 2.0, M: 0, 1.0, 2.0 %/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0212)  Completed 
                                                      • Male Rats: F344/N
                                                      • Dose: IV:O.4 MG/KG; PO:2, 23, 118, 814, 1473 MG/KG.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (438792)  Completed 
                                                      • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Equivocal 
                                                    • In Vitro Cytogenetics (CA/SCE)  (905842)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Weakly Positive 
                                                    • Salmonella  (685556)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Positive 
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                                                    CASRN: 60-13-9

                                                    Formula: C9-H13-N.1/2H2-O4-S

                                                    Synonyms/Common Names

                                                    • alpha-Methylphenethylamine sulfate, (+-)-

                                                    Known Uses

                                                    Treatment of narcolepsy and weight problems; for behavior disorders in children

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C55710)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C55710)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 6.25, 100, M: 0, 25, 400 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C55710)  Report Complete 
                                                      • TR-387 (NIH Number: 91-2842)  (Peer Review Approval 04/25/1990A )
                                                        Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R&M:0, 20, 100 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (381641)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (561780)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Equivocal 
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                                                    CASRN: 123-77-3

                                                    Formula: C2-H4-N4-O2

                                                    Synonyms/Common Names

                                                    • Diazenedicarboxamide

                                                    Known Uses

                                                    Blowing agent for plastics and rubbers. Maturing agent for flours. Food additive. Chemical foaming agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Inhalation)  (C55981C)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Inhalation)  (C55981C)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 50, 100, OR 200 MG/M3.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0457)  Completed 
                                                      • Citation: Gerlach RF, Medinsky MA, Hobbs CH, Bice DE, Bechtold WE, Cheng YS, Gillett NA, Birnbaum LS, Mauderly JL. Effect of four-week repeated inhalation exposure to unconjugated azodicarbonamide on specific and non-specific airway sensitivity of the guinea pig. J Appl Toxicol. 1989 Jun;9(3):145-53.Pubmed Abstract
                                                      • Citation: Shopp GM, Cheng YS, Gillett NA, Bechtold WE, Medinsky MA, Hobbs CH, Birnbaum LS, Mauderly JL. Acute inhalation exposure of azodicarbonamide in the guinea pig. Am Ind Hyg Assoc J. 1987 Feb;48(2):127-32.Pubmed Abstract
                                                      • Guinea Pigs
                                                    • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0458)  Completed 
                                                      • Male Rats: F344/N
                                                      • Dose: 8 UCI, 48 HR STUDY DONE AT IRDC.
                                                    • Toxicokinetic Study (Inhalation)  (S0058)  Completed 
                                                      • Citation: Mewhinney JA, Ayres PH, Bechtold WE, Dutcher JS, Cheng YS, Bond JA, Medinsky MA, Henderson RF, Birnbaum LS. The fate of inhaled azodicarbonamide in rats. Fundam Appl Toxicol. 1987 Apr;8(3):372-81.Pubmed Abstract
                                                      • Male Rats: F344/N

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (998177)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (831837)  Completed 
                                                      • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Salmonella  (727470)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Positive 
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                                                    CASRN: 100-52-7

                                                    Formula: C7-H6-O

                                                    Synonyms/Common Names

                                                    • Benzoic aldehyde

                                                    Known Uses

                                                    Chemical intermediate for dyes. Solvent for oils, resins, some cellulose ethers, cellulose acetate and nitrate, flavoring compounds, synthetic perfumes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Gavage)  (C56133)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 100, 200, 400, 800, OR 1600 MG/KG M: O, 200, 400, 800, 1600, OR 3200 MG/KG; 5/SEX/SPECIES.
                                                    • 13 weeks (Gavage)  (C56133)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 50, 100, 200, 400, OR 800 MG/KG M: 0, 75, 150, 300, 600, OR 1200 MG/KG; 10/SEX/SPECIES.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C56133)  Report Complete 
                                                      • TR-378 (NIH Number: 90-2833)  (Peer Review Approval 06/27/1989A )
                                                        Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Some Evidence 
                                                        • Female Mice Some Evidence 
                                                      • Dose: R&MM: 0, 200, OR 400 MG/KG FM: 0, 300, OR 600 MG/KG; 50/SEX/SPECIES.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (081912)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (143943)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (895369)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (489344)  Completed 
                                                      •  Negative 
                                                    • Salmonella  (930477)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 510-15-6

                                                    Formula: C16-H14-Cl2-O3

                                                    Synonyms/Common Names

                                                    • 4-Chloro-alpha-(4-chlorophenyl)-alpha-hydroxybenzeneacetic acid ethyl ester
                                                    • Ethyl 4,4'-dichlorobenzilate

                                                    Known Uses

                                                    Acaricide for spider mite control (Merck 1989)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C00408)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C00408)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Dose: 0, 1780, 17800 PPM/5 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Dosed-Feed)  (C00408)  Report Complete 
                                                      • TR-075 (NIH Number: 78-1325)  (Peer Review Approval 06/29/1978A )
                                                        Bioassay of Chlorobenzilate for Possible Carcinogenicity (CASRN 510-15-6)
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal 
                                                        • Female Rats Equivocal 
                                                        • Male Mice Positive 
                                                        • Female Mice Positive 
                                                      • Dose: FR: 0, 1175, 2229 (AVG), MR: 0, 1600, 2995 (AVG), FM: 0, 3200, 5908 (AVG), MM: 0, 4231, 7846 (AVG) PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (486951)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (427493)  Completed 
                                                      • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (159650)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • Mouse Lymphoma  (252225)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (313686)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (373410)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (374565)  Completed 
                                                      •  Negative 
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                                                    CASRN: 109-69-3

                                                    Formula: C4-H9-Cl

                                                    Synonyms/Common Names

                                                    • 1-Chlorobutane

                                                    Known Uses

                                                    Butylating agent in organic synthesis, solvent, veterinary antihelmintic (HSDB 1990)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C06155A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C06155A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 30, 500 M: 0, 60, 1000 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 108 weeks (Gavage)  (C06155A)  Report Complete 
                                                      • TR-312 (NIH Number: 86-2568)  (Peer Review Approval 08/14/1985A )
                                                        Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CASRN 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 60, 120 M: 0, 500, 1000 MG/KG/50 PER GROUP.
                                                    • 2 years (Gavage)  (C06155A)  Report Complete 
                                                      • TR-312 (NIH Number: 86-2568)  (Peer Review Approval 08/14/1985A )
                                                        Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CASRN 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 60, 120 M: 0, 500, 1000 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (297558)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (048570)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Inconclusive 
                                                    • Salmonella  (684822)  Completed 
                                                      • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
                                                      •  Negative 
                                                    • Salmonella  (767736)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
                                                      •  Negative 
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                                                    CASRN: 96-48-0

                                                    Formula: C4-H6-O2

                                                    Synonyms/Common Names

                                                    • 2(3H)-Furanone, Dihydro- (8CI)(9CI)

                                                    Known Uses

                                                    Intermediate in the synthesis of polyvinylpyrrolidone, dl-methionine, piperidine, phenylbutyric acid, and thiobutyric acids. Solvent for resins. Constituent of paint removers. Textile aids. Drilling oils. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Gavage)  (C55878)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 75, 150, 300, 600, OR 1, 200 MG/KG M: 0, 87, 175, 350, 700, OR 1, 400 MG/KG ; 5/SEX/SPECIES.
                                                    • 13 weeks (Gavage)  (C55878)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 56, 112, 225, 450 OR 900 MG/KG M: 0, 65, 131, 262, 525, OR 1, 050 MG/KG; 10/SEX/SPECIES.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C55878)  Report Complete 
                                                      • TR-406 (NIH Number: 92-3137)  (Peer Review Approval 07/09/1991A )
                                                        Toxicology and Carcinogenesis Studies of g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: MR: 0, 112, OR 225 MG/KG FR: 0, 225, OR 450 MG/KG M: 0, 262, OR 525 MG/KG; 50/SEX/SPECIES.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (516280)  Completed 
                                                      • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (550692)  Completed 
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Drosophila  (896754)  Completed 
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Salmonella  (910246)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 523-47-7

                                                    Formula: C15-H24

                                                    Synonyms/Common Names

                                                    • Naphthalene, 1,2,4a,5,8,8a-hexahydro-4,7-dimethyl-1-(1-methylethyl)-, [1S-(1?,4a?,8a?)]-

                                                    Known Uses

                                                    Flavoring agent in candies, baked goods, gum, fragrance in soap, detergent, creams, lotions, perfume, occurs in essential oils from juniper, cedar (Merck 1989)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (972780)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Equivocal 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (138289)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (519172)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 2244-16-8

                                                    Formula: C10-H14-O

                                                    Synonyms/Common Names

                                                    • 2-Methyl-5-(1-methylethenyl)-2-cyclohexen-1-one

                                                    Known Uses

                                                    Found in oil of caraway, other plants; flavoring agent for food & beverages; fragrance in perfumery & soaps (Food, Cosm Tox. 1979). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C55867A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C55867A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 93, 1500 MG/KG/30 MALES PER GROUP/10 FEMALES PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C55867A)  Report Complete 
                                                      • TR-381 (NIH Number: 90-2836)  (Peer Review Approval 06/27/1989A )
                                                        Toxicology and Carcinogenesis Studies of d-Carvone (CASRN 2244-16-8) in B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 175, 375, M: 0, 375, 750 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (983543)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Salmonella  (544172)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 120-80-9

                                                    Formula: C6-H6-O2

                                                    Synonyms/Common Names

                                                    • 1,2-Benzenediol

                                                    Known Uses

                                                    Rubber antioxidant, developer in fur dyes, photographic developer, analytical reagent, intermediate, pharmaceuticals, topical antiseptic, anti-fungal preservative for seed potatoes, occurs in many woody plants (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Micronucleus  (A81105)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                    • Salmonella  (113194)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (181204)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 143-50-0

                                                    Formula: C10-Cl10-O

                                                    Synonyms/Common Names

                                                    • 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
                                                    • Kepone

                                                    Known Uses

                                                    Insecticide for fruit trees; as a fungicide; base material for the manufacture of kelevan. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C00191)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C00191)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Dosed-Feed)  (C00191)  Report Complete 
                                                      • TR-000 (143-50-0)   (Peer Review Approval NA)
                                                        Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CASRN 143-50-0)
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Positive 
                                                        • Female Rats Positive 
                                                        • Male Mice Positive 
                                                        • Female Mice Positive 
                                                      • Dose: FR: 0, 18, 26 (AVG), MR: 0, 8, 24 (AVG), FM: 0, 20, 40 (AVG), MM: 0, 20, 23 (AVG) PPM.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0447)  Completed 
                                                      • Citation: Bungay PM, Dedrick RL, Matthews HB. Enteric transport of chlordecone (Kepone) in the rat. J Pharmacokinet Biopharm. 1981 Jun;9(3):309-41.Pubmed Abstract
                                                      • Rats: Sprague Dawley
                                                    • C. elegans  (W10097)  Completed 
                                                      • C. elegans
                                                      • Dose: 100, 75, 50 uM.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (232320)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (163075)  Completed 
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (663576)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (795821)  Completed 
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • Neurotoxicology Assessment (Gavage & Intraperitoneal Injection)  (NTA94020)  Completed 
                                                      • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
                                                      • Male and Female Rats: F344/N
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                                                    CASRN: 106-47-8

                                                    Formula: C6-H6-Cl-N

                                                    Synonyms/Common Names

                                                    • 4-Chlorobenzenamine

                                                    Known Uses

                                                    Dyes; intermediate for pharmaceuticals and agricultural chemicals. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C02039A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C02039A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 70, 1465, M: 0, 255, 17380 PPM/5 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Dosed-Feed)  (C02039A)  Report Complete 
                                                      • TR-189 (NIH Number: 79-1745)  (Peer Review Approval 10/25/1978A )
                                                        Bioassay of p-Chloroaniline for Possible Carcinogenicity (CASRN 106-47-8)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal 
                                                        • Female Rats Negative 
                                                        • Male Mice Equivocal 
                                                        • Female Mice Equivocal 
                                                      • Dose: R: 0, 250, 500, M: 0, 2500, 5000 PPM/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0135)  Completed 
                                                      • Citation: Pharmacokinetics of Xenobiotics
                                                      • Male Rats
                                                      • Dose: PO: 0.3, 3, 30 IV:3 MG/KG.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (096094)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • In Vitro Cytogenetics (CA/SCE)  (883820)  Completed 
                                                      • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                      • Sister Chromatid Exchange Weakly Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Mouse Lymphoma  (147947)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Mice
                                                      •  Positive 
                                                    • Mouse Lymphoma  (845528)  Completed 
                                                      • Mice
                                                      •  Positive 
                                                    • Mouse Lymphoma  (G13922)  Completed 
                                                      • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
                                                      • Mice
                                                    • Mouse Lymphoma  (G75586)  Completed 
                                                      • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                      • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
                                                      • Mice
                                                    • Salmonella  (260964)  Completed 
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
                                                      •  Positive 
                                                    • Salmonella  (417641)  Completed 
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                      • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
                                                      •  Weakly Positive 
                                                    • Salmonella  (619172)  Completed 
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
                                                      •  Negative 
                                                    • Salmonella  (N-9081)  Completed 
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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                                                    CASRN: 69-09-0

                                                    Formula: C17-H19-Cl-N2-S.Cl-H

                                                    Synonyms/Common Names

                                                    • 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, hydrochloride (1:1)

                                                    Known Uses

                                                    Tranquilizer, antiemetic, phenothiazine antipsychotic agent.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (333439)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (447840)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER82055)  Completed 
                                                      • Citation: Teratologic Evaluation of Chlorpromazine Hydrochloride Administered to Fischer 344 Rats on Gestational Days 6 through 15
                                                      • Female Rats: F344/N
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 5, 15, 30, 45 MG/KG/DAY.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER82056)  Completed 
                                                      • Citation: Teratologic Evaluation of Chlorpromazine Hydrochloride Administered to CD-1 Mice on Gestational Days 6 through 15
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Positive 
                                                      • Mice Fetal Positive 
                                                      • Dose: 2.5, 5, 15, 30 MG/KG/DAY.
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                                                    CASRN: 8001-30-7

                                                    Formula: N/F

                                                    Synonyms/Common Names

                                                    • Mazola oil

                                                    Known Uses

                                                    Salad and cooking oil, margarine production, pharmaceutical preparations, in nonyellowing enamel paint, defoaming agent in paper/paperboard manufacturing, vehicle for experimental diets and test compounds. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C00577)  Report Complete 
                                                      • TR-426 (NIH Number: 94-3157)  (Peer Review Approval 12/01/1992A )
                                                        Comparative Toxicology Studies of Corn Oil, Safflower Oil, and Tricaprylin (CASRNs 8001-30-7, 8001-23-8, and 538-23-8) in Male F344/N Rats as Vehicles for Gavage
                                                      • Rats: F344/N
                                                      • Dose: RATS ONLY: 0, 2.5, 5, 10 ML CORN OIL/KG FOR 103 WEEKS./50 PER GROUP.

                                                    Genetic Toxicology

                                                    • Comet Assay (Gavage)  (G10103C)  On Test 
                                                      • Rats: Harlan Sprague-Dawley
                                                    • Micronucleus  (G10103B)  Completed 
                                                      • Rats: Harlan Sprague-Dawley
                                                      • Male No Call 
                                                    • Micronucleus  (G10103)  Completed 
                                                      • Rats: Harlan Sprague-Dawley
                                                      • Male No Call 
                                                    • Salmonella  (655449)  Completed 
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • Dominant Lethal (Female) (Intravenous)  (DLF015)  Completed 
                                                      • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
                                                      • Female Mice: C3H X C57BL
                                                      • Mice Female Negative 
                                                    • Dominant Lethal (Female) (Gavage)  (DLF016)  Completed 
                                                      • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
                                                      • Female Mice: C3H X 101
                                                      • Mice Female Negative 
                                                    • Dominant Lethal (Female) (Gavage)  (DLF017)  Completed 
                                                      • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
                                                      • Female Mice: SEC X C57BL
                                                      • Mice Female Negative 
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER87118)  Completed 
                                                      • Citation: Teratologic Evaluation of Corn Oil or Distilled Water Administered to CD Rats on Gestational Days 6 through 15
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Negative 
                                                      • Rats Fetal Negative 
                                                      • Dose: 5 ML/KG/DAY.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER87119)  Completed 
                                                      • Citation: Teratologic Evaluation of Corn Oil or Distilled Water Administered by Gavage to CD-1 Mice on Gestational Days 6 through 15
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Negative 
                                                      • Mice Fetal Negative 
                                                      • Dose: 0, 3, 10 MIC.O./KG OR 0, 5 ML DIS.W/KG.
                                                    • Total Reproductive Capacity (Gavage)  (TRC98029)  Completed 
                                                      • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
                                                      • Female Mice: B6C3F1
                                                      • Mice Female  - CONTROL
                                                      • - CONTROL

                                                    Toxicogenomics

                                                    • Microarray Analysis (Gavage) Selected (T10103)  
                                                      • Liver Transcriptome Changes During Estrus Cycle
                                                      • Rats: Wistar Han
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                                                    CASRN: 91-64-5

                                                    Formula: C9-H6-O2

                                                    Synonyms/Common Names

                                                    • 2H-1-Benzopyran-2-one

                                                    Known Uses

                                                    Odor enhancing agent in perfumes. Pharmaceutic aid (flavor). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C07103A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 5 days (Gavage)  (C10104)  On Test 
                                                      • 5-Day Transcriptomic Dose-Response Studies
                                                      • Rats: Harlan Sprague-Dawley
                                                      • Dose: Male rats: 0, 3.125, 6.25, 12.5, 25, 50, 100, 200, or 400 mg/kg; N=4.
                                                    • 13-Week (Gavage)  (C07103A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 25, 400, M: 0, 30, 150 MG/KG/5 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C07103B)  Report Complete 
                                                      • TR-422 (NIH Number: 93-3153)  (Peer Review Approval 06/23/1992A )
                                                        Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Some Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, 25, 50, 100; M: 0, 50, 100, 200 MG/KG/60 & 70 PER GROUP RESPECTIVELY.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (020274)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Weakly Positive 
                                                    • Drosophila  (496820)  Completed 
                                                      • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Drosophila  (737193)  Completed 
                                                      • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Drosophila  (820766)  Completed 
                                                      • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Micronucleus  (A80637)  Completed 
                                                      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                      • Female Negative 
                                                    • Salmonella  (879172)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Positive 

                                                    Toxicogenomics

                                                    • 5 days Transcriptome Sequencing (Gavage)  (T10104)  Assigned 
                                                      • 5-Day Transcriptomic Dose-Response Studies
                                                      • Rats: Harlan Sprague-Dawley
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                                                    CASRN: 8024-37-1

                                                    Formula: C21-H20-O6

                                                    Synonyms/Common Names

                                                    • Curcuma longa oils
                                                    • Curcuma oil
                                                    • Curcumin
                                                    • Turmeric oil

                                                    Known Uses

                                                    Condiment. Color for ointments.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13-Week (Dosed-Feed)  (C60015)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, .10, 5%/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C60015)  Report Complete 
                                                      • TR-427 (NIH Number: 93-3158)  (Peer Review Approval 06/23/1992A )
                                                        Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CASRN 8024-37-1) (Major Component 79% Curcumin, CASRN 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice Equivocal Evidence 
                                                      • Dose: R & M: 0, .2, 1.0, AND 5.0%.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (001566)  Completed 
                                                      • Sister Chromatid Exchange Weakly Positive 
                                                      • Chromosome Aberrations Weakly Positive 
                                                    • Salmonella  (857432)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • Continuous Breeding (Legacy) (Dosed-Feed)  (RACB85001)  Completed 
                                                      • Male and Female Rats/Mice: F344/N & B6C3F1
                                                      • Dose: 0, 2, 000, 10, 000, 50, 000 PPM IN FEED.
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                                                    CASRN: 137-09-7

                                                    Formula: C6-H8-N2-O.2Cl-H

                                                    Synonyms/Common Names

                                                    • Dianol

                                                    Known Uses

                                                    Photographic developer. Dyeing furs and hair. Analytical reagent.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C60026)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C60026)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, .012, .200, M: 0, .005, .075 G/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C60026)  Report Complete 
                                                      • TR-401 (NIH Number: 92-2856)  (Peer Review Approval 03/11/1991A )
                                                        NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CASRN 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Some Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 12.5, 25, M: 0, 19, 38 MG/KG/60 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (729737)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (431842)  Completed 
                                                      • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
                                                    • Mouse Lymphoma  (299952)  Completed 
                                                      • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (539410)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Positive 
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                                                    CASRN: 81-11-8

                                                    Formula: C14-H14-N2-O6-S2

                                                    Synonyms/Common Names

                                                    • Amsonic acid
                                                    • Amsonic acid
                                                    • 2,2'-(1,2-Ethylenediyl)bis(5-aminobenzenesulfonic acid)

                                                    Known Uses

                                                    Chemical intermediate for dyes and fluorescent brighteners.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0201)  Completed 
                                                      • Male and Female Rats: F344/N
                                                      • Dose: 0, 150, 1500 MG/KG.
                                                    • Toxicokinetic Study (Dosed-Feed; Intravenous)  (S0136)  Completed 
                                                      • Male and Female Rats
                                                      • Dose: IV: 1 MG/KG.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (610829)  Completed 
                                                      • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (932349)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (636704)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 15663-27-1

                                                    Formula: Cl2-H6-N2-Pt

                                                    Synonyms/Common Names

                                                    • Cisplatin
                                                    • cis-Platinum
                                                    • Diamminedichloroplatinum
                                                    • Platinol
                                                    • Platinum diamminodichloride

                                                    Known Uses

                                                    Antineoplastic agent for treatment of bladder, ovarian, and testicular cancer.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (593235)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (059070)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
                                                      • Sex-Linked Recessive Lethal Positive 
                                                      • Reciprocal Translocation Positive 
                                                    • Salmonella  (839608)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                                      •  Positive 

                                                    Organ Systems Toxicity

                                                    • single exposure Dominant Lethal (Intraperitoneal Injection)  (TER94004)  Completed 
                                                      • Male Rats: Sprague Dawley
                                                      • Dose: 0, 6, 8, 10, 12 MG/KG IN DRF STUDY; 0 & 8 MG/KG DL STUDY.
                                                    • Dominant Lethal (Female) (Gavage)  (DLF061)  Completed 
                                                      • Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
                                                      • Female Mice: C3H X C57BL
                                                      • Mice Female Positive 
                                                    • Dominant Lethal (Female) (Dosed-Feed)  (DLF062)  Completed 
                                                      • Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
                                                      • Female Mice: SEC X C57BL
                                                      • Mice Female Positive 
                                                    • Dominant Lethal (Male) (Dosed-Feed)  (DLM060)  Completed 
                                                      • Citation: Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:230 (1990).
                                                      • Male Mice: C3H X 101
                                                      • Mice Male Negative 
                                                    • Continuous Breeding (Legacy) (Gavage)  (RACB94020)  Completed 
                                                      • Male Rats: CD-1
                                                    • Total Reproductive Capacity (Gavage)  (TRC98027)  Completed 
                                                      • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
                                                      • Female Mice: B6C3F1/N
                                                      • Mice Female Positive 
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                                                    CASRN: 75-35-4

                                                    Formula: C2-H2-Cl2

                                                    Synonyms/Common Names

                                                    • 1,1-Dichloroethene (9CI)
                                                    • Dichloroethylene,1,1

                                                    Known Uses

                                                    Copolymerized with vinychloride or acrylonitrile for saran and saran fibers. A widely used chemical intermediate and monomer.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Inhalation)  (C20303)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1/N
                                                      • Dose: R&M: 0, 25, 50, 100, 200, or 400 ppm; 5/sex/species/dose.
                                                    • 14-Day (Gavage)  (C54262)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13 weeks (Inhalation)  (C20303)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1/N
                                                      • Dose: R&FM: 0, 6.25, 12.5, 25, 50, or 100 ppm; MM: 0, 6.25, 12.5, 25, or 50 ppm; R: 20/sex/dose; M: 10/sex/dose.
                                                    • 13-Week (Gavage)  (C54262)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 5, 250 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C20303)  Completed 
                                                      • TR-582 (NIH Number: 15-5924)  (Peer Review Approval 10/29/2013A )
                                                        Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                                      • Rats: F344/N; Mice: B6C3F1/N
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Some Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, 25, 50, or 100 ppm; M: 0, 6.25, 12.5, or 25 ppm; 50/sex/species/dose.
                                                    • 2-Year (Gavage)  (C54262)  Completed 
                                                      • TR-228 (NIH Number: 82-1784)  (Peer Review Approval 02/18/1981A )
                                                        Carcinogenesis Bioassay of Vinylidene Chloride (CASRN 75-35-4) in F344 Rats and B6C3F1 Mice (Gavage Study)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Negative 
                                                        • Female Rats Negative 
                                                        • Male Mice Negative 
                                                        • Female Mice Negative 
                                                      • Dose: R: 0, 1, 5, M: 0, 2, 10 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • Drosophila  (883501)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (953885)  Completed 
                                                      • Citation: McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
                                                      • Mice
                                                      •  Positive 
                                                    • Micronucleus  (A71539)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                      • Female Negative 
                                                    • Salmonella  (121030)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 540-59-0

                                                    Formula: C2-H2-Cl2

                                                    Synonyms/Common Names

                                                    • Ethene, 1,2-dichloro-

                                                    Known Uses

                                                    Solvent. Fermentation retarder. Organic synthesis. Perfumes. Lacquers. Dye extraction.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Microencapsulation in Feed)  (C56031)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R&M: 0, 3175, 6250, 12500, 25000, OR 50000 (5/SEX/SPECIES/GROUP).

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (820480)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (976471)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 4 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91022)  Completed 
                                                      • Female Mice: Swiss CD-1
                                                      • Dose: 0, .05, .25, .5, 1.0, OR 1.5%.
                                                    • Teratology Pilot Studies (Dosed-Feed)  (TRP91031)  Completed 
                                                      • Mice: Swiss
                                                      • Dose: 0, 1.5, 5, 10%.
                                                    • 6 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91032)  Completed 
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 0, .2, 1, 2, 3, OR 4%.
                                                    • 6 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91033)  Completed 
                                                      • Rats: Sprague Dawley
                                                      • Dose: 0, 4, 7.5, 10%.
                                                    • Teratology Pilot Studies (Gavage)  (TRP92065)  Completed 
                                                      • Rats
                                                      • Dose: 0, 200, 500, 1000, 2000, 3000 MG/KG.
                                                    • Teratology Pilot Studies (Gavage)  (TRP92066)  Completed 
                                                      • Rabbit: New Zealand White
                                                      • Dose: 0, 200, 500, 1000, 2000 MG/KG.
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                                                    CASRN: 78-87-5

                                                    Formula: C3-H6-Cl2

                                                    Synonyms/Common Names

                                                    • Propylene dichloride
                                                    • Propylene dichloride

                                                    Known Uses

                                                    Intermediate; in finishes, dry cleaning fluids, and paint removers; fumigant, insecticide for stored grains, fruits, solvent in plastics, in antiknock compounds (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C55141)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C55141)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 60, 1000, M: 0, 30, 500 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Gavage)  (C55141)  Report Complete 
                                                      • TR-263 (NIH Number: 86-2519)  (Peer Review Approval 06/29/1983A )
                                                        Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CASRN 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Some Evidence 
                                                        • Female Mice Some Evidence 
                                                      • Dose: FR&M: 0, 125, 250, MR: 0, 62, 125 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (568899)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (903632)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (800926)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (552580)  Completed 
                                                      • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
                                                      • Mice
                                                      •  Positive 
                                                    • Mouse Lymphoma  (999130)  Completed 
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (566847)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Weakly Positive 
                                                    • Salmonella  (627177)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Weakly Positive 
                                                    • Sister Chromatid Exchanges  (568899)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Negative 
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                                                    CASRN: 84-66-2

                                                    Formula: C12-H14-O4

                                                    Synonyms/Common Names

                                                    • 1,2-Benzenedicarboxylic acid, diethyl ester
                                                    • DEP

                                                    Known Uses

                                                    In manufacture of celluloid, cosmetics, varnishes, and dopes. Plasticizer for cellulose ester plastics. Insecticide sprays. Used as phthalate plasticizers, in an extensive array of products. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 4 weeks (Topical Application)  (C60048B)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Topical Application)  (C60048B)  Report Complete 
                                                      • TR-429 (NIH Number: 95-3356)  (Peer Review Approval 11/17/1993A )
                                                        Toxicology and Carcinogenesis Studies of Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CASRN 131-11-3) in Male Swiss (CD-1®) Mice
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice Equivocal Evidence 
                                                      • Dose: R: 0, 100, 300 M: 0, 7.5, 15, 30 UL/100 UL SOLUTION /50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Topical Application)  (S0044)  Completed 
                                                      • Male Rats: F344/N

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (306322)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (913646)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (364986)  Completed 
                                                      • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
                                                      •  Negative 
                                                    • Salmonella  (576172)  Completed 
                                                      • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB83092)  Completed 
                                                      • Citation: Final Report - Diethyl Phthalate: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 0, .25, 1.25, 2.5% IN FEED; N/A; 0, 2.5%.
                                                    • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0033A)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                      • Female Mice: Swiss
                                                      • Dose: 4500 MG/KG BODY WEIGHT.
                                                    • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER88065)  Completed 
                                                      • Citation: Developmental Toxicity Evaluation of Diethyl Phthalate Administered to CD Rats on Gestational Days 6 through 15
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 0.25, 2.5, 5.0 %.
                                                    • Utero-Lactational (Gavage)  (R10112)  Completed 
                                                      • Rats: Harlan Sprague-Dawley
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                                                    CASRN: 119-84-6

                                                    Formula: C9-H8-O2

                                                    Synonyms/Common Names

                                                    • 3,4-Dihydro-2H-1-benzopyran-2-one

                                                    Known Uses

                                                    Fragrance in cosmetics and detergents. Flavoring agent in foods and beverages. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C55890A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C55890A)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 75, 1200, M: 0, 100, 1600 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C55890B)  Report Complete 
                                                      • TR-423 (NIH Number: 93-3154)  (Peer Review Approval 06/23/1992A )
                                                        Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice Some Evidence 
                                                      • Dose: R: 0, 150, 300, 600, M: 0, 200, 400, 800 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (733791)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Micronucleus  (A43806)  Completed 
                                                      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                      • Female Negative 
                                                    • Salmonella  (911172)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 828-00-2

                                                    Formula: C8-H14-O4

                                                    Synonyms/Common Names

                                                    • 2,6-Dimethyl-1,3-dioxan-4-ol acetate

                                                    Known Uses

                                                    Preservative for cutting oils, resin emulsions, cosmetics, inks, and water-based paints. Antimicrobial agent in adhesives and textile chemicals. Gasoline additive.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C56213)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C56213)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 31.5, 500 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C56213)  Report Complete 
                                                      • TR-354 (NIH Number: 89-2809)  (Peer Review Approval 10/03/1988A )
                                                        Toxicology and Carcinogenesis Studies of Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: MR: 0, 62.5, 125, FR: 0, 125, 250, M: 0, 250, 500 MG/KG/60 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (028235)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (194110)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
                                                    • Salmonella  (742172)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Positive 
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                                                    CASRN: 91-93-0

                                                    Formula: C16-H12-N2-O4

                                                    Synonyms/Common Names

                                                    • 1,1'-Biphenyl, 4,4'-diisocyanato-3,3'-dimethoxy- (9CI)

                                                    Known Uses

                                                    Polyurethane elastomers; adhesives

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C02175)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C02175)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 800, 5000, M: 0, 215, 4640 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Dosed-Feed)  (C02175)  Report Complete 
                                                      • TR-128 (NIH Number: 79-1383)  (Peer Review Approval 08/31/1978A )
                                                        Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CASRN 91-93-0)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Positive 
                                                        • Female Rats Positive 
                                                        • Male Mice Negative 
                                                        • Female Mice Negative 
                                                      • Dose: 0, 22000, 44000 PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (921234)  Completed 
                                                      • Sister Chromatid Exchange Weakly Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Salmonella  (215133)  Completed 
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Positive 
                                                    • Salmonella  (N-9247)  Completed 
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                      • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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                                                    CASRN: 67-68-5

                                                    Formula: C2-H6-O-S

                                                    Synonyms/Common Names

                                                    • Sulfinylbismethane (9CI)

                                                    Known Uses

                                                    Anti-inflammatory, drug carrier, solvent, in cleaners, in pesticides, for cell preservation, in plant pathology and nutrition. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Special Studies

                                                    • C. elegans  (S0860)  Completed 
                                                      • C. elegans
                                                      • Dose: feed (0, .347, .693, 1.33, 2.13, 2.8, 3.47, 4.27, 4.93, 5.6, 6.3, 6.9) 4/13/06 repro (0, .5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5.0, 5.5) 7/09/04 growth (0, .1, .16, .25, .40, .63, 1, 1.6, 2.5, 4.0, 6.3, 10) 5/04/06.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (272561)  Completed 
                                                      • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (229896)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                                      •  Negative 
                                                    • Salmonella  (939205)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                                      •  Negative 
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                                                    CASRN: 110-80-5

                                                    Formula: C4-H10-O2

                                                    Synonyms/Common Names

                                                    • Cellosolve
                                                    • EGMEE
                                                    • 2-Ethoxyethanol

                                                    Known Uses

                                                    Solvent for nitrocellulose, lacquers, dopes, in varnish remover, cleaning solutions, dye baths, increase stability of emulsions (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Dosed-Water)  (C54853B)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13 weeks (Dosed-Water)  (C54853B)  Report Complete 
                                                      • TOX-26 (NIH Number: 93-3349)
                                                        Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: CORE STUDY: R: 0, 1250, 2500, 5000, 10000, 20000, M: 0, 2500, 5000, 10000, 20000, 40000 PPM/10 PER GROUP STOP STUDY: R: 0, 5000, 10000, 20000 PPM/30 PER GROUP.
                                                    • 8 weeks (Dosed-Water)  (C54853D)  Report Complete 
                                                      • TOX-26 (NIH Number: 93-3349)
                                                        Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
                                                      • Rats: F344/N
                                                      • Dose: MALE RATS ONLY: 0, 2500, 5000 PPM/ 20 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Inhalation)  (S0715)  Completed 
                                                      • Citation: Kennedy CH, Bechtold WE, Chang IY, Henderson RF. Effect of dose on the disposition of 2-ethoxyethanol after inhalation by F344/N rats. Fundam Appl Toxicol. 1993 Nov;21(4):486-91.Pubmed Abstract
                                                      • Male Rats: F344/N
                                                    • Absorption Disposition Metabolism Elimination  (S0776)  Completed 
                                                      • Citation: Medinsky MA, Singh G, Bechtold WE, Bond JA, Sabourin PJ, Birnbaum LS, Henderson RF. Disposition of three glycol ethers administered in drinking water to male F344/N rats. Toxicol Appl Pharmacol. 1990 Mar 1;102(3):443-55.Pubmed Abstract
                                                      • Male Rats: F344/N

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (032435)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (589198)  Completed 
                                                      • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Drosophila  (612734)  Completed 
                                                      • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (075881)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (914172)  Completed 
                                                      • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 5 consecutive days Dominant Lethal (Inhalation)  (T0069D)  Completed 
                                                      • Male Rats: Sprague Dawley
                                                      • Dose: 600 ppm 6 hr/days for 5 consecutive days.
                                                    • 5 consecutive days Dominant Lethal (Topical Application)  (T0069G)  Completed 
                                                      • Male Rats: Sprague Dawley
                                                      • Dose: 0.25, .50 ML 4 TIMES/D FOR 5 CONSEC D.
                                                    • Continuous Breeding (Legacy) (Dosed-Water)  (RACB84050)  Completed 
                                                      • Citation: Final Report - 2-Ethoxyethanol: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Water
                                                      • Male and Female Mice: Swiss
                                                      • Dose: 0, .2, .4, .75, 1.5, 3.0%; 0, .5, 1.0, 2.0%; 0, 2.0%; N/A.
                                                    • Continuous Breeding (Legacy) (Gavage)  (RACB92123)  Completed 
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 0, 70, 250, 700 MG/KG; N/A; N/A.
                                                    • 5 consecutive days Continuous Breeding (Legacy) (Inhalation)  (T0069C)  Completed 
                                                      • Male Mice: B6C3F1
                                                      • Dose: 600 ppm 6 hr/day for 5 consecutive days.
                                                    • 9 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0069J)  Completed 
                                                      • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
                                                      • Female Mice: Swiss
                                                      • Dose: 3605 MG/KG BW.
                                                    • Pregestation: 7 hr/day, 5 day/wk for 3 wks. Gestation: 7 hr/day , 1 to 19 GD Conventional Teratology (Inhalation)  (T0069A)  Completed 
                                                      • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
                                                      • Female Rats: Wistar
                                                      • Dose: Pregestation: 150, 650 ppm. Gestation: 200, 765 ppm.
                                                    • 1 to 18 GD Conventional Teratology (Inhalation)  (T0069B)  Completed 
                                                      • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
                                                      • Female Rabbit: New Zealand White
                                                      • Dose: 160 or 615 ppm 7 hr/day for 18 days.
                                                    • 7 to 16 GD Conventional Teratology (Topical Application)  (T0069E)  Completed 
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 0.25, 0.50 ml 4 times/day for 10 consecutive days.
                                                    • 7 to 16 GD (vaginal sperm = 1 GD) Conventional Teratology (Topical Application)  (T0069F)  Completed 
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 0.25 ML 4 TIMES/D.
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                                                    CASRN: 107-21-1

                                                    Formula: C2-H6-O2

                                                    Synonyms/Common Names

                                                    • 1,2-Ethanediol

                                                    Known Uses

                                                    Antifreeze in cooling and heating systems. Extraction solvent. Cleaning agent. Chemical intermediate for polyesters, urethanes, and alkyd resins, vehicle for pharmaceutical preparations, food extracts, flavorings, skin lotions (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13-Week (Dosed-Feed)  (C00920A)  Completed 
                                                      • Mice: B6C3F1
                                                      • Dose: R&M: 0, .32, 5 %/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C00920A)  Report Complete 
                                                      • TR-413 (NIH Number: 93-3144)  (Peer Review Approval 07/09/1991A )
                                                        Toxicology and Carcinogenesis Studies of Ethylene Glycol (CASRN 107-21-1) in B6C3F1 Mice (Feed Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: MM: 0, .625, 1.25, 2.5%, FM: 0, 1.25, 2.5, 5.0%/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (706666)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Mouse Lymphoma  (062928)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (195794)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84051)  Completed 
                                                      • Citation: Final Report - Ethylene Glycol: Reproduction and Fertility in CD-1 Mice When Administered in Drinking Water
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 0, .25, .5, 1%; N/A; N/A.
                                                    • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84096)  Completed 
                                                      • Citation: Ethylene Glycol: Reproduction and Fertility Assesment In CD-1 Mice When Administered In Drinking Water
                                                      • Male and Female Mice: Swiss
                                                      • Dose: N/A; 0, .5, 1.0, 1.5%; N/A; N/A.
                                                    • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0061A)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                      • Female Mice: Swiss
                                                      • Dose: 11090 MG(10ML UNDILUTED)/KG BD WT.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER84073)  Completed 
                                                      • Citation: Teratologic Evaluation of Ethylene Glycol Administered to CD-1 Mice on Gestational Days 6 through 15
                                                      • Female Mice: Swiss
                                                      • Mice Maternal Positive 
                                                      • Mice Fetal Positive 
                                                      • Dose: 0, 750, 1500, 3000 MG/KG/DAY.
                                                    • 6 to 20 GD Conventional Teratology (Gavage)  (TER84128)  Completed 
                                                      • Citation: Developmental Toxicity Evaluation of Ethylene Glycol in CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Negative 
                                                      • Rats Fetal Positive 
                                                      • Dose: 250, 1250, 2250 MG/KG/DAY.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER89126)  Completed 
                                                      • Citation: Final Report on the Developmental Stages of the CD Rat Skeleton: Part II: Development After Maternal Exposure to Ethylene Glycol
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 0, 2500 MG/KG.
                                                    • Conventional Teratology (Gavage)  (TER90005)  Completed 
                                                      • Citation: Final Report on the Developmental Toxicity of Ethylene Glycol in New Zealand White Rabbits
                                                      • Citation: Final Report on the Developmental Toxicity of Ethylene Glycol in New Zealand White Rabbits
                                                      • Rabbit: New Zealand White
                                                      • Rabbits Maternal Negative 
                                                      • Rabbits Fetal Negative 
                                                      • Dose: 100, 500, 1000, 2000 MG/KG.
                                                    • 6 to 15 GD Conventional Teratology (Gavage)  (TER90072)  Completed 
                                                      • Citation: Final Report: Teratologic Evaluation of Ethylene Glycol Administered to CD Rats on Gestational Days 6 through 15.
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 0, 1250, 2500, 5000 MG/KG/DAY.
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                                                    CASRN: 110-00-9

                                                    Formula: C4-H4-O

                                                    Synonyms/Common Names

                                                    • Oxacyclopentadiene

                                                    Known Uses

                                                    Chemical intermediate. Solvent for resins. In lacquer formation. Organic synthesis. And to prepare copolymers used in machine dishwashing products as alternatives to phosphorus- and nitrogen-containing detergents. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 5 days (Gavage)  (C10119B)  On Test 
                                                      • 5-Day Transcriptomic Dose-Response Studies
                                                      • Rats: Harlan Sprague-Dawley
                                                      • Dose: Male rats: 0, 0.125, 0.25, 0.5, 1, 2, 4, 8, or 16 mg/kg; N=4.
                                                    • 14-Day (Gavage)  (C56202)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C56202)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R & FM: 0, 4, 60, MM: 0, 2, 30 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C10119)  Completed 
                                                      • Rats: F344 (NCTR)
                                                      • Dose: Male Rats only: 0, 0.02, 0.044, 0.092, 0.2, 0.44, 0.92 and 2.0 mg/kg bw/ day/5 days/wk.
                                                    • 2 years (Gavage)  (C56202)  Report Complete 
                                                      • TR-402 (NIH Number: 91-2857)  (Peer Review Approval 03/11/1991A )
                                                        Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats Clear Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, 2, 4, 8, M: 0, 8, 15 MG/KG/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (K10119)  Completed 
                                                      • Male Rats: F344 (NCTR)
                                                      • Dose: 0, 0.05, 0.1, 0.5, 1.0, 2.0, 5.0, 10.0 mg/kg bw.
                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (K10119H)  Completed 
                                                      • Citation: McDaniel LP, Ding W, Dobrovolsky VN, Shaddock JG Jr, Mittelstaedt RA, Doerge DR, Heflich RH. Genotoxicity of furan in Big Blue rats. Mutat Res. 2012 Feb 18;742(1-2):72-8. doi: 10.1016/j.mrgentox.2011.12.011. Epub 2011 Dec 20.Pubmed Abstract
                                                      • Male Rats: Tg.Lac1/C57BL/6 (Big Blue)
                                                      • Dose: 0, 2, 8, 16, 30 mg/kg bw daily for 8 weeks.
                                                    • Absorption Disposition Metabolism Elimination  (S0756)  Completed 
                                                      • Citation: Burka LT, Washburn KD, Irwin RD. Disposition of [14C] furan in the male F344 rat. J Toxicol Environ Health. 1991 Oct;34(2):245-57.Pubmed Abstract
                                                      • Male Rats: F344/N
                                                    • Toxicokinetic Study (Gavage)  (K10119B)  Completed 
                                                      • Male Rats: F344 (NCTR)
                                                      • Dose: 1 mg/kg bw [one dose only].
                                                    • Toxicokinetic Study (Gavage)  (K10119C)  Completed 
                                                      • Male Rats: F344 (NCTR)
                                                      • Dose: 1 mg/kg bw [one dose only].
                                                    • Toxicokinetic Study (Gavage)  (K10119D)  Completed 
                                                      • Male Rats: F344 (NCTR)
                                                      • Dose: 1 mg/kg bw/day.
                                                    • Toxicokinetic Study (Gavage)  (K10119E)  Completed 
                                                      • Male Rats: F344 (NCTR)
                                                      • Dose: 1 mg/kg bw/day.
                                                    • Toxicokinetic Study (Gavage)  (K10119F)  Completed 
                                                      • Male Rats: F344 (NCTR)
                                                      • Dose: 0, 0.1, 0.5, 1.0, 2.0, 4.0 mg/kg bw/ day.
                                                    • Toxicokinetic Study (Gavage)  (K10119G)  Completed 
                                                      • Male Rats: F344 (NCTR)
                                                      • Dose: 8.0 mg/kg bw/ day (dosed daily for 90 days).

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (635376)  Completed 
                                                      • Mice
                                                      •  Positive 
                                                    • Comet Assay  (G10119C)  Completed 
                                                      • Rats
                                                    • 3 days Comet Assay (Gavage) Selected (G10119)  
                                                      • Rats: F344 (NCTR)
                                                    • In Vitro Cytogenetics (CA/SCE)  (950997)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (591334)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (048853)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Positive 
                                                    • Micronucleus  (G10119B)  Completed 
                                                      • Mice: B6C3F1
                                                      • Female Equivocal 
                                                    • Salmonella  (717172)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (734219)  Completed 
                                                      •  Weakly Positive 
                                                    • Sister Chromatid Exchanges  (635376)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Negative 

                                                    Toxicogenomics

                                                    • 5-day Transcriptome Sequencing (Gavage)  (T10119)  Assigned 
                                                      • Rats: Harlan Sprague-Dawley
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                                                    CASRN: 98-01-1

                                                    Formula: C5-H4-O2

                                                    Synonyms/Common Names

                                                    • 2-Furancarboxaldehyde (9CI)

                                                    Known Uses

                                                    Intermediate In plastics preparation, wetting & flavoring agent, preparation of furfural alcohol, insecticide, fungicide, germicide, refining petroleum oils, solvent for cotton, dyes (HSDB 1990). Occurs in essential oils, coffee, rum (food, cosm tox). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C56177)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C56177)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 11, 180, M: 0, 75, 1200 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C56177)  Report Complete 
                                                      • TR-382 (NIH Number: 90-2837)  (Peer Review Approval 11/20/1989A )
                                                        Toxicology and Carcinogenesis Studies of Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice Clear Evidence 
                                                        • Female Mice Some Evidence 
                                                      • Dose: R: 0, 30, 60, M: 0, 50, 100, 175 MG/KG/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0093)  Completed 
                                                      • Citation: Effect of Dose on the Chemical Disposition of Furfural in Rats after Oral Administration.
                                                      • Male Rats
                                                      • Dose: 0.127, 1.15, 12.5 MG/KG.
                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0370)  Completed 
                                                      • Citation: Nomeir AA, Silveira DM, McComish MF, Chadwick M. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab Dispos. 1992 Mar-Apr;20(2):198-204.Pubmed Abstract
                                                      • Male Rats: F344/N
                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0763)  Completed 
                                                      • Citation: Burka LT, Washburn KD, Irwin RD. Disposition of [14C] furan in the male F344 rat. J Toxicol Environ Health. 1991 Oct;34(2):245-57.Pubmed Abstract
                                                      • Male Rats: F344/N

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (991433)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (384163)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (778815)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Sex-Linked Recessive Lethal Positive 
                                                      • Reciprocal Translocation Negative 
                                                    • Mouse Lymphoma  (686415)  Completed 
                                                      • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (363791)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (549472)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Equivocal 
                                                    • Salmonella  (901759)  Completed 
                                                      •  Equivocal 
                                                    • Sister Chromatid Exchanges  (991433)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Negative 
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                                                    CASRN: 98-00-0

                                                    Formula: C5-H6-O2

                                                    Synonyms/Common Names

                                                    • 2-Furanmethanol (9CI)
                                                    • Furylcarbinol
                                                    • 2-Hydroxymethylfuran

                                                    Known Uses

                                                    Solvent for ethers and esters. In manufacture of phenolic and furan resins. Chemical intermediate. Wetting agent. Liquid propellant. Flavoring agent, obtained from processing corncobs, coffee beans. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Inhalation)  (C56224B)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 16, 31, 63, 125 AND 250 PPM (5/S/S).
                                                    • 13 weeks (Inhalation)  (C56224B)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 2, 4, 8, 16 OR 32 PPM / (10/S/S).

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C56224C)  Report Complete 
                                                      • TR-482 (NIH Number: 99-3972)  (Peer Review Approval 12/10/1997A )
                                                        Toxicology and Carcinogenesis Studies of Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Some Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP).

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0094)  Completed 
                                                      • Citation: Nomeir AA, Silveira DM, McComish MF, Chadwick M. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab Dispos. 1992 Mar-Apr;20(2):198-204.Pubmed Abstract
                                                      • Male Rats: F344/N
                                                    • Toxicokinetic Study (Inhalation)  (S0781)  Completed 
                                                      • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
                                                      • Dose: 0, 2, 8, & 32 ppm.

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (150910)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (799233)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Equivocal 
                                                    • Micronucleus  (A08423)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                    • Salmonella  (709717)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Sister Chromatid Exchanges  (150910)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Negative 
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                                                    CASRN: 9005-65-6

                                                    Formula: C32-H60-O10 (mixture)

                                                    Synonyms/Common Names

                                                    • Glycol
                                                    • Polyoxyethylene sorbitan monooleate
                                                    • Tween 80
                                                    • (Z)-Sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)-(9CI)

                                                    Known Uses

                                                    Emulsifier and dispersing agent for internal medicinal products. Defoamer in foods. Neutralizer for quaternary ammonium compounds.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C60286)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C60286)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, .31, 50 %/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C60286)  Report Complete 
                                                      • TR-415 (NIH Number: 92-3146)  (Peer Review Approval 07/10/1991A )
                                                        Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: 0, 2.5, 5.0%/20 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (862010)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Positive 
                                                    • Salmonella  (405466)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • Conventional Teratology (Gavage)  (TER91009)  Completed 
                                                      • Citation: Final Report on the Developmental Toxicity of Polyoxyethylene Sorbitan Monooleate in Sprague-Dawley Rats
                                                      • Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 0, 500, 5000 MG/KG/DAY.
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                                                    CASRN: 59820-43-8

                                                    Formula: C10-H14-N2-O5

                                                    Synonyms/Common Names

                                                    • 2-((2-(2-Hydroxyethoxy)-4-nitrophenyl)amino)ethanol
                                                    • Yellow 4, HC

                                                    Known Uses

                                                    In semi-permanent hair dye formulations (HSDB 1990).

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C56019)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C56019)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 2500, 20000 M: 0, 5000, 80000 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C56019)  Report Complete 
                                                      • TR-419 (NIH Number: 92-3150)  (Peer Review Approval 07/09/1991A )
                                                        Toxicology and Carcinogenesis Studies of HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: MR: 0, 0.25, 0.5%, FR&M: 0, 0.5, 1.0%/70 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (203825)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (048811)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Sex-Linked Recessive Lethal Positive 
                                                      • Reciprocal Translocation Negative 
                                                    • Salmonella  (764380)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Positive 
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                                                    CASRN: 87-68-3

                                                    Formula: C4-Cl6

                                                    Synonyms/Common Names

                                                    • 1,3-Butadiene, 1,1,2,3,4,4,-hexachloro- (8CI)(9CI)

                                                    Known Uses

                                                    Solvent for elastomers; heat-transfer liquid; hydraulic fluid; rubber intermediate; fumigant for grapes (HSDB 1990)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Dosed-Feed)  (C99854A)  Completed 
                                                      • Mice: B6C3F1
                                                    • 13 weeks (Dosed-Feed)  (C99854A)  Report Complete 
                                                      • TOX-01 (NIH Number: 91-3120)
                                                        Toxicity Studies of Hexachloro-1,3-butadiene in B6C3F1 Mice (Feed Studies) (CASRN 87-68-3)
                                                      • Mice: B6C3F1
                                                      • Dose: MICE ONLY 0, 1, 3, 10, 30, 100 PPM.

                                                    Special Studies

                                                    • Toxicokinetic Study (Gavage; Intravenous)  (S0071)  Completed 
                                                      • Male Rats; Male Mice; Male Rats; Male Mice
                                                      • Dose: R:0.58-34 MG/KG; M: 2-24 MG/KG.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (635625)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (812114)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Salmonella  (098967)  Completed 
                                                      •  Negative 
                                                    • Salmonella  (358791)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 17 GD - PND 10 Conventional Teratology (Dosed-Feed)  (T0166)  Completed 
                                                      • Citation: Final Report of the Peri-/Postnatal Evaluation of Hexachloro-1,3-Butadiene (HCBD) Toxicity in CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Dose: 0, 100, 200, 400, 750, 1100, OR 1500 PPM.
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                                                    CASRN: 77-47-4

                                                    Formula: C5-Cl6

                                                    Synonyms/Common Names

                                                    • 1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene (9CI)
                                                    • Perchlorocyclopentadiene

                                                    Known Uses

                                                    Chemical used in the manufacture of flame retardants, resins, and chlorinated cyclodiene pesticides.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13 weeks (Inhalation)  (C55607B)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 0.05, 2.0 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Inhalation)  (C55607B)  Report Complete 
                                                      • TR-437 (NIH Number: 94-3168)  (Peer Review Approval 06/22/1993A )
                                                        Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R:0, .01, .05, .2PPM M:0, .01, .05, .2, .5PPM/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage; Inhalation; Intravenous)  (S0029)  Completed 
                                                      • Citation: el Dareer SM, Noker PE, Tillery KF, Hill DL. Investigations on the basis for the differential toxicity of hexachlorocyclopentadiene administered to rats by various routes. J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):203-11.Pubmed Abstract
                                                      • Male Rats: F344/N; Male Rats; Male Rats: F344/N
                                                      • Dose: PO:4.1, 61; IV:0.59; INH:1.3 (6H), 1.8(72H)MG/KG.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (353427)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (386002)  Completed 
                                                      • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Drosophila  (842404)  Completed 
                                                      • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Micronucleus  (A24947)  Completed 
                                                      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                      • Female Negative 
                                                    • Salmonella  (725996)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (A66714)  Completed 
                                                      •  Negative 
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                                                    CASRN: 67-72-1

                                                    Formula: C2-Cl6

                                                    Synonyms/Common Names

                                                    • Carbon hexachloride

                                                    Known Uses

                                                    Solvent, in explosives, camphor substitute in celluloid, in production of metals, antihelmintic drug, moth repellant, rubber vulcanizing, flame proofing (HSDB 1990)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C04604A)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                    • 14-Day (Gavage)  (C04604B)  Completed 
                                                      • Rats: F344/N
                                                    • 13-Week (Gavage)  (C04604A)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Dose: R: 0, 178, 1780, M: 0, 316, 3160 MG/KG/5 PER GROUP.
                                                    • 13-Week (Gavage)  (C04604B)  Completed 
                                                      • Rats: F344/N
                                                      • Dose: 0, .047, .750 G/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Gavage)  (C04604A)  Report Complete 
                                                      • TR-068 (NIH Number: 78-1318)  (Peer Review Approval 01/18/1978A )
                                                        Bioassay of Hexachloroethane for Possible Carcinogenicity (CASRN 67-72-1)
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Negative 
                                                        • Female Rats Negative 
                                                        • Male Mice Positive 
                                                        • Female Mice Positive 
                                                      • Dose: R: 0, 212, 423 M:0, 590, 1179 MG/KG/50 PER GROUP.
                                                    • 2 years (Gavage)  (C04604B)  Report Complete 
                                                      • TR-361 (NIH Number: 89-2816)  (Peer Review Approval 10/03/1988A )
                                                        Toxicology and Carcinogenesis Studies of Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage Studies)
                                                      • Rats: F344/N
                                                      • Carcinogenesis Results
                                                        • Male Rats Clear Evidence 
                                                        • Female Rats No Evidence 
                                                      • Dose: MR: 0, 10, 20, FR: 0, 80, 160 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (415312)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (188925)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (248997)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 103-90-2

                                                    Formula: C8-H9-N-O2

                                                    Synonyms/Common Names

                                                    • APAP
                                                    • 4'-Hydroxyacetanilide
                                                    • N(4-Hydroxyphenyl)-Acetamide

                                                    Known Uses

                                                    Manufacture of azo dyes, analgesic, intermediate for pharmaceuticals (HSDB 1990); derivative of p-aminophenol. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Planned Carcinogenicity/Toxicity

                                                    • 90 days (Gavage)  (C10127)  Assigned 
                                                      • Rats: Harlan Sprague-Dawley

                                                    Short-Term Toxicity

                                                    • 2 days (Gavage)  (C55801E)  Completed 
                                                      • Rats: F344/N
                                                      • Dose: RATS ONLY: 0, 50, 150, 1000, OR 2000 MG/KG; 6/GROUP.
                                                    • 14-Day (Dosed-Feed)  (C55801)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C55801)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R&M:0, 0.08, 2.50%/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C55801)  Report Complete 
                                                      • TR-394 (NIH Number: 90-2849)  (Peer Review Approval 11/19/1990A )
                                                        Toxicology and Carcinogenesis Studies of Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R&M:0, .06, .3, .6%/60 PER GROUP.

                                                    Special Studies

                                                    • C. elegans  (S0943)  Completed 
                                                      • C. elegans

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (034886)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Salmonella  (413793)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB83079)  Completed 
                                                      • Citation: Final Report - Acetaminophen: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed
                                                      • Male and Female Mice: Swiss
                                                      • Dose: 0, .31, .62, 1.25, 2.5, 5.0%; 0, .25, .5, 1%; N/A; 0, 1%.
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                                                    CASRN: 53-86-1

                                                    Formula: C19-H16-Cl-N-O4

                                                    Synonyms/Common Names

                                                    • 1,(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (9CI)

                                                    Known Uses

                                                    Anti-inflammatory, antipyretic, analgesic

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (282064)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 51-30-9

                                                    Formula: C11-H17-N-O3.Cl-H

                                                    Synonyms/Common Names

                                                    • 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, hydrochloride (9CI)

                                                    Known Uses

                                                    Bronchodilator

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (968791)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Weakly Positive 
                                                    • Salmonella  (838263)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (973172)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Weakly Positive 

                                                    Organ Systems Toxicity

                                                    • 6 to 15 GD Conventional Teratology (Intraperitoneal Injection)  (TER82088)  Completed 
                                                      • Citation: Teratologic Evaluation of Isoproterenol Hydrochloride in CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 20, 40, 80 MG/KG/DAY.
                                                    • 6 to 15 GD Conventional Teratology (Subcutaneous Injection)  (TER90089)  Completed 
                                                      • Citation: Toxicologic Evaluation of Isoproterenol Hydrochloride Administered Subcutaneously to CD Rats
                                                      • Female Rats: Sprague Dawley
                                                      • Rats Maternal Positive 
                                                      • Rats Fetal Positive 
                                                      • Dose: 0.25, 0.50, 1.0, 5.0, 10, 20 MG/KG/DAY.
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                                                    CASRN: 1309-60-0

                                                    Formula: O2-Pb

                                                    Synonyms/Common Names

                                                    • Lead oxide (9CI)

                                                    Known Uses

                                                    Oxidizing agent, pigments, rubber substitutes, explosives, occurs in nature as mineral plattnerite (Merck 1989

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (675388)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 7487-94-7

                                                    Formula: Cl2-Hg

                                                    Synonyms/Common Names

                                                    • Mercury chloride (HgCl2) (9CI)

                                                    Known Uses

                                                    Preserving wood. Embalming. Browning and etching steel and iron. Reagent. Chemical intermediate. Insecticide. Fungicide. Mordant for furs. Veterinary disinfectant and antiseptic.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C60173)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C60173)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, .312, 5.0, M: 0, 1.25, 20.0 MG/KG/40 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C60173)  Report Complete 
                                                      • TR-408 (NIH Number: 93-3139)  (Peer Review Approval 07/10/1991A )
                                                        Toxicology and Carcinogenesis Studies of Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Some Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice Equivocal Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 2.5, 5, M: 0, 5, 10 MG/KG/60 PER GROUP.

                                                    Special Studies

                                                    • C. elegans  (S0954)  Completed 
                                                      • C. elegans

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (700546)  Completed 
                                                      • Sister Chromatid Exchange Weakly Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (515345)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (289120)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (862036)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 62-38-4

                                                    Formula: C8-H8-Hg-O2

                                                    Synonyms/Common Names

                                                    • (Acetato-O)Phenylmercury (9CI)

                                                    Known Uses

                                                    Antiseptic, fungicide, herbicide; mildewcide for paints; slimicide in paper mills; organic mercurials; chemical intermediate for phenylmercuric hydroxide.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (364890)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Equivocal 
                                                    • Salmonella  (399829)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 91-80-5

                                                    Formula: C14-H19-N3-S

                                                    Synonyms/Common Names

                                                    • N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine (9CI)

                                                    Known Uses

                                                    Antihistamine

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Special Studies

                                                    • Cell Proliferation (Dosed-Feed)  (S0550)  Completed 
                                                      • Citation: Cunningham ML, Pippin LL, Anderson NL, Wenk ML. The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. Toxicol Appl Pharmacol. 1995 Apr;131(2):216-23.Pubmed Abstract
                                                      • Male Rats
                                                      • Dose: 50, 100, 250 & 1000 PPM.
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                                                    CASRN: 92-48-8

                                                    Formula: C10-H8-O2

                                                    Synonyms/Common Names

                                                    • 6-Methyl-2H-1-benzopyran-2-one (9CI)

                                                    Known Uses

                                                    Use in perfumes and flavoring agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C55812)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C55812)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 75, 1200, M: 0, 50, 800 MG/KG/10 PER GROUP.

                                                    Genetic Toxicology

                                                    • Micronucleus  (A08341)  Completed 
                                                      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                                      • Mice: B6C3F1
                                                      • Male Equivocal 
                                                      • Female Negative 
                                                    • Salmonella  (644172)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
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                                                    CASRN: 593-56-6

                                                    Formula: C-H5-N-O.Cl-H

                                                    Synonyms/Common Names

                                                    • Methyloxyammonium chloride

                                                    Known Uses

                                                    Analytical reagent for aldehydes & ketones

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (424037)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 79-11-8

                                                    Formula: C2-H3-Cl-O2

                                                    Synonyms/Common Names

                                                    • Acetic acid, chloro- (8CI)(9CI)

                                                    Known Uses

                                                    Chemical intermediate in the manufacture of various dyes and other organic materials. A postemergence contact herbicide.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C60231)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C60231)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 30, 150, M: 0, 25, 200 MG/KG/40 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Gavage)  (C60231)  Report Complete 
                                                      • TR-396 (NIH Number: 92-2851)  (Peer Review Approval 11/20/1990A )
                                                        Toxicology and Carcinogenesis Studies of Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats No Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: R: 0, 15, 30; M: 0, 50, 100 MG/KG/70 & 60 PER GROUP RESPECTIVELY.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (265221)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (255229)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
                                                    • Mouse Lymphoma  (486223)  Completed 
                                                      • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
                                                      • Mice
                                                      •  Positive 
                                                    • Salmonella  (910172)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
                                                    • Salmonella  (A15096)  Completed 
                                                      •  Negative 
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                                                    CASRN: 2163-80-6

                                                    Formula: C-H4-As-Na-O3

                                                    Synonyms/Common Names

                                                    • Methyl arsonic acid monosodium salt (9CI)
                                                    • Monosodium methane arsonate

                                                    Known Uses

                                                    Herbicide and fungicide. Pollutant.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (108987)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Negative 
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                                                    CASRN: 8008-20-6

                                                    Formula: N/F

                                                    Synonyms/Common Names

                                                    • Kerosene

                                                    Known Uses

                                                    Used in illuminating fuels, motor and jet fuels. Heating fuel. In paint thinners. Vehicle for insecticides and fungicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 2 weeks (Topical Application)  (C54784A)  Completed 
                                                      • Mice: B6C3F1
                                                    • 13 weeks (Topical Application)  (C54784A)  Completed 
                                                      • Mice: B6C3F1
                                                      • Dose: 0, 500, 8000 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Topical Application)  (C54784A)  Report Complete 
                                                      • TR-310 (NIH Number: 86-2566)  (Peer Review Approval 08/14/1985A )
                                                        Toxicology and Carcinogenesis Studies of Marine Diesel Fuel and JP-5 Navy Fuel (CASRN 8008-20-6) in B6C3F1 Mice (Dermal Studies)
                                                      • Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: 0, 250, 500 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • Salmonella  (695827)  Completed 
                                                      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                      •  Negative 
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                                                    CASRN: 98-95-3

                                                    Formula: C6-H5-N-O2

                                                    Synonyms/Common Names

                                                    • Oil of mirbane

                                                    Known Uses

                                                    Used in production of pesticides, rubber chemicals, dyes, pharmaceuticals, in soaps, shoe polish, spray paint. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Topical Application)  (C60082B)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Topical Application)  (C60082B)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, 0.05, 0.08 G/KG/10 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (694968)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (193955)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (542172)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 14 days Immunotoxicity (Gavage)  (IMM95003)  Completed 
                                                      • Citation: Burns LA, Bradley SG, White KL Jr, McCay JA, Fuchs BA, Stern M, Brown RD, Musgrove DL, Holsapple MP, Luster MI, Munson, AE. Immunotoxicity of nitrobenzene in female B6C3F1 mice. Drug Chem Toxicol. 1994;17(3):271-315.
                                                      • Female Mice: B6C3F1
                                                      • Dose: 0, 30, 100, AND 300 MG/KG.
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                                                    CASRN: 100-02-7

                                                    Formula: C6-H5-N-O3

                                                    Synonyms/Common Names

                                                    • 4-Nitrophenol (9CI)

                                                    Known Uses

                                                    Intermediate for insecticides. Azo and sulfur dyes. Leather preservatives, fungicide (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Topical Application)  (C55992B)  Report Complete 
                                                      • TR-417 (NIH Number: 93-3148)  (Peer Review Approval 07/09/1991A )
                                                        Toxicology and Carcinogenesis Studies of p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice (Dermal Studies)
                                                      • Mice: Swiss Webster
                                                      • Carcinogenesis Results
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: 0, 40, 80, 175 MG/KG/60 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (333983)  Completed 
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (295493)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Drosophila  (616176)  Completed 
                                                      • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Salmonella  (158764)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0047)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                      • Female Mice: Swiss
                                                      • Dose: 400 MG/KG.
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                                                    CASRN: 1116-54-7

                                                    Formula: C4-H10-N2-O3

                                                    Synonyms/Common Names

                                                    • 2,2'-(Nitrosoimino)bisethanol (9CI)

                                                    Known Uses

                                                    N-nitroso compounds are produced primarily as research chemicals and not for commercial purposes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 13-Week (Dosed-Water)  (C55583)  Completed 
                                                      • Rats: F344/N; Mice: Not Available

                                                    Genetic Toxicology

                                                    • Salmonella  (278013)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Positive 
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                                                    CASRN: 3268-87-9

                                                    Formula: C12-Cl8-O2

                                                    Synonyms/Common Names

                                                    • Dibenzo(b,e )(1,4)dioxin, octachloro- (9CI)

                                                    Known Uses

                                                    Contaminant of herbicides, PCB's. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Gavage)  (S0202)  Completed 
                                                      • Citation: Birnbaum LS, Couture LA. Disposition of octachlorodibenzo-p-dioxin (OCDD) in male rats. Toxicol Appl Pharmacol. 1988 Mar 30;93(1):22-30.Pubmed Abstract
                                                      • Male Rats: F344/N

                                                    Genetic Toxicology

                                                    • Salmonella  (263579)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Negative 
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                                                    CASRN: 112-62-9

                                                    Formula: C19-H36-O2

                                                    Synonyms/Common Names

                                                    • (Z)-9-Octadecanoic acid methylester (9CI)

                                                    Known Uses

                                                    Intermediate for detergents, wetting agents, textile treatment, biochemical research, plasticizers for rubber waxes, intermediate for alkanolamides, fatty alcohols; emulsifier/emollient for cosmetics; leather lubricant, naturally occurs in oils

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (274640)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 7647-10-1

                                                    Formula: Cl2-Pd

                                                    Synonyms/Common Names

                                                    • Palladous chloride

                                                    Known Uses

                                                    In photography, toning solutions, electroplating, manufacture of indelible ink, for detecting carbon monoxide, in manufacture of germicides

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (261095)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 76-01-7

                                                    Formula: C2-H-Cl5

                                                    Synonyms/Common Names

                                                    • Pentalin

                                                    Known Uses

                                                    Solvent, cleansing and degreasing metals

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C53894)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Gavage)  (C53894)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 5, 250, M: 0, 5, 500 MG/KG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Gavage)  (C53894)  Completed 
                                                      • TR-232 (NIH Number: 83-1788)  (Peer Review Approval 06/23/1981A )
                                                        Carcinogenesis Studies of Pentachloroethane (CASRN 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal 
                                                        • Female Rats Negative 
                                                        • Male Mice Positive 
                                                        • Female Mice Positive 
                                                      • Dose: R: 0, 75, 150, M: 0, 250, 500 MG/KG/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (868606)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (818137)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (761216)  Completed 
                                                      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (072127)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
                                                      • Mice
                                                      •  Positive 
                                                    • Micronucleus  (A48831)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                    • Salmonella  (926918)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Sister Chromatid Exchanges  (868606)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Negative (Nonstandard Protocol) 
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                                                    CASRN: 78-11-5

                                                    Formula: C5-H8-N4-O12

                                                    Synonyms/Common Names

                                                    • 2,2-Bis((nitrooxy)-methyl)-1,3-propanediol dinitrate(ester) (9CI)

                                                    Known Uses

                                                    In detonating fuses; vasodilator

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C55743)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C55743)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: 0, .31, 5 %/5 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C55743)  Report Complete 
                                                      • TR-365 (NIH Number: 89-2820)  (Peer Review Approval 10/04/1988A )
                                                        Toxicology and Carcinogenesis Studies of Pentaerythritol Tetranitrate (CASRN 78-11-5) with 80% D-Lactose Monohydrate (PETN, NF) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats Equivocal Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice No Evidence 
                                                      • Dose: FR: 0, 6200, 12500, MR&M: 0, 25000, 50000 PPM.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (896240)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Salmonella  (388086)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 97-18-7

                                                    Formula: C12-H6-Cl4-O2-S

                                                    Synonyms/Common Names

                                                    • Bidiphen
                                                    • 2-Hydroxy-3,5-dichlorophenyl sulphide
                                                    • Lorothiodol

                                                    Known Uses

                                                    Surfactant formulated antimicrobial, antihelmintic, food additive, agricultural fungicide (Merck 1989)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (476434)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Equivocal 
                                                    • Salmonella  (524732)  Completed 
                                                      • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                      •  Negative 
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                                                    CASRN: 673-06-3

                                                    Formula: C9-H11-N-O2

                                                    Synonyms/Common Names

                                                    • D-beta-Phenylalanine (9CI)

                                                    Known Uses

                                                    Nutrient, essential amino acid found in eggs, milk (Merck 1989)

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (244806)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 

                                                    Organ Systems Toxicity

                                                    • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0116)  Completed 
                                                      • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                      • Female Mice: Swiss
                                                      • Dose: 5000 MG/KG BODY WEIGHT.
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                                                    CASRN: 100-65-2

                                                    Formula: C6-H7-N-O

                                                    Synonyms/Common Names

                                                    • N-Hydroxybenzenamine (9CI)

                                                    Known Uses

                                                    Chemical intermediate for cupferron & p-aminophenol

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Genetic Toxicology

                                                    • Salmonella  (764371)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Positive 
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                                                    CASRN: 1918-02-1

                                                    Formula: C6-H3-Cl3-N2-O2

                                                    Synonyms/Common Names

                                                    • 4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid (9CI)

                                                    Known Uses

                                                    Herbicide

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C00237A)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C00237A)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Dose: R: 0, 1250, 20000 (AVG), M: 0, 1250, 30000 (AVG) PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Dosed-Feed)  (C00237A)  Report Complete 
                                                      • TR-023 (NIH Number: 78-823)  (Peer Review Approval 09/26/1977A )
                                                        Bioassay of Picloram for Possible Carcinogenicity (CASRN 1918-02-1)
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Negative 
                                                        • Female Rats Equivocal 
                                                        • Male Mice Negative 
                                                        • Female Mice Negative 
                                                      • Dose: R: 0, 7437, 14875 (AVG), M: 0, 2531, 5062 (AVG) PPM/50 PER GROUP.

                                                    Genetic Toxicology

                                                    • In Vitro Cytogenetics (CA/SCE)  (048749)  Completed 
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Positive 
                                                    • Drosophila  (627427)  Completed 
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
                                                    • Salmonella  (244865)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                      •  Negative 
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                                                    CASRN: 57-41-0

                                                    Formula: C15-H12-N2-O2

                                                    Synonyms/Common Names

                                                    • 2,4-Imidazolidinedione, 5,5-diphenyl-
                                                    • Phenytoin

                                                    Known Uses

                                                    Drug; therapeutic agent used as anticonvulsant, antiepileptic; antiarrhythmic drug

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Dosed-Feed)  (C55765)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                    • 13-Week (Dosed-Feed)  (C55765)  Completed 
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Dose: R: 0, 300, 4800, M: 0, 75, 1200 PPM/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2 years (Dosed-Feed)  (C55765)  Report Complete 
                                                      • TR-404 (NIH Number: 94-2859)  (Peer Review Approval 06/24/1992A )
                                                        Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) (CASRN 57-41-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
                                                      • Rats: F344/N; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Equivocal Evidence 
                                                        • Female Rats No Evidence 
                                                        • Male Mice No Evidence 
                                                        • Female Mice Clear Evidence 
                                                      • Dose: R: 0, 240, 800, 2400, MM: 0, 30, 100, 300, FM: 0, 60, 200, 600 PPM/50 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0450)  Completed 
                                                      • Citation: Colburn WA, Matthews HB. Pharmacokinetics in the interpretation of chronic toxicity tests: the last-in, first-out phenomenon. Toxicol Appl Pharmacol. 1979 May;48(3):387-95.Pubmed Abstract
                                                      • Male Rats: Sprague Dawley
                                                    • C. elegans  (S0923)  Completed 
                                                      • C. elegans
                                                      • Dose: Feed ( 0, .05, .063, .79, .1, .13, .16, .2, .25. .32. .4, .5 mM) 6/27/06 Repro (0, .025, .032, .04, .05, .063, .079, .1, .13, .16, .20, .25 mM) 6/18/06 Growth (0, .025, .032, .04, .05, .063, .079, .1, .13, .16, .20, .25 mM).

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (252423)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (335957)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Positive 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (486572)  Completed 
                                                      • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (404495)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • Micronucleus  (110489)  Completed 
                                                      • Mice: BALB/c
                                                      • Male Negative 
                                                    • Micronucleus  (252424)  Completed 
                                                      • Mice: B6C3F1
                                                      • Male Negative 
                                                      • Female NA 
                                                    • Salmonella  (255790)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Salmonella  (599479)  Completed 
                                                      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                      •  Negative 
                                                    • Sister Chromatid Exchanges  (252423)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Equivocal 
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                                                    CASRN: 1746-01-6

                                                    Formula: C12-H4-Cl4-O2

                                                    Synonyms/Common Names

                                                    • TCDD
                                                    • 2,3,7,8-Tetrachlorodibenzo(B,E)(1,4)dioxin (9CI)
                                                    • 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin

                                                    Known Uses

                                                    Present in certain herbicide and fungicide formulations, such as 2,4,5-T and pentachlorophenols; it has been tested for use in flameproofing polyesters & against insects and wood-destroying fungi. A contaminant created in the manufacture of agent orange. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                    Chemical Properties

                                                    Toxicity Effects (HSDB)

                                                    Short-Term Toxicity

                                                    • 14-Day (Gavage)  (C03714A)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                    • 14-Day (Topical Application)  (C03714B)  Completed 
                                                      • Mice: Swiss Webster
                                                    • 13-Week (Gavage)  (C03714A)  Completed 
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Dose: R: 0, .5, 8, M: 0, 1, 20 UG/KG/WK/10 PER GROUP.
                                                    • 13 weeks (Topical Application)  (C03714B)  Completed 
                                                      • Mice: Swiss Webster
                                                      • Dose: 0, .005, 10 UG/10 PER GROUP.

                                                    Long-Term Carcinogenicity

                                                    • 2-Year (Gavage)  (C03714A)  Report Complete 
                                                      • TR-209 (NIH Number: 82-1765)  (Peer Review Approval 06/27/1980A )
                                                        Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study)
                                                      • Rats: Osborne Mendel; Mice: B6C3F1
                                                      • Carcinogenesis Results
                                                        • Male Rats Positive 
                                                        • Female Rats Positive 
                                                        • Male Mice Positive 
                                                        • Female Mice Positive 
                                                      • Dose: R&MM: 0, .01, .05, .5 UG/KG/WK/50 PER GROUP FM: 0, .04, .2, 2.0 UG/KG/WK/50 PER GROUP.
                                                    • 2 years (Topical Application)  (C03714B)  Report Complete 
                                                      • TR-201 (NIH Number: 82-1757)  (Peer Review Approval 06/27/1980A )
                                                        Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Swiss-Webster Mice (Dermal Study)
                                                      • Mice: Swiss Webster
                                                      • Carcinogenesis Results
                                                        • Male Mice Equivocal 
                                                        • Female Mice Positive 
                                                      • Dose: FM: 0, .005, MM: 0, .001 UG/60 PER GROUP.

                                                    Special Studies

                                                    • Absorption Disposition Metabolism Elimination (Topical Application)  (S0680)  Completed 
                                                      • Citation: Brewster DW, Banks YB, Clark AM, Birnbaum LS. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66.Pubmed Abstract
                                                      • Male Rats: F344/N
                                                    • Absorption Disposition Metabolism Elimination (Topical Application)  (S0684)  Completed 
                                                      • Citation: Banks YB, Brewster DW, Birnbaum LS. Age-related changes in dermal absorption of 2,3,7, 8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran. Fundam Appl Toxicol. 1990 Jul;15(1):163-73.Pubmed Abstract
                                                      • Male Rats: F344/N
                                                    • Absorption Disposition Metabolism Elimination (Topical Application)  (S0685)  Completed 
                                                      • Citation: Banks YB, Birnbaum LS. Absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after low dose dermal exposure. Toxicol Appl Pharmacol. 1991 Feb;107(2):302-10. Pubmed Abstract
                                                      • Male Rats: F344/N
                                                      • Dose: 1 nmol/kg.
                                                    • Absorption Disposition Metabolism Elimination  (S0691)  Completed 
                                                      • Citation: Hébert CD, Birnbaum LS. The influence of aging on intestinal absorption of TCDD in rats. Toxicol Lett. 1987 Jun;37(1):47-55.Pubmed Abstract
                                                      • Male Rats: F344/N
                                                    • Cell Proliferation  (S0692)  Completed 
                                                      • Citation: Hébert CD, Cao QL, Birnbaum LS. Inhibition of high-density growth arrest in human squamous carcinoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Carcinogenesis. 1990 Aug;11(8):1335-42. Pubmed Abstract
                                                      • Citation: Hébert CD, Cao QL, Birnbaum LS. Role of transforming growth factor beta in the proliferative effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on human squamous carcinoma cells. Cancer Res. 1990 Nov 15;50(22):7190-7.Pubmed Abstract
                                                      • Human (Cell Lines)
                                                    • Mechanisms (Gavage)  (S0681)  Completed 
                                                      • Citation: Harris MW, Uriah LC, Birnbaum LS. Acute toxicity of perfluorodecanoic acid in C57BL/6 mice differs from 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 1989 Nov;13(4):723-36.Pubmed Abstract
                                                      • Female Mice: C57BL/6
                                                      • Dose: 0 to 320 mg/kg.
                                                    • Mechanisms (Gavage)  (S0682)  Completed 
                                                      • Citation: Abbott BD, Birnbaum LS. Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD. Toxicol Appl Pharmacol. 1989 Jun 15;99(2):287-301.Pubmed Abstract
                                                      • Male and Female Mice: C57BL/6
                                                    • Mechanisms (Gavage)  (S0683)  Completed 
                                                      • Citation: Brewster DW, Birnbaum LS. The biochemical toxicity of perfluorodecanoic acid in the mouse is different from that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1989 Jul;99(3):544-54.Pubmed Abstract
                                                      • Female Mice: C57BL/6
                                                      • Dose: Ahb/b strain 0, 40, 80, 100, 120, 160 mk/kg: Ahb/d strain 0, 40, 80, 160 mg/kg: Ahd/d strain 0, 40, 80, 120 mk/kg.
                                                    • Mechanisms (Topical Application)  (S0690)  Completed 
                                                      • Citation: Stohs SJ, Abbott BD, Lin FH, Birnbaum LS. Induction of ethoxyresorufin-O-deethylase and inhibition of glucocorticoid receptor binding in skin and liver of haired and hairless HRS/J mice by topically applied 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology. 1990 Dec 17;65(1-2):123-36.Pubmed Abstract
                                                      • Female Mice
                                                      • Dose: 12µg/kg.
                                                    • Toxicokinetic Study (Gavage)  (K01807)  Completed 
                                                      • Female Rats: Sprague Dawley
                                                    • Toxicokinetic Study (Gavage)  (S0621)  Completed 
                                                      • Male and Female Rats: Sprague Dawley
                                                      • Dose: FEMALE RATS: 0, 1, 3, 10, 30, 100 NG/KG MALE RATS TO BE USED AS SENTINELS..

                                                    Genetic Toxicology

                                                    • Chromosome Aberrations  (163229)  Completed 
                                                      • Mice
                                                      •  Negative 
                                                    • In Vitro Cytogenetics (CA/SCE)  (764904)  Completed 
                                                      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                      • Sister Chromatid Exchange Negative 
                                                      • Chromosome Aberrations Negative 
                                                    • Drosophila  (601370)  Completed 
                                                      • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
                                                      • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                    • Mouse Lymphoma  (056688)  Completed 
                                                      • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
                                                      • Mice
                                                      •  Negative 
                                                    • Salmonella  (904370)  Completed 
                                                      • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
                                                      •  Negative 
                                                    • Sister Chromatid Exchanges  (163229)  Completed 
                                                      • Mice
                                                      • Sister Chromatid  Not a Valid Test 

                                                    Organ Systems Toxicity

                                                    • single dose Immunotoxicity (Gavage)  (I10157)  Completed 
                                                      • Female Mice: B6C3F1
                                                      • Dose: 0, 0.1, 0.3, 0.5, 1, or 3 ug/kg.
                                                    • 14 days Immunotoxicity (Gavage)  (IMM95007)  Completed 
                                                      • Female Mice: B6C3F1
                                                      • Dose: 0.86 ug/kg.
                                                    • Teratology Pilot Studies (Gavage & Intraperitoneal Injection)  (TRP92026)  Completed 
                                                      • Male and Female Mice: C57BL/6
                                                      • Dose: 0, 9, 12, OR 15 UG/KG + 10 MG/KG PYRAN.
                                                    • Teratology Pilot Studies (Gavage & Intraperitoneal Injection)  (TRP92061)  Completed 
                                                      • Male and Female Mice: C57BL/6
                                                      • Dose: 0, 12, OR 15 UG/KG + PYRAN 0, 10, 50, OR 100 MG/KG.
                                                    • Teratology Pilot Studies (Gavage & Intraperitoneal Injection)  (TRP92063)  Completed 
                                                      • Male and Female Mice: C57BL/6
                                                      • Dose: 0, 6, 12, OR 24 UG/KG TCDD; PYRAN 0, 10 MG/KG.

                                                    Toxicogenomics

                                                    • Microarray Analysis  (T10157)  Completed 
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                                                      CASRN: 9003-39-8

                                                      Formula: (C6-H9-N-O)x-

                                                      Synonyms/Common Names

                                                      • 1-Ethenyl-2-pyrrolidinone polymers (9CI)

                                                      Known Uses

                                                      In cosmetics, plastics, dyes, inks, wax & polish formulations, soft contact lenses, beverages, defoaming agent in paper/paperboard manufacture, pharmaceutical aid.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Genetic Toxicology

                                                      • Salmonella  (831816)  Completed 
                                                        • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                        •  Negative 
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                                                      CASRN: 57-66-9

                                                      Formula: C13-H19-N-O4-S

                                                      Synonyms/Common Names

                                                      • 4-((Dipropylamino)sulfonyl)benzoic acid (9CI)

                                                      Known Uses

                                                      Uricosuric agent for treatment of gout and gouty arthritis. Probenecid is also used as a therapeutic adjunct to enhance blood levels of penicillin and its action.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Gavage)  (C56097)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                      • 13-Week (Gavage)  (C56097)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R&M: 0, .05, .8, M: 0, .1, 1.6 G/KG/10 PER GROUP.

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Gavage)  (C56097)  Report Complete 
                                                        • TR-395 (NIH Number: 91-2850)  (Peer Review Approval 11/20/1990A )
                                                          Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Carcinogenesis Results
                                                          • Male Rats No Evidence 
                                                          • Female Rats No Evidence 
                                                          • Male Mice No Evidence 
                                                          • Female Mice Some Evidence 
                                                        • Dose: R&M:0, 100, 400 MG/KG/50 PER GROUP.

                                                      Genetic Toxicology

                                                      • In Vitro Cytogenetics (CA/SCE)  (722868)  Completed 
                                                        • Sister Chromatid Exchange Positive 
                                                        • Chromosome Aberrations Negative 
                                                      • Salmonella  (518172)  Completed 
                                                        • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                        •  Negative 

                                                      Organ Systems Toxicity

                                                      • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0007A)  Completed 
                                                        • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
                                                        • Female Mice: Swiss
                                                        • Dose: 1200 MG/KG BODY WEIGHT.
                                                      • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0007B)  Completed 
                                                        • Female Mice: Swiss
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                                                      CASRN: 117-39-5

                                                      Formula: C15-H10-O7

                                                      Synonyms/Common Names

                                                      • 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one (9CI)

                                                      Known Uses

                                                      Capillary protectant (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Dosed-Feed)  (C60106)  Report Complete 
                                                        • TR-409 (NIH Number: 92-3140)  (Peer Review Approval 03/12/1991A )
                                                          Toxicology and Carcinogenesis Studies of Quercetin (CASRN 117-39-5) in F344 Rats (Feed Studies)
                                                        • Rats: F344/N
                                                        • Carcinogenesis Results
                                                          • Male Rats Some Evidence 
                                                          • Female Rats No Evidence 
                                                        • Dose: RATS ONLY:0, 1000, 10000, 40000 PPM/50 PER GROUP.

                                                      Genetic Toxicology

                                                      • In Vitro Cytogenetics (CA/SCE)  (305922)  Completed 
                                                        • Sister Chromatid Exchange Positive 
                                                        • Chromosome Aberrations Positive 
                                                      • Salmonella  (200400)  Completed 
                                                        • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
                                                        •  Positive 
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                                                      CASRN: 106-51-4

                                                      Formula: C6-H4-O2

                                                      Synonyms/Common Names

                                                      • 2,5-Cyclohexadiene-1,4-dione (9CI)

                                                      Known Uses

                                                      Chemical intermediate; rubber accelerator; manufacture of unsaturated polyesters; manufacture of fungicides; determination of amino acid; pharmaceutical industry; in polymer & resins industry; in manufacture of quinhydrone electrodes for pH determinations. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Genetic Toxicology

                                                      • Salmonella  (535797)  Completed 
                                                        • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                        •  Negative 
                                                      • Salmonella  (777291)  Completed 
                                                        • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                        •  Negative 
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                                                      CASRN: 108-46-3

                                                      Formula: C6-H6-O2

                                                      Synonyms/Common Names

                                                      • 1,3-Benezenediol (9CI)

                                                      Known Uses

                                                      Tanning, chemical production, dyes, cosmetics, pharmaceuticals, photography, intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Gavage)  (C05970A)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                      • 13-Week (Gavage)  (C05970A)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R: 0, 32, 520, M: 0, 28, 420 MG/KG/10 PER GROUP.

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Gavage)  (C05970A)  Report Complete 
                                                        • TR-403 (NIH Number: 92-2858)  (Peer Review Approval 03/11/1991A )
                                                          Toxicology and Carcinogenesis Studies of Resorcinol (CASRN 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Carcinogenesis Results
                                                          • Male Rats No Evidence 
                                                          • Female Rats No Evidence 
                                                          • Male Mice No Evidence 
                                                          • Female Mice No Evidence 
                                                        • Dose: MR&M: 0, 112, 225 FR: 0, 50, 100, 150 MG/KG/60 PER GROUP.

                                                      Special Studies

                                                      • Metabolism  (S0713)  Completed 
                                                        • Citation: Kim YC, Matthews HB. Comparative metabolism and excretion of resorcinol in male and female F344 rats. Fundam Appl Toxicol. 1987 Oct;9(3):409-14.Pubmed Abstract
                                                        • Male and Female Rats: F344/N

                                                      Genetic Toxicology

                                                      • In Vitro Cytogenetics (CA/SCE)  (101147)  Completed 
                                                        • Sister Chromatid Exchange Positive 
                                                        • Chromosome Aberrations Positive 
                                                      • Drosophila  (126256)  Completed 
                                                        • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
                                                        • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
                                                      • Mouse Lymphoma  (743596)  Completed 
                                                        • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
                                                        • Mice
                                                        •  Positive 
                                                      • Micronucleus  (A90027)  Completed 
                                                        • Mice: B6C3F1
                                                        • Male Positive 
                                                      • Salmonella  (674324)  Completed 
                                                        • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                        •  Negative 
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                                                      CASRN: 26628-22-8

                                                      Formula: N3-Na

                                                      Synonyms/Common Names

                                                      • Hydrazoic acid, sodium salt

                                                      Known Uses

                                                      Herbicide, pesticide, reagent, diagnostic medicine preservative, fungicide, fumigant (HSDB 1990). It is the principal chemical used to generate nitrogen gas in automobile safety airbags and airplane escape chutes and is a broad-spectrum biocide used in both research and agriculture.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Gavage)  (C06462)  Completed 
                                                        • Rats: F344/N
                                                      • 13-Week (Gavage)  (C06462)  Completed 
                                                        • Rats: F344/N
                                                        • Dose: RATS ONLY:0, .063, 4 MG/ML/10 PER GROUP.

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Gavage)  (C06462)  Report Complete 
                                                        • TR-389 (NIH Number: 91-2844)  (Peer Review Approval 04/25/1990A )
                                                          Toxicology and Carcinogeneis Studies of Sodium Azide (CASRN 26628-22-8) in F344 Rats (Gavage Studies)
                                                        • Rats: F344/N
                                                        • Carcinogenesis Results
                                                          • Male Rats No Evidence 
                                                          • Female Rats No Evidence 
                                                        • Dose: RATS ONLY:0, 5, 10 MG/KG/60 PER GROUP.

                                                      Genetic Toxicology

                                                      • In Vitro Cytogenetics (CA/SCE)  (166603)  Completed 
                                                        • Sister Chromatid Exchange Positive 
                                                        • Chromosome Aberrations Negative 
                                                      • Salmonella  (201201)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
                                                        • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                        •  Positive 
                                                      • Salmonella  (A90612)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
                                                        •  Positive 
                                                      • Salmonella  (G10164)  Completed 
                                                        •  Positive 
                                                      • Salmonella  (N-9164)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
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                                                      CASRN: 2893-78-9

                                                      Formula: C3-H-Cl2-N3-O3.Na

                                                      Synonyms/Common Names

                                                      • 1,3-Dichloro-1,3,5-triazine-2,4,6(1H,3H,5H)-trione sodium salt (9CI)

                                                      Known Uses

                                                      Bleaching and sanitizing agent in cleaning products

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Genetic Toxicology

                                                      • Salmonella  (901479)  Completed 
                                                        • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                        •  Negative 
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                                                      CASRN: 100-42-5

                                                      Formula: C8-H8

                                                      Synonyms/Common Names

                                                      • Ethenylbenzene (9CI)
                                                      • Phenylethylene
                                                      • Vinylbenzene

                                                      Known Uses

                                                      In manufacture of plastics, synthetic rubber, resins. Insulator. Used in construction materials and boats. Chemical intermediate. Flavoring agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Gavage)  (C02200A)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                      • 2 weeks (Inhalation)  (C02200B)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R&M: 0, 30, 100, 300, 1000, 0R 2000 PPM (5/S/S).
                                                      • 13-Week (Gavage)  (C02200A)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R: 0, 681, 3160, M: 0, 147, 681 MG/KG/10 PER GROUP.
                                                      • 13 weeks (Inhalation)  (C02200B)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R: 0, 125, 250, 500, 1000, OR 1500 PPM M: 0, 62.5, 125, 250, OR 500 PPM.

                                                      Long-Term Carcinogenicity

                                                      • 2-Year (Gavage)  (C02200A)  Report Complete 
                                                        • TR-185 (NIH Number: 79-1741)  (Peer Review Approval 10/25/1978A )
                                                          Bioassay of Styrene for Possible Carcinogenicity (CASRN100-42-5)
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Carcinogenesis Results
                                                          • Male Rats Negative 
                                                          • Female Rats Negative 
                                                          • Male Mice Equivocal 
                                                          • Female Mice Negative 
                                                        • Dose: R: 0, 500, 1000, 2000, M: 0, 150, 300 MG/KG/50 PER GROUP.

                                                      Special Studies

                                                      • Mechanisms (Inhalation)  (S0333)  Completed 
                                                        • Citation: Mahler JF, Price HC Jr, O'Connor RW, Wilson RF, Eldridge SR, Moorman MP, Morgan DL. Characterization of hepatocellular resistance and susceptibility to styrene toxicity in B6C3F1 mice. Toxicol Sci. 1999 Mar;48(1):123-33. Pubmed Abstract
                                                        • Citation: Morgan DL, Mahler JF, Dill JA, Price HC Jr, O'Connor RW, Adkins B Jr. Styrene inhalation toxicity studies in mice. II. Sex differences in susceptibility of B6C3F1 mice. Fundam Appl Toxicol. 1993 Oct;21(3):317-25. Pubmed Abstract
                                                        • Citation: Morgan DL, Mahler JF, Dill JA, Price HC Jr, O'Connor RW, Adkins B Jr. Styrene inhalation toxicity studies in mice. III. Strain differences in susceptibility. Fundam Appl Toxicol. 1993 Oct;21(3):326-33.Pubmed Abstract
                                                        • Male and Female Mice: B6C3F1; Male and Female Mice: C57BL/6; Male and Female Mice: Swiss; Male and Female Mice
                                                        • Dose: 125, 250 OR 500 PPM.

                                                      Genetic Toxicology

                                                      • In Vitro Cytogenetics (CA/SCE)  (987609)  Completed 
                                                        • Sister Chromatid Exchange Negative 
                                                        • Chromosome Aberrations Negative 
                                                      • Salmonella  (173117)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                        • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                        •  Negative 
                                                      • Salmonella  (N-9246)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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                                                      CASRN: 14807-96-6

                                                      Formula: H2-O3-Si.3/4Mg

                                                      Synonyms/Common Names

                                                      • Agalite

                                                      Known Uses

                                                      Dusting powder for medicinal and cosmetic preparations. Excipient and filler for pills. Used by rubber, paint, food, asphalt, and paper industries. Improves thermoforced food packaging. Occurs naturally.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Inhalation)  (C06008)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Inhalation)  (C06008)  Report Complete 
                                                        • TR-421 (NIH Number: 93-3152)  (Peer Review Approval 06/23/1992A )
                                                          Toxicology and Carcinogenesis Studies of Talc (CASRN 14807-96-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Carcinogenesis Results
                                                          • Male Rats Some Evidence 
                                                          • Female Rats Clear Evidence 
                                                          • Male Mice No Evidence 
                                                          • Female Mice No Evidence 
                                                        • Dose: R & M: 0, 6, AND 18 MG OF TALC/M3 OF ATMOSPHERE.
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                                                      CASRN: 107-35-7

                                                      Formula: C2-H7-N-O3-S

                                                      Synonyms/Common Names

                                                      • 2-Aminoethanesulfonic acid (9CI)

                                                      Known Uses

                                                      Under investigation as drug for epilepsy. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Genetic Toxicology

                                                      • Salmonella  (744039)  Completed 
                                                        • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                        •  Negative 
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                                                      CASRN: 13494-80-9

                                                      Formula: Te

                                                      Synonyms/Common Names

                                                      • Aurum paradoxum

                                                      Known Uses

                                                      Added to steel, copper, cast iron. Manufacture of malleable iron. Formulation of semiconductors. Coloring agent in china, enamels, glass. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Organ Systems Toxicity

                                                      • postnatal day 17-23 Neurotoxicology Assessment (Dosed-Feed)  (NTA95001)  Completed 
                                                        • Male Rats: Long-Evans Hooded
                                                        • Dose: 2%.
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                                                      CASRN: 109-99-9

                                                      Formula: C4-H8-O

                                                      Synonyms/Common Names

                                                      • 1,4-Epoxybutane

                                                      Known Uses

                                                      Reaction medium for grignard and metal hydride reactions. Packaging fabrication. Solvent for resins and plastics. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Gavage)  (C60560A)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                      • 13-Week (Gavage)  (C60560A)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R: 0, 125, 2000, M: 0, 63, 1000 MG/KG/10 PER GROUP.
                                                      • 13 weeks (Inhalation)  (C60560B)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R&M: 0, 66, 200, 600, 1800, 5000 PPM.

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Inhalation)  (C60560C)  Report Complete 
                                                        • TR-475 (NIH Number: 98-3965)  (Peer Review Approval 12/11/1996A )
                                                          Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Carcinogenesis Results
                                                          • Male Rats Some Evidence 
                                                          • Female Rats No Evidence 
                                                          • Male Mice No Evidence 
                                                          • Female Mice Clear Evidence 
                                                        • Dose: R&M: 0, 200, 600, OR 1800 PPM (50/SEX/SPECIES/GROUP).

                                                      Genetic Toxicology

                                                      • Chromosome Aberrations  (720076)  Completed 
                                                        • Mice
                                                        •  Negative 
                                                      • In Vitro Cytogenetics (CA/SCE)  (378945)  Completed 
                                                        • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
                                                        • Sister Chromatid Exchange Negative 
                                                        • Chromosome Aberrations Negative 
                                                      • Drosophila  (442740)  Completed 
                                                        • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
                                                        • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                      • Micronucleus  (A34612)  Completed 
                                                        • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
                                                        • Mice: B6C3F1
                                                        • Male Equivocal 
                                                        • Female Negative 
                                                      • Salmonella  (551903)  Completed 
                                                        • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                        •  Negative 
                                                      • Salmonella  (620162)  Completed 
                                                        • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
                                                        •  Negative 
                                                      • Sister Chromatid Exchanges  (720076)  Completed 
                                                        • Mice
                                                        • Sister Chromatid  Positive (Nonstandard Protocol) 

                                                      Organ Systems Toxicity

                                                      • 6 to 17 GD for mice Conventional Teratology (Inhalation)  (TER88047)  Completed 
                                                        • Citation: Inhalation Developmental Toxicology Studies: Teratology Study of Tetrahydrofuran in Mice and Rats (August 1988)
                                                        • Female Rats/Mice: Sprague Dawley/Swiss
                                                        • Rats/Mice Maternal Positive 
                                                        • Rats/Mice Fetal Positive 
                                                        • Dose: 600, 1800, 5000 PPM.
                                                      • 6 to 19 days GD Conventional Teratology (Inhalation)  (TER88139)  Completed 
                                                        • Citation: Inhalation Developmental Toxicology Studies: Teratology Study of Tetrahydrofuran in Mice and Rats (August 1988)
                                                        • Female Rats: Sprague Dawley
                                                        • Dose: 0, 600, 1800, 5000 PPM.
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                                                      CASRN: 124-64-1

                                                      Formula: C4-H12-O4-P.Cl

                                                      Synonyms/Common Names

                                                      • Phosphonium, tetrakis(hydroxymethyl)-, chloride
                                                      • THPC

                                                      Known Uses

                                                      Flame retardant for textiles. Broad spectrum disinfectant. Chemical intermediate.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 2 weeks (Gavage)  (C55061)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R: 0, 9.4, 10.8, 37.5, 75, 150 MG/KG; M: 0, 18.8, 37.5, 75, 150, 300 MG/KG.
                                                      • 13 weeks (Gavage)  (C55061)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R: 0, 3.75, 7.5, 15, 30, 60 MG/KG; M: 0, 1.5, 4.5, 15, 45, 135 MG/KG 10 PER GROUP.

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Gavage)  (C55061)  Report Complete 
                                                        • TR-296 (NIH Number: 87-2552)  (Peer Review Approval 03/26/1986A )
                                                          Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CASRN 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Carcinogenesis Results
                                                          • Male Rats No Evidence 
                                                          • Female Rats No Evidence 
                                                          • Male Mice No Evidence 
                                                          • Female Mice No Evidence 
                                                        • Dose: R: 0, 3.75, 7.5, MM: 0, 7.5, 15, FM: 0, 15, 30 MG/KG/50 PER GROUP.

                                                      Genetic Toxicology

                                                      • In Vitro Cytogenetics (CA/SCE)  (523400)  Completed 
                                                        • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
                                                        • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
                                                        • Sister Chromatid Exchange Positive 
                                                        • Chromosome Aberrations Positive 
                                                      • Mouse Lymphoma  (824859)  Completed 
                                                        • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
                                                        • Mice
                                                        •  Positive 
                                                      • Micronucleus  (A09015)  Completed 
                                                        • Mice: B6C3F1
                                                        • Male Negative 
                                                      • Salmonella  (778372)  Completed 
                                                        • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
                                                        •  Negative 

                                                      Organ Systems Toxicity

                                                      • Neurotoxicology Assessment (Gavage)  (NTA94017)  Completed 
                                                        • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
                                                        • Female Rats: F344/N
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                                                      CASRN: 13463-67-7

                                                      Formula: O2-Ti

                                                      Synonyms/Common Names

                                                      • C.I. Pigment White 6
                                                      • Titanium oxide (9CI)

                                                      Known Uses

                                                      White pigment in paints, coatings, paper, plastics, drugs, cosmetics, food industry, capacitors, anticorrosive agents; welding rod coatings & metal production, found in nature as mineral rutile (HSDB 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Dosed-Feed)  (C04240)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                      • 13-Week (Dosed-Feed)  (C04240)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: 0, 6250, 100000 PPM/10 PER GROUP.

                                                      Long-Term Carcinogenicity

                                                      • 2-Year (Dosed-Feed)  (C04240)  Report Complete 
                                                        • TR-097 (NIH Number: 79-1347)  (Peer Review Approval 08/13/1978A )
                                                          Bioassay of Titanium Dioxide for Possible Carcinogenicity (CASRN 13463-67-7)
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Carcinogenesis Results
                                                          • Male Rats Negative 
                                                          • Female Rats Negative 
                                                          • Male Mice Negative 
                                                          • Female Mice Negative 
                                                        • Dose: 0, 25000, 50000 PPM/50 PER GROUP.

                                                      Genetic Toxicology

                                                      • Chromosome Aberrations  (860815)  Completed 
                                                        • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
                                                        • Mice
                                                        •  Negative 
                                                      • In Vitro Cytogenetics (CA/SCE)  (766516)  Completed 
                                                        • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
                                                        • Sister Chromatid Exchange Negative 
                                                        • Chromosome Aberrations Negative 
                                                      • Drosophila  (211708)  Completed 
                                                        • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
                                                        • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
                                                      • Mouse Lymphoma  (006080)  Completed 
                                                        • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
                                                        • Mice
                                                        •  Negative 
                                                      • Micronucleus  (563272)  Completed 
                                                        • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
                                                        • Mice: B6C3F1
                                                        • Male Positive 
                                                      • Salmonella  (004554)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                        • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
                                                        •  Negative 
                                                      • Salmonella  (CV-22)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
                                                      • Sister Chromatid Exchanges  (860815)  Completed 
                                                        • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
                                                        • Mice
                                                        • Sister Chromatid  Negative (Nonstandard Protocol) 
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                                                      CASRN: 1271-19-8

                                                      Formula: C10-H10-Cl2-Ti

                                                      Synonyms/Common Names

                                                      • Dichlorobis(eta(5)-2,4-cyclopentadien-1-yl)-titanium (9CI)

                                                      Known Uses

                                                      It is used as a cocatalyst in polymerization reactions. Research chemical. Catalyst.

                                                      Chemical Properties

                                                      Toxicity Effects (HSDB)

                                                      Short-Term Toxicity

                                                      • 14-Day (Gavage)  (C04502)  Completed 
                                                        • Rats: F344/N
                                                      • 13-Week (Gavage)  (C04502)  Completed 
                                                        • Rats: F344/N; Mice: B6C3F1
                                                        • Dose: R&M: 0, .008, .125 G/KG/10 PER GROUP.

                                                      Long-Term Carcinogenicity

                                                      • 2 years (Gavage)  (C04502)  Report Complete 
                                                        • TR-399 (NIH Number: 91-2854)  (Peer Review Approval 11/19/1990A )
                                                          Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats (Gavage Studies)
                                                        • Rats: F344/N
                                                        • Carcinogenesis Results
                                                          • Male Rats Equivocal Evidence 
                                                          • Female Rats Equivocal Evidence 
                                                        • Dose: RATS ONLY:0, 25, 50 MG/KG/80 PER GROUP.

                                                      Special Studies

                                                      • Toxicokinetic Study  (S0269)  Completed 
                                                        • Male Rats: F344/N

                                                      Genetic Toxicology

                                                      • In Vitro Cytogenetics (CA/SCE)  (241636)  Completed 
                                                        • Sister Chromatid Exchange Negative 
                                                        • Chromosome Aberrations Negative 
                                                      • Salmonella  (813172)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
                                                        • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
                                                        •  Positive 
                                                      • Salmonella  (N-9026)  Completed 
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
                                                        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
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                                                      CASRN: 79-01-6

                                                      Formula: C2-H-Cl3

                                                      Synonyms/Common Names

                                                      • Trichloroethene (9Ci)

                                                      Known Uses

                                                      Degreaser, dry cleaning solvent, manufacture or organic chemicals and pharmaceuticals,