Testing Status of Nanoscale material (Fullerene-C60 50 nanometers) M070009

 

CASRN: 99685-96-8

Formula: C60

Synonyms/Common Names

  • Fullerene-C60 50 nanometers

Known Uses

Part of an NTP evaluation of nanoscale materials (a broadly defined set of substances where at least one critical dimension is less than 100 nm) to evaluate the tox properties of major nanoscale materials classes representing a cross-section of composition, size, surface coatings, & physico-chemical properties, and use these as model systems to investigate how they interact w/ biological systems.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 90 days (Inhalation)  (C20407)  Completed 
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 0.5, or 2.0 mg/m3; R: 20/sex/dose; M: 10/sex/dose.

Genetic Toxicology

  • Micronucleus  (G07009B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G07009)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Inhalation)  (I20407B)  Completed 
    • Male and Female Mice: B6C3F1
    • Dose: 0, 0.5, or 2 mg/m3.
  • Varies Immunotoxicity (Inhalation)  (I20407)  Completed 
    • Male and Female Rats: Wistar Han
    • Dose: 0, 0.5, or 2 mg/m3.