National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m070010

Testing Status of Nanoscale material (Fullerene-C60 1 micron) - M070010

 

CASRN: 99685-96-8

Formula: C60

Synonyms/Common Names

  • Fullerene-C60 1 micron (Nanoscale material)

Known Uses

Part of an NTP evaluation of nanoscale materials (a broadly defined set of substances where at least one critical dimension is less than 100 nm) to evaluate the tox properties of major nanoscale materials classes representing a cross-section of composition, size, surface coatings, & physico-chemical properties, and use these as model systems to investigate how they interact w/ biological systems.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 90 days (Inhalation)  (C20701)  Completed 
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 2, 15, or 30 mg/m3; R: 20/sex/dose; M: 10/sex/dose.

Genetic Toxicology

  • Micronucleus  (G07010B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G07010)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Inhalation)  (I20710B)  Completed 
    • Male and Female Mice: B6C3F1
    • Dose: 0, 2, 15 or 30 mg/m3.
  • Varies Immunotoxicity (Inhalation)  (I20710)  Completed 
    • Male and Female Rats: Wistar Han
    • Dose: 1 micron: 0, 2, 15 or 30 mg/m3.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.