National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m070018

Testing Status of Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride - M070018

 

CASRN: 65039-09-0

Formula: C6-H11-Cl-N2

Synonyms/Common Names

  • Basionic (TM) ST 80
  • 1-Ethyl-3-methylimidazolium Chloride (Ionic Liquid)

Known Uses

Ionic liquid; catalyst, electrolyte component; reactant; solvent

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 90 days (Dosed-Water)  (C07018)  On Test 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 1 3, or 10 mg/mL; M: 0, 3, 10 or 30 mg/mL; 10/sex/species.

Special Studies

  • C. elegans  (W07018)  Completed 
    • C. elegans
    • Dose: Feeding:0,1,4,8,12,16,20,24,28,32,36,40mM; Repro:0,3.5,7,14,21,28,35,42,49,56,63,70mM Growth:0,3,6,12,18,24,30,36,42,48,54,60 mM.

Genetic Toxicology

  • Micronucleus  (G07018B)  Completed 
    • Male & Female B6C3F1 Mice
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Micronucleus  (G07018)  Completed 
    • Male & Female Sprague Dawley Rats
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (A09944)  Completed 
    •  Negative 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (I07018)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 6.25, 12.5, 25, or 50% EMIM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.