National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m070034

Testing Status of Insertional mutagenesis (LTR/SIN vectors) - M070034

 

CASRN: INSERTMUT

Related: INSERTMUT2

Known Uses

Insertional mutagenesis studies using vector exposures

Short-Term Toxicity

  • 12 weeks (Intravenous)  (C20703)  Completed 
    • Mice: B6.SJL-Ptprc[a] Pepc[b]/BoyJ
    • Dose: Female mice/LTR vector (PRSF91.EGFP.PRE*): radiated 10 GY; 50k cells LTR; female mice/SIN vector (PSERS11.SF.EGFP.PRE*): radiated 10 GY; 50k cells SIN; female mice/controls: radiated 10 GY; empty vector cells; 15/group.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.