National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m070036

Testing Status of ortho-Phthalaldehyde - M070036

 

CASRN: 643-79-8

Formula: C8-H6-O2

Synonyms/Common Names

  • 1,2-Benzenedicarboxaldehyde
  • o-Phthaldialdehyde
  • Phthalic aldehyde

Known Uses

Disinfectant, enzyme inhibitor, indicator, and reagent. Also used as an alternative to glutaraldehyde in the sterilization of dental and medical equipment; disinfection of heat sensitive dental and medical devices.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 90 days (Inhalation)  (C20727)  Report Draft 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Highest conc is MACWA; R: 20/sex/conc; M: 10/sex/conc.

Genetic Toxicology

  • Comet Assay  (G07036D)  Completed 
    • Rats
  • Comet Assay  (G07036E)  Completed 
    • Mice
  • Micronucleus  (G07036B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G07036C)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (G07036)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.