Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Dimethylamine Borane M070051


CASRN: 74-94-2

Formula: C2-H10-B-N

Synonyms/Common Names

  • Borane, compd. with dimethylamine (1:1)
  • Boron, trihydro(N-methylmethanamine)-, (beta-4)-
  • DMAB

Known Uses

a reducing agent used in nonelectric plating of semiconductors

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dermal)  (C07051)  Data in Review 
    • Dose range finding
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 15.6, 31.25, 62.5, 125 or 250 mg/kg; 5/sex/group; MM: 0, 15.6, 31.25, 62.5, 125 or 250 mg/kg; 5/sex/group; FM: 0, 31.25, 62.5, 125, 250 or 500 mg/kg; 5/sex/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application; in-vitro)  (K07051)  Completed 
    • Citation: Final Study Report Disposition and Metabolism of Dimethylamine Borane (DMAB) (CAS #74-94-2) in Rats Following Dermal, Oral, and Intravenous Exposure. August 29, 2012
    • Citation: James M. Mathews, Scott L. Watson, Purvi R. Patel, Sherry R. Black, Yan Hong, Keith E. Levine, Glenn Ross, Dori R. Germolec, Sheetal A. Thakur & Suramya Waidyanatha (2013) Metabolism and disposition of [14C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application, Xenobiotica, 44:1, 36-47, DOI: 10.3109/00498254.2013.800662Pubmed Abstract
    • Male Rats: Harlan Sprague-Dawley; Human (Cell Lines)
    • Dose: In vitro; 0.054 and 0.54 mg. gavage; 1.5 mg/kg. intravenous; 1.5 mg/kg. topical; 0.15, 1.5, 15 mg/kg.

Genetic Toxicology

  • Salmonella  (G07051B)  Completed 
    •  Weakly Positive 
  • Salmonella  (G07051)  Completed 
    •  Weakly Positive 

Organ Systems Toxicity

  • 3 to 7 days Immunotoxicity (Topical Application)  (I07051)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 5, 10, 25, or 50%.