National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m070067

Testing Status of Nanoscale Silver - M070067

 

CASRN: 7440-22-4

Formula: Ag

Synonyms/Common Names

  • Silver

Known Uses

Used for electroplating, in dental alloys, in processing foods, in batteries, in photographic materials. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 13 weeks (Gavage)  (C20726)  On Test 
    • Citation: Boudreau MD, Imam MS, Paredes AM, Bryant, MS, Cunningham, CK, Felton, RP, Jones, MY, Davis, KJ, and Olson, GR. Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. Toxicol Sci. 2016 Mar;150(1):131-60. doi: 10.1093/toxsci/kfv318. Epub 2016 Jan 5.Pubmed Abstract
    • Citation: Williams K, Milner J, Boudreau MD, Gokulan K, Cerniglia CE, Khare S. Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats. Nanotoxicology. 2015 May;9(3):279-89. doi: 10.3109/17435390.2014.921346. Epub 2014 May 30. PubMed PMID: 24877679.
    • Rats: Sprague Dawley (NCTR)
    • Dose: Rats: AgNP 10 nm 9, 18, 36 mg/kg bw/day; AgNP 75 nm 9, 18, 36 mg/kg bw/day; AgNP 107 nm 9, 18, 36 mg/kg bw/ day. Silver acetate: 14, 28, 56 mg/kg bw/day.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (K07067C)  Completed 
    • Citation: Boudreau MD, Imam MS, Paredes AM, Bryant, MS, Cunningham, CK, Felton, RP, Jones, MY, Davis, KJ, and Olson, GR. Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. Toxicol Sci. 2016 Mar;150(1):131-60. doi: 10.1093/toxsci/kfv318. Epub 2016 Jan 5.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley
  • Toxicokinetic Study (Intravenous)  (K07067B)  Completed 
    • Citation: Boudreau MD, Imam MS, Paredes AM, Bryant, MS, Cunningham, CK, Felton, RP, Jones, MY, Davis, KJ, and Olson, GR. Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. Toxicol Sci. 2016 Mar;150(1):131-60. doi: 10.1093/toxsci/kfv318. Epub 2016 Jan 5.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley
  • Toxicokinetic Study (Gavage)  (K07067)  Completed 
    • Citation: Boudreau MD, Imam MS, Paredes AM, Bryant, MS, Cunningham, CK, Felton, RP, Jones, MY, Davis, KJ, and Olson, GR. Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. Toxicol Sci. 2016 Mar;150(1):131-60. doi: 10.1093/toxsci/kfv318. Epub 2016 Jan 5.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.