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Testing Status of Tetrabromobisphenol A M200033

 

CASRN: 79-94-7

Formula: C15-H12-Br4-O2

Synonyms/Common Names

  • Phenol, 4,4'-(1-methylethylidene)bis(2,6-dibromo (9CI)
  • TBBPA

Known Uses

Flame retardant for plastics, paper, and textiles.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C20033B)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 4, 8, 16, 125, 250, 500, 1000, or 2000 mg/kg; N=4.
  • 13 weeks (Gavage)  (C20033)  Completed 
    • Toxicogenomics
    • Citation: Sanders JM, Coulter SJ, Knudsen GA, Dunnick JK, Kissling GE, Birnbaum LS. Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A. Toxicol Appl Pharmacol. 2016;298:31-39
    • Rats: Wistar Han
    • Dose: 0, 25, 250, or 1000 mg/kg.
  • 13 weeks (Gavage)  (C20320)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1/N
    • Dose: R&M: 0, 10, 50, 100, 500, or 1000 mg/kg; R: 20/sex/dose; M: 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20320)  Completed 
    • TR-587 (NIH Number: 14-5929)  (Peer Review Approval 10/29/2013A )
      Toxicology Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
    • Rats: Wistar Han; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 250, 500, or 1000 mg/kg; 50/sex/species/dose.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0897)  Completed 
    • Citation: Chemical Disposition in Mammals. Final Report on: Tetrabromobisphenol A (TBBPA). October 1, 2004 - December 31, 2004.
    • Male Rats: F344/N
    • Dose: 2, 20, or 200 mg/kg; 20 mg/kg, 50 uCi/kg, 1 ml/kg.
  • C. elegans  (W20033)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans: N2
    • Dose: Feeding: 0, 2, 3.2, 5, 7.9, 13, 20, 32, 50, 79, 130, 200uMRepro: 0, 2, 3.2, 5, 7.9, 13, 20, 32, 50, 79, 130, 200uMGrowth: 0, 0.2, 0.4, 0.8, 1.6, 3.2, 6.3, 13, 25, 50, 100, 200uM.

Genetic Toxicology

  • Micronucleus  (A13260)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (968573)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (G20033)  Completed 
    •  Negative 

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T20033B)  Assigned 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
  • 13 weeks Microarray Analysis (Gavage)  (T20033)  Completed 
    • Microarray and RT-PCR
    • Rats: Wistar Han
    • Dose: 0, 25, 250, or 1000 mg/kg; 25 rats/group.