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Testing Status of Cumene hydroperoxide M200035

 

CASRN: 80-15-9

Formula: C9-H12-O2

Synonyms/Common Names

  • Hydroperoxide, 1-methyl-1-phenylethyl
  • Hyperiz
  • Isopropylbenzene hydroperoxide
  • Kayacumene H
  • 1-methyl-1-phenylethylhydroperoxide
  • Percumyl H
  • 2-Phenyl-2-propyl Hydroperoxide
  • R 239A
  • Trigonox K 80

Known Uses

Captive chemical intermediate for phenol and acetone. Curing agent for polyester resins. used as an initiator for polymerization of styrene & acrylic monomer & a chemical intermediate for the cross-linking agent, dicumyl peroxide. (exec sum)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C99029)  Completed 
    • Citation: Rider CV, Chan P, Herbert RA, Kissling GE, Fomby LM, Hejtmancik MR, Witt KL, Waidyanatha S, Travlos GS, Kadiiska MB. Dermal exposure to cumene hydroperoxide: Assessing its toxic relevance and oxidant potential. Toxicol Pathol. 2016 Jul;44(5):749-762
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 6.25, 12.5, 25, 50, or 100 mg/kg; 5/sex/species/dose.
  • 13 weeks (Topical Application)  (C99029)  Completed 
    • Citation: Rider CV, Chan P, Herbert RA, Kissling GE, Fomby LM, Hejtmancik MR, Witt KL, Waidyanatha S, Travlos GS, Kadiiska MB. Dermal exposure to cumene hydroperoxide: Assessing its toxic relevance and oxidant potential. Toxicol Pathol. 2016 Jul;44(5):749-762
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.75, 1.5, 3, 6, or 12 mg/kg; R: 20/sex/dose; M: 10/sex/dose.

Genetic Toxicology

  • Micronucleus  (A82256)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (009474)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (A97584)  Completed 
    •  Positive