National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m200035

Testing Status of Cumene hydroperoxide - M200035

 

CASRN: 80-15-9

Formula: C9-H12-O2

Synonyms/Common Names

  • Hydroperoxide, 1-methyl-1-phenylethyl
  • Hyperiz
  • Isopropylbenzene hydroperoxide
  • Kayacumene H
  • 1-methyl-1-phenylethylhydroperoxide
  • Percumyl H
  • 2-Phenyl-2-propyl Hydroperoxide
  • R 239A
  • Trigonox K 80

Known Uses

Captive chemical intermediate for phenol and acetone. Curing agent for polyester resins. used as an initiator for polymerization of styrene & acrylic monomer & a chemical intermediate for the cross-linking agent, dicumyl peroxide. (exec sum)

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C99029)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 6.25, 12.5, 25, 50, OR 100 MG/KG; 5/SEX/SPECIES/DOSE.
  • 13 weeks (Topical Application)  (C99029)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Genetic Toxicology

  • Micronucleus  (A82256)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (009474)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (A97584)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.