National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m200069

Testing Status of Triclocarban - M200069

 

CASRN: 101-20-2

Formula: C13-H9-Cl3-N2-O

Synonyms/Common Names

  • Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)- (9CI)

Known Uses

Antibacterial agent. Disinfectant.

Chemical Properties

Toxicity Effects (HSDB)

Planned Carcinogenicity/Toxicity

  • 2 weeks (Gavage)  (C20069)   
    • Mice: B6C3F1

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Gavage)  (MOG20069)  Assigned 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 90, 175, 350, or 700 mg/kg/day.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dermal; Gavage)  (K20069)  On Test 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
  • C. elegans  (W20069)  Completed 
    • C. elegans

Genetic Toxicology

  • Salmonella  (221813)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
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