Testing Status of Thiophene M200091

 

CASRN: 110-02-1

Formula: C4-H4-S

Synonyms/Common Names

  • Thiotetrole

Known Uses

Chemical intermediate. Organic synthesis. Solvent. Pharmaceuticals. Found in coal tar, coal gas & benzene. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C61950)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: RATS AND MICE: 0, 500, 1000, 2000, 4000, OR 8000 PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0131)  Completed 
    • Citation: Nomeir AA, Markham PM, Chadwick M. Pulmonary absorption and disposition of [14C]thiophene in rats following nose-only inhalation exposure. J Toxicol Environ Health. 1993 Jun;39(2):223-36.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 8000 PPM X 60 MIN NOSE CHAMBER.

Genetic Toxicology

  • Salmonella  (099804)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (764327)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative