Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Thiophene M200091

 

CASRN: 110-02-1

Formula: C4-H4-S

Synonyms/Common Names

  • Thiotetrole

Known Uses

Chemical intermediate. Organic synthesis. Solvent. Pharmaceuticals. Found in coal tar, coal gas & benzene. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C61950)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: RATS AND MICE: 0, 500, 1000, 2000, 4000, OR 8000 PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0131)  Completed 
    • Citation: Nomeir AA, Markham PM, Chadwick M. Pulmonary absorption and disposition of [14C]thiophene in rats following nose-only inhalation exposure. J Toxicol Environ Health. 1993 Jun;39(2):223-36.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 8000 PPM X 60 MIN NOSE CHAMBER.

Genetic Toxicology

  • Salmonella  (099804)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (764327)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative