National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20102

Testing Status of 3,3,5-Trimethylcyclohexyl salicylate - M20102

 

CASRN: 118-56-9

Formula: C16-H22-O3

Synonyms/Common Names

  • Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester (9CI)
  • Homosalate

Known Uses

UV filter in sunscreens.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • 3 days Hershberger Assay (Gavage)  (K20102B)  Completed 
    • Citation: FINAL Report: The Hershberger Bioassay for Padimate-O and Homosalate 07 November 2012
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 320, 1000.
  • 3 days Uterotrophic Assay (Gavage)  (K20102)  Completed 
    • Citation: FINAL Report: The Uterotrophic Assay with Avobenzone, Ensulizole, Homosalate, and Padimate-O 07 November 2012
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 320, 1000.

Genetic Toxicology

  • Salmonella  (216212)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

in vitro Testing

  • Androgen Receptor Binding Assay  (V20102)  Completed 
    • Androgen Receptor Binding [ARB] (Rat Prostate Cytosol)
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