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Testing Status of Methacrylonitrile M20116

 

CASRN: 126-98-7

Formula: C4-H5-N

Synonyms/Common Names

  • MAN
  • 2-Propenenitrile, 2-methyl- (9CI)

Known Uses

Homo- and co-polymers, elastomers, coatings and plastics. Chemical intermediate. Replacement for acrylonitrile in certain uses. (NTP executive summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C88050)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.3, 0.6, 1.2, 2.4, 4.8 G/L; M: 0, 0.15, 0.3, 0.6, 1.2, 2.4 G/L; 5/GRP.
  • 13 weeks (Gavage)  (C88050)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 7.5, 15.0, 30.0, 60.0, 120.0 MG/KG/DAY; M: 0, 0.75, 1.5, 3.0, 6.0, 12.0 MG/KG/DAY; RATS: 20/GRP; MICE: 10/GRP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C88050B)  Completed 
    • TR-497 (NIH Number: 02-4431)  (Peer Review Approval 05/03/2001A )
      Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: RATS: 0, 3, 10, OR 30 MG/KG MICE: 0, 1.5, 3, OR 6 MG/KG; 50/SEX/DOSE/SPECIES.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0679)  Completed 
    • Citation: Ghanayem BI, Sanchez IM, Burka LT. Effects of dose, strain, and dosing vehicle on methacrylonitrile disposition in rats and identification of a novel-exhaled metabolite. Drug Metab Dispos. 1992 Sep-Oct;20(5):643-52.Pubmed Abstract
    • Male Rats: F344/N; Male Rats: Sprague Dawley
    • Dose: 1.15, 11.5, 115 mg/kg.
  • Absorption Disposition Metabolism Elimination  (S0730)  Completed 
    • Citation: Burka LT, Sanchez IM, Ahmed AE, Ghanayem BI. Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats. Arch Toxicol. 1994;68(10):611-8.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism  (S0727)  Completed 
    • Citation: Ghanayem BI, Burka LT. Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats. Drug Metab Dispos. 1996 Apr;24(4):390-4.Pubmed Abstract
    • Male Rats: F344/N
  • Other  (S0728)  Completed 
    • Citation: Demby KB, White TC, Ghanayem BI. Determination of methacrylonitrile in serum using gas chromatography and flame ionization detection. J Chromatogr. 1992 Aug 7;579(1):153-7.Pubmed Abstract
  • Toxicokinetic Study  (S0729)  Completed 
    • Citation: Demby KB, Sanchez IM, Ghanayem BI. Single dose blood toxicokinetics of methacrylonitrile in the F344 rat. Toxicol Appl Pharmacol. 1993 Mar;119(1):115-21.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Drosophila  (042416)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A05400)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A38969)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A63179)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (799133)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (926215)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 16 weeks Continuous Breeding (Legacy) (Gavage)  (RACB94019)  Completed 
    • Citation: Reproductive Toxicity of Methacrylonitrile (CAS # 125-98-7) Administered in Diet to Sprague-Dawley Rats
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 2, 7, OR 20 MG/KG.
  • Conventional Teratology (Gavage)  (TER92117)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats
    • Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 0, 5, 25, 50 MG/KG GD: 6-15.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER92122)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in New Zealand White Rabbits
    • Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 0, 1, 3, 5 MG/KG/DAY.
  • Teratology Pilot Studies (Gavage)  (TRP91020)  Completed 
    • Rabbit: New Zealand White
    • Dose: 0, 5, 10, 25, 50, 75 MG/KG.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP91021)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 10, 50, 75, 100, 125 MG/KG.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP92058)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0 OR 7.5 MG/KG.