National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20124

Testing Status of Diazoaminobenzene - M20124

 

CASRN: 136-35-6

Formula: C12-H11-N3

Synonyms/Common Names

  • DAAB
  • 1-Triazene, 1,3-diphenyl-

Known Uses

Diazoaminobenzene is used as an intermediate, complexing agent, and polymer additive. It is also an impurity in certain color additives used in cosmetics, food products, and pharmaceuticals. Organic synthesis. Dyes. Insecticide.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C96002)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 12.5, 25, 50, 100, OR 200 MG/KG B.W..

Special Studies

  • Toxicokinetic Study (Dosed-Feed)  (S0638)  Completed 
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: oral: 20 mg/kg dermal: 2, 20 mg/cm2 iv: 2 mg/kg.

Genetic Toxicology

  • Micronucleus  (A64807)  Completed 
    • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A72640)  Completed 
    • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (529702)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

in vitro Testing

  • Bovine Corneal Opacity and Premeability Assay (Gavage)  (IVT20003A)  Completed 
    • Mice: B6C3F1
  • Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model (Gavage)  (IVT20003B)  Completed 
    • Mice: B6C3F1
  • Alternate (Intravenous)  (IVT20003B)  Completed 
    • Rats: F344/N
  • Alternate (Gavage)  (IVT20003C)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
  • Alternate (Dosed-Feed)  (IVT20003D)  Completed 
    • Mice: B6C3F1
  • Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes (Dosed-Feed)  (IVT20003D)  Completed 
    • Rats: F344/N
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.