National Toxicology Program

National Toxicology Program

Testing Status of 2-Aminopyridine - M20139


CASRN: 504-29-0

Formula: C5-H6-N2

Synonyms/Common Names

  • o-Aminopyridine
  • 2-Pyridinamine (9CI)
  • 2-Pyridylamine

Known Uses

Intermediate in the manufacture of pharmaceuticals, particularly antihistamines & piroxicam. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14 days (Gavage)  (C20139)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R&M: 0, 3.125, 6.25, 12.5, 25, or 50 mg/kg -- Study I and 0, 25, or 50 mg/kg -- Study II.

Special Studies

  • C. elegans  (W20139)  Completed 
    • C. elegans

Genetic Toxicology

  • Salmonella  (393331)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.