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Testing Status of Benzidine dihydrochloride M20140

 

CASRN: 531-85-1

Formula: C12-H12-N2.2Cl-H

Synonyms/Common Names

  • (1,1'-Biphenyl)-4,4'-diamine, dihydrochloride

Known Uses

Used in making dyes

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Dosed-Water)  (C03361)  Completed 
    • Rats: F344/N

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0009)  Completed 
    • Citation: Morgan DL, Dunnick JK, Goehl T, Jokinen MP, Matthews HB, Zeiger E, and Mennear JH. Summary of the National Toxicology Program benzidine dye initiative. Environ Health Perspect. 1994 Jun; 102(Suppl 2): 63–78.Pubmed Abstract
    • Male Rats: F344/N; Dog

Genetic Toxicology

  • Chromosome Aberrations  (758694)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (445801)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (011624)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (018793)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Micronucleus  (374298)  Completed 
    •  Positive 
  • Salmonella  (689954)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Sister Chromatid Exchanges  (758694)  Completed 
    • Mice
    • Sister Chromatid  Positive