National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20170

Testing Status of Phenformin hydrochloride - M20170

 

CASRN: 834-28-6

Related: PHENFORMIN 114-86-3

Formula: C10-H15-N5.Cl-H

Synonyms/Common Names

  • Imidodicarbonimidic diamine, N-(2-phenethyl)-, monohydrochloride (9CI)

Known Uses

Hypoglycemic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01741)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01741)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 300, 6000, M: 0, 500, 10000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01741)  Report Complete 
    • TR-007 (NIH Number: 77-807)  (Peer Review Approval 03/25/1977A )
      Bioassay of Phenformin for Possible Carcinogenicity (CASRN 114-86-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 400, 800, M: 0, 1200, 2500 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (208878)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (075668)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (218914)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
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