National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20172

Testing Status of N-Methyl-2-pyrrolidone - M20172

 

CASRN: 872-50-4

Formula: C5-H9-N-O

Synonyms/Common Names

  • 1-Methyl-2-pyrrolidinone (8CI)(9CI)

Known Uses

Solvent, pigment dispersant, petroleum processing, intermediate (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0263)  Completed 
    • Male Rats: F344/N
  • Metabolism (Topical Application)  (S0200)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Salmonella  (309283)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (750004)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
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