National Toxicology Program

Testing Status of Divinylbenzene - M20182

CASRN: 1321-74-0

Formula: C10-H10

Synonyms/Common Names

• Benzene, diethenyl-

Known Uses

Cross-linking monomer for copolymerization with styrene or with acrylic or methacrylic acid to produce ion-exchange resins used in home, municipal and industrial water treatment and in chemical, food and pharmaceutical processing. Used in styrene-butadiene rubber to improve the swelling, shrinkage, and extrusion properties. Used in the manufacture of drying oils & contact lenses.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

• 2 weeks (Inhalation)  (C88004B)  Completed 
  • Rats: F344/N; Mice: B6C3F1/N
  • Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM; 5/SEX/SPECIES.
• 2 weeks (Inhalation)  (C88004)  Completed 
  • Rats: Harlan Sprague-Dawley
• 13 weeks (Inhalation)  (C88004B)  Completed 
  • Rats: F344/N; Mice: B6C3F1/N
  • Dose: R: 0, 25, 50, 100, 200, OR 400 PPM M: 0, 12.5, 25, 50, 100, OR 200 PPM; 10/SEX/SPECIES/GROUP.

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C88004B)  Report Complete 
  • TR-534 (NIH Number: 07-4470)  (Peer Review Approval 09/27/2005A )
    Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1/N
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice Equivocal Evidence 
  • Dose: R: 0, 100, 200, OR 400 PPM M: 0, 10, 30, OR 100 PPM.

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0149)  Completed 
  • Male Rats: F344/N
  • Dose: RPT DOSE:200, 400MG/KG-11DAYS; 40, 400, 1200, 2000.
• 6 hour nose only inhalations Absorption Disposition Metabolism Elimination (Inhalation)  (S0619)  Completed 
  • Male Rats: Fischer 344
  • Dose: IV only preliminary TK.
• Absorption Disposition Metabolism Elimination (Intravenous)  (S0619)  Completed 
  • Male Rats: Fischer 344; Male Mice: B6C3F1
  • Dose: IV only preliminary TK.
• Metabolism (Gavage)  (S0666)  Completed 
  • Citation: Comparative Metabolism of [14C] M-Divinylbenzene (MDVB) in Liver Tissue Slices from Rats, Mice and Humans.
  • Male Rats: F344/N; Male Mice: B6C3F1
  • Dose: 1200 mg mDVB/kg for rats.

Genetic Toxicology

• Micronucleus  (A22394)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (281912)  Completed 
  • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
  •  Negative 
• Salmonella  (563294)  Completed 
  • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
  •  Negative 
• Salmonella  (A67622)  Completed 
  •  Negative