Testing Status of Divinylbenzene M20182
CASRN: 1321-74-0
Formula: C10-H10
Synonyms/Common Names
- Benzene, diethenyl-
Known Uses
Cross-linking monomer for copolymerization with styrene or with acrylic or methacrylic acid to produce ion-exchange resins used in home, municipal and industrial water treatment and in chemical, food and pharmaceutical processing. Used in styrene-butadiene rubber to improve the swelling, shrinkage, and extrusion properties. Used in the manufacture of drying oils & contact lenses.
Chemical Properties
Toxicity Effects (HSDB)
Short-Term Toxicity
- 2 weeks (Inhalation)
(C88004B)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM; 5/SEX/SPECIES.
- 2 weeks (Inhalation)
(C88004)
Completed
- Rats: Harlan Sprague-Dawley
- 13 weeks (Inhalation)
(C88004B)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R: 0, 25, 50, 100, 200, OR 400 PPM M: 0, 12.5, 25, 50, 100, OR 200 PPM; 10/SEX/SPECIES/GROUP.
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C88004B)
Completed
- TR-534 (NIH Number: 07-4470)
(Peer Review Approval 09/27/2005A )
Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice Equivocal Evidence
- Dose: R: 0, 100, 200, OR 400 PPM M: 0, 10, 30, OR 100 PPM.
- TR-534 (NIH Number: 07-4470)
(Peer Review Approval 09/27/2005A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0149)
Completed
- For this ADME study, a purified isomer, meta-Divinylbenzene CASRN 108-57-6 was used.
- Male Rats: F344/N
- Dose: RPT DOSE: 200, 400MG/KG-11 DAYS; 40, 400, 1200, 2000.
- 6 hour nose only inhalations Absorption Disposition Metabolism Elimination (Inhalation)
(S0619)
Completed
- Male Rats: Fischer 344
- Dose: IV only preliminary TK.
- Absorption Disposition Metabolism Elimination (Intravenous)
(S0619)
Completed
- Male Rats: Fischer 344; Male Mice: B6C3F1
- Dose: IV only preliminary TK.
- Metabolism (Gavage)
(S0666)
Completed
- Citation: Comparative Metabolism of [14C] M-Divinylbenzene (MDVB) in Liver Tissue Slices from Rats, Mice and Humans.
- Male Rats: F344/N; Male Mice: B6C3F1
- Dose: 1200 mg mDVB/kg for rats.
Genetic Toxicology
- Micronucleus
(A22394)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(281912)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Negative
- Salmonella
(563294)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Negative
- Salmonella
(A67622)
Completed
- Negative