National Toxicology Program

National Toxicology Program

Testing Status of Isophorone diisocyanate - M20231


CASRN: 4098-71-9

Formula: C12-H18-N2-O2

Synonyms/Common Names

  • Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl- (9CI)
  • Isocyanic acid
  • Methylene(3,5,5-trimethyl-3,1-cyclohexylene)ester

Known Uses

Solvent for lacquers, plastics

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (225422)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 5 days Immunotoxicity (Topical Application)  (IMM90001)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Assessment of Contact Hypersensitivity to Isophorone Diisocyanate in Female B6C3F1 Mice
    • Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Female Mice: B6C3F1
    • Mice Female Positive 
    • Dose: 0, 0.1, 0.3, OR 1.0% TREATMENT AND 3.0% CHALLENGE.
  • Immunotoxicity (Topical Application)  (IMM90027)  Completed 
    • Female Guinea Pigs: Hartley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.