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Testing Status of 2-Ethylhexyl p-Methoxycinnamate M20239

 

CASRN: 5466-77-3

Formula: C18-H26-O3

Synonyms/Common Names

  • EHMC
  • 2-Ethylhexyl methoxycinnamate
  • Octinoxate
  • 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester (9CI)

Known Uses

Sunscreen, found in lip balms

Chemical Properties

Toxicity Effects (HSDB)

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Dosed-Feed)  (MOG003)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 2250, 5000, 10000 or 20000 ppm.
  • Developmental Toxicity (Dosed-Feed)  (MOG003B)  Completed 
    • Prenatal Developmental Toxicity
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 3000, or 6000 ppm.
  • F0 Generation (Dosed-Feed)  (MOG003B)  Completed 
    • F0 Generation
    • Rats: Harlan Sprague-Dawley
  • Fertility Assessment (Dosed-Feed)  (MOG003B)  Completed 
    • Fertility Assessment
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 3000, or 6000 ppm.
  • 13-Week Subchronic (Dosed-Feed)  (MOG003B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 3000, or 6000 ppm.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dermal; Gavage; Intravenous)  (K20239)  Completed 
    • Citation: Fennell TR, Mathews JM, Snyder RW, Hong Y, Watson SL, Black SR, McIntyre BS, Waidyanatha S. Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro. Xenobiotica. 2018 Nov;48(11):1142-1156. doi: 10.1080/00498254.2017.1400129. Epub 2017 Nov 23.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 0.8, 8, 80 mg/kg. 8 mg/kg. 8, 80, 800 mg/kg.
  • 3 days Hershberger Assay (Gavage)  (K20239D)  Completed 
    • Citation: Final Report: The Hershberger Bioassay; Oxybenzone, Octylmethoxycinnamate, Octylsalate, Octocrylene. 04 January 2012
    • Male Rats: Harlan Sprague-Dawley
    • Dose: 0, 100, 320, 1000 mg/kg.
  • Preliminary Toxicokinetic Study (Dosed-Feed; Gavage; Intravenous)  (K20239E)  Report Review 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 20, 000 ppm. 8 mg/kg. 80, 800 mg/kg.
  • 3 days Uterotrophic Assay (Gavage)  (K20239C)  Completed 
    • Citation: Final Report. The Uterotrophic Assay with Oxybenzone, Octylmethoxycinnamate, Octylsalate and Octocrylene. 01 September 2011 Revised: 20 April 2012
    • Female Rats: Sprague Dawley
    • Dose: 0, 320, 1000 mg/kg.

Genetic Toxicology

  • Micronucleus  (G20239B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (201557)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (G20239)  Completed 
    •  Negative 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (I20239)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 2.5%, 5.0%, 10%, 25%, 50%.

in vitro Testing

  • Androgen Receptor Binding Assay  (V20239B)  Completed 
    • Androgen receptor Binding Assay
  • Estrogen Receptor Binding Assay  (V20239C)  Completed 
    • Estrogen Receptor Binding Assay
  • H295R Steroidogenesis Assay  (V20239)  Completed 
    • H295R Steroidogenesis Assay
  • Androgen Receptor Transactivation Assay  (V20239D)  Completed 
    • Androgen Receptor Transactivation Assay
  • Estrogen Receptor Transactivation Assay  (V20239E)  Completed 
    • Estrogen Receptor Transactivation Assay
  • Human Recombinant Aromatase Assay  (V20239G)  Completed 
    • Human Recombinant Aromatase Assay