National Toxicology Program

Testing Status of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate - M20247

CASRN: 6197-30-4

Formula: C24-H27-N-O2

Synonyms/Common Names

• Octocrylene
• 2-Propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester (9CI)

Known Uses

Sunscreen. UV stabilizer.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

• 3 days Hershberger Assay (Gavage)  (K20247B)  Completed 
  • Citation: Final Report: The Hershberger Bioassay; Oxybenzone, Octylmethoxycinnamate, Octylsalate, Octocrylene. 04 January 2012
  • Male Rats: Harlan Sprague-Dawley
  • Dose: 20, 64, or 200 mg/ml.
• 3 days Uterotrophic Assay (Gavage)  (K20247)  Completed 
  • Citation: Final Report. The Uterotrophic Assay with Oxybenzone, Octylmethoxycinnamate, Octylsalate and Octocrylene. 01 September 2011 Revised: 20 April 2012
  • Female Rats: Harlan Sprague-Dawley
  • Dose: 5 mL/kg.

Genetic Toxicology

• Salmonella  (066654)  Completed 
  • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
  •  Negative 

in vitro Testing

• Androgen Receptor Binding Assay  (V20247B)  Completed 
  • Androgen Receptor Binding Assay
• Estrogen Receptor Binding Assay  (V20247C)  Completed 
  • Estrogen Receptor Binding Assay
• H295R Steroidogenesis Assay  (V20247)  Completed 
  • H295R Steroidogenesis Assay
• Androgen Receptor Transactivation Assay  (V20247D)  Completed 
  • Androgen Receptor Transactivation Assay
• Estrogen Receptor Transactivation Assay  (V20247E)  Completed 
  • Estrogen Receptor Transactivation Assay
• Human Recombinant Aromatase Assay  (V20247G)  Completed 
  • Human Recombinant Aromatase Assay