Testing Status of Tris(Chloropropyl)phosphate M20263

 

CASRN: 13674-84-5

Formula: C9-H18-Cl3-O4-P

Synonyms/Common Names

  • 2-Propanol, 1-chloro-, phosphate (3:1) (9CI)
  • TCPP
  • Tris(2-chloroisopropyl)phosphate

Known Uses

Flame retardant; commercially used mixture

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C20263)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 18.75, 37.5, 75, 150, 300, 600, 1000, or 2000 mg/kg; N=4.
  • 90 days (Dosed-Feed)  (C20712)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 2500, 5000, 10000, 20000, or 40000 ppm (perinatal only); Mice: 0, 1250, 2500, 5000, 10000, or 20000 ppm; 10/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C20712)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 2500, 5000, 10,000 or 20,000 ppm; Male mice: 0, 1250, 2500, or 5000 ppm; Female mice: 0, 2500, 5000 or 10,000 ppm; 50/sex/species/group.

Special Studies

  • 14 days Palatability (Dosed-Feed)  (K20263B)  Completed 
    • Male and Female Rats: Wistar Han; Male and Female Mice: B6C3F1
    • Dose: 0, 30, 000, 40, 000, and 50, 000 ug/g/day.
  • Preliminary Toxicokinetic Study (Gavage; Intravenous)  (K20263)  Report Draft 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: PTKS11357 [oral]: 100 mg/kg bwt. TKS: 50, 100, 500 mg/kgPTKS: CHEM11357 / MRI2125PBSA: CHEM11865 / MRI2278 (TCPP)PBSA: CHEM12014 / MRI2343 (BCPP). PTKS11357 [oral]: 100 mg/kg bwt. TKS: 50, 100, 500 mg/kgPTKS: CHEM11358 / MRI2126PBSA: CHEM11976 / MRI2324 (TCPP)PBSA: CHEM12107 / MRI2387 (BCPP). PTKS11358 [IV]: 4 mg/kg bwt. TKS: 4.0 mg/kgPTKS: CHEM11357 / MRI2125PBSA: CHEM11865 / MRI2278 (TCPP)PBSA: CHEM12014 / MRI2343 (BCPP). PTKS11358 [IV]: 4 mg/kg bwt. TKS: 4.0 mg/kgPTKS: CHEM11358 / MRI2126PBSA: CHEM11976 / MRI2324 (TCPP)PBSA: CHEM12107 / MRI2387 (BCPP).

Genetic Toxicology

  • Micronucleus  (G20263B)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Negative 
  • Micronucleus  (G20263)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (815918)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (G20263C)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to GD 20 Developmental Toxicity (Gavage)  (R20263B)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 162.5, 325, or 650 mg/kg/day.
  • GD 6 - PND 127 Immunotoxicity (Dosed-Feed)  (I20263)  On Test 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 2500, 5000, or 10000 ppm.
  • ~ 15 days Teratology Pilot Studies (Gavage)  (R20263)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 300, 650, or 1, 000 mg/kg/day.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T20263)  Assigned 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley