National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20292

Testing Status of 1,2-Bis(2,4,6-tribromophenoxy)ethane - M20292

 

CASRN: 37853-59-1

Formula: C14-H8-Br6-O2

Synonyms/Common Names

  • Benzene, 1,1'-(1,2-ethanediylbis(oxy))bis(2,4,6-tribromo- (9CI)
  • 1,2-Bis(2,4,6-tribromophenoxy)ethane
  • BTBPE
  • Firemaster 680
  • Flame Retardant 2

Known Uses

In flame retardants

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C20292)  On Test 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0141)  Completed 
    • Citation: Nomeir AA, Markham PM, Ghanayem BI, Chadwick M. Disposition of the flame retardant 1,2-bis(2,4,6-tribromophenoxy)ethane in rats following administration in the diet. Drug Metab Dispos. 1993 Mar-Apr;21(2):209-14.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Salmonella  (068726)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Dosed-Feed)  (NTA94037)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T20292)  Assigned 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
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