Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 1,2-Bis(2,4,6-tribromophenoxy)ethane M20292

 

CASRN: 37853-59-1

Formula: C14-H8-Br6-O2

Synonyms/Common Names

  • Benzene, 1,1'-(1,2-ethanediylbis(oxy))bis(2,4,6-tribromo- (9CI)
  • 1,2-Bis(2,4,6-tribromophenoxy)ethane
  • BTBPE
  • Firemaster 680
  • Flame Retardant 2

Known Uses

In flame retardants

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C20292)  Data in Review 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0141)  Completed 
    • Citation: Nomeir AA, Markham PM, Ghanayem BI, Chadwick M. Disposition of the flame retardant 1,2-bis(2,4,6-tribromophenoxy)ethane in rats following administration in the diet. Drug Metab Dispos. 1993 Mar-Apr;21(2):209-14.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.05, 0.5, 5% IN FEED.

Genetic Toxicology

  • Comet Assay Selected (G20292)  
    • Salmonella  (068726)  Completed 
      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
      •  Negative 

    Organ Systems Toxicity

    • Neurotoxicology Assessment (Dosed-Feed)  (NTA94037)  Completed 
      • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
      • Male and Female Rats/Mice: F344/N

    Toxicogenomics

    • 5 days Microarray Analysis (Gavage)  (T20292)  Data in Review 
      • Rats: Hsd:Sprague Dawley SD
      • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.